ATE435281T1 - Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung - Google Patents

Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung

Info

Publication number
ATE435281T1
ATE435281T1 AT97936721T AT97936721T ATE435281T1 AT E435281 T1 ATE435281 T1 AT E435281T1 AT 97936721 T AT97936721 T AT 97936721T AT 97936721 T AT97936721 T AT 97936721T AT E435281 T1 ATE435281 T1 AT E435281T1
Authority
AT
Austria
Prior art keywords
cadasil
therapeutic use
diagnostic methods
gene related
gene
Prior art date
Application number
AT97936721T
Other languages
English (en)
Inventor
Elisabeth Tournier-Lasserve
Anne Joutel
Marie-Germaine Bousser
Jean-Francois Bach
Original Assignee
Inst Nat Sante Rech Med
Assist Publ Hopitaux De Paris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9609733A external-priority patent/FR2751985B1/fr
Application filed by Inst Nat Sante Rech Med, Assist Publ Hopitaux De Paris filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of ATE435281T1 publication Critical patent/ATE435281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97936721T 1996-08-01 1997-07-31 Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung ATE435281T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9609733A FR2751985B1 (fr) 1996-08-01 1996-08-01 Gene implique dans le cadasil, methode de diagnostic et application therapeutique
FR9704680A FR2751986B1 (fr) 1996-08-01 1997-04-16 Gene implique dans le cadasil, methode de diagnostic et application therapeutique
PCT/FR1997/001433 WO1998005775A1 (fr) 1996-08-01 1997-07-31 Gene implique dans le cadasil, methode de diagnostic et application therapeutique

Publications (1)

Publication Number Publication Date
ATE435281T1 true ATE435281T1 (de) 2009-07-15

Family

ID=26232895

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97936721T ATE435281T1 (de) 1996-08-01 1997-07-31 Im cadasil bezogenes gen, diagnostikums-verfahren und therapeutische verwendung

Country Status (9)

Country Link
US (3) US6537775B1 (de)
EP (1) EP0915973B1 (de)
JP (2) JP4463329B2 (de)
AT (1) ATE435281T1 (de)
CA (1) CA2262459C (de)
DE (1) DE69739478D1 (de)
ES (1) ES2328304T3 (de)
FR (1) FR2751986B1 (de)
WO (1) WO1998005775A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751986B1 (fr) * 1996-08-01 1998-12-31 Inst Nat Sante Rech Med Gene implique dans le cadasil, methode de diagnostic et application therapeutique
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
EP1438402A2 (de) * 2001-08-22 2004-07-21 Galapagos Genomics N.V. Durch einen screen mit hohem durchsatz identifizierte modulatoren der knochenhomöostase
WO2005111072A2 (en) * 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
CN1763196B (zh) * 2004-09-13 2010-09-08 首都医科大学宣武医院 基因突变类型及基因测序方法
US7585968B2 (en) * 2005-03-28 2009-09-08 Isis Pharmaceuticals, Inc. Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP2500360B1 (de) 2005-10-31 2015-08-05 Oncomed Pharmaceuticals, Inc. Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Krebs
EP1945754B1 (de) * 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von krebs
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
JP5478254B2 (ja) 2006-10-19 2014-04-23 ジェネンテック， インコーポレイテッド 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用
EP2081962B1 (de) 2006-10-19 2018-10-03 Genentech, Inc. Neue anti-notch3-antikörper und ihre verwendung bei dem nachweis und der diagnose von krankheiten
EP2099827B1 (de) * 2006-12-18 2018-11-21 Genentech, Inc. Antagonistische antikörper gegen notch-3 und ihre verwendung zur prävention und behandlung von notch-3-vermittelten krankheiten
EP2106439B1 (de) 2007-01-24 2014-11-12 The Regents of the University of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
WO2008100563A2 (en) * 2007-02-14 2008-08-21 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
AU2008289462B2 (en) 2007-08-23 2014-01-23 The Trustees Of Columbia University In The City Of New York Compositions of humanized notch fusion proteins and methods of treatment
US7807630B2 (en) 2007-09-14 2010-10-05 Vanderbilt University Targeting of Notch3 receptor function for cancer therapy
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
KR20110074846A (ko) 2008-08-22 2011-07-04 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 노치３ 신호전달의 디코이 억제제로서의 인간 노치３ 기반 융합 단백질
EP2331136B1 (de) 2008-09-26 2018-01-10 OncoMed Pharmaceuticals, Inc. Frizzled-bindende stoffe und ihre verwendungen
NZ594281A (en) * 2009-01-26 2013-09-27 Academisch Ziekenhuis Leiden Means and methods for modulating notch3 protein expression and/or the coding region of notch3; compositions and use thereof in the treatment of cadasil
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
MX2012008085A (es) 2010-01-13 2012-09-12 Oncomed Pharm Inc Agentes de union notch1 y metodos de uso de los mismos.
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
WO2011140295A2 (en) * 2010-05-06 2011-11-10 President And Fellows Of Harvard College Modulators of notch receptor signaling and methods of use thereof
AR088048A1 (es) 2011-10-04 2014-05-07 Univ Columbia Señuelos notch1 humanos
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
TW201726746A (zh) 2012-11-07 2017-08-01 輝瑞股份有限公司 抗切口３（ａｎｔｉ-ｎｏｔｃｈ３）抗體及抗體-藥物共軛體
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
US20200103419A1 (en) 2017-03-27 2020-04-02 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
US20230190959A1 (en) * 2017-03-27 2023-06-22 The Schepens Eye Research Institute, Inc. Nucleic acid-based compositions and methods for treating small vessel diseases
KR20240159455A (ko) * 2021-06-02 2024-11-05 리제너론 파마슈티칼스 인코포레이티드 신경성 유전자좌 노치 상동체 단백질 3(notch3) 제제를 이용한 뇌혈관 질환의 치료

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2116628A1 (en) * 1994-02-28 1995-08-29 Anne Marie Gisele Joutel Method for the diagnosis of cadasil
FR2751986B1 (fr) * 1996-08-01 1998-12-31 Inst Nat Sante Rech Med Gene implique dans le cadasil, methode de diagnostic et application therapeutique

Also Published As

Publication number Publication date
ES2328304T3 (es) 2009-11-11
US6537775B1 (en) 2003-03-25
FR2751986B1 (fr) 1998-12-31
EP0915973A1 (de) 1999-05-19
JP4463329B2 (ja) 2010-05-19
CA2262459A1 (fr) 1998-02-12
FR2751986A1 (fr) 1998-02-06
WO1998005775A1 (fr) 1998-02-12
DE69739478D1 (de) 2009-08-13
JP2010042012A (ja) 2010-02-25
US7138234B2 (en) 2006-11-21
EP0915973B1 (de) 2009-07-01
CA2262459C (fr) 2013-03-26
US20030186290A1 (en) 2003-10-02
US6995257B1 (en) 2006-02-07
JP2001500366A (ja) 2001-01-16

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