ATE444966T1 - Verfahren zur herstellung von 3-glutamid gallensäurederivaten durch verwendung von n- geschützten methyl-pyroglutamat - Google Patents
Verfahren zur herstellung von 3-glutamid gallensäurederivaten durch verwendung von n- geschützten methyl-pyroglutamatInfo
- Publication number
- ATE444966T1 ATE444966T1 AT02718087T AT02718087T ATE444966T1 AT E444966 T1 ATE444966 T1 AT E444966T1 AT 02718087 T AT02718087 T AT 02718087T AT 02718087 T AT02718087 T AT 02718087T AT E444966 T1 ATE444966 T1 AT E444966T1
- Authority
- AT
- Austria
- Prior art keywords
- pyroglutamat
- glutamide
- bale
- producing
- acid derivatives
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- HQGPKMSGXAUKHT-BYPYZUCNSA-N methyl (2s)-5-oxopyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCC(=O)N1 HQGPKMSGXAUKHT-BYPYZUCNSA-N 0.000 title 1
- RPAJSBKBKSSMLJ-DFWYDOINSA-N (2s)-2-aminopentanedioic acid;hydrochloride Chemical compound Cl.OC(=O)[C@@H](N)CCC(O)=O RPAJSBKBKSSMLJ-DFWYDOINSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000000941 bile Anatomy 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229960002989 glutamic acid Drugs 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01102490A EP1229041A1 (de) | 2001-02-05 | 2001-02-05 | Verfahren zur Herstellung von 3-Glutamid Gallensauerderivate durch Verwendung von N-tBoc Methyl-pyroglutamate |
| PCT/EP2002/001133 WO2002068449A1 (en) | 2001-02-05 | 2002-02-04 | A process for the preparation of 3-glutamido bile ester derivatives using n-prtotected methyl proglutamate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE444966T1 true ATE444966T1 (de) | 2009-10-15 |
Family
ID=8176389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02718087T ATE444966T1 (de) | 2001-02-05 | 2002-02-04 | Verfahren zur herstellung von 3-glutamid gallensäurederivaten durch verwendung von n- geschützten methyl-pyroglutamat |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040138185A1 (de) |
| EP (2) | EP1229041A1 (de) |
| JP (1) | JP4339594B2 (de) |
| AT (1) | ATE444966T1 (de) |
| CA (1) | CA2435010C (de) |
| DE (1) | DE60233930D1 (de) |
| IL (2) | IL156903A0 (de) |
| WO (1) | WO2002068449A1 (de) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2627988A1 (de) * | 1976-06-23 | 1978-01-05 | Max Planck Gesellschaft | Sekretinbestimmung |
| US4280953A (en) * | 1979-11-08 | 1981-07-28 | The Salk Institute For Biological Studies | Glycosylated analogs of somatostatin |
| IT1304501B1 (it) * | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
-
2001
- 2001-02-05 EP EP01102490A patent/EP1229041A1/de not_active Withdrawn
-
2002
- 2002-02-04 CA CA2435010A patent/CA2435010C/en not_active Expired - Fee Related
- 2002-02-04 DE DE60233930T patent/DE60233930D1/de not_active Expired - Lifetime
- 2002-02-04 WO PCT/EP2002/001133 patent/WO2002068449A1/en not_active Ceased
- 2002-02-04 EP EP02718087A patent/EP1358201B1/de not_active Expired - Lifetime
- 2002-02-04 AT AT02718087T patent/ATE444966T1/de not_active IP Right Cessation
- 2002-02-04 JP JP2002567959A patent/JP4339594B2/ja not_active Expired - Fee Related
- 2002-02-04 US US10/467,204 patent/US20040138185A1/en not_active Abandoned
- 2002-02-04 IL IL15690302A patent/IL156903A0/xx unknown
-
2003
- 2003-07-14 IL IL156903A patent/IL156903A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2435010C (en) | 2010-01-26 |
| EP1229041A1 (de) | 2002-08-07 |
| EP1358201A1 (de) | 2003-11-05 |
| IL156903A0 (en) | 2004-02-08 |
| CA2435010A1 (en) | 2002-09-06 |
| IL156903A (en) | 2010-06-16 |
| JP2004518753A (ja) | 2004-06-24 |
| WO2002068449A1 (en) | 2002-09-06 |
| JP4339594B2 (ja) | 2009-10-07 |
| US20040138185A1 (en) | 2004-07-15 |
| DE60233930D1 (de) | 2009-11-19 |
| EP1358201B1 (de) | 2009-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |