ATE519765T1 - Verfahren zur herstellung von 3-hydroxymorphinan- derivaten - Google Patents
Verfahren zur herstellung von 3-hydroxymorphinan- derivatenInfo
- Publication number
- ATE519765T1 ATE519765T1 AT09717537T AT09717537T ATE519765T1 AT E519765 T1 ATE519765 T1 AT E519765T1 AT 09717537 T AT09717537 T AT 09717537T AT 09717537 T AT09717537 T AT 09717537T AT E519765 T1 ATE519765 T1 AT E519765T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- derivatives
- hydroxymorphinan
- hydroxymorphinan derivatives
- methoxymorphinan
- Prior art date
Links
- IYNWSQDZXMGGGI-NUEKZKHPSA-N 3-hydroxymorphinan Chemical class C1CCC[C@H]2[C@H]3CC4=CC=C(O)C=C4[C@]21CCN3 IYNWSQDZXMGGGI-NUEKZKHPSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- ILNSWVUXAPSPEH-USXIJHARSA-N 3-methoxy-morphinan Chemical class C1CCC[C@H]2[C@H]3CC4=CC=C(OC)C=C4[C@]21CCN3 ILNSWVUXAPSPEH-USXIJHARSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3243508P | 2008-02-29 | 2008-02-29 | |
| PCT/US2009/034343 WO2009111162A1 (en) | 2008-02-29 | 2009-02-18 | Process for the preparation of 3-hydroxymorphinan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519765T1 true ATE519765T1 (de) | 2011-08-15 |
Family
ID=40580910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09717537T ATE519765T1 (de) | 2008-02-29 | 2009-02-18 | Verfahren zur herstellung von 3-hydroxymorphinan- derivaten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7999105B2 (de) |
| EP (2) | EP2250175B1 (de) |
| AT (1) | ATE519765T1 (de) |
| CA (1) | CA2716944A1 (de) |
| WO (1) | WO2009111162A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9969746B2 (en) | 2013-12-05 | 2018-05-15 | The University Of Bath | Opioid compounds and their uses |
| ES2701855T3 (es) | 2016-05-31 | 2019-02-26 | Alcaliber Investig Desarrollo E Innovacion Slu | Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina |
| SK592017A3 (sk) | 2017-07-04 | 2019-01-08 | Saneca Pharmaceuticals A. S. | Spôsob prípravy morfínanových zlúčenín |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451470A (en) | 1982-07-06 | 1984-05-29 | E. I. Du Pont De Nemours And Company | Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| CA2256336C (en) | 1997-03-31 | 2008-01-29 | Toray Industries, Inc. | Quinolinomorphinan derivative and medical use thereof |
| US6177567B1 (en) | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| GB0421149D0 (en) | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
-
2009
- 2009-02-18 EP EP09717537A patent/EP2250175B1/de active Active
- 2009-02-18 WO PCT/US2009/034343 patent/WO2009111162A1/en not_active Ceased
- 2009-02-18 EP EP10015264.4A patent/EP2319845B1/de active Active
- 2009-02-18 AT AT09717537T patent/ATE519765T1/de not_active IP Right Cessation
- 2009-02-18 CA CA2716944A patent/CA2716944A1/en not_active Abandoned
- 2009-02-18 US US12/372,788 patent/US7999105B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009111162A1 (en) | 2009-09-11 |
| US20090221825A1 (en) | 2009-09-03 |
| EP2250175A1 (de) | 2010-11-17 |
| EP2250175B1 (de) | 2011-08-10 |
| US7999105B2 (en) | 2011-08-16 |
| EP2319845A1 (de) | 2011-05-11 |
| CA2716944A1 (en) | 2009-09-11 |
| EP2319845B1 (de) | 2013-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |