ATE440104T1 - 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten - Google Patents

9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Info

Publication number
ATE440104T1
ATE440104T1 AT03744475T AT03744475T ATE440104T1 AT E440104 T1 ATE440104 T1 AT E440104T1 AT 03744475 T AT03744475 T AT 03744475T AT 03744475 T AT03744475 T AT 03744475T AT E440104 T1 ATE440104 T1 AT E440104T1
Authority
AT
Austria
Prior art keywords
homoerythromycin
aza
methyl
dexo
derivatives
Prior art date
Application number
AT03744475T
Other languages
English (en)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominik Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Original Assignee
Pliva Hrvatska D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska D O O filed Critical Pliva Hrvatska D O O
Application granted granted Critical
Publication of ATE440104T1 publication Critical patent/ATE440104T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
AT03744475T 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten ATE440104T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
ATE440104T1 true ATE440104T1 (de) 2009-09-15

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03744475T ATE440104T1 (de) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Country Status (23)

Country Link
US (1) US7569549B2 (de)
EP (2) EP1627883A1 (de)
JP (1) JP2005529082A (de)
KR (1) KR20050002872A (de)
CN (1) CN1642966A (de)
AT (1) ATE440104T1 (de)
AU (1) AU2003215779A1 (de)
BG (1) BG108874A (de)
BR (1) BR0308644A (de)
CA (1) CA2479211A1 (de)
DE (1) DE60328872D1 (de)
EA (1) EA200401217A1 (de)
ES (1) ES2331733T3 (de)
HR (2) HRP20020231A2 (de)
IL (1) IL163836A0 (de)
IS (1) IS7449A (de)
MX (1) MXPA04009009A (de)
NO (1) NO20044341L (de)
NZ (1) NZ535477A (de)
PL (1) PL372468A1 (de)
RS (1) RS82504A (de)
TN (1) TNSN04166A1 (de)
WO (1) WO2003077830A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1648473B1 (de) 2003-07-24 2009-01-28 PLIVA HRVATSKA d.o.o. Schnellösliches azithromycin in einzeldosisform
EP1878432A1 (de) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Schnellösliches Azithromycin in Einzeldosisform
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053651A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate compositions with improved stability
RU2331410C2 (ru) * 2003-12-04 2008-08-20 Пфайзер Продактс Инк. Способ получения фармацевтических мультичастиц
JP2007513147A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 押し出し機を使用して、好ましくはポロキサマーとグリセリドを含有する多粒子結晶性医薬組成物を製造するための噴霧凝結方法
BRPI0417338A (pt) * 2003-12-04 2007-04-17 Pfizer Prod Inc formas de dosagem de azitromicina multiparticulada por processos a base de lìquido
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
MX12213A (es) * 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
WO1994026758A1 (en) 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
US6365574B2 (en) * 1998-11-30 2002-04-02 Teva Pharmaceutical Industries Ltd. Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
US6703372B1 (en) * 1999-06-29 2004-03-09 Biochemie S.A. Macrolides
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
CA2396426A1 (en) 2000-01-04 2001-07-12 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
ES2260047T3 (es) * 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
AU2001280000A1 (en) 2000-08-23 2002-03-04 Jaweed Mukarram, Siddiqui Mohammed Process for preparation of anhydrous azithromycin
HU229488B1 (hu) * 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
DE60209704T2 (de) 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
NZ532707A (en) 2001-12-21 2006-07-28 Pfizer Prod Inc Directly compressible formulations of azithromycin
NZ532063A (en) 2001-12-21 2006-03-31 Pfizer Prod Inc Methods for wet granulating azithromycin
MXPA04007427A (es) 2002-02-01 2004-10-11 Pfizer Prod Inc Formulaciones de azitromicina granuladas por via seca.
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
US20040014951A1 (en) 2004-01-22
WO2003077830A3 (en) 2004-05-13
NO20044341L (no) 2004-11-23
HRP20020231A2 (en) 2003-12-31
EP1485393B1 (de) 2009-08-19
JP2005529082A (ja) 2005-09-29
NZ535477A (en) 2006-11-30
AU2003215779A1 (en) 2003-09-29
RS82504A (sr) 2006-12-15
MXPA04009009A (es) 2005-06-17
TNSN04166A1 (en) 2007-03-12
KR20050002872A (ko) 2005-01-10
EP1627883A1 (de) 2006-02-22
CN1642966A (zh) 2005-07-20
EA200401217A1 (ru) 2005-02-24
CA2479211A1 (en) 2003-09-25
DE60328872D1 (en) 2009-10-01
US7569549B2 (en) 2009-08-04
HRP20040858A2 (en) 2005-06-30
EP1485393A2 (de) 2004-12-15
WO2003077830A2 (en) 2003-09-25
BR0308644A (pt) 2005-01-25
BG108874A (en) 2005-12-30
IS7449A (is) 2004-09-16
PL372468A1 (en) 2005-07-25
IL163836A0 (en) 2005-12-18
ES2331733T3 (es) 2010-01-14

Similar Documents

Publication Publication Date Title
IS7449A (is) Afleiður 9-dexó-9a-asa-9a-metýl-9a-hómóerýþrómýsíns A
EP1505061A4 (de) Verbindung mit pgd-2-rezeptorantagonismus
WO2003006425A3 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
CO5280078A1 (es) Compuestos
NO20050065L (no) Kjemiske forbindelser
DE60208355D1 (de) 2-amino-propanol derivate
NO20034660D0 (no) Spiropyrazolforbindelser
NO20044995L (no) Heterosykliske forbindelser
ECSP088367A (es) Derivados de bifenilo y su uso en el tratamiento de la hepatitis c
NO2012012I2 (no) Pasireotide (som diaspartat salt). Det kjemiske navnet er cyclo[(4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L-phenylalanyl-)
NO20055305L (no) Pyrrolopyridin-2-karboksylsyreamid-inhibitorer av glykogenfosforylase
ATE477256T1 (de) Thienylverbindungen
SE0004245D0 (sv) Novel compounds and their use
NO20072753L (no) 3-Etylidenhydrazinosubstituerte heterocykliske forbindelser som trombopoietinreseptoraktivatorer
NO20054787L (no) Indenderivater som farmasotiske midler
SE0100326D0 (sv) New compounds
DE60015390D1 (de) Antidiabetische thiazolidindione und ihre herstellung
DK1644389T3 (da) Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
BR0115996A (pt) Sulfamidotienopirimidinas
BR0109946A (pt) Derivados de eritromicina substituìda em 6-o tendo tolerância gastrointestinal
ATE263160T1 (de) Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
DK1619185T3 (da) 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf
TW200609228A (en) Substituted n-acyl-2-aminothiazoles
UY26416A1 (es) Compuestos
NO20075505L (no) 7-fluor-1,3-dihydro-indol-2-on oksazolidinoner som antibakterielle forbindelser

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties