ATE439378T1 - Verfahren zur identifizierung von indirekten igf- 1-agonisten - Google Patents

Verfahren zur identifizierung von indirekten igf- 1-agonisten

Info

Publication number
ATE439378T1
ATE439378T1 AT06026832T AT06026832T ATE439378T1 AT E439378 T1 ATE439378 T1 AT E439378T1 AT 06026832 T AT06026832 T AT 06026832T AT 06026832 T AT06026832 T AT 06026832T AT E439378 T1 ATE439378 T1 AT E439378T1
Authority
AT
Austria
Prior art keywords
igf
agonists
identifying
identifying indirect
relates
Prior art date
Application number
AT06026832T
Other languages
English (en)
Inventor
Michelle Schaffer
Mark Ultsch
Felix Vajdos
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE439378T1 publication Critical patent/ATE439378T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
AT06026832T 2001-02-09 2002-02-01 Verfahren zur identifizierung von indirekten igf- 1-agonisten ATE439378T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26797701P 2001-02-09 2001-02-09
US28707201P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
ATE439378T1 true ATE439378T1 (de) 2009-08-15

Family

ID=26952796

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02724908T ATE349469T1 (de) 2001-02-09 2002-02-01 Kristallisierung von igf-1
AT06026832T ATE439378T1 (de) 2001-02-09 2002-02-01 Verfahren zur identifizierung von indirekten igf- 1-agonisten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT02724908T ATE349469T1 (de) 2001-02-09 2002-02-01 Kristallisierung von igf-1

Country Status (19)

Country Link
US (8) US7084240B2 (de)
EP (3) EP1358209B1 (de)
JP (2) JP4489352B2 (de)
KR (1) KR100872613B1 (de)
CN (1) CN100439397C (de)
AT (2) ATE349469T1 (de)
AU (1) AU2002255508B2 (de)
BR (1) BR0207422A (de)
CA (1) CA2431033A1 (de)
DE (3) DE60217066D1 (de)
DK (2) DK1772464T3 (de)
ES (2) ES2331150T3 (de)
HU (1) HUP0500733A3 (de)
IL (2) IL156435A0 (de)
MX (1) MXPA03007042A (de)
NZ (3) NZ526672A (de)
PL (1) PL374181A1 (de)
WO (1) WO2002064627A2 (de)
ZA (1) ZA200304900B (de)

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US6914049B2 (en) * 2001-09-18 2005-07-05 Bioexpertise, Llc IGF-binding protein-derived peptide or small molecule
AU2002324672B2 (en) * 2001-09-18 2007-11-08 Bioexpertise, Llc IGF-binding protein-derived peptide or small molecule
WO2004102151A2 (en) * 2003-05-06 2004-11-25 New Century Pharmaceuticals Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on therir albumin binding properties
EP1684705A4 (de) * 2003-11-03 2008-02-20 New Century Pharmaceuticals Albumin-bindungsstellen zur beurteilung von arzneimittelwechselwirkungen und verfahren zur beurteilung oder zum entwurf von arzneimitteln auf basis ihrer albuminbindungseigenschaften
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WO2005108424A1 (en) * 2004-05-06 2005-11-17 Genentech, Inc. Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use
WO2006001911A2 (en) * 2004-05-06 2006-01-05 Genentech, Inc. Crystal structure of the hepatocyte growth factor beta chain and methods of use
CN103223160B (zh) * 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
US20060110788A1 (en) * 2004-10-01 2006-05-25 Invitrogen Corporation Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
US7556776B2 (en) * 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US7994127B2 (en) * 2007-06-08 2011-08-09 Massachusetts Institute Of Technology Treatment of rett syndrome
WO2009026172A2 (en) * 2007-08-17 2009-02-26 The Regents Of The University Of California New approach for designing diabetes drugs
CN101139391B (zh) * 2007-08-21 2012-07-25 陈志南 Cd147胞外区晶体结构及应用
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
WO2011011071A2 (en) * 2009-07-22 2011-01-27 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (igf-1)
US8759299B2 (en) * 2009-07-22 2014-06-24 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59
US20120266263A1 (en) * 2009-10-14 2012-10-18 Mount Sinai School Of Medicine Method of treating memory disorders and enhancing memory using igf-ii compounds
WO2013148227A1 (en) * 2012-03-28 2013-10-03 Merck Sharp & Dohme Corp. Insulin-like growth factor-1 receptor inhibitors
KR101711584B1 (ko) * 2012-12-18 2017-03-02 재단법인 의약바이오컨버젼스연구단 변형된 eprs 단백질의 결정 구조 및 이의 결정화 방법
ES2872998T3 (es) 2013-12-19 2021-11-03 Puretein Bioscience Llc Procedimientos de tratamiento de animales
EP4027984A4 (de) 2019-09-09 2023-10-18 The University of Chicago Kombinationstherapie zur behandlung von migräne
WO2021248160A1 (en) * 2020-06-01 2021-12-09 Loma Linda University Health Methods of treatment of a cytokine storm
WO2025259950A1 (en) * 2024-06-14 2025-12-18 Cz Biohub Sf, Llc Genetically encoded lysosome targeting chimeras for cell-mediated delivery

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Also Published As

Publication number Publication date
US20060276397A1 (en) 2006-12-07
DE60217066T4 (de) 2010-07-01
US7433788B2 (en) 2008-10-07
US7297763B2 (en) 2007-11-20
IL156435A0 (en) 2004-01-04
HUP0500733A2 (hu) 2005-10-28
MXPA03007042A (es) 2004-05-24
JP4489352B2 (ja) 2010-06-23
HUP0500733A3 (en) 2010-01-28
DK1358209T3 (da) 2007-05-07
US7238658B2 (en) 2007-07-03
US20060281905A1 (en) 2006-12-14
US7596455B2 (en) 2009-09-29
WO2002064627A2 (en) 2002-08-22
IL156435A (en) 2009-09-22
DK1772464T3 (da) 2009-12-14
US20060270839A1 (en) 2006-11-30
ES2331150T3 (es) 2009-12-22
DE60217066D1 (de) 2007-02-08
ES2278020T3 (es) 2007-08-01
US20060287235A1 (en) 2006-12-21
EP1801120A1 (de) 2007-06-27
EP1772464B1 (de) 2009-08-12
CA2431033A1 (en) 2002-08-22
NZ548359A (en) 2007-11-30
EP1772464A3 (de) 2007-10-03
ZA200304900B (en) 2005-07-27
ATE349469T1 (de) 2007-01-15
JP2009215299A (ja) 2009-09-24
KR20040064610A (ko) 2004-07-19
NZ548358A (en) 2008-04-30
EP1358209A2 (de) 2003-11-05
EP1358209B1 (de) 2006-12-27
WO2002064627A3 (en) 2003-07-31
AU2002255508B2 (en) 2008-04-03
HK1060138A1 (en) 2004-07-30
JP2005503329A (ja) 2005-02-03
PL374181A1 (en) 2005-10-03
KR100872613B1 (ko) 2008-12-09
DE60233359D1 (de) 2009-09-24
US7084240B2 (en) 2006-08-01
EP1772464A2 (de) 2007-04-11
CN100439397C (zh) 2008-12-03
DE60217066T2 (de) 2007-07-12
US20050215477A1 (en) 2005-09-29
NZ526672A (en) 2006-10-27
BR0207422A (pt) 2005-04-19
US20060293507A1 (en) 2006-12-28
US20020165155A1 (en) 2002-11-07
CN1703425A (zh) 2005-11-30
US20060287510A1 (en) 2006-12-21
US7354769B2 (en) 2008-04-08

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