ATE431818T1 - Verfahren zur herstellung von fluvastatin-natrium - Google Patents

Verfahren zur herstellung von fluvastatin-natrium

Info

Publication number: ATE431818T1
Authority: AT; Austria
Prior art keywords: fluvastatin sodium; sodium salt; producing; producing fluvastatin; isomer
Prior art date: 2006-04-20

Application number

AT06112856T

Other languages

English (en)

Inventor

Marco Fachini

Original Assignee

Italiana Sint Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-20

Filing date

2006-04-20

Publication date

2009-06-15

2006-04-20 Application filed by Italiana Sint Spa filed Critical Italiana Sint Spa

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE431818T1 publication Critical patent/ATE431818T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 title 1
229960000868 fluvastatin sodium Drugs 0.000 title 1
FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 abstract 2
229960003765 fluvastatin Drugs 0.000 abstract 2
230000007062 hydrolysis Effects 0.000 abstract 2
238000006460 hydrolysis reaction Methods 0.000 abstract 2
125000005907 alkyl ester group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)

AT06112856T 2006-04-20 2006-04-20 Verfahren zur herstellung von fluvastatin-natrium ATE431818T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06112856A EP1847529B1 (de)	2006-04-20	2006-04-20	Verfahren zur Herstellung von Fluvastatin-Natrium

Publications (1)

Publication Number	Publication Date
ATE431818T1 true ATE431818T1 (de)	2009-06-15

Family

ID=36972889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06112856T ATE431818T1 (de)	2006-04-20	2006-04-20	Verfahren zur herstellung von fluvastatin-natrium

Country Status (5)

Country	Link
US (1)	US7662848B2 (de)
EP (1)	EP1847529B1 (de)
AT (1)	ATE431818T1 (de)
DE (1)	DE602006006899D1 (de)
ES (1)	ES2327668T3 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010118757A1 (en) *	2009-04-15	2010-10-21	Pharmathen S.A.	Improved process for the preparation of fluvastatin and salts thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4739073A (en) *	1983-11-04	1988-04-19	Sandoz Pharmaceuticals Corp.	Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
HU204253B (en)	1982-11-22	1991-12-30	Sandoz Ag	Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them
JP2853227B2 (ja)	1988-10-13	1999-02-03	ノバルテイス・アクチエンゲゼルシヤフト	７置換‐ヘプト‐６‐エン酸、ヘプタン酸及び誘導体並びにそれらの中間体の製法
WO1997049681A1 (en)	1996-06-24	1997-12-31	Astra Aktiebolag (Publ)	Polymorphic compounds
CN1217930C (zh) *	2000-05-26	2005-09-07	西巴特殊化学品控股有限公司	吲哚衍生物的制备方法和该方法的中间体
JP4037898B2 (ja) *	2003-06-18	2008-01-23	テバファーマシューティカルインダストリーズリミティド	フルバスタチンナトリウム結晶形ｘｉｖ、ｌｘｘｉｉｉ、ｌｘｘｉｘ、ｌｘｘｘ及びｘｘｘｖｉｉ型、それらの調製方法、それらを含有する組成物及びそれらの使用方法
CA2550742A1 (en) *	2003-12-24	2005-07-14	Teva Pharmaceutical Industries Ltd.	Process for preparation of statins with high syn to anti ratio

2006
- 2006-04-20 AT AT06112856T patent/ATE431818T1/de not_active IP Right Cessation
- 2006-04-20 DE DE602006006899T patent/DE602006006899D1/de not_active Expired - Lifetime
- 2006-04-20 ES ES06112856T patent/ES2327668T3/es not_active Expired - Lifetime
- 2006-04-20 EP EP06112856A patent/EP1847529B1/de not_active Expired - Lifetime
2007
- 2007-04-19 US US11/785,702 patent/US7662848B2/en active Active

Also Published As

Publication number	Publication date
ES2327668T3 (es)	2009-11-02
US20070249704A1 (en)	2007-10-25
EP1847529A1 (de)	2007-10-24
EP1847529B1 (de)	2009-05-20
DE602006006899D1 (de)	2009-07-02
US7662848B2 (en)	2010-02-16

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Legal Events

Date	Code	Title	Description
2009-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties