ATE556054T1 - Verfahren zur herstellung von loperamid - Google Patents
Verfahren zur herstellung von loperamidInfo
- Publication number
- ATE556054T1 ATE556054T1 AT07866264T AT07866264T ATE556054T1 AT E556054 T1 ATE556054 T1 AT E556054T1 AT 07866264 T AT07866264 T AT 07866264T AT 07866264 T AT07866264 T AT 07866264T AT E556054 T1 ATE556054 T1 AT E556054T1
- Authority
- AT
- Austria
- Prior art keywords
- loperamide
- producing
- reaction
- pimozide
- obtaining
- Prior art date
Links
- RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 title 1
- 229960001571 loperamide Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940074076 glycerol formal Drugs 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
- YVUQSNJEYSNKRX-UHFFFAOYSA-N pimozide Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)CCCN1CCC(N2C(NC3=CC=CC=C32)=O)CC1 YVUQSNJEYSNKRX-UHFFFAOYSA-N 0.000 abstract 1
- 229960003634 pimozide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200700030 | 2006-12-28 | ||
| PCT/EP2007/011420 WO2008080601A2 (en) | 2006-12-28 | 2007-12-24 | Process for the preparation of loperamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556054T1 true ATE556054T1 (de) | 2012-05-15 |
Family
ID=39327347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07866264T ATE556054T1 (de) | 2006-12-28 | 2007-12-24 | Verfahren zur herstellung von loperamid |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2357172B1 (de) |
| AT (1) | ATE556054T1 (de) |
| ES (2) | ES2398740T3 (de) |
| PL (1) | PL2132175T3 (de) |
| WO (1) | WO2008080601A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104829591B (zh) * | 2015-04-27 | 2017-05-03 | 梯尔希（南京）药物研发有限公司 | 氘代匹莫齐特的制备方法 |
| CN110357808A (zh) * | 2019-06-13 | 2019-10-22 | 上海上药新亚药业有限公司 | 一种盐酸洛哌丁胺的结晶工艺 |
| CN119932587B (zh) * | 2025-02-19 | 2025-10-03 | 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) | 一种匹莫齐特中间体的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633495A (de) | 1962-06-13 | |||
| US3884916A (en) | 1971-03-30 | 1975-05-20 | Janssen Pharmaceutica Nv | 2,2-Diaryl-4-(4-aryl-4-hydroxy-piperidino)-butyramides |
| JPS50112373A (de) * | 1974-02-27 | 1975-09-03 | ||
| DD243284A1 (de) * | 1985-12-13 | 1987-02-25 | Dresden Arzneimittel | Verfahren zur herstellung von 1-(1-(4,4-bis(4-fluorphenyl)-butyl)-4-piperidyl)-2-benzimidazolinon |
| US5798093A (en) * | 1997-03-14 | 1998-08-25 | Adolor Corporation | Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith |
-
2007
- 2007-12-24 ES ES11159364T patent/ES2398740T3/es active Active
- 2007-12-24 ES ES07866264T patent/ES2387793T3/es active Active
- 2007-12-24 EP EP11159364A patent/EP2357172B1/de not_active Not-in-force
- 2007-12-24 PL PL07866264T patent/PL2132175T3/pl unknown
- 2007-12-24 WO PCT/EP2007/011420 patent/WO2008080601A2/en not_active Ceased
- 2007-12-24 EP EP07866264A patent/EP2132175B1/de not_active Not-in-force
- 2007-12-24 AT AT07866264T patent/ATE556054T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008080601A3 (en) | 2008-10-30 |
| ES2387793T3 (es) | 2012-10-01 |
| EP2132175A2 (de) | 2009-12-16 |
| EP2357172A1 (de) | 2011-08-17 |
| EP2357172B1 (de) | 2012-10-31 |
| EP2132175B1 (de) | 2012-05-02 |
| PL2132175T3 (pl) | 2012-09-28 |
| ES2398740T3 (es) | 2013-03-21 |
| WO2008080601A2 (en) | 2008-07-10 |
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