ATE450606T1 - Mehrfachsubstituierte proteasevarianten - Google Patents
Mehrfachsubstituierte proteasevariantenInfo
- Publication number
- ATE450606T1 ATE450606T1 AT03731960T AT03731960T ATE450606T1 AT E450606 T1 ATE450606 T1 AT E450606T1 AT 03731960 T AT03731960 T AT 03731960T AT 03731960 T AT03731960 T AT 03731960T AT E450606 T1 ATE450606 T1 AT E450606T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- amino acid
- precursor
- variants
- naturally
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 8
- 239000004365 Protease Substances 0.000 title abstract 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 5
- 102000035195 Peptidases Human genes 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- 241000193744 Bacillus amyloliquefaciens Species 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 108090000787 Subtilisin Proteins 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38609—Protease or amylase in solid compositions only
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Meat, Egg Or Seafood Products (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35022202P | 2002-01-16 | 2002-01-16 | |
| PCT/US2003/001448 WO2003062381A2 (en) | 2002-01-16 | 2003-01-16 | Multiply-substituted protease variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450606T1 true ATE450606T1 (de) | 2009-12-15 |
Family
ID=27613372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03731960T ATE450606T1 (de) | 2002-01-16 | 2003-01-16 | Mehrfachsubstituierte proteasevarianten |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US7306937B2 (de) |
| EP (1) | EP1523553B1 (de) |
| JP (2) | JP4703113B2 (de) |
| AT (1) | ATE450606T1 (de) |
| AU (1) | AU2003210552A1 (de) |
| BR (1) | BRPI0306955B1 (de) |
| CA (2) | CA2472725C (de) |
| DE (1) | DE60330346D1 (de) |
| DK (1) | DK1523553T3 (de) |
| ES (1) | ES2336092T3 (de) |
| MX (1) | MXPA04006809A (de) |
| PT (1) | PT1523553E (de) |
| WO (1) | WO2003062381A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2367505T3 (es) * | 1997-10-23 | 2011-11-04 | Danisco Us Inc. | Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes. |
| DK200101090A (da) * | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
| CA2472725C (en) * | 2002-01-16 | 2015-08-11 | Genencor International, Inc. | Multiply-substituted protease variants |
| US7888093B2 (en) * | 2002-11-06 | 2011-02-15 | Novozymes A/S | Subtilase variants |
| US7294499B2 (en) | 2003-01-30 | 2007-11-13 | Novozymes A/S | Subtilases |
| ATE491025T1 (de) * | 2004-04-02 | 2010-12-15 | Novozymes As | Subtilasevarianten mit veränderter immunogenität |
| WO2007061886A2 (en) * | 2005-11-18 | 2007-05-31 | Verenium Corporation | Compositions and methods for ameliorating toxins and virulence factors |
| AU2007256780B2 (en) * | 2006-06-02 | 2013-08-29 | President And Fellows Of Harvard College | Protein surface remodeling |
| KR101486087B1 (ko) | 2006-06-23 | 2015-01-26 | 다니스코 유에스 인크. | 다수의 특성들을 조작하는 부위 평가 라이브러리를 사용한 서열 및 활성 관계에 대한 체계적 평가 |
| KR20150115023A (ko) * | 2006-07-18 | 2015-10-13 | 다니스코 유에스 인크. | 광범위한 온도에 걸쳐 활성인 프로테아제 변이형 |
| BRPI0812446A2 (pt) * | 2007-06-06 | 2014-10-14 | Danisco Us Inc Genecor Division | Métodos para aperfeiçoamento de propriedades de proteína múltiplas |
| EP2297182A4 (de) * | 2008-04-28 | 2012-08-15 | Harvard College | Supergeladene proteine zur zellpenetration |
| CN104694519B (zh) * | 2008-06-06 | 2023-10-27 | 丹尼斯科美国公司 | 包含微生物蛋白酶变体的组合物和方法 |
| EP2362896A2 (de) * | 2008-11-11 | 2011-09-07 | Danisco US Inc. | Bacillus subtilisin mit mindestens einer kombinierbaren mutation |
| MX339402B (es) * | 2008-11-11 | 2016-05-25 | Danisco Us Inc | Composiciones y metodos que comprenden variantes de serina proteasa. |
| US9221886B2 (en) | 2009-04-28 | 2015-12-29 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
| DE102009027045A1 (de) * | 2009-06-19 | 2010-12-30 | Henkel Ag & Co. Kgaa | Neue Proteasen und Mittel enthaltend diese Proteasen |
| BR112012014082B1 (pt) * | 2009-12-09 | 2020-12-15 | Danisco Us Inc | variante de protease isolada e seu método de produção, ácido nucleico isolado, vetor de expressão, célula hospedeira recombinante, composição e método para limpeza de um item ou de uma superfície em necessidade de limpeza |
| EP4159833A3 (de) * | 2009-12-09 | 2023-07-26 | The Procter & Gamble Company | Stoff- und heimpflegeprodukte |
| CN108410585A (zh) * | 2010-05-06 | 2018-08-17 | 宝洁公司 | 具有蛋白酶变体的消费品 |
| FI123942B (fi) | 2010-10-29 | 2013-12-31 | Ab Enzymes Oy | Sieniperäisen seriiniproteaasin variantteja |
| DE102011007313A1 (de) * | 2011-04-13 | 2012-10-18 | Henkel Ag & Co. Kgaa | Expressionsverfahren |
| JP5933688B2 (ja) * | 2011-05-05 | 2016-06-15 | ザ プロクター アンド ギャンブル カンパニー | セリンプロテアーゼ変異体を含む組成物及び方法 |
| JP2015504660A (ja) * | 2011-12-20 | 2015-02-16 | ノボザイムス アクティーゼルスカブ | サブチラーゼ変異体およびそれをコードするポリヌクレオチド |
| WO2017089093A1 (en) | 2015-11-25 | 2017-06-01 | Unilever N.V. | A liquid detergent composition |
| EP3702452A1 (de) * | 2019-03-01 | 2020-09-02 | Novozymes A/S | Waschmittelzusammensetzungen mit zwei proteasen |
| CN110846299B (zh) * | 2019-11-22 | 2021-09-24 | 江南大学 | 一种前导肽突变体及其在角蛋白酶生产中的应用 |
| CA3257053A1 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | COMPOSITIONS AND METHODS FOR THE PREVENTION, TREATMENT, SUPPRESSION AND/OR ELIMINATION OF PHYTOPATHOGENIC INFESTATIONS AND INFECTIONS |
| WO2025202372A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202369A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202374A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4624572A1 (de) | 2024-03-27 | 2025-10-01 | Basf Se | Polypeptide mit proteaseaktivität zur verwendung in waschmittelzusammensetzungen |
| WO2025202370A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202379A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202382A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in cleaning compositions |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557002A (en) * | 1967-11-15 | 1971-01-19 | Procter & Gamble | Stabilized aqueous enzyme preparation |
| US3558498A (en) * | 1967-11-29 | 1971-01-26 | Procter & Gamble | Granular detergent composition containing enzymes and environmental control components |
| GB1240058A (en) * | 1968-04-12 | 1971-07-21 | Procter & Gamble | Enzyme-containing detergent compositions |
| US3623957A (en) * | 1970-01-21 | 1971-11-30 | Baxter Laboratories Inc | Preparation of microbial alkaline protease by fermentation with bacillus subtilis, variety licheniformis |
| BE785666A (fr) * | 1971-07-01 | 1973-01-02 | Procter & Gamble | Procede pour la production de compositions enzymatiques en granules |
| BE792982A (en) * | 1971-12-20 | 1973-06-19 | Procter & Gamble Europ | Proteolytic enzymes detergent - contg cationic and anionic surfactants |
| US4011169A (en) * | 1973-06-29 | 1977-03-08 | The Procter & Gamble Company | Stabilization and enhancement of enzymatic activity |
| IT1106254B (it) * | 1976-03-08 | 1985-11-11 | Procter & Gamble Europ | Composizione detergente liquida contenente enzimi |
| US4090973A (en) * | 1976-06-24 | 1978-05-23 | The Procter & Gamble Company | Method for making stable detergent compositions |
| DE2633601A1 (de) * | 1976-07-27 | 1978-02-02 | Henkel Kgaa | Fluessiges, als wasch- und reinigungsmittel verwendbares, enzymhaltiges konzentrat |
| GB1603640A (en) * | 1977-07-20 | 1981-11-25 | Gist Brocades Nv | Enzyme particles |
| US4261868A (en) * | 1979-08-08 | 1981-04-14 | Lever Brothers Company | Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound |
| US4318818A (en) * | 1979-11-09 | 1982-03-09 | The Procter & Gamble Company | Stabilized aqueous enzyme composition |
| JPS5950280B2 (ja) * | 1980-10-24 | 1984-12-07 | 花王株式会社 | 酵素入り漂白剤組成物 |
| US4404128A (en) * | 1981-05-29 | 1983-09-13 | The Procter & Gamble Company | Enzyme detergent composition |
| EP0080748B1 (de) * | 1981-11-13 | 1985-07-10 | Unilever N.V. | Enzymatische flüssige Reinigungsmittel-Zusammensetzung |
| JPS58144105A (ja) * | 1982-02-12 | 1983-08-27 | Kurabo Ind Ltd | スケ−ル除去獣毛繊維の製法 |
| US5310675A (en) * | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
| US4760025A (en) * | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5972682A (en) * | 1984-05-29 | 1999-10-26 | Genencor International, Inc. | Enzymatically active modified subtilisins |
| US5801038A (en) * | 1984-05-29 | 1998-09-01 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| US5185258A (en) * | 1984-05-29 | 1993-02-09 | Genencor International, Inc. | Subtilisin mutants |
| US5264366A (en) * | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
| US5155033A (en) * | 1989-01-06 | 1992-10-13 | Genencor, Inc. | Subtilisins modified at position 225 resulting in a shift in catalytic activity |
| US5182204A (en) * | 1984-05-29 | 1993-01-26 | Genencor International, Inc. | Non-human carbonyl hydrolase mutants, vectors encoding same and hosts transformed with said vectors |
| US5204015A (en) * | 1984-05-29 | 1993-04-20 | Genencor International, Inc. | Subtilisin mutants |
| IE65767B1 (en) * | 1986-04-30 | 1995-11-15 | Genencor Int | Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors |
| US5314692A (en) * | 1987-08-24 | 1994-05-24 | Cultor Ltd. | Enzyme premix for feed and method |
| DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US5324653A (en) * | 1988-02-11 | 1994-06-28 | Gist-Brocades N.V. | Recombinant genetic means for the production of serine protease muteins |
| PT89702B (pt) * | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem |
| US6287841B1 (en) * | 1988-02-11 | 2001-09-11 | Genencor International, Inc. | High alkaline serine protease |
| DE3841152A1 (de) * | 1988-12-07 | 1990-06-13 | Hoechst Ag | Verwendung von bakterienlysierendem enzymprodukt als zusatzstoff zur verbesserung der futterverwertung in der tierproduktion |
| DK316989D0 (da) * | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
| CA2034486A1 (en) * | 1989-06-26 | 1990-12-27 | Eric Casteleijn | Enzymatic detergent compositions |
| US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| US5352603A (en) * | 1989-08-31 | 1994-10-04 | Kali-Chemie Ag | Highly alkaline proteases |
| DE4224125A1 (de) * | 1991-07-27 | 1993-01-28 | Solvay Enzymes Gmbh & Co Kg | Verfahren zur verbesserung der stabilitaet von enzymen und stabilisierte enzyme |
| JP4028592B2 (ja) * | 1992-07-17 | 2007-12-26 | ジェネンコー インターナショナル インコーポレイテッド | 高アルカリ性セリンプロテアーゼ |
| US6436690B1 (en) * | 1993-09-15 | 2002-08-20 | The Procter & Gamble Company | BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted |
| MA23346A1 (fr) * | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
| ES2287931T3 (es) * | 1993-10-14 | 2007-12-16 | THE PROCTER & GAMBLE COMPANY | Composiciones limpiadoras que contienen proteasa. |
| US6599730B1 (en) * | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
| GB9416841D0 (en) * | 1994-08-19 | 1994-10-12 | Finnfeeds Int Ltd | An enzyme feed additive and animal feed including it |
| US6682924B1 (en) * | 1995-05-05 | 2004-01-27 | Novozymes A/S | Protease variants and compositions |
| US5837517A (en) * | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
| ATE409743T1 (de) * | 1996-11-04 | 2008-10-15 | Novozymes As | Subtilase varianten und verbindungen |
| EP0985042B1 (de) * | 1997-06-04 | 2006-09-06 | Genecor International, Inc. | Protease zur gründlichen reinigung und/oder flecken- und filmreduktion und zusammensetzungen damit |
| BR9811248B1 (pt) * | 1997-08-29 | 2011-10-04 | variante de enzima subtilase derivada de uma subtilase originária selecionada a partir do sub-grupo i-s1 ou do sub-grupo i-s2, dita variante tendo melhorado desempenho de lavagem em detergentes em comparação com a subtilase originária, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processo para produzir uma variante, composição, uso de uma variante de subtilase. | |
| KR20010023468A (ko) * | 1997-08-29 | 2001-03-26 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 프로테아제 변이체 및 조성물 |
| EP0913458B1 (de) | 1997-10-22 | 2004-06-16 | The Procter & Gamble Company | Flüssige Reinigungszusammensetzungen für harte Oberflächen |
| MA24811A1 (fr) * | 1997-10-23 | 1999-12-31 | Procter & Gamble | Compositions de lavage contenant des variantes de proteases multisubstituees |
| US6773907B2 (en) * | 1997-11-21 | 2004-08-10 | Peter Kamp Hansen | Subtilase enzymes |
| US6780629B2 (en) * | 1997-11-21 | 2004-08-24 | Novozymes A/S | Subtilase enzymes |
| DE69830743T2 (de) * | 1997-11-21 | 2006-04-27 | Novozymes A/S | Protease-varianten und zusammensetzungen |
| IT1304768B1 (it) * | 1998-10-05 | 2001-03-29 | Esaote Spa | Lettino porta paziente o simili, e macchina, in particolare macchinaper il rilevamento d'immagini in risonanza magnetica nucleare in |
| EP1124987A2 (de) * | 1998-10-23 | 2001-08-22 | The Procter & Gamble Company | Verfahren zum screenen von proteasevarianten für die verwendung von detergenzienzusammensetzungen |
| US6376450B1 (en) * | 1998-10-23 | 2002-04-23 | Chanchal Kumar Ghosh | Cleaning compositions containing multiply-substituted protease variants |
| US6831053B1 (en) * | 1998-10-23 | 2004-12-14 | The Procter & Gamble Company | Bleaching compositions comprising multiply-substituted protease variants |
| AU6085800A (en) * | 1999-07-22 | 2001-02-13 | Procter & Gamble Company, The | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
| US6727085B2 (en) * | 1999-12-15 | 2004-04-27 | Fanoe Tina Sejersgaard | Subtilase variants having an improved wash performance on egg stains |
| US6777218B1 (en) * | 2000-03-14 | 2004-08-17 | Novozymes A/S | Subtilase enzymes having an improved wash performance on egg stains |
| DE60144145D1 (de) * | 2000-04-03 | 2011-04-14 | Maxygen Inc | Subtilisin-variante |
| WO2001083559A2 (en) * | 2000-04-28 | 2001-11-08 | Novozymes A/S | Production and use of protein variants having modified immunogenecity |
| US7109016B2 (en) * | 2000-08-21 | 2006-09-19 | Novozymes A/S | Subtilase enzymes |
| US6541235B1 (en) * | 2000-09-29 | 2003-04-01 | University Of Maryland Biotechnology Institute | Calcium free subtilisin mutants |
| US6893855B2 (en) * | 2000-10-13 | 2005-05-17 | Novozymes A/S | Subtilase variants |
| DK1373296T3 (da) * | 2001-03-23 | 2012-01-09 | Procter & Gamble | Proteiner, der frembringer et ændret immunogent respons, og fremgangsmåder til fremstilling og anvendelse deraf |
| US20030157645A1 (en) * | 2001-12-21 | 2003-08-21 | Direvo Bio Tech Ag. | Subtilisin variants with improved characteristics |
| CA2472725C (en) * | 2002-01-16 | 2015-08-11 | Genencor International, Inc. | Multiply-substituted protease variants |
| US7985569B2 (en) * | 2003-11-19 | 2011-07-26 | Danisco Us Inc. | Cellulomonas 69B4 serine protease variants |
| KR20150115023A (ko) * | 2006-07-18 | 2015-10-13 | 다니스코 유에스 인크. | 광범위한 온도에 걸쳐 활성인 프로테아제 변이형 |
| CN104694519B (zh) * | 2008-06-06 | 2023-10-27 | 丹尼斯科美国公司 | 包含微生物蛋白酶变体的组合物和方法 |
| EP2362896A2 (de) * | 2008-11-11 | 2011-09-07 | Danisco US Inc. | Bacillus subtilisin mit mindestens einer kombinierbaren mutation |
| MX339402B (es) * | 2008-11-11 | 2016-05-25 | Danisco Us Inc | Composiciones y metodos que comprenden variantes de serina proteasa. |
-
2003
- 2003-01-16 CA CA2472725A patent/CA2472725C/en not_active Expired - Fee Related
- 2003-01-16 BR BRPI0306955A patent/BRPI0306955B1/pt not_active IP Right Cessation
- 2003-01-16 WO PCT/US2003/001448 patent/WO2003062381A2/en not_active Ceased
- 2003-01-16 CA CA2894330A patent/CA2894330A1/en not_active Abandoned
- 2003-01-16 JP JP2003562249A patent/JP4703113B2/ja not_active Expired - Fee Related
- 2003-01-16 MX MXPA04006809A patent/MXPA04006809A/es active IP Right Grant
- 2003-01-16 PT PT03731960T patent/PT1523553E/pt unknown
- 2003-01-16 AU AU2003210552A patent/AU2003210552A1/en not_active Abandoned
- 2003-01-16 EP EP03731960A patent/EP1523553B1/de not_active Expired - Lifetime
- 2003-01-16 US US10/500,943 patent/US7306937B2/en not_active Expired - Lifetime
- 2003-01-16 DE DE60330346T patent/DE60330346D1/de not_active Expired - Lifetime
- 2003-01-16 AT AT03731960T patent/ATE450606T1/de active
- 2003-01-16 ES ES03731960T patent/ES2336092T3/es not_active Expired - Lifetime
- 2003-01-16 DK DK03731960.5T patent/DK1523553T3/da active
-
2007
- 2007-10-30 US US11/929,880 patent/US20080176313A1/en not_active Abandoned
- 2007-10-30 US US11/929,907 patent/US20080124783A1/en not_active Abandoned
- 2007-10-30 US US11/929,929 patent/US20090011489A1/en not_active Abandoned
-
2010
- 2010-05-10 US US12/776,921 patent/US20110091958A1/en not_active Abandoned
- 2010-05-10 US US12/776,932 patent/US20110086412A1/en not_active Abandoned
- 2010-05-10 US US12/776,940 patent/US20110091959A1/en not_active Abandoned
- 2010-10-08 JP JP2010228628A patent/JP2011041571A/ja active Pending
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2012
- 2012-12-21 US US13/723,970 patent/US20130171717A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003210552A1 (en) | 2003-09-02 |
| US20050221461A1 (en) | 2005-10-06 |
| US20110091959A1 (en) | 2011-04-21 |
| EP1523553A4 (de) | 2006-06-21 |
| JP2005519592A (ja) | 2005-07-07 |
| CA2894330A1 (en) | 2003-07-31 |
| US20080124783A1 (en) | 2008-05-29 |
| CA2472725C (en) | 2015-08-11 |
| US20110091958A1 (en) | 2011-04-21 |
| DK1523553T3 (da) | 2010-04-19 |
| US20110086412A1 (en) | 2011-04-14 |
| JP4703113B2 (ja) | 2011-06-15 |
| BRPI0306955B1 (pt) | 2016-03-22 |
| US20130171717A1 (en) | 2013-07-04 |
| WO2003062381A3 (en) | 2005-02-24 |
| WO2003062381A2 (en) | 2003-07-31 |
| BR0306955A (pt) | 2006-12-19 |
| EP1523553A2 (de) | 2005-04-20 |
| PT1523553E (pt) | 2010-03-03 |
| US20080176313A1 (en) | 2008-07-24 |
| JP2011041571A (ja) | 2011-03-03 |
| MXPA04006809A (es) | 2004-10-11 |
| EP1523553B1 (de) | 2009-12-02 |
| ES2336092T3 (es) | 2010-04-08 |
| DE60330346D1 (de) | 2010-01-14 |
| CA2472725A1 (en) | 2003-07-31 |
| US7306937B2 (en) | 2007-12-11 |
| US20090011489A1 (en) | 2009-01-08 |
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