ATE446316T1 - Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung - Google Patents

Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung

Info

Publication number
ATE446316T1
ATE446316T1 AT02741737T AT02741737T ATE446316T1 AT E446316 T1 ATE446316 T1 AT E446316T1 AT 02741737 T AT02741737 T AT 02741737T AT 02741737 T AT02741737 T AT 02741737T AT E446316 T1 ATE446316 T1 AT E446316T1
Authority
AT
Austria
Prior art keywords
proteins
chimere
inducing apoptosis
targeting cells
disclosed
Prior art date
Application number
AT02741737T
Other languages
English (en)
Inventor
David Weiner
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Application granted granted Critical
Publication of ATE446316T1 publication Critical patent/ATE446316T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
AT02741737T 2001-05-25 2002-05-28 Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung ATE446316T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29379401P 2001-05-25 2001-05-25
PCT/US2002/016680 WO2002097042A2 (en) 2001-05-25 2002-05-28 Chimeric proteins for cell targeting and apoptosis induction and methods of using the same

Publications (1)

Publication Number Publication Date
ATE446316T1 true ATE446316T1 (de) 2009-11-15

Family

ID=23130607

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02741737T ATE446316T1 (de) 2001-05-25 2002-05-28 Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung

Country Status (10)

Country Link
US (1) US7592012B2 (de)
EP (1) EP1397386B1 (de)
JP (1) JP2004535415A (de)
KR (1) KR20040014528A (de)
CN (1) CN100497387C (de)
AT (1) ATE446316T1 (de)
AU (1) AU2002314814B2 (de)
CA (1) CA2448100A1 (de)
DE (1) DE60234097D1 (de)
WO (1) WO2002097042A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074865A1 (en) * 2002-08-27 2005-04-07 Compound Therapeutics, Inc. Adzymes and uses thereof
WO2008039173A2 (en) * 2005-09-09 2008-04-03 Government Of The United States Of Amercica, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for inhibiting cell death or enhancing cell proliferation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910486A (en) * 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
AU5965296A (en) * 1995-05-31 1996-12-18 Regents Of The University Of Minnesota Recombinant polypeptide cytotoxins for cancer treatment
US6645490B2 (en) * 1998-03-02 2003-11-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities
AU2185199A (en) 1998-09-30 2000-04-17 Yoko Aida Apoptosis inducers
EP1322338A4 (de) 2000-10-04 2005-04-13 Univ Pennsylvania Zusammensetzungen und methoden zur verwendung des kapsidproteins aus flaviviren oder pestviren
US20040028651A1 (en) 2001-03-29 2004-02-12 Karrupiah Muthumani Composition and methods of using hiv vpr

Also Published As

Publication number Publication date
AU2002314814B2 (en) 2007-12-20
EP1397386B1 (de) 2009-10-21
DE60234097D1 (de) 2009-12-03
EP1397386A4 (de) 2005-01-05
JP2004535415A (ja) 2004-11-25
CA2448100A1 (en) 2002-12-05
CN100497387C (zh) 2009-06-10
EP1397386A2 (de) 2004-03-17
CN1531552A (zh) 2004-09-22
WO2002097042A3 (en) 2003-10-23
KR20040014528A (ko) 2004-02-14
US7592012B2 (en) 2009-09-22
US20040181041A1 (en) 2004-09-16
WO2002097042A2 (en) 2002-12-05

Similar Documents

Publication Publication Date Title
ATE380878T1 (de) Verfahren und zusammensetzungen für die proteinexpression und reinigung
WO2019139645A3 (en) High efficiency base editors comprising gam
BRPI0411112A (pt) proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga
AU2018273986A1 (en) Bipartite base editor (BBE) architectures and type-II-C-Cas9 zinc finger editing
NO20025402D0 (no) Modifiserte ES-celler og ES-spesifikt gen
DK2287288T3 (da) Medium frit for animalsk protein til dyrkning af celler
NZ521396A (en) Fusion proteins comprising two or more Neisseria polypeptides
AR062069A1 (es) Replegado de proteinas recombinantes
NO331271B1 (no) Fusjonsprotein for sekresjon av et protein av interesse til supernatanten til en bakteriekultur, fremgangsmate, plasmid og vertscelle for fremstilling
WO2005003313A3 (en) Methods and compositions for enhanced protein expression and purification
ATE525395T1 (de) Fusions proteine von glp-1-analoga
IS5959A (is) Aðferð til hástigstjáningar virkra lífvessaeiturefnis-ß-þegaónæmisglóbúlínshermiprótína og hreinsunar þeirra
ATE466080T1 (de) Formulierungen und verfahren zum denaturieren von proteinen
WO2003097810A3 (en) Nitrilases, nucleic acids encoding them and methods for making and using them
MXPA04007426A (es) Usos de citosina de mamifero; reactivos relacionados.
DE60230456D1 (de) Faktor-viii-polypeptide auf hohem expressionsnivea und verwendungsverfahren
ATE370159T1 (de) Streptavidin-bindungspeptid
DE602005026855D1 (de) Vorrichtungen und verfahren zur bestimmung von proteaseaktivität
WO2002022662A3 (en) Insect inhibitory bacillus thuringiensis proteins, fusions, and methods of use therefor
DK0981601T3 (da) Fremgangsmåder til dyrkning af celler og opformering af vira
NO20043985L (no) Fremgangsmate for rekombinering av genetiske elementer
DE60234097D1 (de) Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung
DE60325737D1 (de) Verfahren und zusammensetzungen zum targeting sekretorischer lysosomen
AU2003264075A8 (en) Active fusion proteins and method for the production thereof
NO20044186L (no) Peptid-deformylaseinhibitorer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties