ATE452184T1 - Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren - Google Patents

Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren

Info

Publication number: ATE452184T1
Authority: AT; Austria
Prior art keywords: microbial trypsin; chymotrypsin; activity; positions; trypsin variants
Prior art date: 2002-09-24

Application number

AT03759441T

Other languages

English (en)

Inventor

Alan Klotz

Kimberly Brown

Elizabeth Zaretsky

Original Assignee

Novozymes Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-24

Publication date

2010-01-15

2003-09-24 Application filed by Novozymes Inc filed Critical Novozymes Inc

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE452184T1 publication Critical patent/ATE452184T1/de

Links

108090000631 Trypsin Proteins 0.000 title abstract 4
102000004142 Trypsin Human genes 0.000 title abstract 4
230000000813 microbial effect Effects 0.000 title abstract 4
239000012588 trypsin Substances 0.000 title abstract 4
108020004707 nucleic acids Proteins 0.000 title abstract 2
150000007523 nucleic acids Chemical class 0.000 title abstract 2
102000039446 nucleic acids Human genes 0.000 title abstract 2
CFYIUBWVKZQDOG-UHFFFAOYSA-N 4-[[2-[[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid Chemical compound C=1C=C([N+]([O-])=O)C=CC=1NC(=O)C(NC(=O)CNC(=O)CNC(=O)CCC(=O)O)CC1=CC=CC=C1 CFYIUBWVKZQDOG-UHFFFAOYSA-N 0.000 title 1
108090000317 Chymotrypsin Proteins 0.000 title 1
229960002376 chymotrypsin Drugs 0.000 title 1
230000000694 effects Effects 0.000 title 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 3
230000037012 chymotrypsin-like activity Effects 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
238000003780 insertion Methods 0.000 abstract 1
230000037431 insertion Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Mycology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Detergent Compositions (AREA)

AT03759441T 2002-09-24 2003-09-24 Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren ATE452184T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41305702P	2002-09-24	2002-09-24
PCT/US2003/029964 WO2004029202A2 (en)	2002-09-24	2003-09-24	Microbial trypsin variants having chymotrypsin activity and nucleic acids encoding same

Publications (1)

Publication Number	Publication Date
ATE452184T1 true ATE452184T1 (de)	2010-01-15

Family

ID=32043201

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03759441T ATE452184T1 (de)	2002-09-24	2003-09-24	Mikrobielle trypsinvarianten mit chymotrypsinaktivität und diese codierende nukleinsäuren

Country Status (8)

Country	Link
US (4)	US7364892B2 (de)
EP (1)	EP1546318B1 (de)
JP (1)	JP4629439B2 (de)
AT (1)	ATE452184T1 (de)
AU (1)	AU2003275172A1 (de)
DE (1)	DE60330579D1 (de)
DK (1)	DK1546318T3 (de)
WO (1)	WO2004029202A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4549386B2 (ja) *	2005-03-22	2010-09-22	ソデックス株式会社	新規プロテアーゼ、該プロテアーゼを生産する微生物、及びこれらの利用
AU2006291780B2 (en) *	2005-09-14	2011-12-08	F. Hoffmann-La Roche Ag	Cleavage of precursors of insulins by a variant of trypsin
WO2007052780A1 (en) *	2005-11-04	2007-05-10	Nippon Shokubai Co., Ltd.	Composition, protein modifier, and modified protein
WO2009129086A2 (en) *	2008-04-18	2009-10-22	New England Biolabs, Inc.	Endoglycosidases that cleave o-linked glycans
AU2010230165B2 (en) *	2009-04-02	2015-02-12	Novozymes A/S	Process for making a milk-based protein hydrolysate
FI121851B (fi) *	2009-07-08	2011-05-13	Ab Enzymes Oy	Sieniperäinen proteaasi ja sen käyttö
EP2595488B1 (de) *	2010-07-21	2019-12-04	Novozymes A/S	Verfahren zur herstellung von backwaren mit alterungsbeständige amylase und peptidase
FI123942B (fi)	2010-10-29	2013-12-31	Ab Enzymes Oy	Sieniperäisen seriiniproteaasin variantteja
US20210284933A1 (en) *	2016-10-25	2021-09-16	Novozymes A/S	Detergent compositions
US11453871B2 (en) *	2017-03-15	2022-09-27	Danisco Us Inc.	Trypsin-like serine proteases and uses thereof
CN109474254B (zh)	2018-10-31	2020-12-08	武汉衍熙微器件有限公司	一种声波器件及其制作方法
CN111832116A (zh) *	2020-06-05	2020-10-27	中国科学院力学研究所	基于动力学特性与深度学习的点阵夹层板损伤识别方法
US20240057627A1 (en) *	2021-01-05	2024-02-22	Novozymes A/S	Process for Preparing a Plant-Based Fermented Dairy Alternative
CN117402860B (zh) *	2023-10-31	2024-08-23	四川大学	一种链霉菌胰蛋白酶突变体及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE68924654T2 (de) *	1988-01-07	1996-04-04	Novonordisk As	Spezifische Protease.
DK160846C (da) *	1988-11-10	1991-10-07	Atlas Ind As	Roterende toerrer samt anvendelse heraf
DK52393D0 (de) *	1993-05-05	1993-05-05	Novo Nordisk As
DK52293D0 (de) *	1993-05-05	1993-05-05	Novo Nordisk As
CN101659926A (zh) *	1994-06-30	2010-03-03	诺沃奇梅兹有限公司	非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
US6060305A (en) *	1994-06-30	2000-05-09	Novo Nordisk Biotech, Inc.	Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system

2003
- 2003-09-24 JP JP2004540184A patent/JP4629439B2/ja not_active Expired - Fee Related
- 2003-09-24 EP EP03759441A patent/EP1546318B1/de not_active Expired - Lifetime
- 2003-09-24 DE DE60330579T patent/DE60330579D1/de not_active Expired - Lifetime
- 2003-09-24 WO PCT/US2003/029964 patent/WO2004029202A2/en not_active Ceased
- 2003-09-24 AT AT03759441T patent/ATE452184T1/de not_active IP Right Cessation
- 2003-09-24 DK DK03759441.3T patent/DK1546318T3/da active
- 2003-09-24 US US10/669,757 patent/US7364892B2/en not_active Expired - Fee Related
- 2003-09-24 AU AU2003275172A patent/AU2003275172A1/en not_active Abandoned
2008
- 2008-01-30 US US12/022,771 patent/US7705137B2/en not_active Expired - Fee Related
2010
- 2010-02-18 US US12/708,433 patent/US8114635B2/en not_active Expired - Fee Related
2012
- 2012-02-13 US US13/372,185 patent/US20120142075A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60330579D1 (de)	2010-01-28
US8114635B2 (en)	2012-02-14
JP4629439B2 (ja)	2011-02-09
US20090035820A1 (en)	2009-02-05
US20100151515A1 (en)	2010-06-17
DK1546318T3 (da)	2010-04-26
JP2006500069A (ja)	2006-01-05
EP1546318A4 (de)	2007-02-14
US20120142075A1 (en)	2012-06-07
EP1546318A2 (de)	2005-06-29
US20050037368A1 (en)	2005-02-17
US7364892B2 (en)	2008-04-29
US7705137B2 (en)	2010-04-27
WO2004029202A2 (en)	2004-04-08
AU2003275172A1 (en)	2004-04-19
AU2003275172A8 (en)	2004-04-19
EP1546318B1 (de)	2009-12-16
WO2004029202A3 (en)	2005-03-10

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Legal Events

Date	Code	Title	Description
2010-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties