ATE464384T1 - Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein - Google Patents

Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein

Info

Publication number
ATE464384T1
ATE464384T1 AT01961044T AT01961044T ATE464384T1 AT E464384 T1 ATE464384 T1 AT E464384T1 AT 01961044 T AT01961044 T AT 01961044T AT 01961044 T AT01961044 T AT 01961044T AT E464384 T1 ATE464384 T1 AT E464384T1
Authority
AT
Austria
Prior art keywords
glycoprotein
hcv
antibodies
virus
monoclonal antibodies
Prior art date
Application number
AT01961044T
Other languages
English (en)
Inventor
Bernhard Kubanek
Silva Cardoso Marcia Da
Karl Siemoneit
Shlomo Dagan
Rachel Eren
Original Assignee
Drk Blutspendedienst Bw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drk Blutspendedienst Bw filed Critical Drk Blutspendedienst Bw
Application granted granted Critical
Publication of ATE464384T1 publication Critical patent/ATE464384T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C07K16/118—Hepatitis C virus; GB virus C [GBV-C]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01961044T 2000-07-26 2001-07-25 Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein ATE464384T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL137522A IL137522A (en) 2000-07-26 2000-07-26 Human monoclonal antibody against hepatitis c virus e2 glycoprotein
PCT/IL2001/000684 WO2002008292A2 (en) 2000-07-26 2001-07-25 Human monoclonal antibody against hepatitis c virus e2 glycoprotein

Publications (1)

Publication Number Publication Date
ATE464384T1 true ATE464384T1 (de) 2010-04-15

Family

ID=11074445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01961044T ATE464384T1 (de) 2000-07-26 2001-07-25 Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein

Country Status (11)

Country Link
US (1) US7241445B2 (de)
EP (1) EP1305418B1 (de)
JP (1) JP5033298B2 (de)
KR (1) KR100491139B1 (de)
CN (1) CN1545551B (de)
AT (1) ATE464384T1 (de)
AU (2) AU8242501A (de)
CA (1) CA2412460C (de)
DE (1) DE60141832D1 (de)
IL (1) IL137522A (de)
WO (1) WO2002008292A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060188511A1 (en) * 1998-11-05 2006-08-24 Foung Steven K Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
PT1801209E (pt) 2004-08-24 2011-05-26 Toray Industries Arn gen?mico do v?rus humano modificado da hepatite c com capacidade de replica??o aut?noma
CA2644389A1 (en) * 2006-03-03 2007-09-20 Schering Corporation Pharmaceutical combinations of hcv-protease and -ires inhibitors
WO2007111965A2 (en) * 2006-03-22 2007-10-04 Genimmune N.V. Hepatitis c virus neutralizing antibodies
JP5642972B2 (ja) 2007-02-21 2014-12-17 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
US20110033389A1 (en) * 2009-04-29 2011-02-10 Zhifeng Chen Modified antibodies for passive immunotherapy
CN103642792B (zh) * 2013-12-25 2016-03-30 武汉大学 一种抗丙肝病毒的中和性单克隆抗体的制备及其应用
CN107011435B (zh) * 2016-06-01 2019-02-12 苏州银河生物医药有限公司 抗丙型肝炎病毒的全人单克隆抗体8d6
CN109738648B (zh) * 2018-12-29 2021-09-17 山东莱博生物科技有限公司 稳定高效表达丙型肝炎病毒核心抗原抗体的工程细胞株及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849987A (en) * 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US6747136B2 (en) * 1996-04-19 2004-06-08 Karolinska Innovations Ab Human monoclonal antibodies specific for hepatitis C virus (HCV) E2 antigen
CN101088561A (zh) * 1998-07-21 2007-12-19 展马博联合股份有限公司 抗丙型肝炎病毒抗体及其用途
US6072023A (en) 1998-07-21 2000-06-06 Henkel Corporation Polyamides from dimer and trimer acid esters and methods for their preparation
US7091324B2 (en) 1998-11-05 2006-08-15 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
US6692908B1 (en) * 1998-11-05 2004-02-17 Stanford University Prevention and treatment of HCV infection employing antibodies that inhibit the interaction of HCV virions with their receptor

Also Published As

Publication number Publication date
KR20030036632A (ko) 2003-05-09
AU8242501A (en) 2002-02-05
CA2412460C (en) 2012-02-21
WO2002008292A3 (en) 2002-12-12
EP1305418B1 (de) 2010-04-14
KR100491139B1 (ko) 2005-05-24
WO2002008292A2 (en) 2002-01-31
IL137522A (en) 2007-06-17
AU2001282425B2 (en) 2006-06-29
CN1545551B (zh) 2010-04-07
US20040071710A1 (en) 2004-04-15
CN1545551A (zh) 2004-11-10
JP5033298B2 (ja) 2012-09-26
IL137522A0 (en) 2001-07-24
US7241445B2 (en) 2007-07-10
CA2412460A1 (en) 2002-01-31
DE60141832D1 (de) 2010-05-27
JP2004504066A (ja) 2004-02-12
EP1305418A2 (de) 2003-05-02

Similar Documents

Publication Publication Date Title
ATE239756T1 (de) Humaner monoklonaler antikörper gegen hepatitis b virus oberflächen antigen (hbvsag)
EP1127170A4 (de) Menschliche monoklonale antikörper gegen menschlichen pan-hepatitis c virus
ATE256148T1 (de) Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen
FR12C0004I2 (fr) Anticorps contre l'antigene ctla-4 humain et utilisation
FR17C1062I2 (fr) Anticorps specifiques a l' humain cd22 et leurs utilisation therapeutiques et diagnostiques
EP1200109A4 (de) Verwendung von peptid-nukleinsäureverbindungen zur auslösung zellulärer immunantworten gegen hepatitis c
ATE464384T1 (de) Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein
EA201170353A1 (ru) Антитела против гепатита с и их применение
NO913428D0 (no) Humant intra-acrosomalt sperma-antigen for anvendelse i en befruktningshindrende vaksine.
KR910016346A (ko) 광견병 바이러스에 대한 사람 모노클로날 항체, 이의 제조방법 및 용도
EA200401081A1 (ru) Fab-фрагменты моноклонального антитела человека, направленные против гликопротеина e2 hcv и обладающие нейтрализующей активностью in vitro
NO20013911L (no) Humanisert immunoglobulin reaktiv med B7-molekyler og fremgangsmåter for behandling dermed
DE3584872D1 (de) Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag.
EP1256348A4 (de) Heilmittel gegen hepatitis
EA200200974A1 (ru) Моноклональные антитела к рецептору лпнп человека, их получение и применение
WO2002057314A3 (en) Prevention and treatment of hcv infection employing antibodies directed against conformational epitopes
EP1572721A4 (de) Prävention und behandlung von hcv-infektionen unter anwendung von gegen konformationelle und lineare epitope gerichteten antikörpern
ATE167522T1 (de) Monoklonale antikörper gegen mögliche hcv- hüllregionen und methoden diese zu benutzen
DE69941051D1 (de) Expression und charakterisierung eines hiv-1 hüllproteins, das mit einer breitreaktiven neutralisier
ATE430167T1 (de) Humaner rekombinanter antikörper gegen das hepatitis c (hcv) nichtstrukturelles ns3 protein, nukleinsäure und deren verwendungen
CA2254931A1 (en) Human monoclonal antibodies to the hepatitis b surface antigen
Sallberg et al. The Antigen/Antibody Specificity Exchanger: A New Peptide-Based Tool for Re-directing Antibodies of Other Specificities to Recognize the V3 Domain of HIV-1 GP120
DK0569428T3 (da) Fremgangsmåde til diagnosticering in vitro af HIV-1-virusinfektioner
Sa'adu et al. Epitope mapping of HBsAg using a panel of human anti-HBs antibodies
WO2002082089A3 (en) Anti-idiotypic antibody and its use in diagnosis and therapy of hepatitis c virus related diseases

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1305418

Country of ref document: EP