ATE462704T1 - Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür - Google Patents

Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür

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Publication number
ATE462704T1
ATE462704T1 AT05757108T AT05757108T ATE462704T1 AT E462704 T1 ATE462704 T1 AT E462704T1 AT 05757108 T AT05757108 T AT 05757108T AT 05757108 T AT05757108 T AT 05757108T AT E462704 T1 ATE462704 T1 AT E462704T1
Authority
AT
Austria
Prior art keywords
animal
adenosine
purine derivatives
receptor agonists
effective amount
Prior art date
Application number
AT05757108T
Other languages
English (en)
Inventor
Prakash Jagtap
Csaba Szabo
Andrew Salzman
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Application granted granted Critical
Publication of ATE462704T1 publication Critical patent/ATE462704T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

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AT05757108T 2004-05-26 2005-05-25 Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür ATE462704T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57480504P 2004-05-26 2004-05-26
US58826304P 2004-07-15 2004-07-15
PCT/US2005/018381 WO2005117910A2 (en) 2004-05-26 2005-05-25 Purine derivatives as adenosine a1 receptor agonists and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE462704T1 true ATE462704T1 (de) 2010-04-15

Family

ID=35463332

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Application Number Title Priority Date Filing Date
AT05757108T ATE462704T1 (de) 2004-05-26 2005-05-25 Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür

Country Status (24)

Country Link
US (3) US7423144B2 (de)
EP (2) EP1758596B9 (de)
JP (3) JP4484928B2 (de)
KR (2) KR101167342B1 (de)
CN (1) CN103087133B (de)
AT (1) ATE462704T1 (de)
AU (1) AU2005249430B2 (de)
BR (1) BRPI0510406A (de)
CA (1) CA2567289C (de)
CY (1) CY1110159T1 (de)
DE (1) DE602005020286D1 (de)
DK (1) DK1758596T3 (de)
EA (1) EA011826B1 (de)
ES (1) ES2343421T3 (de)
HR (1) HRP20100344T2 (de)
IL (1) IL179400A (de)
ME (1) ME01072B (de)
MX (1) MXPA06013560A (de)
NO (1) NO339450B1 (de)
NZ (1) NZ551951A (de)
PL (1) PL1758596T3 (de)
PT (1) PT1758596E (de)
RS (1) RS51261B (de)
WO (1) WO2005117910A2 (de)

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US7423144B2 (en) * 2004-05-26 2008-09-09 Inotek Pharmaceuticals Corporation Purine Derivatives as adenosine A1 receptor agonists and methods of use thereof
AU2005286946B2 (en) * 2004-09-20 2012-03-15 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
EP1996020A4 (de) * 2006-03-23 2011-04-27 Inotek Pharmaceuticals Corp Purinverbindungen und anwendungsverfahren dafür
EP2001456B1 (de) * 2006-04-04 2009-12-02 Emodys GmbH Verwendung von zusammensetzungen enthaltend kappa-opioidrezeptor-antagonisten zur behandlung von dissoziativen störungen
EP2424546B1 (de) 2009-05-01 2015-10-28 Inotek Pharmaceuticals Corporation Verfahren zur senkung des augeninnendrucks bei menschen
EA201270102A1 (ru) 2009-06-30 2012-08-30 Форест Лэборетериз Холдингз Лимитед Соединения алкокси-карбонил-амино-алкинил-аденозина и их производные в качестве агонистов ar
WO2011053569A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
LT2523669T (lt) 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
LT2555776T (lt) * 2010-03-19 2017-04-25 Inotek Pharmaceuticals Corporation Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui
PL2555775T3 (pl) * 2010-03-19 2017-08-31 Inotek Pharmaceuticals Corporation Kompozycje połączenia agonistów receptora adenozyny A<sub>1</sub> i inhibitorów anhydrazy węglanowej do obniżania ciśnienia wewnątrzgałkowego
KR20130029049A (ko) 2010-03-26 2013-03-21 이노텍 파마슈티컬스 코포레이션 아데노신 화합물 및 이의 용도
CA2792266A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
PL2807178T3 (pl) * 2012-01-26 2017-12-29 Inotek Pharmaceuticals Corporation Bezwodne polimorfy azotanu (2R,3S,4R,5R)-5-(6-(cyklopentyloamino)-9H-puryn-9-ylo)-3,4-dihydroksytetrahydrofuran-2-ylo)metylu i sposoby ich wytwarzania
WO2014152723A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
GB2582361A (en) * 2019-03-21 2020-09-23 Univ Warwick Adenosine receptor agonists
JP2022538408A (ja) * 2019-06-21 2022-09-02 アカデミー オブ ミリタリー メディカル サイエンシズ Ａ２ａアデノシン受容体アゴニスト活性を有する６－ヒドラジノアデノシン化合物
DE102021120112A1 (de) 2021-08-03 2023-02-09 Bayerische Motoren Werke Aktiengesellschaft Schnittwerkzeug für ein Metallblech und ein Verfahren zum Betreiben eines Schnittwerkzeugs für ein Metallblech

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US8183224B2 (en) 2012-05-22
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US20120264706A1 (en) 2012-10-18
CA2567289C (en) 2013-12-31
US20050282768A1 (en) 2005-12-22
US8609833B2 (en) 2013-12-17
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