DK1587830T3 - Peptidinhibitorer af toksiner stammende fra LL-37 - Google Patents
Peptidinhibitorer af toksiner stammende fra LL-37Info
- Publication number
- DK1587830T3 DK1587830T3 DK04705556T DK04705556T DK1587830T3 DK 1587830 T3 DK1587830 T3 DK 1587830T3 DK 04705556 T DK04705556 T DK 04705556T DK 04705556 T DK04705556 T DK 04705556T DK 1587830 T3 DK1587830 T3 DK 1587830T3
- Authority
- DK
- Denmark
- Prior art keywords
- terminal part
- amino acid
- peptide inhibitors
- toxins derived
- sequence
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 108700012359 toxins Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000000688 bacterial toxin Substances 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 1
- 239000002636 mycotoxin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03075274 | 2003-01-28 | ||
| PCT/NL2004/000060 WO2004067563A1 (en) | 2003-01-28 | 2004-01-27 | Peptide inhibitors of toxins derived from ll-37 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1587830T3 true DK1587830T3 (da) | 2009-10-26 |
Family
ID=32798944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04705556T DK1587830T3 (da) | 2003-01-28 | 2004-01-27 | Peptidinhibitorer af toksiner stammende fra LL-37 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7807617B2 (de) |
| EP (1) | EP1587830B1 (de) |
| JP (1) | JP4471968B2 (de) |
| KR (1) | KR100856819B1 (de) |
| CN (1) | CN1798764B (de) |
| AT (1) | ATE435870T1 (de) |
| AU (1) | AU2004207118B2 (de) |
| BR (1) | BRPI0407022A (de) |
| CA (1) | CA2514584C (de) |
| CR (1) | CR7926A (de) |
| DE (1) | DE602004021901D1 (de) |
| DK (1) | DK1587830T3 (de) |
| ES (1) | ES2328571T3 (de) |
| MX (1) | MXPA05008080A (de) |
| NZ (1) | NZ541657A (de) |
| PT (1) | PT1587830E (de) |
| RU (1) | RU2346950C2 (de) |
| WO (1) | WO2004067563A1 (de) |
| ZA (1) | ZA200506411B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1621205A1 (de) * | 2004-07-28 | 2006-02-01 | OctoPlus Technologies B.V. | CAP18 ähnliche Peptide mit antibiotischer Wirkung |
| US7465784B2 (en) * | 2006-10-26 | 2008-12-16 | Board Of Regents Of The University Of Nebraska | Antimicrobial peptides and methods of identifying the same |
| AU2008279087A1 (en) | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of HCV infection using same |
| US20130123201A1 (en) * | 2010-02-25 | 2013-05-16 | University Of Manitoba | Modulation of cytokine-induced chronic inflammatory responses |
| US9580472B2 (en) | 2011-11-21 | 2017-02-28 | Board Of Regents Of The University Of Nebraska | Anti-microbial peptides and methods of use thereof |
| US10723764B2 (en) | 2011-11-21 | 2020-07-28 | Board Of Regents Of The University Of Nebraska | Anti-microbial peptides and methods of use thereof |
| CA2884481C (en) * | 2012-09-17 | 2021-04-27 | Madrigal Pharmaceuticals, Inc. | Method of synthesizing thyroid hormone analogs and polymorphs thereof |
| CA2963175A1 (en) | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Bispecific antibodies and methods of use in ophthalmology |
| RU2584089C1 (ru) * | 2015-06-15 | 2016-05-20 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Саратовский Государственный Медицинский Университет Имени В.И. Разумовского" Министерства Здравоохранения Российской Федерации | Способ снижения летального эффекта бактериального липополисахарида in vitro |
| CN105859867A (zh) * | 2016-05-30 | 2016-08-17 | 黄石市中心医院 | 一种人源抗菌肽ll-37突变体及其应用 |
| CN108892719B (zh) * | 2018-07-09 | 2021-07-30 | 珠海中科先进技术研究院有限公司 | 一种新型人源抗菌肽ll-37衍生物及其应用 |
| CN113116811A (zh) * | 2020-01-14 | 2021-07-16 | 中国科学院上海药物研究所 | 可注射长效镇痛药物组合物及其制备方法和用途 |
| WO2021143745A1 (zh) * | 2020-01-14 | 2021-07-22 | 中国科学院上海药物研究所 | 一种长效罗哌卡因药物组合物及其制备方法和用途 |
| WO2024223887A1 (en) | 2023-04-26 | 2024-10-31 | Karl-Franzens-Universität Graz | Peptides for antimicrobial therapy |
| EP4701648A1 (de) | 2023-04-26 | 2026-03-04 | Karl-Franzens-Universität Graz | Peptide für die krebstherapie |
| CN118754950B (zh) * | 2024-06-07 | 2025-03-07 | 扬州大学 | 一种抗菌衍生肽及其组合物和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103888A (en) * | 1992-07-17 | 2000-08-15 | Panorama Research, Inc. | Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity |
| US5681824A (en) * | 1995-06-05 | 1997-10-28 | Eisai Co., Ltd. | Substituted liposaccharides useful in the treatment and prevention of endotoxemia |
| JP4037525B2 (ja) * | 1998-03-25 | 2008-01-23 | 生化学工業株式会社 | 新規抗菌性ペプチド |
-
2004
- 2004-01-27 AT AT04705556T patent/ATE435870T1/de active
- 2004-01-27 BR BR0407022-4A patent/BRPI0407022A/pt not_active IP Right Cessation
- 2004-01-27 EP EP04705556A patent/EP1587830B1/de not_active Expired - Lifetime
- 2004-01-27 MX MXPA05008080A patent/MXPA05008080A/es not_active Application Discontinuation
- 2004-01-27 US US10/543,521 patent/US7807617B2/en not_active Expired - Fee Related
- 2004-01-27 JP JP2006502728A patent/JP4471968B2/ja not_active Expired - Fee Related
- 2004-01-27 KR KR1020057013964A patent/KR100856819B1/ko not_active Expired - Fee Related
- 2004-01-27 WO PCT/NL2004/000060 patent/WO2004067563A1/en not_active Ceased
- 2004-01-27 DK DK04705556T patent/DK1587830T3/da active
- 2004-01-27 NZ NZ541657A patent/NZ541657A/en not_active IP Right Cessation
- 2004-01-27 CA CA2514584A patent/CA2514584C/en not_active Expired - Fee Related
- 2004-01-27 AU AU2004207118A patent/AU2004207118B2/en not_active Ceased
- 2004-01-27 ES ES04705556T patent/ES2328571T3/es not_active Expired - Lifetime
- 2004-01-27 DE DE602004021901T patent/DE602004021901D1/de not_active Expired - Lifetime
- 2004-01-27 CN CN2004800085269A patent/CN1798764B/zh not_active Expired - Fee Related
- 2004-01-27 PT PT04705556T patent/PT1587830E/pt unknown
- 2004-01-27 RU RU2005127076/04A patent/RU2346950C2/ru not_active IP Right Cessation
-
2005
- 2005-07-28 CR CR7926A patent/CR7926A/es not_active Application Discontinuation
- 2005-08-11 ZA ZA200506411A patent/ZA200506411B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE435870T1 (de) | 2009-07-15 |
| MXPA05008080A (es) | 2006-02-08 |
| EP1587830A1 (de) | 2005-10-26 |
| ZA200506411B (en) | 2006-04-26 |
| DE602004021901D1 (de) | 2009-08-20 |
| WO2004067563A1 (en) | 2004-08-12 |
| CN1798764B (zh) | 2010-05-12 |
| KR20060012261A (ko) | 2006-02-07 |
| PT1587830E (pt) | 2009-09-23 |
| AU2004207118B2 (en) | 2009-12-17 |
| CR7926A (es) | 2006-02-07 |
| ES2328571T3 (es) | 2009-11-16 |
| CN1798764A (zh) | 2006-07-05 |
| KR100856819B1 (ko) | 2008-09-05 |
| WO2004067563A8 (en) | 2004-12-02 |
| US20060223755A1 (en) | 2006-10-05 |
| CA2514584A1 (en) | 2004-08-12 |
| EP1587830B1 (de) | 2009-07-08 |
| JP2007528696A (ja) | 2007-10-18 |
| JP4471968B2 (ja) | 2010-06-02 |
| US7807617B2 (en) | 2010-10-05 |
| BRPI0407022A (pt) | 2006-01-10 |
| RU2005127076A (ru) | 2006-01-20 |
| CA2514584C (en) | 2012-05-29 |
| AU2004207118A1 (en) | 2004-08-12 |
| HK1088613A1 (zh) | 2006-11-10 |
| RU2346950C2 (ru) | 2009-02-20 |
| NZ541657A (en) | 2009-01-31 |
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