ATE442450T1 - Neue expressionswerkzeuge für multiproteinanwendungen - Google Patents
Neue expressionswerkzeuge für multiproteinanwendungenInfo
- Publication number
- ATE442450T1 ATE442450T1 AT04803271T AT04803271T ATE442450T1 AT E442450 T1 ATE442450 T1 AT E442450T1 AT 04803271 T AT04803271 T AT 04803271T AT 04803271 T AT04803271 T AT 04803271T AT E442450 T1 ATE442450 T1 AT E442450T1
- Authority
- AT
- Austria
- Prior art keywords
- multiprotein
- applications
- new expression
- host cells
- expression tools
- Prior art date
Links
- 241000701447 unidentified baculovirus Species 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 244000292604 Salvia columbariae Species 0.000 abstract 1
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 abstract 1
- 235000001498 Salvia hispanica Nutrition 0.000 abstract 1
- 235000014167 chia Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/70—Vectors containing special elements for cloning, e.g. topoisomerase, adaptor sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55207204P | 2004-03-09 | 2004-03-09 | |
| PCT/EP2004/013381 WO2005085456A1 (en) | 2004-03-09 | 2004-11-25 | New expression tools for multiprotein applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442450T1 true ATE442450T1 (de) | 2009-09-15 |
Family
ID=34919595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04803271T ATE442450T1 (de) | 2004-03-09 | 2004-11-25 | Neue expressionswerkzeuge für multiproteinanwendungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080004228A1 (de) |
| EP (2) | EP2133428A1 (de) |
| JP (1) | JP4597188B2 (de) |
| AT (1) | ATE442450T1 (de) |
| AU (1) | AU2004316874B2 (de) |
| CA (1) | CA2558313C (de) |
| DE (1) | DE602004023128D1 (de) |
| ES (1) | ES2333228T3 (de) |
| WO (1) | WO2005085456A1 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008000985A (es) | 2005-07-21 | 2008-04-07 | Abbott Lab | Expresion de gen multiple que incluye construcciones y metodos sorf (cuadro de lectura abierta simple) con poliproteinas, pro-proteinas y proteolisis. |
| EP1783228A1 (de) * | 2005-11-08 | 2007-05-09 | ETH Zürich | Rekombinante Expression von Multiproteinkomplexen mit Hilfe von Multigenen |
| JP5152962B2 (ja) * | 2007-06-08 | 2013-02-27 | 国立大学法人静岡大学 | 目的タンパク質の製造方法 |
| GB0820631D0 (en) * | 2008-11-11 | 2008-12-17 | London School Hygiene & Tropical Medicine | Vectors |
| US8709798B2 (en) | 2009-03-06 | 2014-04-29 | Europaisches Laboratorium Fur Molekularbiologie | Nucleic acids for cloning and expressing multiprotein complexes |
| EP2414512A1 (de) | 2009-04-03 | 2012-02-08 | Deutsches Krebsforschungszentrum | Verbesserte herstellung papillomavirus-ähnlicher partikel mit einem modifizierten baculovirus-expressionssystem |
| EP2424980A1 (de) * | 2009-05-01 | 2012-03-07 | Redbiotec AG | Von einem vektor mit mehreren genen codierte rekombinante virusähnliche partikel |
| CN101947317B (zh) * | 2010-09-27 | 2012-05-30 | 武汉大学 | 一种h5n1禽流感病毒样颗粒疫苗的规模化制备方法 |
| FR2978456B1 (fr) * | 2011-07-27 | 2015-02-20 | Genethon | Systeme baculoviral pour l'expression d'un vecteur de therapie genique |
| WO2013078433A1 (en) | 2011-11-23 | 2013-05-30 | University Of Hawaii | Auto-processing domains for polypeptide expression |
| WO2013100713A2 (ko) * | 2011-12-30 | 2013-07-04 | 이화여자대학교 산학협력단 | 효모 염색체 통합 또는 산업 스트레인 형질전환용 효모 발현 벡터, 그리고 이들의 용도 |
| KR101328481B1 (ko) * | 2011-12-30 | 2013-11-13 | 이화여자대학교 산학협력단 | 염색체 통합용 효모 발현 벡터 및 이의 용도 |
| CN105392362B (zh) | 2012-06-12 | 2018-11-09 | 替代基因表达公司 | 用于在宿主昆虫中表达重组蛋白的杆状病毒dna元件 |
| ES2612854T3 (es) * | 2012-06-12 | 2017-05-19 | Alternative Gene Expression, S.L. | Elementos de ADN recombinante para la expresión de proteínas recombinantes en una célula huésped |
| US9982239B2 (en) | 2012-06-12 | 2018-05-29 | Alternative Gene Expression S.L. | Baculoviral DNA elements for the expression of recombinant proteins in a host cell |
| US20160130588A1 (en) * | 2013-03-14 | 2016-05-12 | Friedrich Miescher Institute For Biomedical Research (Fmi) | Method for the generation of polycystronic vectors |
| TWI696700B (zh) * | 2015-01-16 | 2020-06-21 | 國立研究開發法人產業技術總合研究所 | 使用具有匿跡性之ｒｎａ的基因表現系統及含有該ｒｎａ的基因導入、表現載體 |
| CN104630271A (zh) * | 2015-02-05 | 2015-05-20 | 浙江大学 | 可视化红色荧光杆状病毒的构建方法 |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US10262981B2 (en) * | 2016-04-29 | 2019-04-16 | Taiwan Semiconductor Manufacturing Company, Ltd. | Integrated circuit, system for and method of forming an integrated circuit |
| NZ762100A (en) | 2017-08-09 | 2025-12-19 | Bioverativ Therapeutics Inc | Nucleic acid molecules and uses thereof |
| CN107988259B (zh) * | 2018-01-12 | 2020-01-21 | 中国科学院生物物理研究所 | SmartBac杆状病毒表达系统及其应用 |
| EP3830250A1 (de) | 2018-07-31 | 2021-06-09 | Imophoron Limited | Multimerisierende polypeptide aus einer jelly-roll-faltungsdomäne der adenovirus-pentonbase |
| EP3833766A1 (de) | 2018-08-09 | 2021-06-16 | Bioverativ Therapeutics Inc. | Nukleinsäuremoleküle und verwendungen davon zur nichtviralen gentherapie |
| WO2020072844A1 (en) * | 2018-10-05 | 2020-04-09 | Voyager Therapeutics, Inc. | Engineered nucleic acid constructs encoding aav production proteins |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| JP7805169B2 (ja) * | 2019-06-26 | 2026-01-23 | ビロベク，インコーポレイテッド | バキュロウイルス発現系 |
| WO2021110993A1 (en) * | 2019-12-04 | 2021-06-10 | Synbionik Gmbh | An efficient shuttle vector system for the expression of heterologous and homologous proteins for the genus zymomonas |
| WO2021156489A1 (en) | 2020-02-05 | 2021-08-12 | Imophoron Limited | Engineered polypeptides derived from variable domain of adenovirus penton base |
| CN111593072B (zh) * | 2020-05-12 | 2021-04-27 | 深圳海关动植物检验检疫技术中心 | 一种在昆虫细胞中共表达非洲猪瘟病毒四种结构蛋白的方法及其应用 |
| EP4168426A1 (de) | 2020-06-18 | 2023-04-26 | The University of Bristol | Fettsäurekomplexe des coronavirus-spike-proteins und deren verwendung |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
| MX2024002333A (es) * | 2021-08-23 | 2024-03-07 | Bioverativ Therapeutics Inc | Sistema de expresion de baculovirus. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169784A (en) * | 1990-09-17 | 1992-12-08 | The Texas A & M University System | Baculovirus dual promoter expression vector |
| US5871986A (en) * | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US6355240B1 (en) * | 1995-07-26 | 2002-03-12 | Basf Aktiengellschaft | Enhanced insecticidal insect virus through the expression of heterologous proteins with early promoters |
| EP2316919B1 (de) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen |
| JP2005532829A (ja) * | 2002-07-18 | 2005-11-04 | インヴィトロジェン コーポレーション | 組換え部位を含むウイルスベクター |
-
2004
- 2004-11-25 EP EP09011354A patent/EP2133428A1/de not_active Withdrawn
- 2004-11-25 CA CA2558313A patent/CA2558313C/en not_active Expired - Fee Related
- 2004-11-25 DE DE602004023128T patent/DE602004023128D1/de not_active Expired - Lifetime
- 2004-11-25 US US10/592,066 patent/US20080004228A1/en not_active Abandoned
- 2004-11-25 ES ES04803271T patent/ES2333228T3/es not_active Expired - Lifetime
- 2004-11-25 AU AU2004316874A patent/AU2004316874B2/en not_active Ceased
- 2004-11-25 WO PCT/EP2004/013381 patent/WO2005085456A1/en not_active Ceased
- 2004-11-25 JP JP2007502200A patent/JP4597188B2/ja not_active Expired - Fee Related
- 2004-11-25 EP EP04803271A patent/EP1723246B1/de not_active Expired - Lifetime
- 2004-11-25 AT AT04803271T patent/ATE442450T1/de not_active IP Right Cessation
-
2015
- 2015-12-11 US US14/966,258 patent/US20160177336A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2558313C (en) | 2011-05-17 |
| EP2133428A1 (de) | 2009-12-16 |
| CA2558313A1 (en) | 2005-09-15 |
| AU2004316874A1 (en) | 2005-09-15 |
| AU2004316874B2 (en) | 2011-01-06 |
| US20080004228A1 (en) | 2008-01-03 |
| US20160177336A1 (en) | 2016-06-23 |
| WO2005085456A1 (en) | 2005-09-15 |
| DE602004023128D1 (de) | 2009-10-22 |
| JP4597188B2 (ja) | 2010-12-15 |
| ES2333228T3 (es) | 2010-02-18 |
| EP1723246A1 (de) | 2006-11-22 |
| EP1723246B1 (de) | 2009-09-09 |
| JP2007527722A (ja) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |