ATE443071T1 - Verfahren zum entschützen von oligonukleotiden - Google Patents

Verfahren zum entschützen von oligonukleotiden

Info

Publication number
ATE443071T1
ATE443071T1 AT00907140T AT00907140T ATE443071T1 AT E443071 T1 ATE443071 T1 AT E443071T1 AT 00907140 T AT00907140 T AT 00907140T AT 00907140 T AT00907140 T AT 00907140T AT E443071 T1 ATE443071 T1 AT E443071T1
Authority
AT
Austria
Prior art keywords
oligonucleotide
substrate
protecting groups
phosphate protecting
attached
Prior art date
Application number
AT00907140T
Other languages
English (en)
Inventor
Anila Bhan
Lars Holmberg
Original Assignee
Ge Healthcare Bio Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Bio Sciences filed Critical Ge Healthcare Bio Sciences
Application granted granted Critical
Publication of ATE443071T1 publication Critical patent/ATE443071T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00907140T 1999-02-05 2000-02-05 Verfahren zum entschützen von oligonukleotiden ATE443071T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11857599P 1999-02-05 1999-02-05
PCT/US2000/002845 WO2000046231A1 (en) 1999-02-05 2000-02-05 Method for deprotecting oligonucleotides

Publications (1)

Publication Number Publication Date
ATE443071T1 true ATE443071T1 (de) 2009-10-15

Family

ID=22379444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00907140T ATE443071T1 (de) 1999-02-05 2000-02-05 Verfahren zum entschützen von oligonukleotiden

Country Status (10)

Country Link
US (1) US6887990B1 (de)
EP (1) EP1149109B1 (de)
JP (1) JP4705716B2 (de)
AT (1) ATE443071T1 (de)
AU (1) AU767509B2 (de)
CA (1) CA2361079C (de)
DE (1) DE60042962D1 (de)
DK (1) DK1149109T3 (de)
NO (1) NO20013804L (de)
WO (1) WO2000046231A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041007A2 (en) 1998-02-11 1999-08-19 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
CA2714353A1 (en) 2000-12-05 2002-06-13 Avecia Biotechnology Inc Process for the preparation of phosphorothioate oligonucleotides
US6768005B2 (en) 2000-12-20 2004-07-27 Avecia Limited Process
ATE312841T1 (de) 2001-03-08 2005-12-15 Applera Corp Verfahren zum entschützen von oligonukleotide
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
US20030153741A1 (en) * 2002-02-08 2003-08-14 Marek Kwiatkowski Methods for separating oligonucleotides
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
CA2721969C (en) * 2008-04-24 2016-06-07 Girindus America, Inc. Process for the manufacture of oligonucleotides
JPWO2021045141A1 (de) * 2019-09-04 2021-03-11
JP7640461B2 (ja) 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
JP7667788B2 (ja) 2020-01-29 2025-04-23 住友化学株式会社 核酸オリゴマーの製造方法
EP4098655A4 (de) 2020-01-29 2024-02-28 Sumitomo Chemical Company, Limited Verfahren zum produzieren von nukleinsäure-oligomeren
EP4130018A4 (de) 2020-03-27 2024-04-17 Sumitomo Chemical Company, Limited Verfahren zur herstellung eines nukleinsäureoligomers
CN115867559A (zh) 2020-07-09 2023-03-28 住友化学株式会社 核酸寡聚物的制造方法
KR20230074205A (ko) 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN117980285A (zh) 2021-09-28 2024-05-03 住友化学株式会社 纯化二氯乙酸的制造方法
EP4201947A1 (de) 2021-12-22 2023-06-28 F. Hoffmann-La Roche AG Verfahren zur entschützung des rückgrats von oligonukleotiden mit endständiger alkylphosphonatgruppe
CN114573652B (zh) * 2022-03-15 2025-02-07 安徽瑞拜药业有限公司 药用核酸合成工艺
US12509485B2 (en) 2022-03-23 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
EP4559925A1 (de) 2022-07-22 2025-05-28 Sumitomo Chemical Company, Limited Verfahren zur herstellung von oligonukleotiden
JPWO2024024873A1 (de) 2022-07-28 2024-02-01
CN119855824A (zh) * 2022-09-07 2025-04-18 株式会社日本触媒 核酸的制造方法、杂质的去除方法以及杂质少的核酸
WO2024089953A1 (ja) 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
US12415172B2 (en) 2022-12-22 2025-09-16 Synthego Corporation Systems and method for automated oligonucleotide synthesis
JPWO2024143276A1 (de) 2022-12-26 2024-07-04

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4426517A (en) * 1981-08-24 1984-01-17 Eli Lilly And Company Process for de-cyanoethylating blocked nucleotides
US4417046A (en) * 1981-08-24 1983-11-22 Eli Lilly And Company Process for isolating oligonucleotide product from a coupling reaction mixture
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US5362866A (en) * 1983-09-02 1994-11-08 Molecular Biosystems, Inc. Oligonucleotide polymeric support system with an oxidation cleavable link
WO1985001051A1 (en) * 1983-09-02 1985-03-14 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
US4672110A (en) * 1983-11-29 1987-06-09 Northwestern University Method of deprotecting polynucleotide trimethylethyl phosphotriesters
JPS6242997A (ja) * 1985-08-19 1987-02-24 Akira Kaji ヌクレオシドアルキルホスホネイトの製造方法
SE9003743D0 (sv) 1990-11-26 1990-11-26 Pharmacia Ab Method and means for oligonucleotide synthesis
DE19627898A1 (de) * 1996-07-11 1998-01-15 Hoechst Ag Festphasensynthese von Oligonucleotiden
US6127533A (en) * 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US6465628B1 (en) * 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds

Also Published As

Publication number Publication date
AU767509B2 (en) 2003-11-13
CA2361079C (en) 2010-05-25
NO20013804L (no) 2001-08-22
US6887990B1 (en) 2005-05-03
WO2000046231A1 (en) 2000-08-10
EP1149109A1 (de) 2001-10-31
DK1149109T3 (da) 2010-01-11
JP2002536381A (ja) 2002-10-29
EP1149109B1 (de) 2009-09-16
JP4705716B2 (ja) 2011-06-22
AU2868700A (en) 2000-08-25
DE60042962D1 (de) 2009-10-29
NO20013804D0 (no) 2001-08-03
CA2361079A1 (en) 2000-08-10

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