ATE441415T1 - Substituierte piperidin-derivate als somatostatin-sst1-rezeptorantagonisten - Google Patents
Substituierte piperidin-derivate als somatostatin-sst1-rezeptorantagonistenInfo
- Publication number
- ATE441415T1 ATE441415T1 AT06762563T AT06762563T ATE441415T1 AT E441415 T1 ATE441415 T1 AT E441415T1 AT 06762563 T AT06762563 T AT 06762563T AT 06762563 T AT06762563 T AT 06762563T AT E441415 T1 ATE441415 T1 AT E441415T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- substituted piperidine
- piperidine derivatives
- sst1 receptor
- somatostatin
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 102100029563 Somatostatin Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
- 101150029725 sst1 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0514615.4A GB0514615D0 (en) | 2005-07-15 | 2005-07-15 | Organic compounds |
| PCT/EP2006/006867 WO2007009662A1 (en) | 2005-07-15 | 2006-07-13 | Substituted piperidine derivatives as somatostatin sst1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441415T1 true ATE441415T1 (de) | 2009-09-15 |
Family
ID=34897328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06762563T ATE441415T1 (de) | 2005-07-15 | 2006-07-13 | Substituierte piperidin-derivate als somatostatin-sst1-rezeptorantagonisten |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7754719B2 (de) |
| EP (1) | EP1909792B1 (de) |
| JP (1) | JP2009501180A (de) |
| KR (1) | KR20080025731A (de) |
| CN (1) | CN101222924A (de) |
| AT (1) | ATE441415T1 (de) |
| AU (1) | AU2006272049A1 (de) |
| BR (1) | BRPI0612994A2 (de) |
| CA (1) | CA2615236A1 (de) |
| DE (1) | DE602006008957D1 (de) |
| ES (1) | ES2333165T3 (de) |
| GB (1) | GB0514615D0 (de) |
| MX (1) | MX2008000709A (de) |
| PL (1) | PL1909792T3 (de) |
| PT (1) | PT1909792E (de) |
| RU (1) | RU2008105362A (de) |
| WO (1) | WO2007009662A1 (de) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149817A (en) | 1990-03-05 | 1992-09-22 | Shionogi & Co., Ltd. | Teirahydropyridine derivatives |
| JP2001502712A (ja) * | 1996-10-31 | 2001-02-27 | ノボ ノルディスク アクティーゼルスカブ | 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト |
| CA2316767A1 (en) | 1999-09-01 | 2001-03-01 | Bridget Mccarthy Cole | Somatostatin antagonists and agonists that act at the sst subtype 2 receptor |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| GB0127008D0 (en) | 2001-11-09 | 2002-01-02 | Novartis Ag | Organic compounds |
| AU2003248122A1 (en) | 2002-07-25 | 2004-02-16 | Kotobuki Pharmaceutical Co., Ltd. | Sodium channel inhibitor |
-
2005
- 2005-07-15 GB GBGB0514615.4A patent/GB0514615D0/en not_active Ceased
-
2006
- 2006-07-13 PL PL06762563T patent/PL1909792T3/pl unknown
- 2006-07-13 US US11/995,725 patent/US7754719B2/en not_active Expired - Fee Related
- 2006-07-13 CN CNA2006800259166A patent/CN101222924A/zh active Pending
- 2006-07-13 MX MX2008000709A patent/MX2008000709A/es not_active Application Discontinuation
- 2006-07-13 EP EP06762563A patent/EP1909792B1/de not_active Expired - Lifetime
- 2006-07-13 DE DE602006008957T patent/DE602006008957D1/de not_active Expired - Lifetime
- 2006-07-13 ES ES06762563T patent/ES2333165T3/es not_active Expired - Lifetime
- 2006-07-13 BR BRPI0612994-3A patent/BRPI0612994A2/pt not_active IP Right Cessation
- 2006-07-13 AT AT06762563T patent/ATE441415T1/de active
- 2006-07-13 KR KR1020087001023A patent/KR20080025731A/ko not_active Withdrawn
- 2006-07-13 WO PCT/EP2006/006867 patent/WO2007009662A1/en not_active Ceased
- 2006-07-13 CA CA002615236A patent/CA2615236A1/en not_active Abandoned
- 2006-07-13 JP JP2008520800A patent/JP2009501180A/ja active Pending
- 2006-07-13 AU AU2006272049A patent/AU2006272049A1/en not_active Abandoned
- 2006-07-13 RU RU2008105362/04A patent/RU2008105362A/ru not_active Application Discontinuation
- 2006-07-13 PT PT06762563T patent/PT1909792E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1909792A1 (de) | 2008-04-16 |
| MX2008000709A (es) | 2008-03-18 |
| PT1909792E (pt) | 2009-12-09 |
| EP1909792B1 (de) | 2009-09-02 |
| ES2333165T3 (es) | 2010-02-17 |
| CA2615236A1 (en) | 2007-01-25 |
| GB0514615D0 (en) | 2005-08-24 |
| US20080255142A1 (en) | 2008-10-16 |
| WO2007009662A1 (en) | 2007-01-25 |
| KR20080025731A (ko) | 2008-03-21 |
| DE602006008957D1 (de) | 2009-10-15 |
| CN101222924A (zh) | 2008-07-16 |
| AU2006272049A1 (en) | 2007-01-25 |
| RU2008105362A (ru) | 2009-08-20 |
| PL1909792T3 (pl) | 2010-02-26 |
| JP2009501180A (ja) | 2009-01-15 |
| US7754719B2 (en) | 2010-07-13 |
| BRPI0612994A2 (pt) | 2010-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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