ATE440104T1 - 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten - Google Patents

9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Info

Publication number
ATE440104T1
ATE440104T1 AT03744475T AT03744475T ATE440104T1 AT E440104 T1 ATE440104 T1 AT E440104T1 AT 03744475 T AT03744475 T AT 03744475T AT 03744475 T AT03744475 T AT 03744475T AT E440104 T1 ATE440104 T1 AT E440104T1
Authority
AT
Austria
Prior art keywords
homoerythromycin
aza
methyl
dexo
derivatives
Prior art date
Application number
AT03744475T
Other languages
English (en)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominik Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Original Assignee
Pliva Hrvatska D O O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Hrvatska D O O filed Critical Pliva Hrvatska D O O
Application granted granted Critical
Publication of ATE440104T1 publication Critical patent/ATE440104T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
AT03744475T 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten ATE440104T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08
PCT/IB2003/000987 WO2003077830A2 (en) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
ATE440104T1 true ATE440104T1 (de) 2009-09-15

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03744475T ATE440104T1 (de) 2002-03-18 2003-03-18 9-dexo-9a-aza-9a-methyl-9a-homoerythromycin a derivaten

Country Status (23)

Country Link
US (1) US7569549B2 (de)
EP (2) EP1485393B1 (de)
JP (1) JP2005529082A (de)
KR (1) KR20050002872A (de)
CN (1) CN1642966A (de)
AT (1) ATE440104T1 (de)
AU (1) AU2003215779A1 (de)
BG (1) BG108874A (de)
BR (1) BR0308644A (de)
CA (1) CA2479211A1 (de)
DE (1) DE60328872D1 (de)
EA (1) EA200401217A1 (de)
ES (1) ES2331733T3 (de)
HR (2) HRP20020231A2 (de)
IL (1) IL163836A0 (de)
IS (1) IS7449A (de)
MX (1) MXPA04009009A (de)
NO (1) NO20044341L (de)
NZ (1) NZ535477A (de)
PL (1) PL372468A1 (de)
RS (1) RS82504A (de)
TN (1) TNSN04166A1 (de)
WO (1) WO2003077830A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1878432A1 (de) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Schnellösliches Azithromycin in Einzeldosisform
WO2005009447A1 (en) * 2003-07-24 2005-02-03 Pliva - Research And Development Ltd. Single dose fast dissolving azithromycin
JP2007513139A (ja) 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
CA2547239A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Azithromycin multiparticulate dosage forms by liquid-based processes
CA2549225A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
JP2007513145A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 医薬用多微粒子の製造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
RO107257B1 (ro) * 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
ES2104386T3 (es) 1993-05-19 1997-10-01 Pfizer Compuesto intermedio para la acitromicina.
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
JP2002531409A (ja) * 1998-11-30 2002-09-24 テバ ファーマシューティカル インダストリーズ リミティド アジスロマイシンのエタノール付加物、その製造方法、及びその医薬製剤
ATE469910T1 (de) * 1999-06-29 2010-06-15 Sandoz Ag Azithromycinmonohydrat
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
AU2928701A (en) 2000-01-04 2001-07-16 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
ATE320441T1 (de) * 2000-07-25 2006-04-15 Silanes Sa De Cv Lab Einstufiges verfahren zur herstellung von 7,16-
DE60114028T2 (de) 2000-08-23 2006-07-13 Wockhardt Ltd. Verfahren zur herstellung von wasserfreiem azithromycin
CA2429639C (en) 2000-11-27 2009-07-14 Biochemie S.A. Stable azithromycin monohydrate
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
IL158591A0 (en) 2001-05-22 2004-05-12 Pfizer Prod Inc Crystal forms of azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1455757A2 (de) 2001-12-21 2004-09-15 Pfizer Products Inc. Verfahren zur feuchtgranulierung von azithromycin
IL161996A0 (en) 2001-12-21 2005-11-20 Pfizer Prod Inc Directly compressible formulations of azithromycin
BR0307331A (pt) 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
TNSN04166A1 (en) 2007-03-12
WO2003077830A2 (en) 2003-09-25
CA2479211A1 (en) 2003-09-25
EP1485393B1 (de) 2009-08-19
US7569549B2 (en) 2009-08-04
MXPA04009009A (es) 2005-06-17
JP2005529082A (ja) 2005-09-29
HRP20020231A2 (en) 2003-12-31
WO2003077830A3 (en) 2004-05-13
BR0308644A (pt) 2005-01-25
HRP20040858A2 (en) 2005-06-30
AU2003215779A1 (en) 2003-09-29
US20040014951A1 (en) 2004-01-22
NZ535477A (en) 2006-11-30
RS82504A (sr) 2006-12-15
IL163836A0 (en) 2005-12-18
DE60328872D1 (en) 2009-10-01
CN1642966A (zh) 2005-07-20
BG108874A (en) 2005-12-30
EP1485393A2 (de) 2004-12-15
KR20050002872A (ko) 2005-01-10
EP1627883A1 (de) 2006-02-22
PL372468A1 (en) 2005-07-25
EA200401217A1 (ru) 2005-02-24
NO20044341L (no) 2004-11-23
IS7449A (is) 2004-09-16
ES2331733T3 (es) 2010-01-14

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