ATE440865T1 - Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region - Google Patents

Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Info

Publication number
ATE440865T1
ATE440865T1 AT99914138T AT99914138T ATE440865T1 AT E440865 T1 ATE440865 T1 AT E440865T1 AT 99914138 T AT99914138 T AT 99914138T AT 99914138 T AT99914138 T AT 99914138T AT E440865 T1 ATE440865 T1 AT E440865T1
Authority
AT
Austria
Prior art keywords
protein
receptors
mammal
coupled
new
Prior art date
Application number
AT99914138T
Other languages
English (en)
Inventor
Aaron Hsueh
Sheau Hsu
Shan-Guang Liang
Der Spek Petrus Van
Original Assignee
Univ Leland Stanford Junior
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Akzo Nobel Nv filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE440865T1 publication Critical patent/ATE440865T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99914138T 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region ATE440865T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7950198P 1998-03-26 1998-03-26
PCT/US1999/006573 WO1999048921A1 (en) 1998-03-26 1999-03-25 Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions

Publications (1)

Publication Number Publication Date
ATE440865T1 true ATE440865T1 (de) 2009-09-15

Family

ID=22150958

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914138T ATE440865T1 (de) 1998-03-26 1999-03-25 Neue g-protein-gekoppelte rezeptoren aus säugetieren mit extrazellulären leucin-reicher region

Country Status (6)

Country Link
EP (1) EP1066324B1 (de)
JP (2) JP2002507406A (de)
AT (1) ATE440865T1 (de)
DE (1) DE69941330D1 (de)
ES (1) ES2332025T3 (de)
WO (1) WO1999048921A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
WO2001009322A1 (fr) * 1999-07-29 2001-02-08 Helix Research Institute Recepteurs couples a la proteine de liaison guanosine triphosphate, genes correspondants, et leur production et utilisation
WO2001014548A2 (en) * 1999-08-19 2001-03-01 Merck Patent Gmbh New g-protein coupled receptor and dna sequences thereof
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
GB9924956D0 (en) * 1999-10-21 1999-12-22 Pfizer Ltd Novel polypeptide
WO2001036471A2 (en) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
AU2001239756A1 (en) * 2000-02-08 2001-08-20 Curagen Corporation Novel proteins and nucleic acids encoding same
AU2001259156A1 (en) * 2000-04-27 2001-11-07 Lexicon Genetics Incorporated Novel membrane proteins and polynucleotides encoding the same
WO2001092297A2 (en) * 2000-05-30 2001-12-06 Bayer Aktiengesellschaft Regulation of human lgr4-like g protein-coupled receptor
WO2002000689A2 (en) * 2000-06-30 2002-01-03 Ingenium Pharmaceuticals Ag HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR11, AND USES THEREOF
US20040248321A1 (en) * 2000-07-07 2004-12-09 Takeo Moriya Novel g protein-coupled receptor protein and dna thereof
MXPA03001183A (es) * 2000-08-10 2003-06-30 Amgen Inc Proteina g que contiene una repeticion rica en leucina. acoplada con moleculas del receptor 8 y usos de la misma.
WO2002016600A2 (en) * 2000-08-25 2002-02-28 Curagen Corporation Novel proteins and nucleic acids encoding same
WO2002026824A2 (en) * 2000-09-27 2002-04-04 Bristol-Myers Squibb Company A novel human g-protein coupled receptor, hgprbmy5, expressed highly in brain and ovarian tissues
EP1366165A2 (de) * 2001-02-07 2003-12-03 Incyte Genomics, Inc. G-protein gekoppelte rezeptoren
US20030088884A1 (en) 2001-08-17 2003-05-08 Hsu Sheau Yu Mammalian relaxin receptors
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
AU2003224112A1 (en) * 2002-05-02 2003-11-17 Bayer Aktiengesellschaft Diagnostics and drug screening for diseases associated with leucine-rich repeat-containing g-protein coupled receptor 7 (lgr7)
EP1380644A1 (de) * 2002-07-08 2004-01-14 Kylix B.V. Verwendung spezifischer TCF Zielgene zur Identifizierung von Medikamenten zur Behandlung von Krebsarten, insbesondere Colorectalkrebs, bei denen TCF/beta-catenin/WNT Signaltransduktion eine zentrale Rolle spielt
EP1581812B1 (de) * 2003-01-06 2008-07-16 Wyeth Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs
DE10339820A1 (de) * 2003-08-22 2005-03-17 Hinzmann, Bernd, Dr. Verwendung von an GPR49 bindenden Substanzen zur Diagnose und Behandlung von Krebs
WO2005040828A2 (en) * 2003-10-24 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 49 (gpr49)
US7189539B2 (en) 2003-11-25 2007-03-13 Bristol-Myers Squibb Company Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1
DK2173379T3 (en) 2007-07-02 2015-12-07 Oncomed Pharm Inc Compositions and methods for treatment and diagnosis of cancer
WO2009063970A1 (ja) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. 抗gpr49抗体を用いる癌の診断および治療
KR20110099762A (ko) * 2008-12-26 2011-09-08 고쿠리츠다이가쿠호우진 도쿄다이가쿠 항ｌｇｒ７항체를 사용하는 암의 진단 및 치료
JPWO2010113988A1 (ja) * 2009-03-31 2012-10-11 国立大学法人三重大学 抗ｇｐｃｒ抗体の製造方法および抗ｇｐｃｒ抗体
WO2013012747A1 (en) 2011-07-15 2013-01-24 Oncomed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
SG11201500233PA (en) 2012-07-13 2015-04-29 Oncomed Pharm Inc Rspo3 binding agents and uses thereof
US10064937B2 (en) 2014-09-16 2018-09-04 Oncomed Pharmaceuticals, Inc. Treatment of dermal fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5858716A (en) * 1997-05-30 1999-01-12 Smithkline Beecham Corporation H2CAA71 polynucleotides
EP1017709A4 (de) * 1997-09-24 2001-12-12 Merck & Co Inc Über g-protein gekuppelter glykoprotein-hormonrezeptor aomf05

Also Published As

Publication number Publication date
EP1066324A4 (de) 2005-06-15
JP2010166923A (ja) 2010-08-05
WO1999048921A1 (en) 1999-09-30
EP1066324A1 (de) 2001-01-10
ES2332025T3 (es) 2010-01-22
DE69941330D1 (de) 2009-10-08
JP2002507406A (ja) 2002-03-12
EP1066324B1 (de) 2009-08-26

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