ATE454460T1 - Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino- beta-hydroxybuttersäure ((r)-gabob) und (r)- carnitin - Google Patents

Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino- beta-hydroxybuttersäure ((r)-gabob) und (r)- carnitin

Info

Publication number
ATE454460T1
ATE454460T1 AT05824669T AT05824669T ATE454460T1 AT E454460 T1 ATE454460 T1 AT E454460T1 AT 05824669 T AT05824669 T AT 05824669T AT 05824669 T AT05824669 T AT 05824669T AT E454460 T1 ATE454460 T1 AT E454460T1
Authority
AT
Austria
Prior art keywords
gabob
carnitine
gamma
beta
amino
Prior art date
Application number
AT05824669T
Other languages
English (en)
Inventor
Ahmed Kamal
Gollapalli B R Khanna
T Krishnaji
Rondla Ramu
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Application granted granted Critical
Publication of ATE454460T1 publication Critical patent/ATE454460T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05824669T 2005-04-15 2005-11-29 Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino- beta-hydroxybuttersäure ((r)-gabob) und (r)- carnitin ATE454460T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN963DE2005 2005-04-15
PCT/IN2005/000387 WO2006109322A1 (en) 2005-04-15 2005-11-29 A chemoenzymatic process for the stereoselective preparation of (r)-gamma-amino-beta-hydroxybutyric acid ((r) -gabob) and (r)-carnitine

Publications (1)

Publication Number Publication Date
ATE454460T1 true ATE454460T1 (de) 2010-01-15

Family

ID=36087740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05824669T ATE454460T1 (de) 2005-04-15 2005-11-29 Chemisch-enzymatisches verfahren zur stereoselektiven herstellung von (r)-gamma-amino- beta-hydroxybuttersäure ((r)-gabob) und (r)- carnitin

Country Status (5)

Country Link
US (1) US7816119B2 (de)
EP (1) EP1869199B1 (de)
AT (1) ATE454460T1 (de)
DE (1) DE602005018834D1 (de)
WO (1) WO2006109322A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102432483A (zh) * 2011-09-23 2012-05-02 李氏大药厂（香港）有限公司 乙酰左卡尼汀盐酸盐的制备方法及其药物用途
CN111621494B (zh) * 2020-07-07 2021-04-02 厦门庚能新材料技术有限公司 一种磁性固定化脂肪酶的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248601A (en) * 1986-03-14 1993-09-28 Franco Francalanci Process for preparing L(-)-carnitine chloride
JPH0227995A (ja) 1988-07-15 1990-01-30 Earth Chem Corp Ltd ｌ‐カルニチンクロライドの製造法
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
US7374926B2 (en) * 2004-12-23 2008-05-20 Council Of Scientific And Industrial Research Enantioconvergent chemoenzymatic synthesis of (R)-γ-amino-β-hydroxybutyric acid ((R)-GABOB)

Also Published As

Publication number Publication date
EP1869199B1 (de) 2010-01-06
US20090233337A1 (en) 2009-09-17
WO2006109322A1 (en) 2006-10-19
US7816119B2 (en) 2010-10-19
EP1869199A1 (de) 2007-12-26
DE602005018834D1 (de) 2010-02-25

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