ATE466864T1 - Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung - Google Patents
Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE466864T1 ATE466864T1 AT00980769T AT00980769T ATE466864T1 AT E466864 T1 ATE466864 T1 AT E466864T1 AT 00980769 T AT00980769 T AT 00980769T AT 00980769 T AT00980769 T AT 00980769T AT E466864 T1 ATE466864 T1 AT E466864T1
- Authority
- AT
- Austria
- Prior art keywords
- aggregative
- official
- production
- nucleotide analogs
- oligomers containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002773 nucleotide Substances 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- 238000009396 hybridization Methods 0.000 abstract 2
- QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical compound C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003212 purines Chemical class 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/447,936 US6660845B1 (en) | 1999-11-23 | 1999-11-23 | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
| PCT/US2000/032265 WO2001038584A2 (en) | 1999-11-23 | 2000-11-21 | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466864T1 true ATE466864T1 (de) | 2010-05-15 |
Family
ID=23778351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00980769T ATE466864T1 (de) | 1999-11-23 | 2000-11-21 | Nichtaggregierende, nichtausschaltende oligomere, nukleotid-analoga enthaltend; verfahren zu deren herstellung und verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6660845B1 (de) |
| EP (1) | EP1232157B1 (de) |
| JP (1) | JP2003527579A (de) |
| AT (1) | ATE466864T1 (de) |
| AU (1) | AU1798901A (de) |
| CA (1) | CA2392033C (de) |
| DE (1) | DE60044367D1 (de) |
| ES (1) | ES2344337T3 (de) |
| WO (1) | WO2001038584A2 (de) |
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| JP2025539043A (ja) | 2022-11-14 | 2025-12-03 | バイオンテック・エスイー | Ｒｎａキャッピング効率アッセイ |
| KR20260025139A (ko) | 2023-06-14 | 2026-02-23 | 사노피 백신즈 유에스 인크. | 메신저 rna의 캡핑 및 테일링 변형을 동시에 식별하거나 정량화하는 방법 |
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| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
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-
1999
- 1999-11-23 US US09/447,936 patent/US6660845B1/en not_active Expired - Lifetime
-
2000
- 2000-11-21 DE DE60044367T patent/DE60044367D1/de not_active Expired - Lifetime
- 2000-11-21 JP JP2001539925A patent/JP2003527579A/ja active Pending
- 2000-11-21 ES ES00980769T patent/ES2344337T3/es not_active Expired - Lifetime
- 2000-11-21 AU AU17989/01A patent/AU1798901A/en not_active Abandoned
- 2000-11-21 EP EP00980769A patent/EP1232157B1/de not_active Expired - Lifetime
- 2000-11-21 AT AT00980769T patent/ATE466864T1/de not_active IP Right Cessation
- 2000-11-21 WO PCT/US2000/032265 patent/WO2001038584A2/en not_active Ceased
- 2000-11-21 CA CA2392033A patent/CA2392033C/en not_active Expired - Lifetime
-
2003
- 2003-11-04 US US10/702,007 patent/US6972328B2/en not_active Expired - Lifetime
-
2005
- 2005-05-13 US US11/129,003 patent/US20050239121A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001038584A3 (en) | 2001-10-25 |
| JP2003527579A (ja) | 2003-09-16 |
| US6660845B1 (en) | 2003-12-09 |
| DE60044367D1 (de) | 2010-06-17 |
| US20040116689A1 (en) | 2004-06-17 |
| EP1232157B1 (de) | 2010-05-05 |
| WO2001038584A2 (en) | 2001-05-31 |
| US6972328B2 (en) | 2005-12-06 |
| EP1232157A2 (de) | 2002-08-21 |
| ES2344337T3 (es) | 2010-08-25 |
| AU1798901A (en) | 2001-06-04 |
| US20050239121A1 (en) | 2005-10-27 |
| CA2392033C (en) | 2010-02-09 |
| CA2392033A1 (en) | 2001-05-31 |
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