ATE439350T1 - Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex - Google Patents

Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Info

Publication number
ATE439350T1
ATE439350T1 AT02801319T AT02801319T ATE439350T1 AT E439350 T1 ATE439350 T1 AT E439350T1 AT 02801319 T AT02801319 T AT 02801319T AT 02801319 T AT02801319 T AT 02801319T AT E439350 T1 ATE439350 T1 AT E439350T1
Authority
AT
Austria
Prior art keywords
improved substrate
substrate imaging
paramagnetic complex
reversible bonding
imaging
Prior art date
Application number
AT02801319T
Other languages
English (en)
Inventor
Enzo Terreno
Silvio Aime
Mauro Botta
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE439350T1 publication Critical patent/ATE439350T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT02801319T 2001-10-11 2002-10-09 Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex ATE439350T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01124440A EP1302465A1 (de) 2001-10-11 2001-10-11 Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
PCT/EP2002/011271 WO2003033479A1 (en) 2001-10-11 2002-10-09 Enhanced substrate imaging by reversible binding to a paramagnetic complex

Publications (1)

Publication Number Publication Date
ATE439350T1 true ATE439350T1 (de) 2009-08-15

Family

ID=8178947

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02801319T ATE439350T1 (de) 2001-10-11 2002-10-09 Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Country Status (6)

Country Link
US (1) US7608249B2 (de)
EP (2) EP1302465A1 (de)
JP (1) JP4817600B2 (de)
AT (1) ATE439350T1 (de)
DE (1) DE60233338D1 (de)
WO (1) WO2003033479A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1331012A1 (de) 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Magnetisch beeinflussbare paramagnetische Kontrastmittel für Magnetresonanzbildgebung
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
EP1716870A1 (de) 2005-04-29 2006-11-02 Bracco Imaging S.p.A. Kontrastmittel für Kernspintomographie mit konzentrationsunabhängiger Empfanglichkeit
EP2051739A2 (de) * 2006-08-18 2009-04-29 GE Healthcare AS Bildgebungsmedium mit laktat und hyperpolarisiertem 13c-pyruvat
SG178716A1 (en) 2007-01-16 2012-03-29 Ipintl Llc Novel composition for treating metabolic syndrome
CA2666036C (en) 2008-05-16 2017-09-12 Chien-Hung Chen Novel compositions and methods for treating hyperproliferative diseases
WO2010056590A2 (en) * 2008-11-14 2010-05-20 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
US20120156139A1 (en) * 2009-08-31 2012-06-21 Rachel Katz-Brull Isotopically labeled neurochemical agents and uses therof for diagnosing conditions and disorders
FR3025317B1 (fr) * 2014-08-26 2022-09-23 Imabiotech Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse
US12569170B2 (en) * 2021-06-10 2026-03-10 Yale University Paramagnetic sodium NMR macrocyclic-based biosensors, and associated methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4933441A (en) * 1987-01-27 1990-06-12 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
FR2725449B1 (fr) * 1994-10-05 1996-12-27 Air Liquide Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
IT1293778B1 (it) * 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
FR2802928B1 (fr) * 1999-12-22 2003-01-31 Air Liquide Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds

Also Published As

Publication number Publication date
JP4817600B2 (ja) 2011-11-16
EP1434768A1 (de) 2004-07-07
WO2003033479A1 (en) 2003-04-24
EP1302465A1 (de) 2003-04-16
EP1434768B1 (de) 2009-08-12
JP2005508965A (ja) 2005-04-07
US20040258618A1 (en) 2004-12-23
DE60233338D1 (de) 2009-09-24
US7608249B2 (en) 2009-10-27

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