ATE433491T1 - Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential - Google Patents
Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potentialInfo
- Publication number
- ATE433491T1 ATE433491T1 AT02722030T AT02722030T ATE433491T1 AT E433491 T1 ATE433491 T1 AT E433491T1 AT 02722030 T AT02722030 T AT 02722030T AT 02722030 T AT02722030 T AT 02722030T AT E433491 T1 ATE433491 T1 AT E433491T1
- Authority
- AT
- Austria
- Prior art keywords
- chimeric proteins
- immunogenic potential
- oligomeric complexes
- enhanced immunogenic
- complexes
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title 1
- 102000007474 Multiprotein Complexes Human genes 0.000 abstract 1
- 108010085220 Multiprotein Complexes Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200193 | 2001-01-18 | ||
| PCT/EP2002/000628 WO2002074795A2 (en) | 2001-01-18 | 2002-01-18 | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433491T1 true ATE433491T1 (de) | 2009-06-15 |
Family
ID=8179773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02722030T ATE433491T1 (de) | 2001-01-18 | 2002-01-18 | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7449188B2 (de) |
| EP (1) | EP1362109B1 (de) |
| AT (1) | ATE433491T1 (de) |
| AU (1) | AU2002252978B9 (de) |
| CA (1) | CA2435000C (de) |
| DE (1) | DE60232577D1 (de) |
| DK (1) | DK1362109T3 (de) |
| ES (1) | ES2327719T3 (de) |
| WO (1) | WO2002074795A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101241272B1 (ko) | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 면역 요법으로서의 효모계 백신 |
| ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
| ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
| RU2009105099A (ru) | 2006-07-14 | 2010-08-27 | Санофи Пастер Байолоджикс Ко. (Us) | Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса |
| KR20090096414A (ko) | 2006-09-29 | 2009-09-10 | 사노피 파스테르 바이오로직스 씨오 | 재조합 리노바이러스 벡터 |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| NZ587108A (en) | 2007-11-27 | 2013-04-26 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| AU2009236585B2 (en) | 2008-04-18 | 2013-03-07 | Vaxinnate Corporation | Deletion mutants of flagellin and methods of use |
| WO2009133463A1 (en) * | 2008-04-30 | 2009-11-05 | University Of Copenhagen | Soluble influenza vaccine |
| DK2294202T3 (en) * | 2008-07-08 | 2015-08-31 | Medicago Inc | SOLUBLE RECOMBINANT INFLUENZA ANTIGENES |
| SI2445928T1 (en) | 2009-06-24 | 2018-05-31 | Medicago Inc. | HYPER PARTICULARS, SIMILAR VIRUSES OF GRIPE, WHICH HAVE EXPOSED HEMAGLUTININE |
| KR20120052369A (ko) | 2009-07-31 | 2012-05-23 | 팍스박스, 인코포레이티드 | 아데노바이러스계 벡터 |
| SG178918A1 (en) | 2009-09-22 | 2012-04-27 | Medicago Inc | Method of preparing plant-derived vlps |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| MX340735B (es) * | 2010-04-09 | 2016-07-22 | Univ Utrecht Holding Bv | Proteinas multimericas recombinantes de la influenza. |
| CA2805741C (en) | 2010-07-23 | 2019-08-13 | Karin Bengtsson Loevgren | Composition including an iscom matrix and ectodomains |
| ES2535421T3 (es) | 2011-03-22 | 2015-05-11 | Mucosis B.V. | Composiciones inmunogénicas en forma particulada y métodos para producir las mismas |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| AU2013295647B2 (en) | 2012-07-26 | 2018-02-08 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Multimeric fusion protein vaccine and immunotherapeutic |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| HK1208355A1 (en) * | 2012-11-05 | 2016-03-04 | Georgia State University Research Foundation, Inc. | Universal influenza vaccine based on heterologous multiple m2e proteins |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN109477074B (zh) | 2016-02-19 | 2023-01-24 | 威斯康星旧生研究基金会 | 用于疫苗开发的改进的乙型流感病毒复制 |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| EP3512874A2 (de) | 2017-11-30 | 2019-07-24 | Grifols Diagnostic Solutions Inc. | Immunoassays und manipulierte proteine zur überwachung von antikörperbehandlungen gegen die immun-checkpoint-inhibitoren pd-1 und pd-l1 |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (de) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vektoren zur auslösung von immunantworten auf nicht-dominante epitope im hämagglutinin (ha)-protein |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| EP4093415A1 (de) * | 2020-01-24 | 2022-11-30 | Wisconsin Alumni Research Foundation (WARF) | Rekombinante influenza-viren mit stabilisiertem na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| EP4277918A4 (de) * | 2021-01-13 | 2025-07-30 | Purdue Research Foundation | Supramolekulare anordnungen, zusammensetzungen und verfahren zur herstellung und verwendung davon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
| ATE240394T1 (de) | 1992-10-23 | 2003-05-15 | Immunex Corp | Methoden zur herstellung löslicher, oligomerer proteine |
| US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
| WO1999062953A1 (en) * | 1998-06-04 | 1999-12-09 | Shanghai Second Medical University | A human leucine zipper protein gene (bmh) (cblayd06) |
| PL192016B1 (pl) * | 1998-11-30 | 2006-08-31 | Cytos Biotechnology Ag | Kompozycja, sposób wytwarzania sztucznego, uporządkowanego i powtarzalnego układu antygenu, zastosowanie kompozycji oraz kompozycja szczepionki |
| AU4770300A (en) * | 1999-05-14 | 2000-12-05 | Medical Research Council | Protein scaffold and its use to multimerise monomeric polypeptides |
| IL147270A0 (en) | 1999-07-02 | 2002-08-14 | Genentech Inc | Fusion peptides comprising a peptide ligand domain and a multimerization domain |
| DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
2002
- 2002-01-18 US US10/466,655 patent/US7449188B2/en not_active Expired - Lifetime
- 2002-01-18 WO PCT/EP2002/000628 patent/WO2002074795A2/en not_active Ceased
- 2002-01-18 DK DK02722030T patent/DK1362109T3/da active
- 2002-01-18 CA CA2435000A patent/CA2435000C/en not_active Expired - Lifetime
- 2002-01-18 AT AT02722030T patent/ATE433491T1/de active
- 2002-01-18 ES ES02722030T patent/ES2327719T3/es not_active Expired - Lifetime
- 2002-01-18 EP EP02722030A patent/EP1362109B1/de not_active Expired - Lifetime
- 2002-01-18 AU AU2002252978A patent/AU2002252978B9/en not_active Expired
- 2002-01-18 DE DE60232577T patent/DE60232577D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20040116664A1 (en) | 2004-06-17 |
| AU2002252978B2 (en) | 2006-12-07 |
| WO2002074795A2 (en) | 2002-09-26 |
| US7449188B2 (en) | 2008-11-11 |
| DE60232577D1 (de) | 2009-07-23 |
| EP1362109B1 (de) | 2009-06-10 |
| CA2435000C (en) | 2014-03-25 |
| CA2435000A1 (en) | 2002-09-26 |
| DK1362109T3 (da) | 2009-07-27 |
| EP1362109A2 (de) | 2003-11-19 |
| ES2327719T3 (es) | 2009-11-03 |
| AU2002252978B9 (en) | 2007-02-01 |
| AU2002252978A1 (en) | 2002-10-03 |
| WO2002074795A3 (en) | 2003-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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