ATE438722T1 - Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein - Google Patents
Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoproteinInfo
- Publication number
- ATE438722T1 ATE438722T1 AT01930179T AT01930179T ATE438722T1 AT E438722 T1 ATE438722 T1 AT E438722T1 AT 01930179 T AT01930179 T AT 01930179T AT 01930179 T AT01930179 T AT 01930179T AT E438722 T1 ATE438722 T1 AT E438722T1
- Authority
- AT
- Austria
- Prior art keywords
- sugar chain
- reduction
- protein
- mannose phosphate
- glycoprotein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 9
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 102000003886 Glycoproteins Human genes 0.000 title abstract 4
- 108090000288 Glycoproteins Proteins 0.000 title abstract 4
- NDVRKEKNSBMTAX-MVNLRXSJSA-N (2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O NDVRKEKNSBMTAX-MVNLRXSJSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 4
- 241000235648 Pichia Species 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000144643 | 2000-05-17 | ||
| PCT/JP2001/004070 WO2001088143A1 (en) | 2000-05-17 | 2001-05-16 | Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE438722T1 true ATE438722T1 (de) | 2009-08-15 |
Family
ID=18651270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01930179T ATE438722T1 (de) | 2000-05-17 | 2001-05-16 | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7198921B2 (de) |
| EP (1) | EP1283265B1 (de) |
| JP (2) | JP4969011B2 (de) |
| AT (1) | ATE438722T1 (de) |
| AU (1) | AU2001256762A1 (de) |
| DE (1) | DE60139467D1 (de) |
| DK (1) | DK1283265T3 (de) |
| ES (1) | ES2328106T3 (de) |
| WO (1) | WO2001088143A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE438722T1 (de) * | 2000-05-17 | 2009-08-15 | Mitsubishi Tanabe Pharma Corp | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
| CA2434364C (en) | 2001-01-19 | 2013-03-19 | The Dow Chemical Company | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
| CA2551484C (en) | 2003-12-24 | 2015-03-31 | Glycofi, Inc. | Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins |
| CN101084233B (zh) * | 2004-04-29 | 2012-08-15 | 格利科菲公司 | 用于在糖蛋白产生中减少或消除α-甘露糖苷酶抗性聚糖的方法 |
| CA2623197A1 (en) * | 2005-09-22 | 2007-03-29 | Prosci Incorporated | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
| CA2679732A1 (en) * | 2007-03-07 | 2008-09-18 | Glycofi, Inc. | Production of glycoproteins with modified fucosylation |
| EP2134853B1 (de) | 2007-04-03 | 2018-07-18 | Oxyrane UK Limited | Glycosylierung von molekülen |
| NZ580510A (en) | 2007-04-17 | 2011-06-30 | Stichting Dienst Landbouwkundi | Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases |
| US8637435B2 (en) * | 2007-11-16 | 2014-01-28 | Merck Sharp & Dohme Corp. | Eukaryotic cell display systems |
| JP5960947B2 (ja) * | 2007-12-19 | 2016-08-02 | グライコフィ， インコーポレイテッド | タンパク質の製造のための酵母株 |
| JP2011514157A (ja) * | 2008-02-20 | 2011-05-06 | グライコフィ， インコーポレイテッド | 蛋白質生産用ベクター及び酵母株 |
| EP2263089B1 (de) * | 2008-03-03 | 2015-01-28 | GlycoFi, Inc. | Oberflächenanzeige rekombinanter proteine bei niederen eukaryoten |
| US8067339B2 (en) * | 2008-07-09 | 2011-11-29 | Merck Sharp & Dohme Corp. | Surface display of whole antibodies in eukaryotes |
| EP2324121B1 (de) | 2008-08-12 | 2012-11-07 | GlycoFi, Inc. | Verbesserte vektoren und hefestämme zur proteinproduktion: ca2+-atpase-überexpression |
| EP2401378B1 (de) | 2009-02-25 | 2013-08-14 | Merck Sharp & Dohme Corp. | Stoffwechselmanipulation eines galaktoseassimilationswegs bei der glycoengineerten hefe pichia pastoris |
| US9598682B2 (en) | 2009-09-29 | 2017-03-21 | Vib Vzw | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
| CN102648286A (zh) | 2009-10-16 | 2012-08-22 | 默沙东公司 | 在巴斯德毕赤氏酵母中生产缺乏与针对宿主细胞抗原的抗体的可检测交叉结合活性的蛋白质的方法 |
| AU2010313608A1 (en) | 2009-10-30 | 2012-06-07 | Merck Sharp & Dohme Corp. | Methods for the production of recombinant proteins with improved secretion efficiencies |
| US9528116B2 (en) | 2009-10-30 | 2016-12-27 | Merck Sharp & Dohme Corp. | Method for producing therapeutic proteins in Pichia pastoris lacking dipeptidyl aminopeptidase activity |
| JP2013511272A (ja) | 2009-11-19 | 2013-04-04 | オキシレイン ユーケー リミテッド | 哺乳類様複合ｎ−グリカンを生成する酵母株 |
| KR101930961B1 (ko) | 2010-02-24 | 2018-12-19 | 머크 샤프 앤드 돔 코포레이션 | 피키아 파스토리스에서 생산된 치료 당단백질 상의 ｎ-글리코실화 부위 점유를 증가시키는 방법 |
| RU2604811C2 (ru) | 2010-05-27 | 2016-12-10 | Мерк Шарп Энд Домэ Корп. | Способ получения антител с улучшенными свойствами |
| SG189110A1 (en) | 2010-09-29 | 2013-05-31 | Oxyrane Uk Ltd | De-mannosylation of phosphorylated n-glycans |
| WO2012042386A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
| WO2012074948A2 (en) | 2010-12-01 | 2012-06-07 | Merck Sharp & Dohme Corp. | Surface, anchored fc-bait antibody display system |
| KR20140114278A (ko) | 2011-02-25 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | 변형된 ｏ-글리코실화를 갖는 단백질의 생산을 위한 효모 균주 |
| JP2014517846A (ja) | 2011-05-25 | 2014-07-24 | メルク・シャープ・アンド・ドーム・コーポレーション | 改善された特性を有するＦｃ含有ポリペプチドの製造方法 |
| CA2853341A1 (en) | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | Engineered lower eukaryotic host strains for recombinant protein expression |
| JP6194324B2 (ja) | 2012-03-15 | 2017-09-06 | オキシレイン ユーケー リミテッド | ポンペ病の処置のための方法および材料 |
| US9890378B2 (en) | 2012-05-11 | 2018-02-13 | Merck Sharp & Dohme Corp. | Surface anchored light chain bait antibody display system |
| DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
| US20150275222A1 (en) | 2012-10-22 | 2015-10-01 | Bo Jiang | Crz1 mutant fungal cells |
| US9707276B2 (en) | 2012-12-03 | 2017-07-18 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues |
| AU2015293949B2 (en) | 2014-07-21 | 2019-07-25 | Teknologian Tutkimuskeskus Vtt Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82935A0 (en) | 1986-08-12 | 1987-12-20 | Phillips Petroleum Co | Secretion of heterologous proteins from yeast |
| JPH093097A (ja) * | 1995-06-16 | 1997-01-07 | Green Cross Corp:The | ピキア属酵母由来の糖鎖伸長タンパク、該蛋白質をコードするｄｎａ、修飾該ｄｎａおよび形質転換体 |
| JP2770010B2 (ja) | 1996-03-29 | 1998-06-25 | 工業技術院長 | 酵母のマンノース−１−リン酸転移を正に制御する遺伝子ならびにこの遺伝子の欠損変異株を利用する高マンノース型中性糖鎖の製造方法 |
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| ATE438722T1 (de) * | 2000-05-17 | 2009-08-15 | Mitsubishi Tanabe Pharma Corp | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
| ATE440959T1 (de) * | 2000-06-28 | 2009-09-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
-
2001
- 2001-05-16 AT AT01930179T patent/ATE438722T1/de not_active IP Right Cessation
- 2001-05-16 DE DE60139467T patent/DE60139467D1/de not_active Expired - Lifetime
- 2001-05-16 DK DK01930179T patent/DK1283265T3/da active
- 2001-05-16 ES ES01930179T patent/ES2328106T3/es not_active Expired - Lifetime
- 2001-05-16 US US10/276,075 patent/US7198921B2/en not_active Expired - Lifetime
- 2001-05-16 JP JP2001584525A patent/JP4969011B2/ja not_active Expired - Lifetime
- 2001-05-16 WO PCT/JP2001/004070 patent/WO2001088143A1/ja not_active Ceased
- 2001-05-16 EP EP01930179A patent/EP1283265B1/de not_active Expired - Lifetime
- 2001-05-16 AU AU2001256762A patent/AU2001256762A1/en not_active Abandoned
-
2007
- 2007-02-16 US US11/707,737 patent/US7488591B2/en not_active Expired - Lifetime
-
2008
- 2008-08-01 US US12/184,334 patent/US7872111B2/en not_active Expired - Fee Related
-
2011
- 2011-12-24 JP JP2011282526A patent/JP2012105652A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1283265A4 (de) | 2004-10-20 |
| ES2328106T3 (es) | 2009-11-10 |
| US7872111B2 (en) | 2011-01-18 |
| WO2001088143A1 (en) | 2001-11-22 |
| US20040014170A1 (en) | 2004-01-22 |
| DK1283265T3 (da) | 2009-11-09 |
| EP1283265A1 (de) | 2003-02-12 |
| AU2001256762A1 (en) | 2001-11-26 |
| DE60139467D1 (de) | 2009-09-17 |
| JP2012105652A (ja) | 2012-06-07 |
| US20070202569A1 (en) | 2007-08-30 |
| EP1283265B1 (de) | 2009-08-05 |
| JP4969011B2 (ja) | 2012-07-04 |
| US7488591B2 (en) | 2009-02-10 |
| US7198921B2 (en) | 2007-04-03 |
| US20090004725A1 (en) | 2009-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |