ATE466572T1 - Verfahren zur hemmung der gefässpermeabilität und apoptose - Google Patents

Verfahren zur hemmung der gefässpermeabilität und apoptose

Info

Publication number: ATE466572T1
Authority: AT; Austria
Prior art keywords: sphingosine; vascular endothelial; vascular permeability; apoptosis; receptor agonists
Prior art date: 2003-06-24

Application number

AT04776717T

Other languages

English (en)

Inventor

Timothy Hla

Teresa Sanchez

Ji-Hye Paik

Kevin Claffey

Original Assignee

Univ Connecticut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-24

Filing date

2004-06-18

Publication date

2010-05-15

2004-06-18 Application filed by Univ Connecticut filed Critical Univ Connecticut

2010-05-15 Application granted granted Critical

2010-05-15 Publication of ATE466572T1 publication Critical patent/ATE466572T1/de

Links

230000008728 vascular permeability Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
230000006907 apoptotic process Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 4
108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 4
239000000018 receptor agonist Substances 0.000 abstract 3
229940044601 receptor agonist Drugs 0.000 abstract 3
210000004204 blood vessel Anatomy 0.000 abstract 2
230000004528 endothelial cell apoptotic process Effects 0.000 abstract 2
230000003511 endothelial effect Effects 0.000 abstract 2
230000002792 vascular Effects 0.000 abstract 2
210000003556 vascular endothelial cell Anatomy 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
102100027662 Sphingosine kinase 2 Human genes 0.000 abstract 1
101710156532 Sphingosine kinase 2 Proteins 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 abstract 1
229960000556 fingolimod Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT04776717T 2003-06-24 2004-06-18 Verfahren zur hemmung der gefässpermeabilität und apoptose ATE466572T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48223403P	2003-06-24	2003-06-24
PCT/US2004/019420 WO2005002559A2 (en)	2003-06-24	2004-06-18	Methods of inhibiting vascular permeability and apoptosis

Publications (1)

Publication Number	Publication Date
ATE466572T1 true ATE466572T1 (de)	2010-05-15

Family

ID=33563841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04776717T ATE466572T1 (de)	2003-06-24	2004-06-18	Verfahren zur hemmung der gefässpermeabilität und apoptose

Country Status (14)

Country	Link
US (3)	US7838562B2 (de)
EP (1)	EP1643983B1 (de)
JP (2)	JP2007523858A (de)
CN (2)	CN100431534C (de)
AT (1)	ATE466572T1 (de)
AU (1)	AU2004253473B2 (de)
BR (1)	BRPI0411831A (de)
CA (3)	CA2778309C (de)
DE (1)	DE602004027045D1 (de)
ES (1)	ES2342396T3 (de)
MX (1)	MXPA05014216A (de)
PL (1)	PL1643983T3 (de)
PT (1)	PT1643983E (de)
WO (1)	WO2005002559A2 (de)

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US20080279897A1 (en) *	2005-01-21	2008-11-13	Medvet Science Pty. Ltd.	Method of Treating Cellular Damage
KR100773765B1 (ko)	2005-11-24	2007-11-12	재단법인서울대학교산학협력재단	개선된 스핑고신 유사체의 제조 방법
EP1905434A1 (de) *	2006-09-26	2008-04-02	Novartis AG	Organische S1P Rezeptor Agonist Verbindungen und ihre therapeutische Verwendung
SI3103448T1 (sl) *	2006-09-26	2019-11-29	Novartis Ag	Farmacevtski sestavek, ki vsebuje modulator S1P
PL2083811T3 (pl)	2006-11-22	2017-05-31	Clinical Research Associates, Llc	Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu
PT2465492E (pt)	2007-10-12	2015-10-15	Novartis Ag	Composições que compreendem moduladores de receptores de esfingosina-1-fosfato (s1p)
CN102464590B (zh) *	2010-11-18	2013-10-23	中国科学院上海药物研究所	一类免疫调节剂及其制备方法和用途
ES2388273B1 (es) *	2011-03-16	2013-10-01	Consejo Superior De Investigaciones Científicas (Csic)	Uso de inhibidores de receptores de s1p para el tratamiento de la estenosis aórtica calcificada
CN104334556B (zh)	2012-03-26	2017-05-17	爱若优生物科技有限公司	新型1‑磷酸鞘氨醇受体拮抗剂
US9220706B2 (en) *	2012-06-01	2015-12-29	National Institutes Of Health (Nih)	Inhibition of leukemic stem cells by PP2A activating agents
EP2895184A4 (de) *	2012-09-12	2016-09-07	Oklahoma Med Res Found	Modulation einer podoplaninvermittelten blutplättchenaktivierung
JP6294872B2 (ja) *	2013-04-26	2018-03-14	国立大学法人京都大学	脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物
US10574647B2 (en) *	2014-09-01	2020-02-25	Passlogy Co., Ltd.	User authentication method and system for implementing same
WO2016115092A1 (en) *	2015-01-12	2016-07-21	La Jolla Institute For Allergy And Immunology	Methods for targeting host vascular mechanism for therapeutic protection against hemorrhagic fever
US10111841B2 (en)	2015-06-19	2018-10-30	University Of South Florida	Stabilization of alcohol intoxication-induced cardiovascular instability
CN105395530A (zh) *	2015-11-27	2016-03-16	天津医科大学总医院	芬戈莫德的新用途
CN105640928A (zh) *	2016-02-26	2016-06-08	南京医科大学	Fty720在制备预防与治疗缺血性脑卒药物中的应用
CN108939074B (zh) *	2017-05-22	2022-06-10	北京蔚蓝之源医药科技有限公司	治疗再生障碍性贫血的方法和药物组合物
KR20200116953A (ko) *	2018-02-02	2020-10-13	고쿠리츠 다이가쿠 호진 교토 다이가쿠	안내 혈관 신생 및/또는 안내 혈관 투과성 항진을 수반하는 안과 질환의 예방 또는 치료를 위한 의약
EP3677259A1 (de) *	2019-01-07	2020-07-08	Mosaiques Diagnostics And Therapeutics AG	Verwendung von arachidonyl-trifluormethyl-keton
JP7824930B2 (ja) *	2020-08-19	2026-03-05	バイオジェン・エムエイ・インコーポレイテッド	高コレステロール血症の治療方法

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2004
- 2004-06-18 MX MXPA05014216A patent/MXPA05014216A/es active IP Right Grant
- 2004-06-18 AT AT04776717T patent/ATE466572T1/de active
- 2004-06-18 CN CNB2004800175481A patent/CN100431534C/zh not_active Expired - Fee Related
- 2004-06-18 PL PL04776717T patent/PL1643983T3/pl unknown
- 2004-06-18 CN CN200810212366A patent/CN101518524A/zh active Pending
- 2004-06-18 WO PCT/US2004/019420 patent/WO2005002559A2/en not_active Ceased
- 2004-06-18 DE DE602004027045T patent/DE602004027045D1/de not_active Expired - Lifetime
- 2004-06-18 PT PT04776717T patent/PT1643983E/pt unknown
- 2004-06-18 CA CA2778309A patent/CA2778309C/en not_active Expired - Fee Related
- 2004-06-18 CA CA2529318A patent/CA2529318C/en not_active Expired - Fee Related
- 2004-06-18 EP EP04776717A patent/EP1643983B1/de not_active Expired - Lifetime
- 2004-06-18 BR BRPI0411831-6A patent/BRPI0411831A/pt not_active IP Right Cessation
- 2004-06-18 US US10/562,305 patent/US7838562B2/en not_active Expired - Fee Related
- 2004-06-18 CA CA2778126A patent/CA2778126A1/en not_active Abandoned
- 2004-06-18 AU AU2004253473A patent/AU2004253473B2/en not_active Ceased
- 2004-06-18 ES ES04776717T patent/ES2342396T3/es not_active Expired - Lifetime
- 2004-06-18 JP JP2006517361A patent/JP2007523858A/ja not_active Withdrawn
2010
- 2010-09-30 US US12/894,783 patent/US9101575B2/en not_active Expired - Fee Related
2014
- 2014-01-07 JP JP2014001034A patent/JP2014088421A/ja active Pending
2015
- 2015-06-18 US US14/743,352 patent/US20150283154A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602004027045D1 (de)	2010-06-17
CA2778309C (en)	2014-12-02
WO2005002559A3 (en)	2005-04-14
JP2007523858A (ja)	2007-08-23
WO2005002559A2 (en)	2005-01-13
EP1643983B1 (de)	2010-05-05
CN100431534C (zh)	2008-11-12
PT1643983E (pt)	2010-06-18
AU2004253473B2 (en)	2010-03-04
US20080039530A1 (en)	2008-02-14
CA2529318C (en)	2013-09-17
CN1826104A (zh)	2006-08-30
CA2778309A1 (en)	2005-01-13
CA2529318A1 (en)	2005-01-13
US20150283154A1 (en)	2015-10-08
BRPI0411831A (pt)	2006-08-08
US20110015159A1 (en)	2011-01-20
MXPA05014216A (es)	2006-03-13
CA2778126A1 (en)	2005-01-13
US9101575B2 (en)	2015-08-11
PL1643983T3 (pl)	2010-10-29
CN101518524A (zh)	2009-09-02
AU2004253473A1 (en)	2005-01-13
EP1643983A2 (de)	2006-04-12
JP2014088421A (ja)	2014-05-15
US7838562B2 (en)	2010-11-23
ES2342396T3 (es)	2010-07-06

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DE602004027045D1 (de)	2010-06-17	Verfahren zur hemmung der gefässpermeabilität und apoptose
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