ATE434621T1 - Neue verbindungen als inhibitoren der ns3- serinprotease des hepatitis-c-virus - Google Patents
Neue verbindungen als inhibitoren der ns3- serinprotease des hepatitis-c-virusInfo
- Publication number
- ATE434621T1 ATE434621T1 AT05723590T AT05723590T ATE434621T1 AT E434621 T1 ATE434621 T1 AT E434621T1 AT 05723590 T AT05723590 T AT 05723590T AT 05723590 T AT05723590 T AT 05723590T AT E434621 T1 ATE434621 T1 AT E434621T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- virus
- inhibitors
- serine protease
- new compounds
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 102000012479 Serine Proteases Human genes 0.000 title 1
- 108010022999 Serine Proteases Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54853504P | 2004-02-27 | 2004-02-27 | |
| PCT/US2005/005773 WO2005087725A2 (en) | 2004-02-27 | 2005-02-24 | Novel compounds as inhibitors of hepatitis c virus ns3 serine protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE434621T1 true ATE434621T1 (de) | 2009-07-15 |
Family
ID=34962125
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08102711T ATE478889T1 (de) | 2004-02-27 | 2005-02-24 | Neuartige verbindungen als hemmer von hepatitis c-virus ns3-serinprotease |
| AT05723590T ATE434621T1 (de) | 2004-02-27 | 2005-02-24 | Neue verbindungen als inhibitoren der ns3- serinprotease des hepatitis-c-virus |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08102711T ATE478889T1 (de) | 2004-02-27 | 2005-02-24 | Neuartige verbindungen als hemmer von hepatitis c-virus ns3-serinprotease |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7186747B2 (de) |
| EP (2) | EP1939213B1 (de) |
| JP (1) | JP2007525511A (de) |
| KR (1) | KR20060124729A (de) |
| CN (1) | CN1972956A (de) |
| AR (1) | AR047903A1 (de) |
| AT (2) | ATE478889T1 (de) |
| AU (1) | AU2005222056A1 (de) |
| BR (1) | BRPI0508186A (de) |
| CA (1) | CA2557249A1 (de) |
| DE (2) | DE602005015093D1 (de) |
| EC (1) | ECSP066794A (de) |
| ES (2) | ES2349328T3 (de) |
| IL (1) | IL177627A0 (de) |
| NO (1) | NO20064357L (de) |
| RU (1) | RU2006134002A (de) |
| TW (1) | TW200529823A (de) |
| WO (1) | WO2005087725A2 (de) |
| ZA (1) | ZA200607053B (de) |
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| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| US20060276407A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| AU2006252623A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis C virus |
| WO2006130552A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| US20060281689A1 (en) * | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
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| CA2418199A1 (en) | 2000-07-21 | 2002-01-31 | Corvas International, Inc. | Peptides as ns3-serine protease inhibitors of hepatitis c virus |
| KR20030081297A (ko) | 2000-07-21 | 2003-10-17 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 신규한 펩티드 |
| US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| DK1385870T3 (da) | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| KR20030091946A (ko) | 2000-12-12 | 2003-12-03 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 디아릴 펩티드 |
| JP2002349498A (ja) * | 2001-05-24 | 2002-12-04 | Ishikawajima Harima Heavy Ind Co Ltd | 低騒音ファン静翼 |
-
2005
- 2005-02-24 US US11/065,531 patent/US7186747B2/en not_active Expired - Lifetime
- 2005-02-24 DE DE602005015093T patent/DE602005015093D1/de not_active Expired - Lifetime
- 2005-02-24 ES ES08102711T patent/ES2349328T3/es not_active Expired - Lifetime
- 2005-02-24 RU RU2006134002/04A patent/RU2006134002A/ru not_active Application Discontinuation
- 2005-02-24 EP EP08102711A patent/EP1939213B1/de not_active Expired - Lifetime
- 2005-02-24 AT AT08102711T patent/ATE478889T1/de not_active IP Right Cessation
- 2005-02-24 JP JP2007500947A patent/JP2007525511A/ja not_active Ceased
- 2005-02-24 AU AU2005222056A patent/AU2005222056A1/en not_active Abandoned
- 2005-02-24 CN CNA2005800126954A patent/CN1972956A/zh active Pending
- 2005-02-24 WO PCT/US2005/005773 patent/WO2005087725A2/en not_active Ceased
- 2005-02-24 KR KR1020067017296A patent/KR20060124729A/ko not_active Withdrawn
- 2005-02-24 ES ES05723590T patent/ES2327544T3/es not_active Expired - Lifetime
- 2005-02-24 DE DE602005023224T patent/DE602005023224D1/de not_active Expired - Lifetime
- 2005-02-24 TW TW094105642A patent/TW200529823A/zh unknown
- 2005-02-24 CA CA002557249A patent/CA2557249A1/en not_active Abandoned
- 2005-02-24 AT AT05723590T patent/ATE434621T1/de not_active IP Right Cessation
- 2005-02-24 EP EP05723590A patent/EP1737881B1/de not_active Expired - Lifetime
- 2005-02-24 BR BRPI0508186-6A patent/BRPI0508186A/pt not_active IP Right Cessation
- 2005-02-25 AR ARP050100721A patent/AR047903A1/es unknown
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2006
- 2006-08-22 IL IL177627A patent/IL177627A0/en unknown
- 2006-08-23 ZA ZA200606953A patent/ZA200607053B/xx unknown
- 2006-08-25 EC EC2006006794A patent/ECSP066794A/es unknown
- 2006-09-26 NO NO20064357A patent/NO20064357L/no not_active Application Discontinuation
- 2006-12-21 US US11/644,708 patent/US7425576B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20070142300A1 (en) | 2007-06-21 |
| WO2005087725A3 (en) | 2005-10-27 |
| US7186747B2 (en) | 2007-03-06 |
| HK1095837A1 (en) | 2007-05-18 |
| ATE478889T1 (de) | 2010-09-15 |
| CN1972956A (zh) | 2007-05-30 |
| AU2005222056A1 (en) | 2005-09-22 |
| AR047903A1 (es) | 2006-03-01 |
| US7425576B2 (en) | 2008-09-16 |
| JP2007525511A (ja) | 2007-09-06 |
| EP1939213B1 (de) | 2010-08-25 |
| EP1737881B1 (de) | 2009-06-24 |
| DE602005023224D1 (de) | 2010-10-07 |
| ECSP066794A (es) | 2006-11-16 |
| TW200529823A (en) | 2005-09-16 |
| IL177627A0 (en) | 2006-12-31 |
| KR20060124729A (ko) | 2006-12-05 |
| ES2349328T3 (es) | 2010-12-30 |
| WO2005087725A2 (en) | 2005-09-22 |
| HK1118066A1 (en) | 2009-01-30 |
| BRPI0508186A (pt) | 2007-08-14 |
| CA2557249A1 (en) | 2005-09-22 |
| ES2327544T3 (es) | 2009-10-30 |
| US20050245458A1 (en) | 2005-11-03 |
| EP1939213A1 (de) | 2008-07-02 |
| ZA200607053B (en) | 2009-02-25 |
| RU2006134002A (ru) | 2008-04-10 |
| NO20064357L (no) | 2006-11-24 |
| DE602005015093D1 (de) | 2009-08-06 |
| EP1737881A2 (de) | 2007-01-03 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |