ATE442143T1 - Reduziertes vitamin b2 enthaltende arzneimittel - Google Patents

Reduziertes vitamin b2 enthaltende arzneimittel

Info

Publication number: ATE442143T1
Authority: AT; Austria
Prior art keywords: agent; reduced; containing vitamin; drugs containing; reductant
Prior art date: 2001-03-21

Application number

AT02705355T

Other languages

English (en)

Inventor

Seiichi Araki

Mamoru Suzuki

Yoshiki Sugihara

Toshio Toyosawa

Original Assignee

Eisai R&D Man Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-21

Filing date

2002-03-19

Publication date

2009-09-15

2002-03-19 Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE442143T1 publication Critical patent/ATE442143T1/de

Links

AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title abstract 3
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 3
206010040047 Sepsis Diseases 0.000 abstract 2
206010040070 Septic Shock Diseases 0.000 abstract 2
239000003638 chemical reducing agent Substances 0.000 abstract 2
230000003308 immunostimulating effect Effects 0.000 abstract 2
230000036303 septic shock Effects 0.000 abstract 2
208000035473 Communicable disease Diseases 0.000 abstract 1
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
229960002477 riboflavin Drugs 0.000 abstract 1
235000019192 riboflavin Nutrition 0.000 abstract 1
239000002151 riboflavin Substances 0.000 abstract 1
150000003287 riboflavins Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02705355T 2001-03-21 2002-03-19 Reduziertes vitamin b2 enthaltende arzneimittel ATE442143T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001080578		2001-03-21
PCT/JP2002/002616 WO2002074313A1 (en)	2001-03-21	2002-03-19	Drugs containing reduced vitamin b¿2?

Publications (1)

Publication Number	Publication Date
ATE442143T1 true ATE442143T1 (de)	2009-09-15

Family

ID=18936834

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02705355T ATE442143T1 (de)	2001-03-21	2002-03-19	Reduziertes vitamin b2 enthaltende arzneimittel

Country Status (6)

Country	Link
US (1)	US7579325B2 (de)
EP (1)	EP1371370B1 (de)
JP (1)	JP4278384B2 (de)
AT (1)	ATE442143T1 (de)
DE (1)	DE60233647D1 (de)
WO (1)	WO2002074313A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2914135A1 (de) *	2012-11-01	2015-09-09	Rijksuniversiteit Groningen	Verfahren und zusammensetzungen zum anregen von nützlichen bakterien im verdauungstrakt
JP6129395B1 (ja) *	2016-10-29	2017-05-17	誠一荒木	ミトコンドリア活性化に起因した血管内皮細胞保護回復用還元型ビタミンｂ２製剤
JP2018070581A (ja) *	2017-04-19	2018-05-10	誠一荒木	還元型ビタミンｂ２製剤

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2970995A (en) *	1959-03-20	1961-02-07	Gen Mills Inc	Reductive acylated products of riboflavin
HU203198B (en)	1987-10-26	1991-06-28	Sandoz Ag	Process for producing pharmaceutical compositions having immunity-inhibiting, monokin-, particularly interleukin-1-inhibiting effect
FR2674753B1 (fr)	1991-04-02	1995-03-10	Jean Berque	Nouvelles indications therapeutiques, en particulier pour le traitement du sida, d'un medicament deja existant et fabrique a partir d'une molecule denuee de contre-indications et d'effets indesirables.
JP2979767B2 (ja)	1991-09-09	1999-11-15	味の素株式会社	発酵法によるリボフラビンの製造法
JP3636207B2 (ja)	1991-09-13	2005-04-06	エーザイ株式会社	免疫賦活・感染防御剤及びその製造方法
NZ244270A (en)	1991-09-13	1995-07-26	Eisai Co Ltd	Injectable composition comprising riboflavin
DE4328871A1 (de)	1993-08-27	1995-03-02	Beiersdorf Ag	Mittel gegen empfindliche, hyperreaktive Hautzustände, atopische Dermatiden, Pruritus, Psoriasis Prurigo, Photodermatosen und Ichthyosis
AU1881095A (en)	1994-02-28	1995-09-11	James P. Cox	Sulfur and oxygen deodorant compositions
US5714469A (en) *	1994-09-01	1998-02-03	Smithkline Beecham Corporation	Method of treating sepsis
US6506792B1 (en) *	1997-03-04	2003-01-14	Sterix Limited	Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
JP3286831B2 (ja)	1996-04-01	2002-05-27	エーザイ株式会社	ビタミンｂ２含有医薬
JPH09301861A (ja)	1996-05-13	1997-11-25	Showa Denko Kk	ラジカル疾患用注射・点滴薬剤
JPH11199486A (ja)	1998-01-13	1999-07-27	Eisai Co Ltd	ビタミンｂ２含有医薬組成物
JPH11199513A (ja)	1998-01-14	1999-07-27	Eisai Co Ltd	高濃度リン酸リボフラビンナトリウム注射剤
ID25649A (id)	1998-03-09	2000-10-19	Takeda Chemical Industries Ltd	Turunan-turunan sikloalkena, produksi serta penggunaannya
JP2000080046A (ja)	1998-09-03	2000-03-21	Dai Ichi Seiyaku Co Ltd	多臓器障害の予防・治療剤
JP5073884B2 (ja)	1998-10-09	2012-11-14	三井製糖株式会社	感染予防治療剤、抗エンドトキシン剤、ワクチンアジュバント剤および成長促進剤
JP2000297049A (ja)	1999-04-15	2000-10-24	Mitsui Chemicals Inc	アルキルベンゼンの製造方法
JP2000302768A (ja)	1999-04-16	2000-10-31	Sumitomo Pharmaceut Co Ltd	ヒドラゾン誘導体
GB0017060D0 (en) *	2000-07-11	2000-08-30	Hunter Fleming Ltd	Production, stabilisation and use of reduced forms of pharmaceutical compounds
US20030143265A1 (en)	2001-12-19	2003-07-31	Seiichi Araki	Method for treatment of sepsis
US20030162751A1 (en)	2001-12-19	2003-08-28	Adam Grobin	Pharmaceutical composition comprising 5' monophosphate ester of riboflavin and solubilized riboflavin
US20030161871A1 (en)	2001-12-19	2003-08-28	Geoffrey Hird	Solubilized riboflavin

2002
- 2002-03-19 EP EP02705355A patent/EP1371370B1/de not_active Expired - Lifetime
- 2002-03-19 AT AT02705355T patent/ATE442143T1/de not_active IP Right Cessation
- 2002-03-19 DE DE60233647T patent/DE60233647D1/de not_active Expired - Lifetime
- 2002-03-19 JP JP2002573020A patent/JP4278384B2/ja not_active Expired - Fee Related
- 2002-03-19 US US10/472,621 patent/US7579325B2/en not_active Expired - Fee Related
- 2002-03-19 WO PCT/JP2002/002616 patent/WO2002074313A1/ja not_active Ceased

Also Published As

Publication number	Publication date
DE60233647D1 (de)	2009-10-22
EP1371370A1 (de)	2003-12-17
US20040106562A1 (en)	2004-06-03
WO2002074313A1 (en)	2002-09-26
EP1371370A4 (de)	2006-07-26
EP1371370B1 (de)	2009-09-09
JP4278384B2 (ja)	2009-06-10
US7579325B2 (en)	2009-08-25
JPWO2002074313A1 (ja)	2004-07-08

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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ATE442143T1 (de)	2009-09-15	Reduziertes vitamin b2 enthaltende arzneimittel
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