ATE435199T1 - Diarylharnstoffderivate und deren verwendung als chloridkanalblocker - Google Patents
Diarylharnstoffderivate und deren verwendung als chloridkanalblockerInfo
- Publication number
- ATE435199T1 ATE435199T1 AT03793605T AT03793605T ATE435199T1 AT E435199 T1 ATE435199 T1 AT E435199T1 AT 03793605 T AT03793605 T AT 03793605T AT 03793605 T AT03793605 T AT 03793605T AT E435199 T1 ATE435199 T1 AT E435199T1
- Authority
- AT
- Austria
- Prior art keywords
- channel blockers
- chloride channel
- diarylurea derivatives
- compounds
- relates
- Prior art date
Links
- 108010062745 Chloride Channels Proteins 0.000 title abstract 2
- 102000011045 Chloride Channels Human genes 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000003651 basophil Anatomy 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200201310 | 2002-09-05 | ||
| DKPA200201306 | 2002-09-05 | ||
| PCT/DK2003/000575 WO2004022529A2 (en) | 2002-09-05 | 2003-09-04 | Diarylurea derivatives and their use as chloride channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435199T1 true ATE435199T1 (de) | 2009-07-15 |
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ID=31979712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03793605T ATE435199T1 (de) | 2002-09-05 | 2003-09-04 | Diarylharnstoffderivate und deren verwendung als chloridkanalblocker |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060160856A1 (de) |
| EP (1) | EP1537075B1 (de) |
| JP (1) | JP2005538152A (de) |
| CN (1) | CN100497302C (de) |
| AT (1) | ATE435199T1 (de) |
| CA (1) | CA2495284A1 (de) |
| DE (1) | DE60328202D1 (de) |
| MX (1) | MXPA05002493A (de) |
| NZ (1) | NZ538513A (de) |
| WO (1) | WO2004022529A2 (de) |
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| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
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| JP2007504202A (ja) * | 2003-09-04 | 2007-03-01 | ポセイドン ファーマシュティカルズ アクティーゼルスカブ | 心臓不整脈を治療するためのergチャネル開口薬 |
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| EP1827411A2 (de) * | 2004-12-17 | 2007-09-05 | Neurosearch A/S | Als kaliumkanal-aktivatoren geeignete diphenyl-harnstoff-derivate |
| WO2006078621A2 (en) | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
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| ATE502924T1 (de) | 2005-06-27 | 2011-04-15 | Bristol Myers Squibb Co | Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden |
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| TW200726764A (en) | 2005-06-27 | 2007-07-16 | Bristol Myers Squibb Co | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
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| WO2007107352A1 (en) * | 2006-03-21 | 2007-09-27 | The European Molecular Biology Laboratory | Agents that disrupt cellular replication and their use in inhibiting pathological conditions |
| WO2008024963A1 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Benzene, pyridine, and pyridazine derivatives |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| WO2008047067A1 (en) * | 2006-10-20 | 2008-04-24 | University Court Of The University Of Edinburgh | Treatment of inflammatory disease |
| US20120071475A1 (en) * | 2009-04-27 | 2012-03-22 | Shionogi & Co., Ltd. | Urea derivatives having pi3k-inhibiting activity |
| IN2012DN01983A (de) * | 2009-08-24 | 2015-07-24 | Ascepion Pharmaceuticals Inc | |
| CN106518742B (zh) | 2011-10-26 | 2020-01-21 | 阿勒根公司 | 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物 |
| ES2802251T3 (es) | 2012-01-06 | 2021-01-18 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| DE102012007558A1 (de) * | 2012-04-14 | 2013-10-17 | Alf Hammes | Gabe substituierter bis-aryl-harnstoffderivate zur behandlung von anämien |
| BR112015021392B1 (pt) * | 2013-03-06 | 2021-11-16 | Allergan, Inc | Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas |
| BR122017004254B1 (pt) * | 2013-03-06 | 2021-04-13 | Allergan, Inc. | Uso de agonistas de receptor de formil peptídeo 2 para tratar doenças inflamatórias oculares |
| WO2014193969A2 (en) * | 2013-05-28 | 2014-12-04 | The Regents Of The University Of California | Compounds for the treatment of hypertension and hypertensive end stage renal disease |
| CN104277060A (zh) * | 2014-09-23 | 2015-01-14 | 河南科技学院 | 一种合成2-氨基-4-烷氧羰基苯硼酸盐酸盐的方法 |
| US20170273922A1 (en) * | 2014-10-03 | 2017-09-28 | The Royal Institution For The Advacement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| CN105566341B (zh) * | 2014-10-10 | 2017-11-24 | 中国科学院宁波材料技术与工程研究所 | 一种7‑氧杂二环[2.2.1]庚‑5‑烯单体及其制备方法和应用 |
| EP3256461B1 (de) * | 2015-02-13 | 2023-09-13 | Azienda Ospedaliera Universitaria Senese | Harnstoff- und sulfonamidderivate als humane helikase ddx3-hemmer zur behandlung von viruserkrankungen |
| CN105348168B (zh) * | 2015-11-06 | 2018-04-10 | 厦门大学 | 1‑(2‑(金刚烷‑1‑基)‑1h‑吲哚‑5‑基)‑3‑取代脲衍生物及制备和用途 |
| ITUA20161994A1 (it) | 2016-03-24 | 2017-09-24 | Azienda Ospedaliera Univ Senese | Uso degli inibitori ddx3 come agenti anti-iperproliferativi |
| CN106008577A (zh) * | 2016-06-03 | 2016-10-12 | 南开大学 | 一种含有苯硼酸官能团的琥珀酰亚胺酯及其制备方法 |
| JP7092356B2 (ja) * | 2016-06-22 | 2022-06-28 | フーダン ユニヴァーシティ | ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用 |
| US11253525B2 (en) | 2018-08-29 | 2022-02-22 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| JP7336133B2 (ja) * | 2019-08-07 | 2023-08-31 | 国立大学法人東北大学 | ジフェニル尿素化合物誘導体 |
| US12433876B2 (en) | 2019-08-30 | 2025-10-07 | University Of Rochester | Septin inhibitors for treatment of cancers |
| CN112076185A (zh) * | 2020-08-17 | 2020-12-15 | 西安交通大学 | 一类卤代二芳基脲类化合物及其在制备抗过敏药物中的应用 |
| US20230348450A1 (en) * | 2020-09-14 | 2023-11-02 | Genzyme Corporation | Carboxylic acid-containing compounds as modulators of bis-phosphoglycerate mutase for the treatment of sickle cell disease |
| WO2022268520A1 (de) * | 2021-06-21 | 2022-12-29 | Bayer Aktiengesellschaft | Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen. |
| CN117229258B (zh) * | 2022-06-07 | 2024-07-19 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
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| JPS55153763A (en) * | 1979-05-21 | 1980-11-29 | Kyowa Hakko Kogyo Co Ltd | Modifier for citrus fruits |
| DE3242344A1 (de) * | 1982-11-16 | 1984-05-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue alkylendiaminoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| FR2646847B1 (fr) * | 1989-05-12 | 1991-07-12 | Rhone Poulenc Sante | N-phenyl amides, leurs procedes de preparation et les medicaments les contenant |
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| US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| US6653310B2 (en) * | 2000-04-07 | 2003-11-25 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO2002039987A2 (en) * | 2000-11-14 | 2002-05-23 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
| US20040077634A1 (en) * | 2001-02-15 | 2004-04-22 | Ulrik Lademann | Treatment of diseases characterized by excessive or insufficient cell death |
| JP2004530690A (ja) * | 2001-05-16 | 2004-10-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症性薬剤として有用なジアリールウレア誘導体 |
| WO2003000245A1 (en) * | 2001-06-22 | 2003-01-03 | Poseidon Pharmaceuticals A/S | Compounds for use in disorders associated with mast cell or basophil activity |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US7119120B2 (en) * | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
-
2003
- 2003-09-04 CN CNB038209853A patent/CN100497302C/zh not_active Expired - Fee Related
- 2003-09-04 WO PCT/DK2003/000575 patent/WO2004022529A2/en not_active Ceased
- 2003-09-04 CA CA002495284A patent/CA2495284A1/en not_active Abandoned
- 2003-09-04 US US10/526,208 patent/US20060160856A1/en not_active Abandoned
- 2003-09-04 AT AT03793605T patent/ATE435199T1/de not_active IP Right Cessation
- 2003-09-04 MX MXPA05002493A patent/MXPA05002493A/es active IP Right Grant
- 2003-09-04 JP JP2004533214A patent/JP2005538152A/ja active Pending
- 2003-09-04 DE DE60328202T patent/DE60328202D1/de not_active Expired - Lifetime
- 2003-09-04 NZ NZ538513A patent/NZ538513A/en unknown
- 2003-09-04 EP EP03793605A patent/EP1537075B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2495284A1 (en) | 2004-03-18 |
| CN100497302C (zh) | 2009-06-10 |
| US20060160856A1 (en) | 2006-07-20 |
| WO2004022529A3 (en) | 2004-05-13 |
| NZ538513A (en) | 2007-02-23 |
| WO2004022529A2 (en) | 2004-03-18 |
| EP1537075A2 (de) | 2005-06-08 |
| EP1537075B1 (de) | 2009-07-01 |
| DE60328202D1 (de) | 2009-08-13 |
| JP2005538152A (ja) | 2005-12-15 |
| AU2003258490A1 (en) | 2004-03-29 |
| CN1678573A (zh) | 2005-10-05 |
| MXPA05002493A (es) | 2005-05-27 |
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