ATE455088T1 - Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten - Google Patents
Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivatenInfo
- Publication number
- ATE455088T1 ATE455088T1 AT04773427T AT04773427T ATE455088T1 AT E455088 T1 ATE455088 T1 AT E455088T1 AT 04773427 T AT04773427 T AT 04773427T AT 04773427 T AT04773427 T AT 04773427T AT E455088 T1 ATE455088 T1 AT E455088T1
- Authority
- AT
- Austria
- Prior art keywords
- acid derivatives
- amino acid
- reductive amination
- acid
- produce amino
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 3
- 150000004723 keto acid derivatives Chemical class 0.000 title 1
- 238000006268 reductive amination reaction Methods 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000004715 keto acids Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003326939 | 2003-09-18 | ||
| PCT/JP2004/014048 WO2005028419A2 (en) | 2003-09-18 | 2004-09-17 | Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455088T1 true ATE455088T1 (de) | 2010-01-15 |
Family
ID=34372851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04773427T ATE455088T1 (de) | 2003-09-18 | 2004-09-17 | Asymmetrische reduktive aminierung von ketosäurederivaten zur herstellung von aminosäurederivaten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7626034B2 (de) |
| EP (2) | EP2100875B1 (de) |
| JP (1) | JP4705031B2 (de) |
| AT (1) | ATE455088T1 (de) |
| DE (1) | DE602004025132D1 (de) |
| ES (1) | ES2337061T3 (de) |
| WO (1) | WO2005028419A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4878600B2 (ja) | 2005-09-14 | 2012-02-15 | 独立行政法人科学技術振興機構 | アセチレン化合物の水和反応によるケト酸類、アミノ酸類の合成方法 |
| TW200808731A (en) | 2006-03-30 | 2008-02-16 | Tanabe Seiyaku Co | A process for preparing tetrahydroquinoline derivatives |
| EP2041070A1 (de) * | 2006-07-06 | 2009-04-01 | Basf Se | Verfahren zur herstellung von optisch aktiven 3-aminocarbonsäureestern |
| CN101633625B (zh) * | 2008-07-23 | 2013-02-13 | 江苏恒瑞医药股份有限公司 | R-β-氨基苯丁酸衍生物的制备方法 |
| CN105566138A (zh) * | 2014-10-11 | 2016-05-11 | 上海科胜药物研发有限公司 | 一种合成西他列汀中间体的方法 |
| CN105254519B (zh) * | 2015-11-25 | 2017-05-17 | 常州吉恩药业有限公司 | 一种西他列汀关键中间体的合成方法 |
| CN109851506B (zh) | 2019-01-30 | 2020-09-15 | 凯特立斯（深圳）科技有限公司 | 钌-双膦催化剂催化的简单酮的不对称还原胺化制备手性伯胺 |
| WO2020212399A1 (en) | 2019-04-15 | 2020-10-22 | Janssen Pharmaceutica Nv | Method for preparing an alkyl trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid ester compound |
| US20230210112A1 (en) * | 2020-06-05 | 2023-07-06 | Taminco Bv | Method for growing plants |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265971A (de) * | 1968-05-21 | 1972-03-08 | ||
| US3664356A (en) * | 1970-07-30 | 1972-05-23 | M & J Valve Co | Pumping station sphere handling method and system |
| US4386090A (en) * | 1980-12-22 | 1983-05-31 | Delalande S.A. | Nitrogen containing 2,3-dihydro naphthalenes, compositions and use |
| DE3467754D1 (de) | 1983-10-03 | 1988-01-07 | Squibb & Sons Inc | Enkephalinase inhibitors |
| IE58243B1 (en) * | 1983-12-07 | 1993-08-11 | Lonza Ag | A process for the preparation of optically-active 3-amino carboxylic acids |
| US4521624A (en) | 1984-04-16 | 1985-06-04 | Ethyl Corporation | Process for making cyclic amines |
| JPH0678277B2 (ja) * | 1988-02-19 | 1994-10-05 | 高砂香料工業株式会社 | 光学活性アルコールおよびその誘導体の製造方法 |
| KR20020015031A (ko) | 1999-03-22 | 2002-02-27 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 3-아미노-3-아릴 프로파노에이트의 합성 |
| DE19933611A1 (de) | 1999-07-17 | 2001-01-18 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von Aminen durch homogen katalysierte reduktive Aminierung von Carbonylverbindungen |
| AU2001239239A1 (en) * | 2000-02-04 | 2001-08-14 | Lonza A.G. | Method for producing acetoacetylated aromatic amines |
| US6646130B2 (en) * | 2001-07-19 | 2003-11-11 | Merck & Co., Inc. | Process to chiral integrin antagonist beta-amino acid intermediate |
| US20040147762A1 (en) | 2002-11-06 | 2004-07-29 | Xumu Zhang | Asymmetric reductive amination of ketones |
| AR043515A1 (es) * | 2003-03-19 | 2005-08-03 | Merck & Co Inc | Procedimiento para preparar derivados quirales beta aminoacidos mediante hidrogenacion asimetrica |
| US7145030B2 (en) * | 2003-04-24 | 2006-12-05 | Ajinomoto Co., Inc. | Production method for optically active N-aryl-β-amino acid compounds |
-
2004
- 2004-09-17 EP EP09163497.2A patent/EP2100875B1/de not_active Expired - Lifetime
- 2004-09-17 JP JP2006526814A patent/JP4705031B2/ja not_active Expired - Lifetime
- 2004-09-17 AT AT04773427T patent/ATE455088T1/de active
- 2004-09-17 WO PCT/JP2004/014048 patent/WO2005028419A2/en not_active Ceased
- 2004-09-17 EP EP04773427A patent/EP1685092B1/de not_active Expired - Lifetime
- 2004-09-17 DE DE602004025132T patent/DE602004025132D1/de not_active Expired - Lifetime
- 2004-09-17 ES ES04773427T patent/ES2337061T3/es not_active Expired - Lifetime
- 2004-09-17 US US10/571,855 patent/US7626034B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2100875A1 (de) | 2009-09-16 |
| US20070142443A1 (en) | 2007-06-21 |
| EP2100875B1 (de) | 2016-11-16 |
| DE602004025132D1 (de) | 2010-03-04 |
| JP4705031B2 (ja) | 2011-06-22 |
| EP1685092B1 (de) | 2010-01-13 |
| US7626034B2 (en) | 2009-12-01 |
| JP2007505896A (ja) | 2007-03-15 |
| WO2005028419A3 (en) | 2005-06-02 |
| WO2005028419A2 (en) | 2005-03-31 |
| ES2337061T3 (es) | 2010-04-20 |
| EP1685092A2 (de) | 2006-08-02 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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