ATE464913T1 - Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden - Google Patents

Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden

Info

Publication number
ATE464913T1
ATE464913T1 AT04788783T AT04788783T ATE464913T1 AT E464913 T1 ATE464913 T1 AT E464913T1 AT 04788783 T AT04788783 T AT 04788783T AT 04788783 T AT04788783 T AT 04788783T AT E464913 T1 ATE464913 T1 AT E464913T1
Authority
AT
Austria
Prior art keywords
polynucleotids
vivo delivery
polyacetals
biodegradable
biodegradable polyacetals
Prior art date
Application number
AT04788783T
Other languages
English (en)
Inventor
Sang Van
Jiadong Zhou
Xiaoli Fu
Lei Yu
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Application granted granted Critical
Publication of ATE464913T1 publication Critical patent/ATE464913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
AT04788783T 2003-09-29 2004-09-16 Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden ATE464913T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50716103P 2003-09-29 2003-09-29
PCT/US2004/030323 WO2005032597A1 (en) 2003-09-29 2004-09-16 Biodegradable polyacetals for in vivo polynucleotide delivery

Publications (1)

Publication Number Publication Date
ATE464913T1 true ATE464913T1 (de) 2010-05-15

Family

ID=34421587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04788783T ATE464913T1 (de) 2003-09-29 2004-09-16 Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden

Country Status (6)

Country Link
US (2) US7794696B2 (de)
EP (1) EP1667732B1 (de)
JP (1) JP4586022B2 (de)
AT (1) ATE464913T1 (de)
DE (1) DE602004026747D1 (de)
WO (1) WO2005032597A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
WO2005032597A1 (en) 2003-09-29 2005-04-14 Nitto Denko Corporation Biodegradable polyacetals for in vivo polynucleotide delivery
US7446099B2 (en) * 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
DE102004023117A1 (de) * 2004-05-11 2005-12-08 A. u. K. Müller GmbH & Co KG Elektromagnetventil für flüssige Medien, insbesondere Heißwasser
US7358223B2 (en) * 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
US7674452B2 (en) 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
US7588754B2 (en) 2005-05-10 2009-09-15 Nitto Denko Corporation Biodegradable polyacetals and methods
US20060263328A1 (en) * 2005-05-19 2006-11-23 Sang Van Hydrophilic polymers with pendant functional groups and method thereof
US7700541B2 (en) 2006-04-06 2010-04-20 Nitto Denko Corporation Biodegradable cationic polymers
JP2010523656A (ja) * 2007-04-12 2010-07-15 エモリー・ユニバーシティ ミセルおよび粒子を用いた、活性物質の送達のための新規の戦略
EP3794017A4 (de) 2018-05-17 2022-03-09 Lumen Bioscience, Inc. Orale arthrospira-platensis-impfstoffabgabeplattform
US12252513B2 (en) 2018-07-16 2025-03-18 Lumen Bioscience, Inc. Thermostable phycobiliproteins produced from recombinant arthrospira
EP3994152A4 (de) 2019-07-03 2023-08-02 Lumen Bioscience, Inc. Nicht-parenterale therapeutische arthrospira-platensis-abgabeplattform

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS254355B1 (en) * 1985-04-10 1988-01-15 Vladimir Saudek Soluble and biodegradatable copolymeres activated for bond of biologicaly active substances
US4713441A (en) * 1986-08-01 1987-12-15 Sandoz Pharmaceuticals Corp. Polyacetal hydrogels formed from divinyl ethers and polyols
US6258354B1 (en) * 1989-09-29 2001-07-10 Joel S. Greenberger Method for homing hematopoietic stem cells to bone marrow stromal cells
WO1991013108A1 (fr) * 1990-02-27 1991-09-05 Asahi Kasei Kogyo Kabushiki Kaisha Copolymere greffe thermoplastique et sa production
US20030087985A1 (en) * 1990-10-15 2003-05-08 Hubbell Jeffrey A. Gels for encapsulation of biological materials
AU653771B2 (en) 1991-01-03 1994-10-13 Alkermes Controlled Therapeutics, Inc. Stabilization of proteins by cationic biopolymers
DE4142130A1 (de) * 1991-12-20 1993-06-24 Basf Ag Verwendung von polyacetalen auf basis von vinylethern und dihydroxyverbindungen in wasch- und reinigungsmitteln und polyacetale
JPH07309943A (ja) 1994-05-16 1995-11-28 Mitsubishi Chem Corp 酸性アミノ酸系樹脂
NO180167C (no) * 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5811510A (en) * 1995-04-14 1998-09-22 General Hospital Corporation Biodegradable polyacetal polymers and methods for their formation and use
US5902246A (en) * 1996-03-26 1999-05-11 Lifespex, Incorporated Method and apparatus for calibrating an optical probe
TW371617B (en) * 1996-10-09 1999-10-11 Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
ATE203157T1 (de) 1996-12-20 2001-08-15 Alza Corp Injizierbare depotgelzubereitung und herstellungsverfahren
ATE257014T1 (de) * 1997-04-29 2004-01-15 Amersham Health As Lichtbilderzeugungskontrastmitteln
CA2297025A1 (en) 1997-07-25 1999-02-04 Sdg, Inc. Polymer based pharmaceutical compositions for targeted delivery of biologically active agents
US6383811B2 (en) * 1997-12-30 2002-05-07 Mirus Corporation Polyampholytes for delivering polyions to a cell
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US6866842B1 (en) * 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
JPH11335269A (ja) * 1998-05-19 1999-12-07 Hisamitsu Pharmaceut Co Inc 遺伝子関連医薬の経口投与固形製剤
US7396919B1 (en) 1998-07-17 2008-07-08 Mirus Bio Corporation Charge reversal of polyion complexes
US7018654B2 (en) * 1999-03-05 2006-03-28 New River Pharmaceuticals Inc. Pharmaceutical composition containing an active agent in an amino acid copolymer structure
US7160924B2 (en) 2002-07-19 2007-01-09 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
EP1209971A4 (de) 1999-08-20 2004-04-14 Mirus Corp Ladungswechsel von polyion-komplexen
CA2388920A1 (en) 1999-11-02 2001-05-10 Canadian Space Agency Photosolubilizable layers
US20020052335A1 (en) * 1999-11-29 2002-05-02 Rozema David B. Charge reversal of polyion complexes
EP1248838A4 (de) 1999-12-31 2004-08-25 Mirus Corp Polyampholyte zur einbringung von polyionen in zellen
US7033607B2 (en) * 1999-12-31 2006-04-25 Mirus Bio Corporation pH-titratable polyampholytes for delivering polyions to a cell
US6881576B2 (en) * 1999-12-31 2005-04-19 Mirus Bio Corporation Formation of polyampholytes in the presence of a polyion
EP1326655A2 (de) 2000-08-23 2003-07-16 Surfarc APS Biokompatible materialien
EP1315777B1 (de) 2000-09-06 2007-10-31 AP Pharma, Inc. Abbaubare polyacetal-polymere
US6534243B1 (en) * 2000-10-23 2003-03-18 Advanced Micro Devices, Inc. Chemical feature doubling process
US20030049320A1 (en) 2000-12-18 2003-03-13 Wockhardt Limited Novel in-situ forming controlled release microcarrier delivery system
US20030120355A1 (en) * 2001-06-08 2003-06-26 Urs Hafeli Biocompatible and biodegradable polymers for diagnostic and therapeutic radioisotope delivery
RU2323106C2 (ru) * 2001-08-15 2008-04-27 Дау Глобал Текнолоджиз Инк. Усовершенствованная система сидений
JP3493608B2 (ja) * 2001-11-28 2004-02-03 学校法人慶應義塾 医用高分子及びその用途
JP3969109B2 (ja) * 2002-02-08 2007-09-05 コニカミノルタホールディングス株式会社 感光性平版印刷版及びその記録方法
AU2003220161A1 (en) * 2002-03-12 2003-09-29 Nitto Denko Corporation Vector for transfection of eukaryotic cells
US20030191458A1 (en) * 2002-04-03 2003-10-09 Cornelius Diamond Light-activated drug delivery method and device
US20030215395A1 (en) * 2002-05-14 2003-11-20 Lei Yu Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
US8030459B2 (en) 2002-07-19 2011-10-04 The General Hospital Corporation Oxime conjugates and methods for their formation and use
US20040258669A1 (en) * 2002-11-05 2004-12-23 Dzau Victor J. Mesenchymal stem cells and methods of use thereof
US6878374B2 (en) * 2003-02-25 2005-04-12 Nitto Denko Corporation Biodegradable polyacetals
US7727969B2 (en) * 2003-06-06 2010-06-01 Massachusetts Institute Of Technology Controlled release nanoparticle having bound oligonucleotide for targeted delivery
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
US7048925B2 (en) * 2003-08-28 2006-05-23 Nitto Denko Corporation Acid-sensitive polyacetals and methods
WO2005032597A1 (en) 2003-09-29 2005-04-14 Nitto Denko Corporation Biodegradable polyacetals for in vivo polynucleotide delivery
US7163677B2 (en) * 2003-10-24 2007-01-16 Nitto Denko Corporation Cationic polymers having degradable crosslinks
US7368240B2 (en) * 2003-11-11 2008-05-06 Nitto Denko Corporation Microscope system and methods for intracellular studies
US7446099B2 (en) * 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
US7358223B2 (en) * 2004-10-04 2008-04-15 Nitto Denko Corporation Biodegradable cationic polymers
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
US7588754B2 (en) * 2005-05-10 2009-09-15 Nitto Denko Corporation Biodegradable polyacetals and methods
US20060263328A1 (en) * 2005-05-19 2006-11-23 Sang Van Hydrophilic polymers with pendant functional groups and method thereof

Also Published As

Publication number Publication date
JP2007511465A (ja) 2007-05-10
HK1092727A1 (en) 2007-02-16
WO2005032597A1 (en) 2005-04-14
US20050080033A1 (en) 2005-04-14
EP1667732A1 (de) 2006-06-14
US8383091B2 (en) 2013-02-26
JP4586022B2 (ja) 2010-11-24
US7794696B2 (en) 2010-09-14
US20110015344A1 (en) 2011-01-20
EP1667732B1 (de) 2010-04-21
DE602004026747D1 (de) 2010-06-02

Similar Documents

Publication Publication Date Title
ATE464913T1 (de) Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden
ATE476450T1 (de) Vernetzte polysaccharidzusammensetzung
MX2008008321A (es) Metodos para elaborar articulos polimericos y los articulos polimericos formados por este medio.
DE602005021788D1 (de) Systeme und verfahren für die ex-vivo-organpflege
ATE424159T1 (de) Katheter
CY1108344T1 (el) Φορεις εκφρασης που περιεχουν τον mcmv ie2 υποκινητη
ATE427763T1 (de) Ballonkatheter
ATE428305T1 (de) Komprimierte kaugummitablette
AU304845S (en) Wireless transmitter
ATE431749T1 (de) Topische zusammensetzung enthaltend ein cyclofructan, einen träger und einen arzneistoff
DK2206736T3 (da) Polyglutamat-aminosyre-konjugater og fremgangsmåder
ATE462466T1 (de) Ballonkatheter und herstellungsverfahren dafür
AU304944S (en) Container
AU314656S (en) Automobile
MXPA05006688A (es) Conjugados de polimero con una variante de cianovirina.
DK1809661T3 (da) Humant interferon-beta-mutein
DE602004025050D1 (de) Spinosyne für die wundheilung
DE602004022921D1 (de) Antisense oligonukleotide, die die ausprägungsstufe von hif-1 hemmen
ATE487379T1 (de) Antimikrobielle mittel, die polymere stabilisatoren enthalten
AU302605S (en) Aquarium
EP1874729A4 (de) Biologisch abbaubare polyphosphazene mit pyrrolidonseitengruppen
NO20071330L (no) Enzyminhibitor i leukemi
AU308295S (en) Radio
ATE411810T1 (de) Medikament aus laminarin oder oligolaminarinen zur behandlung von septikämie und schock
BRPI0717083A2 (pt) Nitrilas alfa, insaturadas como frangrâncias

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties