ATE464886T1 - Verbessertes transdermales therapeutisches system für die behandlung der parkinson-krankheit - Google Patents

Verbessertes transdermales therapeutisches system für die behandlung der parkinson-krankheit

Info

Publication number: ATE464886T1
Authority: AT; Austria
Prior art keywords: parkinson; therapeutic system; transdermal therapeutic; disease; treatment
Prior art date: 2001-05-08

Application number

AT02735338T

Other languages

English (en)

Inventor

Thomas Lauterbach

Dietrich Schacht

Hans-Michael Wolff

Walter Mueller

Original Assignee

Ucb Pharma Gmbh

Lohmann Therapie Syst Lts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-08

Filing date

2002-05-06

Publication date

2010-05-15

2002-05-06 Application filed by Ucb Pharma Gmbh, Lohmann Therapie Syst Lts filed Critical Ucb Pharma Gmbh

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE464886T1 publication Critical patent/ATE464886T1/de

Links

208000018737 Parkinson disease Diseases 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000902 placebo Substances 0.000 abstract 1
229940068196 placebo Drugs 0.000 abstract 1
229920001296 polysiloxane Polymers 0.000 abstract 1
KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 abstract 1
229960003179 rotigotine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

AT02735338T 2001-05-08 2002-05-06 Verbessertes transdermales therapeutisches system für die behandlung der parkinson-krankheit ATE464886T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01111110A EP1256340B1 (de)	2001-05-08	2001-05-08	Verbessertes transdermales therapeutisches System zur Behandlung von Morbus Parkinson
PCT/EP2002/004975 WO2002089777A1 (en)	2001-05-08	2002-05-06	Improved transdermal therapeutic system for the treatment of parkinson's disese

Publications (1)

Publication Number	Publication Date
ATE464886T1 true ATE464886T1 (de)	2010-05-15

Family

ID=8177357

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01111110T ATE246919T1 (de)	2001-05-08	2001-05-08	Verbessertes transdermales therapeutisches system zur behandlung von morbus parkinson
AT02735338T ATE464886T1 (de)	2001-05-08	2002-05-06	Verbessertes transdermales therapeutisches system für die behandlung der parkinson-krankheit

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT01111110T ATE246919T1 (de)	2001-05-08	2001-05-08	Verbessertes transdermales therapeutisches system zur behandlung von morbus parkinson

Country Status (17)

Country	Link
EP (3)	EP1256340B1 (de)
JP (1)	JP2004528359A (de)
KR (1)	KR100968293B1 (de)
CN (1)	CN100457095C (de)
AT (2)	ATE246919T1 (de)
AU (1)	AU2002310805B8 (de)
CY (1)	CY1111880T1 (de)
DE (2)	DE60100595T2 (de)
DK (2)	DK1256340T3 (de)
ES (2)	ES2203563T3 (de)
HK (1)	HK1049448B (de)
HU (1)	HU229353B1 (de)
PT (2)	PT1256340E (de)
RU (1)	RU2273477C2 (de)
SI (1)	SI1256340T1 (de)
WO (1)	WO2002089777A1 (de)
ZA (1)	ZA200209980B (de)

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US8246980B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system
US8246979B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system for the administration of rotigotine
EP1386604A1 (de) *	2002-07-30	2004-02-04	Schwarz Pharma Ag	Verbessertes transdermales Verabreichungssystem
EP1386605A1 (de) *	2002-07-30	2004-02-04	Schwarz Pharma Ag	Verbessertes transdermales System für die Verabreichung von Rotigotin
DE10234673B4 (de) *	2002-07-30	2007-08-16	Schwarz Pharma Ag	Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
DE10261696A1 (de) *	2002-12-30	2004-07-15	Schwarz Pharma Ag	Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de)	2003-07-26	2007-07-05	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung von Depressionen
DE10334187A1 (de) *	2003-07-26	2005-03-03	Schwarz Pharma Ag	Substituierte 2-Aminotetraline zur Behandlung von Depressionen
US8815215B2 (en) †	2003-08-15	2014-08-26	Colgate-Palmolive Company	Hydrophobic tooth whitening system and methods of use
DE10338174A1 (de) *	2003-08-20	2005-03-24	Lts Lohmann Therapie-Systeme Ag	Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit
DE10359528A1 (de)	2003-12-18	2005-07-28	Schwarz Pharma Ag	(S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
DE10361259A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
DE10361258A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
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US8344165B2 (en)	2007-05-30	2013-01-01	Chemagis Ltd.	Crystalline rotigotine base and preparation process therefor
PL2215072T3 (pl)	2007-11-28	2015-12-31	Ucb Pharma Gmbh	Polimorficzna postać rotygotyny
DE102008060203A1 (de)	2008-12-07	2010-06-10	Dietrich Wilhelm Schacht	Wirkstoffstabilisierende flächenförmige Vorrichtung
EP2201941A1 (de)	2008-12-29	2010-06-30	UCB Pharma GmbH	Pflaster-Herstellungstechnologie
EP2281559A1 (de)	2009-06-26	2011-02-09	UCB Pharma GmbH	Pharmazeutische Zusammensetzung enthaltend Rotigotin (Salze oder Na), insbesondere für Iontophorese
DE102009052972A1 (de)	2009-11-12	2011-09-15	Lts Lohmann Therapie-Systeme Ag	Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
WO2011076879A1 (en)	2009-12-22	2011-06-30	Ucb Pharma Gmbh	Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
EP2531486B1 (de)	2010-02-05	2017-06-21	UCB Biopharma SPRL	Neues verfahren für die herstellung von stickstoffsubstituierten aminotetralinderivaten
CA2798815C (en)	2010-06-25	2017-01-03	Ucb Pharma Gmbh	Novel process for the preparation of nitrogen substituted aminotetralins derivatives
CN102475692A (zh) *	2010-11-29	2012-05-30	重庆医药工业研究院有限责任公司	一种防止雷沙吉兰挥发的透皮贴片
EP2559435A1 (de)	2011-08-19	2013-02-20	UCB Pharma GmbH	Rotigotin in der Behandlung von Hemineglekt, Schlaganfall und Defiziten nach einem Schlaganfall
CN102499906B (zh) *	2011-10-12	2013-04-17	长春健欣生物医药科技开发有限公司	一种罗替戈汀盐酸盐或自由碱成膜凝胶制剂及其制备方法
WO2013075822A1 (en)	2011-11-22	2013-05-30	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermal therapeutic system (tts) with rotigotine
DE102012013439A1 (de)	2012-07-03	2014-01-23	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor
DE102012013421A1 (de)	2012-07-03	2014-01-09	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermales therapeutisches System (TTS) mit Rotigotin
KR101558042B1 (ko) *	2012-07-05	2015-10-07	에스케이케미칼주식회사	로티고틴을 함유한 경피흡수제제
TW201431570A (zh)	2012-11-22	2014-08-16	Ucb Pharma Gmbh	用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
WO2014198422A1 (de) *	2013-06-14	2014-12-18	Tesa Labtec Gmbh	Transdermales therapiesystem (tts) mit rotigotin
CN105358139B (zh)	2013-07-03	2020-10-16	Lts罗曼治疗方法有限公司	具有电子元件的经皮治疗系统
JP6573913B2 (ja) *	2014-05-20	2019-09-11	エルテーエスローマンテラピー−ジステーメアーゲー	ロチゴチンを含む経皮送達システム
CN106456567A (zh)	2014-05-20	2017-02-22	Lts勒曼治疗系统股份公司	在经皮递送系统中调节活性剂释放的方法
ES2954087T3 (es)	2014-05-20	2023-11-20	Lts Lohmann Therapie Systeme Ag	Sistema de administración transdérmica que incluye un mediador de interfase
DK3854388T3 (da)	2020-01-24	2023-11-27	Luye Pharma Switzerland Ag	Transdermalt terapeutisk system omfattende rotigotin og mindst et ikke-aminresistent silikoneklæbestof

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2001
- 2001-05-08 PT PT01111110T patent/PT1256340E/pt unknown
- 2001-05-08 EP EP01111110A patent/EP1256340B1/de not_active Expired - Lifetime
- 2001-05-08 EP EP03002051A patent/EP1325742A1/de not_active Withdrawn
- 2001-05-08 DE DE60100595T patent/DE60100595T2/de not_active Expired - Lifetime
- 2001-05-08 DK DK01111110T patent/DK1256340T3/da active
- 2001-05-08 ES ES01111110T patent/ES2203563T3/es not_active Expired - Lifetime
- 2001-05-08 AT AT01111110T patent/ATE246919T1/de active
- 2001-05-08 SI SI200130030T patent/SI1256340T1/xx unknown
2002
- 2002-05-06 WO PCT/EP2002/004975 patent/WO2002089777A1/en not_active Ceased
- 2002-05-06 KR KR1020027018012A patent/KR100968293B1/ko not_active Expired - Lifetime
- 2002-05-06 JP JP2002586914A patent/JP2004528359A/ja not_active Withdrawn
- 2002-05-06 PT PT02735338T patent/PT1392256E/pt unknown
- 2002-05-06 CN CNB028015827A patent/CN100457095C/zh not_active Expired - Lifetime
- 2002-05-06 ES ES02735338T patent/ES2344782T3/es not_active Expired - Lifetime
- 2002-05-06 AU AU2002310805A patent/AU2002310805B8/en not_active Ceased
- 2002-05-06 AT AT02735338T patent/ATE464886T1/de active
- 2002-05-06 RU RU2003128642/14A patent/RU2273477C2/ru active IP Right Revival
- 2002-05-06 EP EP02735338A patent/EP1392256B1/de not_active Expired - Lifetime
- 2002-05-06 HU HU0302897A patent/HU229353B1/hu unknown
- 2002-05-06 DK DK02735338.2T patent/DK1392256T3/da active
- 2002-05-06 DE DE60236078T patent/DE60236078D1/de not_active Expired - Lifetime
- 2002-12-10 ZA ZA200209980A patent/ZA200209980B/xx unknown
2003
- 2003-03-05 HK HK03101634.7A patent/HK1049448B/en unknown
2010
- 2010-07-06 CY CY20101100624T patent/CY1111880T1/el unknown

Also Published As

Publication number	Publication date
SI1256340T1 (en)	2003-12-31
AU2002310805B2 (en)	2005-09-08
ES2203563T3 (es)	2004-04-16
EP1256340B1 (de)	2003-08-13
HK1049448B (en)	2003-12-12
PT1256340E (pt)	2003-12-31
KR20030025941A (ko)	2003-03-29
EP1256340A1 (de)	2002-11-13
ZA200209980B (en)	2003-02-24
WO2002089777A1 (en)	2002-11-14
KR100968293B1 (ko)	2010-07-07
PT1392256E (pt)	2010-07-13
HK1049448A1 (en)	2003-05-16
DE60100595D1 (de)	2003-09-18
DK1392256T3 (da)	2010-08-02
CY1111880T1 (el)	2015-11-04
DE60100595T2 (de)	2004-06-24
HU229353B1 (en)	2013-11-28
EP1392256B1 (de)	2010-04-21
AU2002310805B8 (en)	2006-01-12
ES2344782T3 (es)	2010-09-07
HUP0302897A2 (hu)	2003-12-29
EP1392256A1 (de)	2004-03-03
HUP0302897A3 (en)	2005-02-28
EP1325742A1 (de)	2003-07-09
DK1256340T3 (da)	2003-12-01
HK1061194A1 (en)	2004-09-10
RU2003128642A (ru)	2005-03-27
DE60236078D1 (de)	2010-06-02
ATE246919T1 (de)	2003-08-15
CN1462185A (zh)	2003-12-17
JP2004528359A (ja)	2004-09-16
CN100457095C (zh)	2009-02-04
RU2273477C2 (ru)	2006-04-10

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2010-12-15

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Publication	Publication Date	Title
DE60236078D1 (de)	2010-06-02	Verbessertes transdermales therapeutisches system für die behandlung der parkinson-krankheit
DE60100994D1 (de)	2003-11-20	Transdermales therapeutisches System für die Erzielung hoher Plasmaspiegel von Rotigotin in der Therapie von Morbus Parkinson
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