ATE444743T1 - Verwendung von 2,5-dihydroxybenzolsulfonsäure bei der herstellung von medikamenten zur behandlung von angiogenesis-abhängigen erkrankungen wie krebs und psoriasis - Google Patents
Verwendung von 2,5-dihydroxybenzolsulfonsäure bei der herstellung von medikamenten zur behandlung von angiogenesis-abhängigen erkrankungen wie krebs und psoriasisInfo
- Publication number
- ATE444743T1 ATE444743T1 AT05708114T AT05708114T ATE444743T1 AT E444743 T1 ATE444743 T1 AT E444743T1 AT 05708114 T AT05708114 T AT 05708114T AT 05708114 T AT05708114 T AT 05708114T AT E444743 T1 ATE444743 T1 AT E444743T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- psoriasis
- production
- compounds
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000004681 Psoriasis Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- IKQCSJBQLWJEPU-UHFFFAOYSA-N 2,5-dihydroxybenzenesulfonic acid Chemical compound OC1=CC=C(O)C(S(O)(=O)=O)=C1 IKQCSJBQLWJEPU-UHFFFAOYSA-N 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 206010018338 Glioma Diseases 0.000 abstract 1
- 230000002095 anti-migrative effect Effects 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000861 pro-apoptotic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200400371A ES2238924B1 (es) | 2004-02-17 | 2004-02-17 | Uso del acido 2,5-dihidroxibencenosulfonico, en la fabricacion de medicamentos de aplicacion en el tratamiento de enfermedades angiodependientes. |
| PCT/ES2005/070017 WO2005077352A1 (es) | 2004-02-17 | 2005-02-16 | Uso del ácido 2,5-dihidroxibencenosulfónico, en la fabricación de medicamentos de aplicación en el tratamiento de enfermedades angiogénicas como el cáncer y la psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444743T1 true ATE444743T1 (de) | 2009-10-15 |
Family
ID=34854892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05708114T ATE444743T1 (de) | 2004-02-17 | 2005-02-16 | Verwendung von 2,5-dihydroxybenzolsulfonsäure bei der herstellung von medikamenten zur behandlung von angiogenesis-abhängigen erkrankungen wie krebs und psoriasis |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7968531B2 (de) |
| EP (1) | EP1719509B1 (de) |
| JP (4) | JP4892360B2 (de) |
| KR (1) | KR20070007783A (de) |
| CN (1) | CN101014330A (de) |
| AT (1) | ATE444743T1 (de) |
| AU (1) | AU2005211956B2 (de) |
| CA (1) | CA2555248C (de) |
| DE (1) | DE602005017015D1 (de) |
| DK (1) | DK1719509T3 (de) |
| ES (2) | ES2238924B1 (de) |
| IL (1) | IL177238A (de) |
| MX (1) | MXPA06009295A (de) |
| PT (1) | PT1719509E (de) |
| RU (1) | RU2006133305A (de) |
| UA (1) | UA86399C2 (de) |
| WO (1) | WO2005077352A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2238924B1 (es) * | 2004-02-17 | 2006-12-01 | Investread Europa, S.L. | Uso del acido 2,5-dihidroxibencenosulfonico, en la fabricacion de medicamentos de aplicacion en el tratamiento de enfermedades angiodependientes. |
| US20070149618A1 (en) | 2004-02-17 | 2007-06-28 | Action Medicines, S.L. | Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis |
| US20080125485A1 (en) | 2004-02-17 | 2008-05-29 | Action Medicines | Use of 2,5-Dihydroxybenzene Derivatives for Treating Actinic Keratosis |
| US8541467B2 (en) * | 2006-08-16 | 2013-09-24 | Action Medicines, S.L. | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ |
| ES2315118B1 (es) * | 2006-08-16 | 2009-12-30 | Action Medicines, S.L. | Uso de los compuestos y derivados 2,5-dihidroxibencenicos en la preparacion de medicamentos utiles en el tratamiento de rosacea y psoriasis. |
| PT2056815E (pt) * | 2006-08-16 | 2013-04-03 | Amderma Pharmaceuticals Llc | Utilização de derivados de 2,5-dihidroxibenzeno para tratar dermatite |
| WO2008113863A2 (en) * | 2007-03-22 | 2008-09-25 | Action Medicines, S.L. | Nitrosated derivatives of 2,5-dihydroxybenzene compounds |
| US9012692B2 (en) * | 2008-01-03 | 2015-04-21 | AmDerma Pharmaceuticals, LLC | Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts |
| US20110196040A1 (en) * | 2008-02-15 | 2011-08-11 | Action Medicines S.L. | Skin Penetration Enhancing Systems for Polar Drugs |
| CN110092736A (zh) * | 2018-12-05 | 2019-08-06 | 湖北广辰药业有限公司 | 一种减少羟苯双磺酸钙杂质含量的羟苯磺酸钙制备方法 |
| WO2022035300A1 (ko) | 2020-08-14 | 2022-02-17 | (주) 엔피홀딩스 | 플라즈마 발생 장치, 및 플라즈마 발생 장치를 포함하는 공정 처리 장치 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954767A (en) * | 1972-05-17 | 1976-05-04 | Esteve Subirana Antonio | Piperazine salts of 2,5-dihydroxy benzene sulfonic acid mono- and diesters |
| US4115648A (en) | 1974-09-13 | 1978-09-19 | Laboratorios Del Dr. Esteve, S.A. | 2,5-Dihydroxy benzene sulfonic acid mono esters |
| ATE69548T1 (de) | 1985-05-15 | 1991-12-15 | Roshdy Ismail | Vitamin e-haltiges mittel zur verbesserung der eigenschaften des blutes. |
| US4837378A (en) | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| GB8620073D0 (en) | 1986-08-18 | 1986-10-01 | Delandale Lab Ltd | Pharmaceutical compositions |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| DE4230262A1 (de) | 1992-09-10 | 1994-03-17 | Behringwerke Ag | Substituierte Phenole, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von zellproliferationsbedingten Erkrankungen |
| US5374772A (en) | 1992-12-08 | 1994-12-20 | Hoffmann-Laroche Inc. | Substituted benzoic acids, inhibitors of phospholipases A2 |
| FR2717078B1 (fr) | 1994-03-08 | 1996-12-13 | Oreal | Utilisation des acides sulfoniques comme agents antivieillissement dans une composition cosmétique ou dermatologique. |
| WO1996017589A1 (en) | 1994-12-08 | 1996-06-13 | Kao Corporation | Method of smoothing or removing wrinkles and method of stimulating collagen synthesis |
| US5610185A (en) | 1995-02-17 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the treatment of hyperproliferative epithelial skin diseases by topical application of hydroxylated aromatic protein cross-linking compounds |
| JPH08283152A (ja) | 1995-04-12 | 1996-10-29 | Kao Corp | 細胞接着抑制剤 |
| FR2782269B1 (fr) | 1998-08-17 | 2001-08-31 | Oreal | Composition cosmetique et/ou dermatologique contenant de l'acide salicylique ou un derive d'acide salicylique et son utilisation |
| US6258821B1 (en) | 1999-04-26 | 2001-07-10 | Medimmune Oncology, Inc. | Compositions comprising trimetrexate and methods of their synthesis and use |
| US6787573B2 (en) | 1999-07-02 | 2004-09-07 | Universiteit Utrecht | Antiviral therapy |
| GB9927629D0 (en) | 1999-11-24 | 2000-01-19 | Croda Int Plc | Compounds |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7691905B2 (en) | 2002-12-24 | 2010-04-06 | New York University | Inhibition of melanogenesis and melanoma metastasis with p-aminobenzoic acid (PABA) |
| EP1457485A1 (de) | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonsäuren, deren Derivate sowie sie enthaltenden pharmazeutischen Zubereitungen |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| ES2222831B2 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
| US20050175559A1 (en) | 2004-02-10 | 2005-08-11 | Pcr Technology Holdings, Lc | Method and preparation for reducing skin hyperpigmentation |
| US20080125485A1 (en) | 2004-02-17 | 2008-05-29 | Action Medicines | Use of 2,5-Dihydroxybenzene Derivatives for Treating Actinic Keratosis |
| US20070149618A1 (en) | 2004-02-17 | 2007-06-28 | Action Medicines, S.L. | Methods of use for 2,5-dihydroxybenzene sulfonic acid compounds for the treatment of cancer, rosacea and psoriasis |
| ES2238924B1 (es) * | 2004-02-17 | 2006-12-01 | Investread Europa, S.L. | Uso del acido 2,5-dihidroxibencenosulfonico, en la fabricacion de medicamentos de aplicacion en el tratamiento de enfermedades angiodependientes. |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| EP1799228B1 (de) | 2004-09-14 | 2010-04-14 | Ajinomoto Omnichem S.A. | Topische zusammensetzungen mit phosphorylierten polyphenolen |
| EP1676573A1 (de) | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Pharmazeutische Zusammensetzung enthaltend eine 2,5-Dihydroxybenzolsulfonsäure-Verbindung, einen Kalium Kanal Modulator und einen Phosphodiesterase 5 Inhibitor |
| WO2008020033A1 (en) | 2006-08-16 | 2008-02-21 | Action Medicines, S.L. | Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain |
| PT2056815E (pt) | 2006-08-16 | 2013-04-03 | Amderma Pharmaceuticals Llc | Utilização de derivados de 2,5-dihidroxibenzeno para tratar dermatite |
| US8541467B2 (en) | 2006-08-16 | 2013-09-24 | Action Medicines, S.L. | Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ |
-
2004
- 2004-02-17 ES ES200400371A patent/ES2238924B1/es not_active Expired - Fee Related
-
2005
- 2005-02-16 JP JP2006553602A patent/JP4892360B2/ja not_active Expired - Fee Related
- 2005-02-16 ES ES05708114T patent/ES2334447T3/es not_active Expired - Lifetime
- 2005-02-16 UA UAA200609127A patent/UA86399C2/ru unknown
- 2005-02-16 AU AU2005211956A patent/AU2005211956B2/en not_active Ceased
- 2005-02-16 MX MXPA06009295A patent/MXPA06009295A/es active IP Right Grant
- 2005-02-16 US US10/588,166 patent/US7968531B2/en not_active Expired - Fee Related
- 2005-02-16 CN CNA2005800051873A patent/CN101014330A/zh active Pending
- 2005-02-16 EP EP05708114A patent/EP1719509B1/de not_active Expired - Lifetime
- 2005-02-16 PT PT05708114T patent/PT1719509E/pt unknown
- 2005-02-16 WO PCT/ES2005/070017 patent/WO2005077352A1/es not_active Ceased
- 2005-02-16 CA CA2555248A patent/CA2555248C/en not_active Expired - Fee Related
- 2005-02-16 RU RU2006133305/15A patent/RU2006133305A/ru not_active Application Discontinuation
- 2005-02-16 AT AT05708114T patent/ATE444743T1/de not_active IP Right Cessation
- 2005-02-16 DE DE602005017015T patent/DE602005017015D1/de not_active Expired - Lifetime
- 2005-02-16 DK DK05708114.3T patent/DK1719509T3/da active
- 2005-02-16 KR KR1020067016184A patent/KR20070007783A/ko not_active Ceased
-
2006
- 2006-08-02 IL IL177238A patent/IL177238A/en active IP Right Grant
-
2011
- 2011-06-27 US US13/169,781 patent/US8435971B2/en not_active Expired - Fee Related
- 2011-10-04 JP JP2011219725A patent/JP5639029B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-21 US US13/772,790 patent/US20130203851A1/en not_active Abandoned
-
2014
- 2014-10-03 JP JP2014205125A patent/JP5973518B2/ja not_active Expired - Fee Related
-
2016
- 2016-04-07 JP JP2016077339A patent/JP6216826B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP6216826B2 (ja) | 2017-10-18 |
| JP2007522256A (ja) | 2007-08-09 |
| JP5639029B2 (ja) | 2014-12-10 |
| WO2005077352A1 (es) | 2005-08-25 |
| AU2005211956A1 (en) | 2005-08-25 |
| JP5973518B2 (ja) | 2016-08-23 |
| US7968531B2 (en) | 2011-06-28 |
| CA2555248A1 (en) | 2005-08-25 |
| EP1719509B1 (de) | 2009-10-07 |
| AU2005211956B2 (en) | 2011-07-28 |
| US20130203851A1 (en) | 2013-08-08 |
| JP2014240445A (ja) | 2014-12-25 |
| IL177238A0 (en) | 2006-12-10 |
| MXPA06009295A (es) | 2007-03-23 |
| KR20070007783A (ko) | 2007-01-16 |
| CA2555248C (en) | 2013-04-16 |
| US8435971B2 (en) | 2013-05-07 |
| JP2016145243A (ja) | 2016-08-12 |
| US20080293816A1 (en) | 2008-11-27 |
| US20120142780A1 (en) | 2012-06-07 |
| RU2006133305A (ru) | 2008-03-27 |
| PT1719509E (pt) | 2010-01-13 |
| ES2238924B1 (es) | 2006-12-01 |
| ES2334447T3 (es) | 2010-03-10 |
| DK1719509T3 (da) | 2010-02-08 |
| JP4892360B2 (ja) | 2012-03-07 |
| CN101014330A (zh) | 2007-08-08 |
| ES2238924A1 (es) | 2005-09-01 |
| EP1719509A1 (de) | 2006-11-08 |
| DE602005017015D1 (de) | 2009-11-19 |
| JP2012012413A (ja) | 2012-01-19 |
| IL177238A (en) | 2013-06-27 |
| UA86399C2 (ru) | 2009-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |