ATE405296T1 - Blut- pool kontrastmittel zur verwendung in der magnetischen resonanzs-diagnostik - Google Patents

Blut- pool kontrastmittel zur verwendung in der magnetischen resonanzs-diagnostik

Info

Publication number
ATE405296T1
ATE405296T1 AT99963556T AT99963556T ATE405296T1 AT E405296 T1 ATE405296 T1 AT E405296T1 AT 99963556 T AT99963556 T AT 99963556T AT 99963556 T AT99963556 T AT 99963556T AT E405296 T1 ATE405296 T1 AT E405296T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
contrast agents
blood pool
pool contrast
resonance diagnostics
Prior art date
Application number
AT99963556T
Other languages
English (en)
Inventor
Pier Lucio Anelli
Marino Brocchetta
Haen Christoph De
Ornella Gazzotti
Luciano Lattuada
Giovanna Lux
Giuseppe Manfredi
Pierfrancesco Morosini
Daniela Palano
Michele Serleti
Fulvio Uggeri
Massimo Visigalli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of ATE405296T1 publication Critical patent/ATE405296T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99963556T 1998-12-23 1999-12-16 Blut- pool kontrastmittel zur verwendung in der magnetischen resonanzs-diagnostik ATE405296T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002802A IT1304501B1 (it) 1998-12-23 1998-12-23 Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza

Publications (1)

Publication Number Publication Date
ATE405296T1 true ATE405296T1 (de) 2008-09-15

Family

ID=11381326

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99963556T ATE405296T1 (de) 1998-12-23 1999-12-16 Blut- pool kontrastmittel zur verwendung in der magnetischen resonanzs-diagnostik

Country Status (20)

Country Link
US (1) US6461588B1 (de)
EP (2) EP1140209B1 (de)
JP (1) JP4733271B2 (de)
KR (1) KR100736298B1 (de)
CN (2) CN100450996C (de)
AT (1) ATE405296T1 (de)
AU (1) AU773876B2 (de)
CA (1) CA2355888C (de)
CZ (1) CZ302195B6 (de)
DE (1) DE69939398D1 (de)
HK (1) HK1042432B (de)
HU (1) HU228048B1 (de)
IL (2) IL143730A0 (de)
IT (1) IT1304501B1 (de)
MX (1) MXPA01006344A (de)
NO (1) NO322551B1 (de)
PL (1) PL196474B1 (de)
RU (2) RU2395490C2 (de)
WO (1) WO2000038738A1 (de)
ZA (1) ZA200104820B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
ES2206996T3 (es) 1997-10-02 2004-05-16 Epix Medical Inc Metodo de formacion de imagenes para diagnostico con contraste mejorado para monitorizar terapias de intervencion.
IT1317862B1 (it) * 2000-02-29 2003-07-15 Bracco Spa Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso.
IT1318485B1 (it) * 2000-04-21 2003-08-25 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari
AU2002230398A1 (en) * 2000-10-06 2002-04-29 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
EP1229041A1 (de) * 2001-02-05 2002-08-07 Bracco Imaging S.p.A. Verfahren zur Herstellung von 3-Glutamid Gallensauerderivate durch Verwendung von N-tBoc Methyl-pyroglutamate
US7053076B2 (en) 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
EP1302465A1 (de) * 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Verbesserte MRI-Bildgebung mittels umkehrbares binding zu einem paramagnetischen Komplex
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7850947B2 (en) * 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
ATE435035T1 (de) * 2003-01-13 2009-07-15 Bracco Imaging Spa Verbesserte linker für radiopharmazeutische verbindungen
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
AU2004314112A1 (en) * 2003-12-24 2005-07-28 Bracco Imaging S.P.A. Improved gastrin releasing peptide compounds
RU2425831C2 (ru) * 2005-12-02 2011-08-10 Джи-И Хелткер АС Мультимерные контрастные агенты для магнитного резонанса
US8529872B2 (en) 2007-07-11 2013-09-10 Board Of Regents, The University Of Texas System Seeds and markers for use in imaging
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
CA2824521C (en) * 2011-01-20 2016-06-28 Board Of Regents, The University Of Texas System Mri markers, delivery and extraction systems, and related methods
AU2013229631B2 (en) 2012-03-05 2017-09-14 Bracco Imaging Spa Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues
CN102766188B (zh) * 2012-07-24 2016-01-13 上海交通大学 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
AU2018261888B2 (en) 2017-05-05 2022-06-30 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
MA52762A (fr) * 2018-05-30 2021-04-14 Translate Bio Inc Lipides cationiques comprenant une fraction stéroïdienne
MX2023014582A (es) * 2021-07-27 2023-12-13 Bracco Imaging Spa Fabricacion de agentes de contraste dimericos.
WO2025163025A1 (en) 2024-01-31 2025-08-07 Bracco Imaging Spa Pyridophane macrocyclic ligands and fe(iii) complexes thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
AU620841B2 (en) * 1987-12-24 1992-02-27 Bracco International B.V. Macrocyclic chelating agents and chelates thereof
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
NO940115D0 (no) * 1994-01-13 1994-01-13 Nycomed Imaging As Kontrastmidler for roentgen- og magnettomografisk avbildning
CA2188292A1 (en) * 1994-04-20 1995-11-02 Larry Margerum Contrast agents
IT1269839B (it) * 1994-05-26 1997-04-15 Bracco Spa Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
JPH11116542A (ja) * 1997-10-06 1999-04-27 Sogo Pharmaceut Co Ltd γ−グルタミン酸アミド類の製造法

Also Published As

Publication number Publication date
HK1042432B (zh) 2007-01-26
JP2002533420A (ja) 2002-10-08
EP1935435B1 (de) 2017-09-06
KR20010099889A (ko) 2001-11-09
ITMI982802A1 (it) 2000-06-23
CN1263515C (zh) 2006-07-12
KR100736298B1 (ko) 2007-07-06
AU773876B2 (en) 2004-06-10
WO2000038738A1 (en) 2000-07-06
PL196474B1 (pl) 2008-01-31
HUP0104715A3 (en) 2005-11-28
CN100450996C (zh) 2009-01-14
JP4733271B2 (ja) 2011-07-27
CZ302195B6 (cs) 2010-12-08
RU2004127136A (ru) 2006-02-27
IL143730A (en) 2007-09-20
EP1140209B1 (de) 2008-08-20
EP1935435A2 (de) 2008-06-25
NO322551B1 (no) 2006-10-23
RU2395490C2 (ru) 2010-07-27
ZA200104820B (en) 2002-06-13
MXPA01006344A (es) 2002-06-04
CA2355888C (en) 2009-02-24
IL143730A0 (en) 2002-04-21
NO20013154L (no) 2001-08-23
DE69939398D1 (de) 2008-10-02
IT1304501B1 (it) 2001-03-19
HUP0104715A2 (hu) 2002-04-29
AU1980700A (en) 2000-07-31
HU228048B1 (en) 2012-09-28
EP1935435A3 (de) 2009-01-21
US6461588B1 (en) 2002-10-08
NO20013154D0 (no) 2001-06-22
HK1042432A1 (zh) 2002-08-16
EP1140209A1 (de) 2001-10-10
CA2355888A1 (en) 2000-07-06
CN1854122A (zh) 2006-11-01
PL349488A1 (en) 2002-07-29
CN1333695A (zh) 2002-01-30
CZ20012330A3 (cs) 2002-01-16
RU2250765C2 (ru) 2005-04-27

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