ATE434038T1 - Mutierte abl-kinase-domänen - Google Patents

Mutierte abl-kinase-domänen

Info

Publication number: ATE434038T1
Authority: AT; Austria
Prior art keywords: polypeptides; kinase domain; amino acid; nucleic acid; acid molecules
Prior art date: 2001-10-05

Application number

AT02782829T

Other languages

English (en)

Inventor

Christophe Barthe

Susan Branford

Amie Corbin

Brian Druker

Justus Duyster

Andreas Hochhaus

Timothy Hughes

Sebastian Kreil

Thibaut Leguay

Francois-Xavier Mahon

Gerald Marit

Martin Mueller

Christian Peschel

Claude Preudhomme

Lestienne Catherine Roche

Zbigniew Rudzki

Original Assignee

Novartis Ag

Univ Victor Segalen Bordeaux 2

Univ Muenchen Tech

Univ Oregon Health & Science

Univ Heidelberg

Chru De Lille Ct Hospitalier R

Medvet Science Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-05

Filing date

2002-10-04

Publication date

2009-07-15

2002-10-04 Application filed by Novartis Ag, Univ Victor Segalen Bordeaux 2, Univ Muenchen Tech, Univ Oregon Health & Science, Univ Heidelberg, Chru De Lille Ct Hospitalier R, Medvet Science Pty Ltd filed Critical Novartis Ag

2009-07-15 Application granted granted Critical

2009-07-15 Publication of ATE434038T1 publication Critical patent/ATE434038T1/de

Links

229920001184 polypeptide Polymers 0.000 abstract 6
102000004196 processed proteins & peptides Human genes 0.000 abstract 6
108090000765 processed proteins & peptides Proteins 0.000 abstract 6
108091000080 Phosphotransferase Proteins 0.000 abstract 3
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 3
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 3
150000001413 amino acids Chemical group 0.000 abstract 3
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
102000020233 phosphotransferase Human genes 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02782829T 2001-10-05 2002-10-04 Mutierte abl-kinase-domänen ATE434038T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US32738901P	2001-10-05	2001-10-05
US32874001P	2001-10-12	2001-10-12
US34735102P	2002-01-11	2002-01-11
PCT/EP2002/011144 WO2003031608A2 (en)	2001-10-05	2002-10-04	Mutated abl kinase domains

Publications (1)

Publication Number	Publication Date
ATE434038T1 true ATE434038T1 (de)	2009-07-15

Family

ID=27406519

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT02782829T ATE434038T1 (de)	2001-10-05	2002-10-04	Mutierte abl-kinase-domänen
AT08166771T ATE490308T1 (de)	2001-10-05	2002-10-04	Mutante der kinase domäne des abl

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT08166771T ATE490308T1 (de)	2001-10-05	2002-10-04	Mutante der kinase domäne des abl

Country Status (7)

Country	Link
US (4)	US20050202519A1 (de)
EP (8)	EP2246416A1 (de)
JP (2)	JP4243191B2 (de)
AT (2)	ATE434038T1 (de)
DE (2)	DE60238511D1 (de)
PT (1)	PT2017335E (de)
WO (1)	WO2003031608A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60232370D1 (de)	2001-06-14	2009-06-25	Univ California	Mutationen in der mit der resistenz gegenüber sti-
GB0201384D0 (en) *	2002-01-22	2002-03-13	European Molecular Biology Lab Embl	Tyrosine kinase inhibitors
EP1684762A4 (de)	2003-11-13	2009-06-17	Ambit Biosciences Corp	Harnstoff-derivate als kinase-modulatoren
EP3461813A1 (de)	2004-05-23	2019-04-03	Gerard M. Housey	Theramuteinmodulatoren
CA2616517A1 (en) *	2005-07-26	2007-02-01	Vertex Pharmaceuticals Incorporated	Abl kinase inhibition
WO2007058991A2 (en) *	2005-11-14	2007-05-24	Novartis Ag	Mutations and polymorphisms of c-abl
CN103789389B (zh)	2005-11-23	2017-01-04	杰勒德·M·豪斯	鉴定、合成、优化和表征蛋白调节剂的化合物和方法
HUE055524T2 (hu)	2007-06-01	2021-11-29	Wyeth Llc	A bcrabl génben 1457T>C mutációt tartalmazó, imatinibbel szemben ellenálló krónikus mielogén leukémia kezelése bozutinib vegyület alkalmazásával
US9232968B2 (en)	2007-12-19	2016-01-12	DePuy Synthes Products, Inc.	Polymeric pedicle rods and methods of manufacturing
US9909170B2 (en)	2008-09-05	2018-03-06	Washington University	Method for multiplexed nucleic acid patch polymerase chain reaction
US8586310B2 (en)	2008-09-05	2013-11-19	Washington University	Method for multiplexed nucleic acid patch polymerase chain reaction
US11111514B2 (en)	2008-09-05	2021-09-07	Washington University	Method for multiplexed nucleic acid patch polymerase chain reaction
US9702877B2 (en)	2008-10-31	2017-07-11	Quest Diagnostics Investments Incorporated	BCR-ABL variants
US8641734B2 (en)	2009-02-13	2014-02-04	DePuy Synthes Products, LLC	Dual spring posterior dynamic stabilization device with elongation limiting elastomers
US9320543B2 (en)	2009-06-25	2016-04-26	DePuy Synthes Products, Inc.	Posterior dynamic stabilization device having a mobile anchor
WO2011041308A1 (en)	2009-09-30	2011-04-07	Quest Diagnostics Investments Incorporated	Bcr-abl truncation mutations
JP5359924B2 (ja) *	2010-02-18	2013-12-04	株式会社島津製作所	質量分析装置
US9445844B2 (en)	2010-03-24	2016-09-20	DePuy Synthes Products, Inc.	Composite material posterior dynamic stabilization spring rod
US8603740B2 (en)	2010-12-29	2013-12-10	Quest Diagnostics Investments Incorporated	BCR-ABL1 splice variants and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW225528B (de)	1992-04-03	1994-06-21	Ciba Geigy Ag
CO4940418A1 (es)	1997-07-18	2000-07-24	Novartis Ag	Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
DE60232370D1 (de) *	2001-06-14	2009-06-25	Univ California	Mutationen in der mit der resistenz gegenüber sti-
US20030170851A1 (en) *	2001-10-05	2003-09-11	Christophe Barthe	Organic compounds

2002
- 2002-10-04 PT PT08166771T patent/PT2017335E/pt unknown
- 2002-10-04 EP EP10155600A patent/EP2246416A1/de not_active Withdrawn
- 2002-10-04 WO PCT/EP2002/011144 patent/WO2003031608A2/en not_active Ceased
- 2002-10-04 EP EP10186259A patent/EP2343367A1/de not_active Withdrawn
- 2002-10-04 JP JP2003534578A patent/JP4243191B2/ja not_active Expired - Fee Related
- 2002-10-04 EP EP10186180A patent/EP2343366A1/de not_active Withdrawn
- 2002-10-04 EP EP10186089A patent/EP2341133A1/de not_active Withdrawn
- 2002-10-04 EP EP08166771A patent/EP2017335B1/de not_active Expired - Lifetime
- 2002-10-04 EP EP10174534A patent/EP2290056A3/de not_active Withdrawn
- 2002-10-04 US US10/491,603 patent/US20050202519A1/en not_active Abandoned
- 2002-10-04 DE DE60238511T patent/DE60238511D1/de not_active Expired - Lifetime
- 2002-10-04 AT AT02782829T patent/ATE434038T1/de not_active IP Right Cessation
- 2002-10-04 AT AT08166771T patent/ATE490308T1/de active
- 2002-10-04 EP EP02782829A patent/EP1436384B1/de not_active Expired - Lifetime
- 2002-10-04 DE DE60232670T patent/DE60232670D1/de not_active Expired - Lifetime
- 2002-10-04 EP EP10186114A patent/EP2343365A1/de not_active Withdrawn
2008
- 2008-06-30 US US12/165,217 patent/US20090117641A1/en not_active Abandoned
- 2008-11-17 JP JP2008293586A patent/JP2009165464A/ja active Pending
2009
- 2009-08-21 US US12/545,113 patent/US20100021920A1/en not_active Abandoned
- 2009-08-21 US US12/545,133 patent/US20100021921A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2003031608A3 (en)	2003-12-18
DE60238511D1 (de)	2011-01-13
ATE490308T1 (de)	2010-12-15
EP2343365A1 (de)	2011-07-13
JP2005504549A (ja)	2005-02-17
EP1436384A2 (de)	2004-07-14
EP2343366A1 (de)	2011-07-13
JP2009165464A (ja)	2009-07-30
PT2017335E (pt)	2011-03-02
EP2017335B1 (de)	2010-12-01
EP1436384B1 (de)	2009-06-17
EP2290056A3 (de)	2011-06-01
EP2290056A2 (de)	2011-03-02
US20100021920A1 (en)	2010-01-28
EP2343367A1 (de)	2011-07-13
EP2341133A1 (de)	2011-07-06
US20100021921A1 (en)	2010-01-28
WO2003031608A2 (en)	2003-04-17
EP2017335A1 (de)	2009-01-21
US20050202519A1 (en)	2005-09-15
JP4243191B2 (ja)	2009-03-25
EP2246416A1 (de)	2010-11-03
US20090117641A1 (en)	2009-05-07
DE60232670D1 (de)	2009-07-30

Legal Events

Date	Code	Title	Description
2009-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE434038T1 (de)	2009-07-15	Mutierte abl-kinase-domänen
DE60335794D1 (de)	2011-03-03	Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden
DE60215534D1 (de)	2006-11-30	Antimikrobielle polypeptide aus pseudoplectania nigrella
ATE503009T1 (de)	2011-04-15	Polypeptide mit lipase-aktivität und diese kodierende polynukleotide
ATE469216T1 (de)	2010-06-15	Modifizierte vitamin-k-abhängige polypeptide
WO2004032877A3 (en)	2005-10-06	Compositions, organisms and methodologies employing a novel human kinase
BR0315327A (pt)	2005-08-16	Antagonistas de il-15
EP1347056A4 (de)	2004-07-14	Acetolactat-synthasegen codierendes gen
ATE399869T1 (de)	2008-07-15	Verbesserte bacillus-wirtszelle
Eijsink et al.	1992	Increasing the thermostability of a neutral protease by replacing positively charged amino acids in the N-terminal turn of α-helices
EP1279744A3 (de)	2004-05-26	Identifizierung und Verwendung von Molekülen, die mit Schmerzempfinden impliziert sind
EP1284297A3 (de)	2004-05-26	Identifizierung und Verwendung von Molekülen, welche mit Schmerz in Verbindung stehen
ATE342971T1 (de)	2006-11-15	Den zellzyklus regulierende proteine
Stoll et al.	2008	Extracellular SH3 domain containing proteins-features of a new protein family
BRPI0516504A (pt)	2008-09-16	polipeptìdeo tendo atividade de fitase e seqüência de nucleotìdeo codificando o mesmo
DE60232812D1 (de)	2009-08-13	Allele des glucokinasegens von coryneformen bakterien
NO980122D0 (no)	1998-01-12	Emaljematriksrelatert polypeptid
ATE513906T1 (de)	2011-07-15	Galactosyltransferase
DE60225699D1 (de)	2008-04-30	Nierenspezifischer urattransporter und dessen gen
WO2007058267A8 (ja)	2008-02-14	新規タンパク質及びそれをコードする遺伝子
DE60226220D1 (de)	2008-06-05	Tau-opathy modell
EA200601749A1 (ru)	2007-06-29	Коспептин, космедин и варианты их применения
DK1863834T3 (da)	2010-11-01	Polypeptider og nukleinsyrer, der koder disse
WO2002059149A3 (en)	2002-10-10	Pro-apoptotic proteins and dna molecules encoding them
DK1328621T3 (da)	2007-04-10	13245, en ny human proteinkinase af den myotoniske dystrofitype og anvendelser deraf