ATE433491T1 - Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential - Google Patents
Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potentialInfo
- Publication number
- ATE433491T1 ATE433491T1 AT02722030T AT02722030T ATE433491T1 AT E433491 T1 ATE433491 T1 AT E433491T1 AT 02722030 T AT02722030 T AT 02722030T AT 02722030 T AT02722030 T AT 02722030T AT E433491 T1 ATE433491 T1 AT E433491T1
- Authority
- AT
- Austria
- Prior art keywords
- chimeric proteins
- immunogenic potential
- oligomeric complexes
- enhanced immunogenic
- complexes
- Prior art date
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title 1
- 102000007474 Multiprotein Complexes Human genes 0.000 abstract 1
- 108010085220 Multiprotein Complexes Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200193 | 2001-01-18 | ||
| PCT/EP2002/000628 WO2002074795A2 (en) | 2001-01-18 | 2002-01-18 | Oligomeric complexes of chimeric proteins with enhanced immunogenic potential |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433491T1 true ATE433491T1 (de) | 2009-06-15 |
Family
ID=8179773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02722030T ATE433491T1 (de) | 2001-01-18 | 2002-01-18 | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7449188B2 (de) |
| EP (1) | EP1362109B1 (de) |
| AT (1) | ATE433491T1 (de) |
| AU (1) | AU2002252978B9 (de) |
| CA (1) | CA2435000C (de) |
| DE (1) | DE60232577D1 (de) |
| DK (1) | DK1362109T3 (de) |
| ES (1) | ES2327719T3 (de) |
| WO (1) | WO2002074795A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101241272B1 (ko) | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 면역 요법으로서의 효모계 백신 |
| ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
| ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| EP3011969A1 (de) * | 2006-03-07 | 2016-04-27 | Vaxinnate Corporation | Zusammensetzungen mit hämagglutinin, verfahren zur herstellung und verfahren zur verwendung davon |
| JP2009543554A (ja) | 2006-07-14 | 2009-12-10 | サノフィ パスツール バイオロジクス カンパニー | ベクターウイルスタンパク質への外来免疫決定基の直接トランスポゾン媒介挿入による組換え型ウイルスワクチンの構築 |
| CA2664791A1 (en) | 2006-09-29 | 2008-08-21 | Sanofi Pasteur Biologics Co. | Recombinant rhinovirus vectors |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| PT2610345E (pt) | 2007-11-27 | 2016-01-11 | Medicago Inc | Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina |
| WO2009128952A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of papillomavirus proteins and methods of use |
| WO2009133463A1 (en) * | 2008-04-30 | 2009-11-05 | University Of Copenhagen | Soluble influenza vaccine |
| EP2294202B1 (de) * | 2008-07-08 | 2015-05-20 | Medicago Inc. | Lösliche rekombinante influenza-antigene |
| JP5871796B2 (ja) | 2009-06-24 | 2016-03-01 | メディカゴ インコーポレイテッド | ヘマグルチニンを含むキメラインフルエンザウイルス様粒子 |
| RU2012107702A (ru) | 2009-07-31 | 2013-09-10 | Пэксвэкс, Инк. | Векторы на основе аденовирусов |
| ES2662778T3 (es) | 2009-09-22 | 2018-04-09 | Medicago Inc. | Método de preparación de proteínas derivadas de plantas |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| EP2555795B1 (de) * | 2010-04-09 | 2016-07-13 | Universiteit Utrecht Holding B.V. | Rekombinante multimere influenzaproteine |
| EP2595653B1 (de) * | 2010-07-23 | 2017-06-28 | Novavax AB | Influenza-impfstoff |
| EP2689016B1 (de) | 2011-03-22 | 2015-03-11 | Mucosis B.V. | Immunogene zusammensetzungen in partikelform und verfahren zu ihrer herstellung |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| EP2877205A4 (de) | 2012-07-26 | 2016-04-06 | Jackson H M Found Military Med | Impfstoff mit einem multimeren fusionsprotein und immuntherapeutikum |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| WO2014070848A1 (en) * | 2012-11-05 | 2014-05-08 | Georgia State University Research Foundation | Universal influenza vaccine based on heterologous multiple m2e proteins |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| KR20190065234A (ko) | 2017-11-30 | 2019-06-11 | 그리폴스 다이어그노스틱 솔루션즈 인크. | 면역 관문 억제제인 pd-1 및 pd-l1에 대한 항체 치료를 모니터링하기 위한 면역분석 및 조작된 단백질 |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| CN113874496A (zh) | 2019-02-08 | 2021-12-31 | 威斯康星校友研究基金会(Warf) | 人源化细胞系 |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| WO2021150874A1 (en) * | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| WO2022155373A2 (en) * | 2021-01-13 | 2022-07-21 | Purdue Research Foundation | Supramolecular assemblies, compositions and methods for producing and using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5041385A (en) * | 1986-11-01 | 1991-08-20 | Oxford Gene Systems Limited | Vector expressing fusion proteins and particles |
| WO1994010308A1 (en) | 1992-10-23 | 1994-05-11 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
| WO1999062953A1 (en) * | 1998-06-04 | 1999-12-09 | Shanghai Second Medical University | A human leucine zipper protein gene (bmh) (cblayd06) |
| CN1193791C (zh) * | 1998-11-30 | 2005-03-23 | 希托斯生物技术股份公司 | 抗原的有序分子呈递,制备及使用的方法 |
| JP2003502024A (ja) * | 1999-05-14 | 2003-01-21 | メディカル リサーチ カウンシル | タンパク質骨格および単量体ポリペプチドを多量体化するためのその使用 |
| WO2001002440A1 (en) * | 1999-07-02 | 2001-01-11 | Genentech, Inc. | Fusion peptides comprising a peptide ligand domain and a multimerization domain |
| DE19963859A1 (de) * | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| US20020015951A1 (en) | 2000-01-06 | 2002-02-07 | Bader Joel S. | Method of analyzing a nucleic acid |
-
2002
- 2002-01-18 EP EP02722030A patent/EP1362109B1/de not_active Expired - Lifetime
- 2002-01-18 CA CA2435000A patent/CA2435000C/en not_active Expired - Lifetime
- 2002-01-18 ES ES02722030T patent/ES2327719T3/es not_active Expired - Lifetime
- 2002-01-18 DE DE60232577T patent/DE60232577D1/de not_active Expired - Lifetime
- 2002-01-18 DK DK02722030T patent/DK1362109T3/da active
- 2002-01-18 WO PCT/EP2002/000628 patent/WO2002074795A2/en not_active Ceased
- 2002-01-18 AT AT02722030T patent/ATE433491T1/de active
- 2002-01-18 US US10/466,655 patent/US7449188B2/en not_active Expired - Lifetime
- 2002-01-18 AU AU2002252978A patent/AU2002252978B9/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002252978B9 (en) | 2007-02-01 |
| WO2002074795A3 (en) | 2003-09-04 |
| AU2002252978A1 (en) | 2002-10-03 |
| EP1362109B1 (de) | 2009-06-10 |
| AU2002252978B2 (en) | 2006-12-07 |
| US20040116664A1 (en) | 2004-06-17 |
| ES2327719T3 (es) | 2009-11-03 |
| CA2435000A1 (en) | 2002-09-26 |
| DE60232577D1 (de) | 2009-07-23 |
| US7449188B2 (en) | 2008-11-11 |
| WO2002074795A2 (en) | 2002-09-26 |
| DK1362109T3 (da) | 2009-07-27 |
| CA2435000C (en) | 2014-03-25 |
| EP1362109A2 (de) | 2003-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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