|
DE102005042073B4
(de)
*
|
2005-08-31 |
2010-11-11 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Faserlaser
|
|
EP2505647A1
(en)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of DGAT2
|
|
EP2505646A1
(en)
*
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of CRP
|
|
EP2410053B2
(en)
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
EA200900741A1
(ru)
*
|
2006-11-27 |
2010-04-30 |
Айзис Фармасьютикалз, Инк. |
Способы лечения гиперхолестеринемии
|
|
EP2188298B1
(en)
|
2007-08-15 |
2013-09-18 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
EP2220230A2
(en)
|
2007-11-09 |
2010-08-25 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 9 expression
|
|
CN102076852A
(zh)
|
2007-11-09 |
2011-05-25 |
Isis药物公司 |
因子7表达的调节
|
|
EP2265627A2
(en)
|
2008-02-07 |
2010-12-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
US8426378B2
(en)
*
|
2008-03-21 |
2013-04-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use
|
|
US8846639B2
(en)
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
US9290534B2
(en)
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
US8541387B2
(en)
*
|
2008-05-22 |
2013-09-24 |
Isis Pharmaceuticals, Inc. |
Modulation of SMRT expression
|
|
CA2726052A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
|
AU2009276763B2
(en)
|
2008-07-29 |
2015-07-16 |
The Board Of Regents Of The University Of Texas Sytem |
Selective inhibition of polyglutamine protein expression
|
|
WO2010036696A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
|
CA2740785C
(en)
|
2008-10-15 |
2017-06-20 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 11 expression
|
|
EP2358397B1
(en)
|
2008-10-24 |
2020-01-01 |
Ionis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
EP2447274B1
(en)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
BRPI0923225A2
(pt)
|
2008-12-02 |
2016-10-04 |
Chiralgen Ltd |
metodo para sintese de acidos nucleicos modificados no atomo de fosforo
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
EP2393825A2
(en)
|
2009-02-06 |
2011-12-14 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
EP2414520A2
(en)
|
2009-03-31 |
2012-02-08 |
Altair Therapeutics, Inc. |
Methods of modulating an immune response to a viral infection
|
|
JP5685526B2
(ja)
*
|
2009-03-31 |
2015-03-18 |
武田薬品工業株式会社 |
ヌクレオシドの製造方法
|
|
WO2010124231A2
(en)
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
|
KR20220084437A
(ko)
|
2009-06-17 |
2022-06-21 |
바이오젠 엠에이 인코포레이티드 |
대상에게서 smn2 스플라이싱을 조정하기 위한 조성물 및 방법
|
|
WO2010150789A1
(ja)
|
2009-06-23 |
2010-12-29 |
武田薬品工業株式会社 |
核酸の合成法
|
|
EP2451461A4
(en)
|
2009-07-06 |
2013-05-29 |
Ontorii Inc |
NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
|
|
JP2011024434A
(ja)
|
2009-07-22 |
2011-02-10 |
Galaxy Pharma Inc |
オリゴヌクレオチドのスクリーニング方法及びオリゴヌクレオチドライブラリー
|
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
EP3626823A1
(en)
|
2009-09-11 |
2020-03-25 |
Ionis Pharmaceuticals, Inc. |
Modulation of huntingtin expression
|
|
AU2010312751B2
(en)
*
|
2009-10-29 |
2014-07-24 |
Osaka University |
Bridged artificial nucleoside and nucleotide
|
|
US20110110860A1
(en)
|
2009-11-02 |
2011-05-12 |
The Board Of Regents Of The University Of Texas System |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
|
WO2011085271A2
(en)
|
2010-01-08 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2524038A4
(en)
*
|
2010-01-12 |
2013-11-20 |
Isis Pharmaceuticals Inc |
MODULATION OF TRANSFORMING A GROWTH FACTOR BETA-1 EXPRESSION
|
|
WO2011090052A1
(ja)
|
2010-01-20 |
2011-07-28 |
国立大学法人 東京大学 |
リン酸化試薬
|
|
WO2011097388A1
(en)
|
2010-02-03 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Selective inhibition of polyglutamine protein expression
|
|
ES2733708T3
(es)
|
2010-02-08 |
2019-12-02 |
Ionis Pharmaceuticals Inc |
Reducción selectiva de variantes alélicas
|
|
JP6018506B2
(ja)
|
2010-02-08 |
2016-11-02 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
対立遺伝子多様体の選択的低減
|
|
WO2011106689A1
(en)
*
|
2010-02-26 |
2011-09-01 |
Isis Pharmaceuticals, Inc. |
Modulation of smad3 expression
|
|
WO2011115817A1
(en)
|
2010-03-16 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
Methods of preparing 2'-o-substituted purine nucleosides
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3578657B1
(en)
|
2010-04-06 |
2024-03-20 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of cd274/pd-l1 gene
|
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
|
WO2011133876A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139702A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
ES2625689T3
(es)
|
2010-04-29 |
2017-07-20 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de transtiretina
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
EP3456827A3
(en)
|
2010-06-02 |
2019-05-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011159836A2
(en)
|
2010-06-15 |
2011-12-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
|
ES2756326T3
(es)
|
2010-07-19 |
2020-04-27 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de distrofia miotónica-proteína quinasa (DMPK)
|
|
US9127280B2
(en)
|
2010-08-31 |
2015-09-08 |
Osaka University |
Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient
|
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
|
WO2012064758A2
(en)
|
2010-11-08 |
2012-05-18 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
|
EP3521451A1
(en)
|
2010-11-17 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
WO2012079046A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
|
US9193973B2
(en)
|
2010-12-10 |
2015-11-24 |
Alynylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (EPO) production
|
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
EP2495336B8
(en)
|
2011-03-04 |
2014-07-23 |
Roche Diagnostics GmbH |
A new type of universal probes for the detection of genomic variants
|
|
KR102104401B1
(ko)
|
2011-03-29 |
2020-04-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
|
KR20190092590A
(ko)
|
2011-04-01 |
2019-08-07 |
아이오니스 파마수티컬즈, 인코포레이티드 |
전사 신호 전달 인자 및 활성 인자 3(stat3) 발현 조절
|
|
US10086043B2
(en)
|
2011-04-03 |
2018-10-02 |
The General Hospital Corporation |
Efficient protein expression in vivo using modified RNA (MOD-RNA)
|
|
CN105886506A
(zh)
*
|
2011-04-13 |
2016-08-24 |
Isis制药公司 |
Ptp1b 表达的反义调节
|
|
SI3505528T1
(sl)
|
2011-04-21 |
2021-04-30 |
Glaxo Group Limited |
Modulacija izražanja virusa hepatitisa B (HBV)
|
|
MX393138B
(es)
|
2011-04-25 |
2025-03-24 |
Sanofi Sa |
Compuestos de microarn y metodos para modular la actividad de mir-21.
|
|
SG194671A1
(en)
|
2011-04-27 |
2013-12-30 |
Isis Pharmaceuticals Inc |
Modulation of apolipoprotein ciii (apociii) expression
|
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2012170945A2
(en)
|
2011-06-10 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
|
US9187749B2
(en)
|
2011-06-10 |
2015-11-17 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
|
AU2012271357A1
(en)
|
2011-06-16 |
2013-05-02 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
|
CA2839573A1
(en)
|
2011-06-21 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
|
US20140235693A1
(en)
|
2011-06-23 |
2014-08-21 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
|
AU2012275096B2
(en)
|
2011-06-29 |
2016-02-04 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (KLKB1) expression
|
|
CN107365339A
(zh)
|
2011-07-19 |
2017-11-21 |
波涛生命科学有限公司 |
合成官能化核酸的方法
|
|
JP2014526887A
(ja)
|
2011-08-01 |
2014-10-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
造血幹細胞移植の成功率を改善する方法
|
|
US20140303235A1
(en)
|
2011-08-11 |
2014-10-09 |
Isis Pharmaceuticals, Inc. |
Linkage modified gapped oligomeric compounds and uses thereof
|
|
EP2751269B1
(en)
|
2011-08-29 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
US10023861B2
(en)
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
EP2758533B1
(en)
|
2011-09-20 |
2018-04-11 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of gcgr expression
|
|
WO2013059740A1
(en)
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
|
AU2012328680A1
(en)
|
2011-10-25 |
2014-05-01 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
|
EP2776564B1
(en)
|
2011-11-07 |
2019-10-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of tmprss6 expression
|
|
US9243291B1
(en)
|
2011-12-01 |
2016-01-26 |
Isis Pharmaceuticals, Inc. |
Methods of predicting toxicity
|
|
CN104126010B
(zh)
|
2011-12-16 |
2021-04-06 |
国立大学法人东京医科齿科大学 |
嵌合的双链核酸
|
|
ES2673960T3
(es)
|
2011-12-22 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Métodos para modular la expresión de un transcrito-1 de adenocarcinoma en pulmón asociado a metástasis (MALAT-1)
|
|
IL266882B2
(en)
|
2012-01-11 |
2025-11-01 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulation of ikbkap splicing
|
|
EP3330278A1
(en)
|
2012-02-08 |
2018-06-06 |
Ionis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
|
US9340784B2
(en)
|
2012-03-19 |
2016-05-17 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
|
CA2866392C
(en)
|
2012-03-30 |
2023-10-24 |
Washington University |
Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
EP3336189A1
(en)
|
2012-04-20 |
2018-06-20 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
MY173600A
(en)
|
2012-04-25 |
2020-02-08 |
Sanofi Sa |
Microrna compounds and methods for modulating mir-21 activity
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
|
US20160002624A1
(en)
|
2012-05-17 |
2016-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
|
WO2013177248A2
(en)
|
2012-05-22 |
2013-11-28 |
Isis Pharmaceuticals, Inc. |
Modulation of enhancer rna mediated gene expression
|
|
RU2624028C2
(ru)
|
2012-05-24 |
2017-06-30 |
Ионис Фармасьютикалз, Инк. |
Способы и композиции для модулирования экспрессии аполипопротеина (а)
|
|
US9828602B2
(en)
|
2012-06-01 |
2017-11-28 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
WO2013181666A2
(en)
|
2012-06-01 |
2013-12-05 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
|
ES2809199T3
(es)
|
2012-06-25 |
2021-03-03 |
Ionis Pharmaceuticals Inc |
Modulación de la expresión de UBE3A-ATS
|
|
DK2872147T3
(da)
|
2012-07-13 |
2023-02-20 |
Wave Life Sciences Ltd |
Fremgangsmåde til fremstilling af kirale oligonukleotider
|
|
SG11201500243WA
(en)
|
2012-07-13 |
2015-04-29 |
Shin Nippon Biomedical Lab Ltd |
Chiral nucleic acid adjuvant
|
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
|
EP3693460A1
(en)
|
2012-07-27 |
2020-08-12 |
Ionis Pharmaceuticals, Inc. |
Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
|
|
WO2014028739A1
(en)
|
2012-08-15 |
2014-02-20 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
|
WO2014045126A2
(en)
|
2012-09-18 |
2014-03-27 |
Uti Limited Partnership |
Treatment of pain by inhibition of usp5 de-ubiquitinase
|
|
EP2899197B1
(en)
|
2012-09-21 |
2017-03-22 |
Osaka University |
Oligonucleotide and artificial nucleoside having guanidine bridge
|
|
WO2014051076A1
(ja)
|
2012-09-28 |
2014-04-03 |
株式会社Bna |
Bnaクランプ法
|
|
US9695418B2
(en)
|
2012-10-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
|
WO2014059364A1
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Methods of treating kennedy's disease
|
|
US9175291B2
(en)
|
2012-10-11 |
2015-11-03 |
Isis Pharmaceuticals Inc. |
Modulation of androgen receptor expression
|
|
EP2906255B1
(en)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
|
EP4086347A3
(en)
|
2012-10-12 |
2023-01-11 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
FI2906696T4
(fi)
|
2012-10-15 |
2023-03-18 |
|
Menetelmiä c9orf72:n ilmentymisen moduloimiseksi
|
|
EP2906697A4
(en)
|
2012-10-15 |
2016-06-22 |
Ionis Pharmaceuticals Inc |
METHOD FOR MONITORING THE C9ORF72 EXPRESSION
|
|
US10443052B2
(en)
|
2012-10-15 |
2019-10-15 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating C9ORF72 expression
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP3483273A1
(en)
|
2012-10-31 |
2019-05-15 |
Ionis Pharmaceuticals, Inc. |
Cancer treatment
|
|
EP4223770A3
(en)
|
2012-11-05 |
2023-10-18 |
Foundation Medicine, Inc. |
Novel fusion molecules and uses thereof
|
|
EP2914621B1
(en)
|
2012-11-05 |
2023-06-07 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
BR112015012051A2
(pt)
|
2012-11-26 |
2017-12-12 |
Roche Innovation Ct Copenhagen As |
composições e métodos para modulação de expressão de fgfr3
|
|
EP2929050A1
(en)
|
2012-12-10 |
2015-10-14 |
AdvanDx, Inc. |
Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
|
|
US9695475B2
(en)
|
2012-12-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Competitive modulation of microRNAs
|
|
WO2014112463A1
(ja)
*
|
2013-01-15 |
2014-07-24 |
国立大学法人大阪大学 |
スルホンアミド構造を有するヌクレオシドおよびヌクレオチド
|
|
CA2898326C
(en)
|
2013-01-18 |
2022-05-17 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
CA2893801A1
(en)
|
2013-01-30 |
2014-08-07 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotide carbohydrate conjugates
|
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
DK2951191T3
(da)
|
2013-01-31 |
2019-01-14 |
Ionis Pharmaceuticals Inc |
Fremgangsmåde til fremstilling af oligomeriske forbindelser under anvendelse af modificerede koblingsprotokoller
|
|
EP2951304B1
(en)
|
2013-02-04 |
2020-07-08 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
KR20200123263A
(ko)
|
2013-02-14 |
2020-10-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
지질단백질 리파제 결핍 (lpld) 모집단에서 아포지질단백질 c-iii (apociii) 발현의 조절
|
|
WO2014126229A1
(ja)
|
2013-02-18 |
2014-08-21 |
塩野義製薬株式会社 |
含窒素複素環構造を有するヌクレオシド及びヌクレオチド
|
|
US20150366890A1
(en)
|
2013-02-25 |
2015-12-24 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
|
EP2961853B1
(en)
|
2013-02-28 |
2018-09-19 |
The Board of Regents of The University of Texas System |
Methods for classifying a cancer as susceptible to tmepai-directed therapies and treating such cancers
|
|
WO2014132671A1
(en)
|
2013-03-01 |
2014-09-04 |
National University Corporation Tokyo Medical And Dental University |
Chimeric single-stranded antisense polynucleotides and double-stranded antisense agent
|
|
US9914979B2
(en)
|
2013-03-04 |
2018-03-13 |
Fry Laboratories, LLC |
Method and kit for characterizing microorganisms
|
|
PT2970974T
(pt)
|
2013-03-14 |
2017-11-29 |
Alnylam Pharmaceuticals Inc |
Composições de irna de componente do complemento c5 e métodos para a sua utilização
|
|
BR112015022156A2
(pt)
|
2013-03-14 |
2017-11-14 |
Isis Pharmaceuticals Inc |
composições e métodos para modular a expressão de tau
|
|
EP2978446B1
(en)
|
2013-03-27 |
2020-03-04 |
The General Hospital Corporation |
Anti-cd33 antibody for use in treating alzheimer's disease
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
|
JP2016518842A
(ja)
|
2013-05-01 |
2016-06-30 |
レグルス セラピューティクス インコーポレイテッド |
マイクロRNA化合物およびmiR−122をモジュレートする方法
|
|
PL2992098T3
(pl)
|
2013-05-01 |
2019-09-30 |
Ionis Pharmaceuticals, Inc. |
Kompozycje i sposoby modulowania ekspresji hbv i ttr
|
|
EP2992096B1
(en)
|
2013-05-01 |
2021-03-03 |
Regulus Therapeutics Inc. |
Compounds and methods for enhanced cellular uptake
|
|
TWI664187B
(zh)
|
2013-05-22 |
2019-07-01 |
阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
AU2014268529C1
(en)
|
2013-05-22 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
TMPRSS6 iRNA compositions and methods of use thereof
|
|
JP6472087B2
(ja)
|
2013-05-30 |
2019-02-27 |
国立大学法人 東京医科歯科大学 |
治療用オリゴヌクレオチドを送達するための二本鎖剤
|
|
US20160113911A1
(en)
|
2013-06-06 |
2016-04-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
|
CN105324119A
(zh)
|
2013-06-16 |
2016-02-10 |
国立大学法人东京医科齿科大学 |
具有外显子跳跃效应的双链反义核酸
|
|
EP3656386A1
(en)
|
2013-06-21 |
2020-05-27 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile
|
|
WO2014205451A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
|
MX367083B
(es)
|
2013-06-27 |
2019-08-05 |
Roche Innovation Ct Copenhagen As |
Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).
|
|
JP6487913B2
(ja)
|
2013-07-02 |
2019-03-20 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
成長ホルモン受容体のモジュレータ
|
|
WO2015009731A2
(en)
|
2013-07-15 |
2015-01-22 |
The Regents Of The University Of California |
Azacyclic constrained analogs of fty720
|
|
TWI702046B
(zh)
|
2013-07-19 |
2020-08-21 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
|
EP3027617B1
(en)
|
2013-07-31 |
2026-02-18 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
AU2014306271A1
(en)
|
2013-08-08 |
2016-03-24 |
The Scripps Research Institute |
A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
US9670492B2
(en)
|
2013-08-28 |
2017-06-06 |
Ionis Pharmaceuticals, Inc. |
Modulation of prekallikrein (PKK) expression
|
|
PL3043827T3
(pl)
|
2013-09-13 |
2020-03-31 |
Ionis Pharmaceuticals, Inc. |
Modulatory czynnika b dopełniacza
|
|
US9943604B2
(en)
|
2013-09-20 |
2018-04-17 |
Ionis Pharmaceuticals, Inc. |
Targeted therapeutic nucleosides and their use
|
|
MX385871B
(es)
|
2013-10-02 |
2025-03-18 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion del gen lect2.
|
|
WO2015051318A1
(en)
|
2013-10-04 |
2015-04-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the alas1 gene
|
|
MY192689A
(en)
|
2013-10-11 |
2022-09-01 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
EP3502270B1
(en)
|
2013-10-21 |
2020-03-18 |
The General Hospital Corporation |
Methods relating to circulating tumor cell clusters and the treatment of cancer
|
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
WO2015061536A1
(en)
|
2013-10-25 |
2015-04-30 |
Regulus Therapeutics Inc. |
Microrna compounds and methods for modulating mir-21 activity
|
|
DK3077510T3
(da)
|
2013-12-02 |
2020-06-08 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser og anvendelser deraf
|
|
WO2015089368A2
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
|
AU2014364520B2
(en)
|
2013-12-20 |
2020-01-02 |
The General Hospital Corporation |
Methods and assays relating to circulating tumor cells
|
|
PL3087183T3
(pl)
|
2013-12-24 |
2021-01-11 |
Ionis Pharmaceuticals, Inc. |
Modulacja ekspresji białka angiopoetynopodobnego 3
|
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
|
EP3095459A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
|
|
EP3095461A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
EP3094728B1
(en)
|
2014-01-16 |
2022-03-09 |
Wave Life Sciences Ltd. |
Chiral design
|
|
EP3105331B1
(en)
|
2014-02-11 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
|
EP3109254B1
(en)
|
2014-02-18 |
2018-04-11 |
Osaka University |
Crosslinked nucleoside and nucleotide
|
|
EP3119789B1
(en)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
SI3119888T1
(sl)
|
2014-03-19 |
2021-11-30 |
Ionis Pharmaceuticals, Inc. |
Sestavki za moduliranje izražanja ataksina 2
|
|
HUE050704T2
(hu)
|
2014-04-01 |
2020-12-28 |
Biogen Ma Inc |
Összetételek a SOD-1 expressziójának modulálására
|
|
EP3129493B1
(en)
|
2014-04-09 |
2021-07-07 |
The Scripps Research Institute |
Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
|
|
US20170044538A1
(en)
|
2014-04-17 |
2017-02-16 |
Biogen Ma Inc. |
Compositions and Methods for Modulation of SMN2 Splicing in a Subject
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
US9926556B2
(en)
|
2014-04-28 |
2018-03-27 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
EP3137115B1
(en)
|
2014-05-01 |
2020-10-14 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
WO2015168589A2
(en)
|
2014-05-01 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating angiopoietin-like 3 expression
|
|
CR20160554A
(es)
|
2014-05-01 |
2017-03-07 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para modular la expresión del factor b del complemento
|
|
HUE052709T2
(hu)
|
2014-05-01 |
2021-05-28 |
Ionis Pharmaceuticals Inc |
Módosított antiszensz oligonukleotidok konjugátumai és azok alkalmazása PKK expressziójának módosítására
|
|
WO2015168618A2
(en)
|
2014-05-01 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating growth hormone receptor expression
|
|
TW201607559A
(zh)
|
2014-05-12 |
2016-03-01 |
阿尼拉製藥公司 |
治療serpinc1相關疾患之方法和組成物
|
|
SG11201609376SA
(en)
|
2014-05-22 |
2016-12-29 |
Alnylam Pharmaceuticals Inc |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
|
US10570169B2
(en)
|
2014-05-22 |
2020-02-25 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
|
JP2017518307A
(ja)
|
2014-06-02 |
2017-07-06 |
チルドレンズ メディカル センター コーポレーション |
免疫調節のための方法および組成物
|
|
MA40463A
(fr)
|
2014-08-07 |
2017-06-14 |
Regulus Therapeutics Inc |
Ciblage de micro-arn pour traiter des troubles métaboliques
|
|
US10385343B2
(en)
|
2014-08-29 |
2019-08-20 |
Children's Medical Center Corporation |
Methods and compositions for the treatment of cancer
|
|
WO2016040748A1
(en)
|
2014-09-12 |
2016-03-17 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for detection of smn protein in a subject and treatment of a subject
|
|
WO2016040589A1
(en)
|
2014-09-12 |
2016-03-17 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
TWI864340B
(zh)
|
2014-10-10 |
2024-12-01 |
美商艾爾妮蘭製藥公司 |
用於抑制hao1(羥酸氧化酶1(乙醇酸鹽氧化酶))基因表現的組合物及方法
|
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
EP3904519A1
(en)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
|
TWI769565B
(zh)
|
2014-11-10 |
2022-07-01 |
美商阿尼拉製藥公司 |
B型肝炎病毒(HBV)iRNA組成物及其用途方法
|
|
US10287584B2
(en)
|
2014-11-12 |
2019-05-14 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of COMP
|
|
AU2015346042A1
(en)
|
2014-11-14 |
2017-04-27 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of proteins
|
|
WO2016077704A1
(en)
|
2014-11-14 |
2016-05-19 |
The Regents Of The University Of California |
Modulation of agpat5 expression
|
|
WO2016081444A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
|
WO2016086104A1
(en)
|
2014-11-25 |
2016-06-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of ube3a-ats expression
|
|
AU2015360794B2
(en)
|
2014-12-08 |
2021-07-08 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
|
US20170369872A1
(en)
|
2014-12-18 |
2017-12-28 |
Alnylam Pharmaceuticals, Inc. |
Reversir tm compounds
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
JP2018510621A
(ja)
|
2015-02-13 |
2018-04-19 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
パタチン様ホスホリパーゼドメイン含有3(PNPLA3)iRNA組成物およびその使用方法
|
|
MX391217B
(es)
|
2015-02-26 |
2025-03-21 |
Ionis Pharmaceuticals Inc |
Moduladores de rodopsina p23h con especificidad de alelo.
|
|
EP3265098B1
(en)
|
2015-03-03 |
2025-03-26 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
|
WO2016141145A1
(en)
|
2015-03-03 |
2016-09-09 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating mecp2 expression
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
BR112017020750A2
(en)
|
2015-03-27 |
2018-06-26 |
President And Fellows Of Harvard College |
modified t-cells and methods of producing and using them
|
|
CN107429250B
(zh)
|
2015-04-03 |
2022-03-01 |
Ionis制药公司 |
用于调节tmprss6表达的化合物和方法
|
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016168592A2
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
|
EP3307316A1
(en)
|
2015-06-12 |
2018-04-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
修飾crispr rna及び修飾単一crispr rnaならびにその使用
|
|
CA2991894A1
(en)
|
2015-07-10 |
2017-01-19 |
Ionis Pharmaceuticals, Inc. |
Modulators of diacyglycerol acyltransferase 2 (dgat2)
|
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
|
CA3205381A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
CN117965536A
(zh)
|
2015-07-22 |
2024-05-03 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
US20180201937A1
(en)
|
2015-08-04 |
2018-07-19 |
The University Of Chicago |
Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
|
|
US10889813B2
(en)
|
2015-09-02 |
2021-01-12 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof
|
|
KR102764250B1
(ko)
|
2015-09-14 |
2025-02-07 |
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 |
지질양이온성 덴드리머 및 이의 용도
|
|
TW201718618A
(zh)
|
2015-09-18 |
2017-06-01 |
田邊三菱製藥股份有限公司 |
架橋型核酸GuNA,其製造方法,及中間體化合物
|
|
US10844376B2
(en)
|
2015-09-18 |
2020-11-24 |
University Of Tokyo |
Structurally-enhanced miRNA inhibitor S-TuD
|
|
EP3352753A4
(en)
|
2015-09-24 |
2019-03-13 |
The Regents of The University of California |
SYNTHETIC SPHINGOLIPIDE-SIMILAR MOLECULES, MEDICAMENTS, METHODS FOR THEIR SYNTHESIS AND TREATMENT PROCEDURES
|
|
HK1251624A1
(zh)
|
2015-09-24 |
2019-02-01 |
Ionis Pharmaceuticals, Inc. |
Kras表达的调节剂
|
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
|
MX392014B
(es)
|
2015-10-08 |
2025-03-21 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para modular la expresión de angiotensinógeno.
|
|
WO2017079291A1
(en)
|
2015-11-02 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating c90rf72
|
|
AU2016349625B2
(en)
|
2015-11-06 |
2022-07-07 |
Ionis Pharmaceuticals, Inc. |
Modulating apolipoprotein (a) expression
|
|
LT4119569T
(lt)
|
2015-11-06 |
2024-09-25 |
Ionis Pharmaceuticals, Inc. |
Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje
|
|
EP3389670A4
(en)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
METHODS OF TREATING BREAST CANCER
|
|
IL308717A
(en)
|
2015-12-07 |
2024-01-01 |
Genzyme Corp |
Methods and compositions for treating a serpinc1-associated disorder
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
WO2017117496A1
(en)
|
2015-12-31 |
2017-07-06 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing ataxin-2 expression
|
|
EP3400300A4
(en)
|
2016-01-05 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
PROCESS FOR REDUCING LRRK2 EXPRESSION
|
|
EP3409779A4
(en)
|
2016-01-26 |
2019-07-03 |
Nissan Chemical Corporation |
Single-stranded oligonucleotide
|
|
US11384112B2
(en)
|
2016-02-17 |
2022-07-12 |
Tokyo Institute Of Technology |
Artificial nucleoside and artificial nucleotide, and artificial oligonucleotide
|
|
AU2017229778A1
(en)
|
2016-03-09 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for inhibiting PMP22 expression
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
|
WO2017180835A1
(en)
|
2016-04-13 |
2017-10-19 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing c9orf72 expression
|
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
|
CN109475568B
(zh)
|
2016-05-06 |
2026-07-17 |
Ionis制药公司 |
Glp-1受体配体部分缀合的寡核苷酸及其用途
|
|
CN114656378A
(zh)
|
2016-05-16 |
2022-06-24 |
得克萨斯州大学系统董事会 |
阳离子磺酰胺氨基脂质和两亲性两性离子氨基脂质
|
|
EP3469083A1
(en)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
|
KR102461234B1
(ko)
|
2016-06-14 |
2022-10-28 |
바이오젠 엠에이 인코포레이티드 |
올리고뉴클레오타이드의 정제를 위한 소수성 상호 작용 크로마토그래피
|
|
AU2017286811A1
(en)
|
2016-06-17 |
2018-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
EP3475295B1
(en)
|
2016-06-24 |
2022-08-10 |
The Scripps Research Institute |
Novel nucleoside triphosphate transporter and uses thereof
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
PL3484524T3
(pl)
|
2016-07-15 |
2023-03-20 |
Ionis Pharmaceuticals, Inc. |
Związki i sposoby modulacji smn2
|
|
US20190321387A1
(en)
|
2016-07-15 |
2019-10-24 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of transcript processing
|
|
WO2018045317A1
(en)
|
2016-09-02 |
2018-03-08 |
Dicerna Pharmaceuticals, Inc. |
4'-phosphate analogs and oligonucleotides comprising the same
|
|
MD3519572T2
(ro)
|
2016-09-29 |
2024-03-31 |
Biogen Ma Inc |
Compuși și procedee de reducere a expresiei Tau
|
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
TW202313978A
(zh)
|
2016-11-23 |
2023-04-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
|
US11033570B2
(en)
|
2016-12-02 |
2021-06-15 |
Cold Spring Harbor Laboratory |
Modulation of Lnc05 expression
|
|
KR102568559B1
(ko)
|
2016-12-14 |
2023-08-18 |
얀센 바이오테크 인코포레이티드 |
Cd8a-결합 섬유결합소 iii형 도메인
|
|
WO2018111978A1
(en)
|
2016-12-14 |
2018-06-21 |
Janssen Biotech, Inc. |
Cd137 binding fibronectin type iii domains
|
|
TWI865997B
(zh)
|
2016-12-16 |
2024-12-11 |
美商阿尼拉製藥公司 |
使用甲狀腺素運載蛋白(TTR)iRNA組成物於治療或預防TTR相關疾病之方法
|
|
JP7188087B2
(ja)
|
2017-02-06 |
2022-12-13 |
日産化学株式会社 |
一本鎖オリゴヌクレオチド
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
JP7306653B2
(ja)
*
|
2017-03-17 |
2023-07-11 |
国立大学法人千葉大学 |
構造強化されたS-TuDを用いた新規がん治療法
|
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
|
EP3603648B1
(en)
|
2017-03-29 |
2025-09-17 |
Shionogi & Co., Ltd |
Complex of nucleic acid medicine and multibranched lipid
|
|
WO2018195165A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
|
US11401519B2
(en)
|
2017-06-07 |
2022-08-02 |
University Of Massachusetts |
Anti-ADAM33 oligonucleotides and related methods
|
|
JP2020530442A
(ja)
|
2017-07-10 |
2020-10-22 |
ジェンザイム・コーポレーション |
血友病を有する対象の出血事象を処置するための方法および組成物
|
|
WO2019014262A1
(en)
|
2017-07-11 |
2019-01-17 |
The Scripps Research Institute |
INCORPORATION OF NON-NATURAL NUCLEOTIDES AND METHODS OF IN VIVO USE THEREOF
|
|
TWI821192B
(zh)
|
2017-07-11 |
2023-11-11 |
美商新索思股份有限公司 |
非天然核苷酸之導入及其方法
|
|
AU2018301829B2
(en)
|
2017-07-13 |
2024-08-01 |
Alnylam Pharmaceuticals, Inc. |
Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase) gene expression
|
|
CA3069868A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
|
|
US11555188B2
(en)
|
2017-07-26 |
2023-01-17 |
Nissan Chemical Corporation |
Single-stranded oligonucleotide
|
|
IL321812A
(en)
|
2017-08-03 |
2025-08-01 |
Synthorx Inc |
Cytokine complexes for the treatment of autoimmune diseases
|
|
CA3071033A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
WO2019045075A1
(ja)
|
2017-08-31 |
2019-03-07 |
田辺三菱製薬株式会社 |
Il-33アンタゴニストを含む子宮内膜症治療剤
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
US11225660B2
(en)
|
2017-10-12 |
2022-01-18 |
Emory University |
Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors
|
|
CA3078971A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
EP3710587A1
(en)
|
2017-11-16 |
2020-09-23 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
|
WO2019118916A1
(en)
|
2017-12-14 |
2019-06-20 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
|
WO2019126097A1
(en)
|
2017-12-18 |
2019-06-27 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
JP7429642B2
(ja)
|
2017-12-29 |
2024-02-08 |
ザ スクリプス リサーチ インスティテュート |
非天然塩基対組成物および使用の方法
|
|
MY203356A
(en)
|
2018-01-12 |
2024-06-25 |
Bristol Myers Squibb Co |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
|
WO2019140236A1
(en)
|
2018-01-12 |
2019-07-18 |
Bristol-Myers Squibb Company |
Antisense oligonucleotides targeting alpha-synuclein and uses thereof
|
|
CA3088522A1
(en)
|
2018-01-15 |
2019-07-18 |
Ionis Pharmaceuticals, Inc. |
Modulators of dnm2 expression
|
|
AU2019218987B2
(en)
|
2018-02-12 |
2025-04-24 |
Ionis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
|
AU2019224159B2
(en)
|
2018-02-26 |
2025-05-29 |
Sanofi |
IL-15 conjugates and uses thereof
|
|
WO2019169243A1
(en)
|
2018-03-02 |
2019-09-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-beta precursor protein
|
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
|
EP3770256A4
(en)
|
2018-03-20 |
2021-12-22 |
Tokyo Institute of Technology |
ANTISENSE OLIGONUCLEOTIDE WITH REDUCED TOXICITY
|
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
|
WO2019200172A1
(en)
|
2018-04-11 |
2019-10-17 |
Ionis Pharmaceuticals, Inc. |
Modulators of ezh2 expression
|
|
WO2019213016A1
(en)
|
2018-04-30 |
2019-11-07 |
The Children's Hospital Of Philadelphia |
Methods of improving anemias by combining agents
|
|
CA3098623A1
(en)
|
2018-05-07 |
2019-11-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
|
JP2021522800A
(ja)
|
2018-05-09 |
2021-09-02 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Atxn3発現を低減するための化合物及び方法
|
|
IL277970B2
(en)
|
2018-05-09 |
2025-03-01 |
Ionis Pharmaceuticals Inc |
Oligomeric compounds comprising modified oligonucleotides and conjugated groups for use in the treatment of end-stage renal disease, chronic kidney disease and coronary artery disease
|
|
TWI851574B
(zh)
|
2018-05-14 |
2024-08-11 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
|
WO2020018558A1
(en)
|
2018-07-17 |
2020-01-23 |
Aronora, Inc. |
Methods for safely reducing thrombopoietin
|
|
AU2019310097A1
(en)
|
2018-07-25 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN2 expression
|
|
WO2020036862A1
(en)
|
2018-08-13 |
2020-02-20 |
Alnylam Pharmaceuticals, Inc. |
HEPATITIS B VIRUS (HBV) dsRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
JP7431802B2
(ja)
|
2018-08-15 |
2024-02-15 |
イルミナ インコーポレイテッド |
ライブラリー富化を改善するための組成物および方法
|
|
AR115960A1
(es)
|
2018-08-16 |
2021-03-17 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para inhibir la expresión del gen lect2
|
|
CA3110211A1
(en)
|
2018-08-20 |
2020-02-27 |
Rogcon, Inc. |
Antisense oligonucleotides targeting scn2a for the treatment of scn1a encephalopathies
|
|
EP3620520A1
(en)
|
2018-09-10 |
2020-03-11 |
Universidad del Pais Vasco |
Novel target to treat a metabolic disease in an individual
|
|
JP2022500003A
(ja)
|
2018-09-18 |
2022-01-04 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
ケトヘキソキナーゼ(KHK)iRNA組成物およびその使用方法
|
|
TWI869213B
(zh)
|
2018-09-19 |
2025-01-01 |
美商Ionis製藥公司 |
Pnpla3表現之調節劑
|
|
CA3114396A1
(en)
|
2018-09-28 |
2020-04-02 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
TW202031284A
(zh)
|
2018-11-08 |
2020-09-01 |
美商新索思股份有限公司 |
介白素10結合物及其用途
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
MX2021005758A
(es)
|
2018-11-15 |
2021-09-21 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresión de irf5.
|
|
US12281305B2
(en)
|
2018-11-21 |
2025-04-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing prion expression
|
|
EP3894559A4
(en)
|
2018-12-03 |
2023-04-05 |
Triplet Therapeutics, Inc. |
METHODS OF TREATMENT OF TRINUCLEOTIDE REPEAT EXPANSION DISORDERS RELATED TO MLH3 ACTIVITY
|
|
PT4285929T
(pt)
|
2018-12-20 |
2026-01-02 |
Humabs Biomed Sa |
Terapêutica de combinação contra o vhb
|
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ, インコーポレイテッド |
Kcnt1関連障害の治療のための組成物及び方法
|
|
SG11202106378VA
(en)
|
2018-12-21 |
2021-07-29 |
Ionis Pharmaceuticals Inc |
Modulators of hsd17b13 expression
|
|
CA3126933A1
(en)
|
2019-01-16 |
2020-07-23 |
Genzyme Corporation |
Serpinc1 irna compositions and methods of use thereof
|
|
TW202214854A
(zh)
|
2019-01-31 |
2022-04-16 |
美商Ionis製藥公司 |
Yap1表現之調節劑
|
|
MA54952A
(fr)
|
2019-02-06 |
2022-05-11 |
Synthorx Inc |
Conjugués d'il-2 et méthodes d'utilisation de ceux-ci
|
|
WO2020176771A1
(en)
|
2019-02-27 |
2020-09-03 |
Ionis Pharmaceuticals, Inc. |
Modulators of malat1 expression
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
EP3981431A4
(en)
|
2019-03-14 |
2023-06-28 |
Rena Therapeutics Inc. |
Nucleic acid complex for modulating ihh expression
|
|
WO2020191177A1
(en)
|
2019-03-21 |
2020-09-24 |
Sudhir Agrawal |
Antisense oligonucleotides for allele specificity
|
|
JP7413362B2
(ja)
|
2019-03-29 |
2024-01-15 |
シスメックス株式会社 |
新規人工核酸、その製造方法及び用途
|
|
TW202104595A
(zh)
|
2019-03-29 |
2021-02-01 |
日商田邊三菱製藥股份有限公司 |
用來調節dux4的表現之化合物、方法及醫藥組成物
|
|
WO2020205473A1
(en)
|
2019-03-29 |
2020-10-08 |
Decerna Pharmaceuticals, Inc. |
Compositions and methods for the treatment of kras associated diseases or disorders
|
|
TW202536179A
(zh)
|
2019-03-29 |
2025-09-16 |
美商Ionis製藥公司 |
用於調節ube3a-ats之化合物及方法
|
|
WO2020226960A1
(en)
|
2019-05-03 |
2020-11-12 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
|
EP3966328A4
(en)
|
2019-05-06 |
2023-10-18 |
University Of Massachusetts |
Anti-c9orf72 oligonucleotides and related methods
|
|
WO2020232024A1
(en)
|
2019-05-13 |
2020-11-19 |
Vir Biotechnology, Inc. |
Compositions and methods for treating hepatitis b virus (hbv) infection
|
|
WO2020236600A1
(en)
|
2019-05-17 |
2020-11-26 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
|
WO2020243021A2
(en)
|
2019-05-24 |
2020-12-03 |
Foundation Medicine, Inc. |
Ntrk fusion molecules and uses thereof
|
|
WO2020243292A1
(en)
|
2019-05-28 |
2020-12-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing fus expression
|
|
WO2020252262A1
(en)
|
2019-06-14 |
2020-12-17 |
The Scripps Research Institute |
Reagents and methods for replication, transcription, and translation in semi-synthetic organisms
|
|
PL3956450T3
(pl)
|
2019-07-26 |
2025-12-22 |
Ionis Pharmaceuticals, Inc. |
Związki i sposoby modulowania gfap
|
|
JP7692829B2
(ja)
|
2019-07-30 |
2025-06-16 |
塩野義製薬株式会社 |
Murf1を標的とする核酸医薬
|
|
EP4007812A1
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Serpin family f member 2 (serpinf2) irna compositions and methods of use thereof
|
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
KR20220062517A
(ko)
|
2019-08-15 |
2022-05-17 |
아이오니스 파마수티컬즈, 인코포레이티드 |
결합 변형된 올리고머 화합물 및 이의 용도
|
|
EP4013454A1
(en)
|
2019-08-15 |
2022-06-22 |
Synthorx, Inc. |
Immuno oncology combination therapies with il-2 conjugates
|
|
CA3148135A1
(en)
|
2019-08-23 |
2021-03-04 |
Carolina E. CAFFARO |
Il-15 conjugates and uses thereof
|
|
US20220290152A1
(en)
|
2019-09-03 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
WO2021050554A1
(en)
|
2019-09-10 |
2021-03-18 |
Synthorx, Inc. |
Il-2 conjugates and methods of use to treat autoimmune diseases
|
|
US12503699B2
(en)
|
2019-10-04 |
2025-12-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing UGT1a1 gene expression
|
|
CN114728017B
(zh)
|
2019-10-14 |
2025-10-28 |
阿斯利康(瑞典)有限公司 |
Pnpla3表达的调节剂
|
|
CN114786682B
(zh)
|
2019-10-14 |
2024-07-16 |
Aro生物疗法公司 |
结合cd71的纤维粘连蛋白iii型结构域
|
|
WO2021076543A1
(en)
|
2019-10-14 |
2021-04-22 |
Aro Biotherapeutics Company |
Epcam binding fibronectin type iii domains
|
|
US11781138B2
(en)
|
2019-10-14 |
2023-10-10 |
Aro Biotherapeutics Company |
FN3 domain-siRNA conjugates and uses thereof
|
|
EP4045652A1
(en)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
|
CA3158320A1
(en)
|
2019-10-22 |
2021-04-29 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
WO2021087036A1
(en)
|
2019-11-01 |
2021-05-06 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
|
JP2022554272A
(ja)
|
2019-11-04 |
2022-12-28 |
シンソークス, インコーポレイテッド |
インターロイキン10コンジュゲートおよびその使用
|
|
WO2021092371A2
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
|
EP4055165A1
(en)
|
2019-11-06 |
2022-09-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
IL292865A
(en)
|
2019-11-13 |
2022-07-01 |
Alnylam Pharmaceuticals Inc |
Methods and preparations for the treatment of angiotensinogen-related disorder - (agt)
|
|
EP4061945A1
(en)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
|
WO2021113773A2
(en)
|
2019-12-04 |
2021-06-10 |
Pai Athma A |
Identifying non-productive splice sites
|
|
IL293824A
(en)
|
2019-12-13 |
2022-08-01 |
Alnylam Pharmaceuticals Inc |
Compositions of RNA material (c9orf72) human chromosome 9 open reading frame 72 and methods of using them
|
|
CN115176007A
(zh)
|
2019-12-16 |
2022-10-11 |
阿尔尼拉姆医药品有限公司 |
含类PATATIN磷脂酶结构域3(PNPLA3)iRNA组合物及其使用方法
|
|
EP4058032A4
(en)
|
2019-12-19 |
2024-01-10 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
TW202140043A
(zh)
|
2020-01-15 |
2021-11-01 |
美商戴瑟納製藥股份有限公司 |
4’-o-亞甲基膦酸酯核酸及其類似物
|
|
CN114929876A
(zh)
|
2020-01-31 |
2022-08-19 |
株式会社三和化学研究所 |
Atn1的反义寡核苷酸
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
PH12022552080A1
(en)
|
2020-02-10 |
2024-02-12 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for silencing vegf-a expression
|
|
EP4103715A4
(en)
|
2020-02-14 |
2024-03-06 |
University Of Massachusetts |
FRATAXIN-TARGETING OLIGONUCLEOTIDES AND RELATED METHODS
|
|
CN115397989A
(zh)
|
2020-02-18 |
2022-11-25 |
阿尔尼拉姆医药品有限公司 |
载脂蛋白C3(APOC3)iRNA组合物及其使用方法
|
|
AU2021225957A1
(en)
|
2020-02-28 |
2022-09-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating SMN2
|
|
JP7773730B2
(ja)
|
2020-03-02 |
2025-11-20 |
国立大学法人京都大学 |
miR-33b阻害物質による動脈瘤の予防または治療
|
|
WO2021177418A1
(ja)
|
2020-03-04 |
2021-09-10 |
日産化学株式会社 |
Calm2のアンチセンスオリゴヌクレオチド
|
|
EP4114947A1
(en)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
MX2022011009A
(es)
|
2020-03-06 |
2022-10-07 |
Alnylam Pharmaceuticals Inc |
Composiciones de acido ribonucleico de interferencia (arni) de ketohexocinasa (khk) y metodos de uso de las mismas.
|
|
AU2021232029A1
(en)
|
2020-03-06 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin (TTR)
|
|
EP4121534A1
(en)
|
2020-03-18 |
2023-01-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
|
WO2021195307A1
(en)
|
2020-03-26 |
2021-09-30 |
Alnylam Pharmaceuticals, Inc. |
Coronavirus irna compositions and methods of use thereof
|
|
US20230190785A1
(en)
|
2020-03-30 |
2023-06-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
EP4127134A4
(en)
|
2020-04-01 |
2024-07-31 |
Alnylam Pharmaceuticals, Inc. |
COMPOSITIONS OF ALPHA-2A ADRENERGIC RECEPTOR (ADRA2A) ARNI AGENTS AND METHODS OF USE THEREOF
|
|
IL297121A
(en)
|
2020-04-06 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for silencing myoc expression
|
|
EP4133077A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
|
AU2021251754A1
(en)
|
2020-04-07 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing SCN9A expression
|
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
JP2023522957A
(ja)
|
2020-04-21 |
2023-06-01 |
フラッグシップ パイオニアリング, インコーポレイテッド |
二機能性分子およびその使用方法
|
|
JP7844347B2
(ja)
|
2020-04-27 |
2026-04-13 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アポリポタンパク質E(ApoE)iRNA剤組成物およびその使用方法
|
|
MX2022013606A
(es)
|
2020-04-30 |
2023-01-16 |
Alnylam Pharmaceuticals Inc |
Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas.
|
|
TWI901676B
(zh)
|
2020-05-01 |
2025-10-21 |
美商Ionis製藥公司 |
調節atxn1之化合物及方法
|
|
JP7776420B2
(ja)
|
2020-05-12 |
2025-11-26 |
田辺三菱製薬株式会社 |
Ataxin 3発現を調節するための化合物、方法及び医薬組成物
|
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
|
EP4150088A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
EP4150077A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
EP4150090A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
EP4150087A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
|
EP4150086A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
|
CN116075592A
(zh)
|
2020-06-09 |
2023-05-05 |
阿尔尼拉姆医药品有限公司 |
用于沉默gpam(线粒体甘油-3-磷酸酰基转移酶1)表达的sirna组合物和方法
|
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
|
AU2021292296A1
(en)
|
2020-06-18 |
2023-01-19 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (XDH) iRNA compositions and methods of use thereof
|
|
BR112022026316A2
(pt)
|
2020-06-24 |
2023-03-07 |
Vir Biotechnology Inc |
Anticorpos neutralizantes do vírus da hepatite b engenheirados e usos dos mesmos
|
|
WO2021263026A1
(en)
|
2020-06-25 |
2021-12-30 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and anti-egfr antibodies
|
|
TW202216996A
(zh)
|
2020-06-29 |
2022-05-01 |
美商Ionis製藥公司 |
調節plp1之化合物及方法
|
|
US20230257745A1
(en)
|
2020-07-10 |
2023-08-17 |
Alnylam Pharmaceuticals, Inc. |
Circular siRNAs
|
|
EP4183416A4
(en)
|
2020-07-17 |
2025-08-27 |
Mitsubishi Tanabe Pharma Corp |
AGENT FOR PREVENTING OR TREATING MUSCULAR DISEASE
|
|
MX2023001222A
(es)
|
2020-07-28 |
2023-04-26 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para reducir la expresion de app.
|
|
JP2023537499A
(ja)
|
2020-08-04 |
2023-09-01 |
ディセルナ ファーマシューティカルズ インコーポレイテッド |
オリゴヌクレオチドの全身送達
|
|
IL300258A
(en)
|
2020-08-07 |
2023-03-01 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulating SCN2A
|
|
AU2021333063A1
(en)
|
2020-08-31 |
2023-05-04 |
Seegene, Inc. |
Computer-implemented method for providing nucleic acid sequence data set for design of oligonucleotide
|
|
TW202227102A
(zh)
|
2020-09-22 |
2022-07-16 |
瑞典商阿斯特捷利康公司 |
治療脂肪肝病之方法
|
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
EP4219517A4
(en)
*
|
2020-09-25 |
2024-09-25 |
Riken Genesis Co., Ltd. |
NOVEL ARTIFICIAL NUCLEIC ACID, METHOD FOR PRODUCING THE SAME AND USE THEREOF
|
|
EP4225917A1
(en)
|
2020-10-05 |
2023-08-16 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
|
IL301612A
(en)
|
2020-10-09 |
2023-05-01 |
Synthorx Inc |
Immuno oncology therapies with il-2 conjugates
|
|
EP4225376A1
(en)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and pembrolizumab
|
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
CN116761885A
(zh)
|
2020-10-23 |
2023-09-15 |
斯克利普斯研究所 |
包含非天然核苷酸的多核苷酸的逆转录
|
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
|
CA3200595A1
(en)
|
2020-11-13 |
2022-05-19 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor v (f5) irna compositions and methods of use thereof
|
|
KR20230108728A
(ko)
|
2020-11-18 |
2023-07-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
|
|
WO2022107025A1
(en)
|
2020-11-18 |
2022-05-27 |
Lemba Bv |
Umlilo antisense transcription inhibitors
|
|
AU2021382146A1
(en)
|
2020-11-23 |
2022-05-27 |
Alpha Anomeric Sas |
Nucleic acid duplexes
|
|
WO2022119873A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
|
WO2022125490A1
(en)
|
2020-12-08 |
2022-06-16 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
|
CR20230308A
(es)
|
2020-12-11 |
2023-09-08 |
Civi Biopharma Inc |
Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
|
|
AR124408A1
(es)
|
2020-12-18 |
2023-03-22 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para modular el factor xii
|
|
KR20230135585A
(ko)
|
2020-12-23 |
2023-09-25 |
플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 |
변형된 trem의 조성물 및 이의 용도
|
|
US20240336914A1
(en)
|
2020-12-31 |
2024-10-10 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
|
US20240343746A1
(en)
|
2020-12-31 |
2024-10-17 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
|
EP4274896A1
(en)
|
2021-01-05 |
2023-11-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component 9 (c9) irna compositions and methods of use thereof
|
|
EP4291654A2
(en)
|
2021-02-12 |
2023-12-20 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
|
TW202302148A
(zh)
|
2021-02-12 |
2023-01-16 |
美商欣爍克斯公司 |
使用il-2接合物和抗pd-1抗體或其抗原結合片段的肺癌組合療法
|
|
WO2022174101A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Skin cancer combination therapy with il-2 conjugates and cemiplimab
|
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
|
CA3211059A1
(en)
|
2021-02-26 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
|
BR112023017737A2
(pt)
|
2021-03-04 |
2023-10-03 |
Alnylam Pharmaceuticals Inc |
Composições de irna de angiopoietina-semelhantes 3 (angptl3) e métodos de uso das mesmas
|
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
|
BR112023019981A2
(pt)
|
2021-03-29 |
2023-12-12 |
Alnylam Pharmaceuticals Inc |
Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
|
|
KR20240009393A
(ko)
|
2021-03-31 |
2024-01-22 |
엔트라다 테라퓨틱스, 인크. |
사이클릭 세포 침투 펩티드
|
|
EP4314293A1
(en)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
|
US20250270575A1
(en)
|
2021-04-07 |
2025-08-28 |
Neoplants Sas |
Compositions and methods for indoor air remediation
|
|
KR20240031947A
(ko)
|
2021-04-14 |
2024-03-08 |
에이알오 바이오테라퓨틱스 컴패니 |
Fn3 도메인-시르나 접합체 및 이의 용도
|
|
JP2024517610A
(ja)
|
2021-04-14 |
2024-04-23 |
アロ・バイオセラピューティクス・カンパニー |
Cd71に結合するフィブロネクチンiii型ドメイン
|
|
CA3216106A1
(en)
|
2021-04-26 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
|
EP4331606A4
(en)
|
2021-04-30 |
2025-05-07 |
Kyoto University |
PREVENTION OR TREATMENT OF MYOPATHY USING A MIR-33B INHIBITOR
|
|
JP2024518476A
(ja)
|
2021-05-10 |
2024-05-01 |
エントラーダ セラピューティクス,インコーポレイティド |
mRNAスプライシングを調節するための組成物及び方法
|
|
IL308353A
(en)
|
2021-05-10 |
2024-01-01 |
Entrada Therapeutics Inc |
Compositions and methods for modulating tissue distribution of intracellular therapies
|
|
US20250051393A1
(en)
|
2021-05-10 |
2025-02-13 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
JP2024522068A
(ja)
|
2021-05-18 |
2024-06-11 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ナトリウム-グルコース共輸送体2(sglt2)irna組成物およびその使用方法
|
|
US20240263177A1
(en)
|
2021-05-20 |
2024-08-08 |
Korro Bio, Inc. |
Methods and Compositions for Adar-Mediated Editing
|
|
MX2023014008A
(es)
|
2021-05-27 |
2023-12-11 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para silenciar la expresion de anhidrasa carbonica 2.
|
|
EP4347829A1
(en)
|
2021-05-29 |
2024-04-10 |
1Globe Health Institute LLC |
Asymmetric short duplex dna as a novel gene silencing technology and use thereof
|
|
AU2022286925A1
(en)
|
2021-05-29 |
2023-12-21 |
1Globe Health Institute Llc |
Short duplex dna as a novel gene silencing technology and use thereof
|
|
EP4353266A4
(en)
|
2021-05-31 |
2026-04-29 |
Rena Therapeutics Inc |
LIGAND-BOND NUCLEIC ACID COMPLEX
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
WO2022256395A1
(en)
|
2021-06-02 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
WO2022256534A1
(en)
|
2021-06-03 |
2022-12-08 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
|
MX2023014168A
(es)
|
2021-06-04 |
2024-02-27 |
Alnylam Pharmaceuticals Inc |
Marco de lectura abierto 72 del cromosoma humano 9 (c9orf72) composiciones de agente de arni y metodos de uso de este.
|
|
JP2024523000A
(ja)
|
2021-06-08 |
2024-06-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
シュタルガルト病及び/又は網膜結合タンパク質4(rbp4)関連障害を治療又は予防するための組成物及び方法
|
|
US11753644B2
(en)
|
2021-06-18 |
2023-09-12 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing IFNAR1 expression
|
|
AU2022298774A1
(en)
|
2021-06-23 |
2023-12-14 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
|
WO2023278410A1
(en)
|
2021-06-29 |
2023-01-05 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
IL309296A
(en)
|
2021-06-30 |
2024-02-01 |
Alnylam Pharmaceuticals Inc |
Methods and compositions for the treatment of angiotensinogen-related disorder (AGT-)
|
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
|
EP4372329A4
(en)
|
2021-07-12 |
2025-07-09 |
Seegene Inc |
METHOD AND SYSTEM FOR DETERMINING THE HEIGHT OF A SOLUTION CONTAINED IN A CONTAINER
|
|
JP2024528659A
(ja)
|
2021-07-19 |
2024-07-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
非原発性高シュウ酸尿症疾患または障害を有するまたは発症するリスクがある対象を治療するための方法および組成物
|
|
IL309897A
(en)
|
2021-07-21 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Target gene IRNA compositions associated with a metabolic disorder and methods of using them
|
|
TW202325312A
(zh)
|
2021-07-23 |
2023-07-01 |
美商艾拉倫製藥股份有限公司 |
β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法
|
|
JP2024529437A
(ja)
|
2021-07-29 |
2024-08-06 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
3-ヒドロキシ-3-メチルグリタル-COAレダクターゼ(HMGCR)iRNA組成物およびその使用方法
|
|
AR126675A1
(es)
|
2021-08-03 |
2023-11-01 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE ARNi CONTRA LA TRANSTIRRETINA (TTR) Y SUS MÉTODOS DE USO
|
|
CA3228255A1
(en)
|
2021-08-04 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing angiotensinogen (agt)
|
|
CN118076737A
(zh)
|
2021-08-13 |
2024-05-24 |
阿尔尼拉姆医药品有限公司 |
因子XII(F12)iRNA组合物及其使用方法
|
|
TW202325311A
(zh)
|
2021-08-31 |
2023-07-01 |
美商艾拉倫製藥公司 |
誘導細胞死亡之DFFA樣效應子B (CIDEB) iRNA組合物及其使用方法
|
|
EP4395829A1
(en)
|
2021-09-01 |
2024-07-10 |
Entrada Therapeutics, Inc. |
Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
|
|
US11833221B2
(en)
|
2021-09-01 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds for reducing DMPK expression
|
|
JP2024535850A
(ja)
|
2021-09-17 |
2024-10-02 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体成分(C3)をサイレンシングするためのiRNA組成物および方法
|
|
JP2024535888A
(ja)
|
2021-09-20 |
2024-10-02 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
インヒビンサブユニットベータe(inhbe)モジュレーター組成物およびその使用方法
|
|
KR20240067943A
(ko)
|
2021-09-24 |
2024-05-17 |
알닐람 파마슈티칼스 인코포레이티드 |
미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법
|
|
US20250288692A1
(en)
|
2021-09-30 |
2025-09-18 |
Akouos, Inc. |
Compositions and methods for treating kcnq4-associated hearing loss
|
|
US20240401045A1
(en)
|
2021-10-01 |
2024-12-05 |
Adarx Pharmaceuticals, Inc. |
Angiotensinogen-modulating compositions and methods of use thereof
|
|
AU2022357561A1
(en)
|
2021-10-01 |
2024-04-18 |
Adarx Pharmaceuticals, Inc. |
Prekallikrein-modulating compositions and methods of use thereof
|
|
EP4416284A1
(en)
|
2021-10-15 |
2024-08-21 |
Alnylam Pharmaceuticals, Inc. |
Extra-hepatic delivery irna compositions and methods of use thereof
|
|
AU2022370009A1
(en)
|
2021-10-22 |
2024-05-16 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
|
EP4423272A2
(en)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
|
AR127477A1
(es)
|
2021-10-29 |
2024-01-31 |
Alnylam Pharmaceuticals Inc |
COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS
|
|
US20260185102A1
(en)
|
2021-11-02 |
2026-07-02 |
Rena Therapeutics Inc. |
Ligand-binding nucleic acid complex
|
|
EP4430187A2
(en)
|
2021-11-10 |
2024-09-18 |
University of Rochester |
Antisense oligonucleotides for modifying protein expression
|
|
US20250019702A1
(en)
|
2021-11-10 |
2025-01-16 |
University Of Rochester |
Gata4-targeted therapeutics for treatment of cardiac hypertrophy
|
|
EP4441224A4
(en)
|
2021-12-03 |
2026-03-11 |
Quralis Corp |
Antisense oligonucleotides with modified skeletal chemicals
|
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
|
KR102728359B1
(ko)
|
2021-12-10 |
2024-11-11 |
니토 보세키 가부시기가이샤 |
2 본쇄 핵산의 융해 온도 상승화제 및 그 용도
|
|
CN118369437B
(zh)
|
2021-12-10 |
2025-03-25 |
日东纺绩株式会社 |
用于检测核酸的对象碱基序列中的变异的方法、选择性地抑制核酸的扩增的方法、及用于实施这些的试剂盒
|
|
JP7421718B2
(ja)
|
2021-12-10 |
2024-01-25 |
日東紡績株式会社 |
核酸の対象塩基配列中における変異を検出するための方法、核酸の増幅を選択的に阻害する方法、およびこれらを実施するためのキット
|
|
EP4452327A1
(en)
|
2021-12-20 |
2024-10-30 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
|
WO2023122762A1
(en)
|
2021-12-22 |
2023-06-29 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
|
WO2023127857A1
(ja)
|
2021-12-27 |
2023-07-06 |
株式会社理研ジェネシス |
新規人工核酸、その製造方法及び用途
|
|
KR20240131441A
(ko)
|
2022-01-10 |
2024-08-30 |
오스퍼바이오 테라퓨틱스 인크. |
B형 간염 바이러스(hbv) 발현의 조절
|
|
EP4469575A2
(en)
|
2022-01-24 |
2024-12-04 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
WO2023177866A1
(en)
|
2022-03-18 |
2023-09-21 |
Dicerna Pharmaceuticals, Inc. |
Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy- nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy- nucleotide
|
|
EP4522742A2
(en)
|
2022-05-13 |
2025-03-19 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
KR20250022763A
(ko)
|
2022-06-10 |
2025-02-17 |
캠프4 테라퓨틱스 코포레이션 |
조절 rna를 표적으로 하는 안티센스 올리고뉴클레오타이드를 사용하여 프로그래뉼린 발현을 조절하는 방법
|
|
EP4547683A2
(en)
|
2022-06-30 |
2025-05-07 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
|
US20260049309A1
(en)
|
2022-08-15 |
2026-02-19 |
Novo Nordisk A/S |
Regulation of activity of rnai molecules
|
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
|
WO2024042489A1
(en)
|
2022-08-25 |
2024-02-29 |
LifeEDIT Therapeutics, Inc. |
Chemical modification of guide rnas with locked nucleic acid for rna guided nuclease-mediated gene editing
|
|
EP4581143A1
(en)
|
2022-08-29 |
2025-07-09 |
University of Rochester |
Antisense oligonucleotide-based anti-fibrotic therapeutics
|
|
CN119907856A
(zh)
|
2022-09-15 |
2025-04-29 |
阿尔尼拉姆医药品有限公司 |
第13型17β-羟基类固醇脱氢酶(HSD17B13)iRNA组合物及其使用方法
|
|
JP2025532127A
(ja)
|
2022-09-23 |
2025-09-29 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Mecp2発現を低減する化合物及び方法
|
|
JP2025532985A
(ja)
|
2022-09-30 |
2025-10-03 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
修飾二本鎖rna剤
|
|
JPWO2024101446A1
(da)
|
2022-11-10 |
2024-05-16 |
|
|
|
EP4627084A1
(en)
|
2022-12-01 |
2025-10-08 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|
|
IL322261A
(en)
|
2023-02-09 |
2025-09-01 |
Alnylam Pharmaceuticals Inc |
Reverser molecules and methods of using them
|
|
WO2024178172A1
(en)
|
2023-02-23 |
2024-08-29 |
University Of Rochester |
Agents and methods for making closed-end dna thread molecules
|
|
CN121263208A
(zh)
|
2023-03-20 |
2026-01-02 |
新索思股份有限公司 |
使用il-2 peg缀合物的癌症疗法
|
|
US12383615B2
(en)
|
2023-03-23 |
2025-08-12 |
Carbon Biosciences, Inc. |
Protoparvovirus compositions comprising a protoparvovirus variant VP1 capsid polypeptide and related methods
|
|
WO2024196965A1
(en)
|
2023-03-23 |
2024-09-26 |
Carbon Biosciences, Inc. |
Parvovirus compositions and related methods for gene therapy
|
|
KR20260021596A
(ko)
|
2023-04-05 |
2026-02-13 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Pln 발현을 감소시키는 화합물 및 방법
|
|
IL323663A
(en)
|
2023-04-06 |
2025-11-01 |
Shanghai Argo Biopharmaceutical Co Ltd |
Nucleoside analog for 5'-phosphonate modification and oligonucleotide prepared therefrom
|
|
JP2026514045A
(ja)
|
2023-04-12 |
2026-05-01 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
二本鎖rna剤の肝外デリバリー
|
|
EP4698652A2
(en)
|
2023-04-20 |
2026-02-25 |
Adarx Pharmaceuticals, Inc. |
Mapt-modulating compositions and methods of use thereof
|
|
WO2024220746A2
(en)
|
2023-04-21 |
2024-10-24 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting fatty acid synthase and related methods
|
|
KR20260007576A
(ko)
|
2023-04-28 |
2026-01-14 |
빔 테라퓨틱스, 인크. |
변형된 가이드 rna
|
|
WO2024233864A2
(en)
|
2023-05-10 |
2024-11-14 |
Dicerna Pharmaceuticals, Inc. |
Galnac-conjugated rnai oligonucleotides
|
|
WO2024238396A1
(en)
|
2023-05-12 |
2024-11-21 |
Adarx Pharmaceuticals, Inc. |
Nmda ligand conjugated compounds and uses thereof
|
|
WO2024238385A2
(en)
|
2023-05-12 |
2024-11-21 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
WO2024249328A2
(en)
|
2023-05-26 |
2024-12-05 |
Adarx Pharmaceuticals, Inc. |
Sod1-modulating compositions and methods of use thereof
|
|
CN121712891A
(zh)
|
2023-06-20 |
2026-03-20 |
阿达尔克斯制药有限公司 |
Lrrk2调节组合物及其使用方法
|
|
AU2024287308A1
(en)
|
2023-07-13 |
2025-12-18 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
EP4743577A1
(en)
|
2023-07-13 |
2026-05-20 |
Korro Bio, Inc. |
RNA EDITING OLIGONUCLEOTIDES AND THEIR USES
|
|
KR20260044219A
(ko)
|
2023-07-21 |
2026-04-01 |
매로우 테라퓨틱스, 인크. |
조혈 세포 표적화 접합체 및 관련 방법
|
|
JP2026525612A
(ja)
|
2023-07-25 |
2026-07-31 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
Casエンドヌクレアーゼ及び関連方法
|
|
KR20260044217A
(ko)
|
2023-07-25 |
2026-04-01 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
Cas 엔도뉴클레아제 및 관련 방법
|
|
WO2025023659A1
(ko)
|
2023-07-25 |
2025-01-30 |
주식회사 씨젠 |
타겟 핵산 서열에 대한 올리고뉴클레오타이드 서열의 얼라인먼트 정보를 제공하는 컴퓨터-구현 방법
|
|
EP4754255A1
(en)
|
2023-08-04 |
2026-06-10 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating ctnnb1-associated disorders
|
|
WO2025047953A1
(ja)
|
2023-08-30 |
2025-03-06 |
株式会社Stratoimmune |
RasGRP4のアンチセンスオリゴヌクレオチド
|
|
WO2025054459A1
(en)
|
2023-09-08 |
2025-03-13 |
Dicerna Pharmaceuticals, Inc. |
Rnai oligonucleotide conjugates
|
|
KR20260089666A
(ko)
|
2023-09-14 |
2026-06-15 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Apociii 발현을 감소시키기 위한 화합물 및 방법
|
|
WO2025059511A1
(en)
|
2023-09-15 |
2025-03-20 |
Praxis Precision Medicines, Inc. |
Elsunersen / prax-222 for use in the treatment of scn2a-related disorders
|
|
UY40897A
(es)
|
2023-09-21 |
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Ionis Pharmaceuticals Inc |
Compuestos y métodos para inhibir lpa
|
|
WO2025064660A2
(en)
|
2023-09-21 |
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Alnylam Pharmaceuticals, Inc. |
Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof
|
|
WO2025063261A1
(ja)
|
2023-09-22 |
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塩野義製薬株式会社 |
ウイルス由来タンパク質をコードするポリヌクレオチド
|
|
WO2025072331A1
(en)
|
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Cas nucleases and related methods
|
|
EP4784172A1
(en)
|
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Judo Bio Inc. |
Polymyxins for delivery of agents to the kidney
|
|
AU2024348221A1
(en)
|
2023-09-27 |
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Judo Bio Inc. |
Aminoglycosides for delivery of agents to the kidney
|
|
EP4784753A2
(en)
|
2023-09-27 |
2026-08-05 |
Judo Bio Inc. |
Slc6a19-targeting modulatory nucleic acid agents
|
|
WO2025076031A2
(en)
|
2023-10-03 |
2025-04-10 |
Alnylam Pharmaceuticals, Inc. |
Peritoneal macrophages comprising a nanoparticle encapsulating a nucleic acid molecule and methods of use thereof
|
|
US20250115914A1
(en)
|
2023-10-04 |
2025-04-10 |
Lemba Bv |
Compounds for inhibition of il-1beta expression
|
|
KR20260085131A
(ko)
|
2023-10-04 |
2026-06-08 |
렘바 비브이 |
Amanzi를 억제하기 위한 화합물
|
|
EP4791878A1
(en)
|
2023-10-13 |
2026-08-19 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for treating conditions associated with cartilage oligomeric matrix protein (comp) mutations
|
|
WO2025096809A1
(en)
|
2023-10-31 |
2025-05-08 |
Korro Bio, Inc. |
Oligonucleotides comprising phosphoramidate internucleotide linkages
|
|
WO2025117877A2
(en)
|
2023-12-01 |
2025-06-05 |
Flagship Pioneering Innovations Vii, Llc |
Cas nucleases and related methods
|
|
WO2025128799A1
(en)
|
2023-12-12 |
2025-06-19 |
Korro Bio, Inc. |
Double-stranded rna-editing oligonucleotides and uses thereof
|
|
AU2024397279A1
(en)
|
2023-12-13 |
2026-07-02 |
Ultragenyx Pharmaceutical Inc. |
Compositions and methods for treating conditions associated with ube3a overexpression
|
|
WO2025143262A1
(ja)
|
2023-12-28 |
2025-07-03 |
日産化学株式会社 |
カルバモイルエチル修飾を含有する二本鎖rna
|
|
WO2025158385A1
(en)
|
2024-01-25 |
2025-07-31 |
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Pegylated il-2 for suppressing adaptive immune response to gene therapy
|
|
WO2025165891A1
(en)
|
2024-01-29 |
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Arnatar Therapeutics, Inc |
Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof
|
|
WO2025165154A1
(ko)
|
2024-01-30 |
2025-08-07 |
소바젠 주식회사 |
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|
|
US20250263702A1
(en)
|
2024-02-19 |
2025-08-21 |
Flagship Pioneering Innovations Vii, Llc |
Rnai agents targeting cideb and related methods
|
|
WO2025199231A2
(en)
|
2024-03-20 |
2025-09-25 |
Vertex Pharmaceuticals Incorporated |
Mucin-5b (muc5b) targeted sirna and antisense oligonucleotides and methods of use thereof
|
|
TW202603156A
(zh)
|
2024-03-25 |
2026-01-16 |
美商欣爍克斯公司 |
用於生產多肽之合成tRNA合成酶及包含合成分子的細胞
|
|
GB202404290D0
(en)
|
2024-03-26 |
2024-05-08 |
Senisca Ltd |
Novel oligoncleotides
|
|
WO2025217275A2
(en)
|
2024-04-10 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Immune cell targeted compositions and related methods
|
|
WO2025255388A1
(en)
|
2024-06-05 |
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Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
|
TW202615058A
(zh)
|
2024-06-12 |
2026-04-16 |
美商艾拉倫製藥股份有限公司 |
失養強直性肌肉蛋白質激酶(dmpk)irna組成物及其使用方法
|
|
WO2025259743A1
(en)
|
2024-06-12 |
2025-12-18 |
Alnylam Pharmaceuticals, Inc. |
Dual conjugate compounds for extrahepatic delivery
|
|
WO2026006151A2
(en)
|
2024-06-24 |
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University Of Rochester |
Functionalization of ace-trna encoding synthetic linear picovectors
|
|
WO2026006436A1
(en)
|
2024-06-25 |
2026-01-02 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of tar dna binding protein 43 kda (tdp43)
|
|
WO2026050243A1
(en)
|
2024-08-26 |
2026-03-05 |
Korro Bio, Inc. |
Galnac conjugated oligonucleotides for rna editing
|
|
WO2026055461A1
(en)
|
2024-09-05 |
2026-03-12 |
Aperture Therapeutics, Inc. |
Antibody oligonucleotide conjugates comprising an antisense polynucleotide agent conjugated to a cd33 antibody and methods of use thereof
|
|
WO2026057749A1
(en)
|
2024-09-11 |
2026-03-19 |
Sixfold Bioscience Ltd. |
Method and product
|
|
WO2026062247A1
(en)
|
2024-09-20 |
2026-03-26 |
Astrazeneca Ab |
Liquid-phase oligonucleotide synthesis using 2-(2-nitrophenyl)propyloxycarbonyl (nppoc) as a protecting group
|
|
WO2026064736A1
(en)
|
2024-09-23 |
2026-03-26 |
Carbon Biosciences, Inc. |
Parvovirus compositions and related methods for gene therapy
|
|
WO2026064739A1
(en)
|
2024-09-23 |
2026-03-26 |
Carbon Biosciences, Inc. |
Parvovirus compositions and related methods for gene therapy
|
|
WO2026068485A1
(en)
|
2024-09-25 |
2026-04-02 |
Les Laboratoires Servier |
New process for the synthesis of 2',4'-bna ncnucleoside analogues
|
|
WO2026080323A1
(en)
|
2024-10-09 |
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Quralis Corporation |
Treatment of neurological diseases using modulators of unc13a gene transcripts
|
|
WO2026122478A1
(en)
|
2024-12-02 |
2026-06-11 |
Korro Bio, Inc. |
Extrahepatic delivery formulations and methods
|
|
WO2026122779A1
(en)
|
2024-12-06 |
2026-06-11 |
Alnylam Pharmaceuticals, Inc. |
Cd81 irna compositions and methods of use thereof
|
|
WO2026136379A1
(en)
|
2024-12-17 |
2026-06-25 |
Korro Bio, Inc. |
Rna-editing oligonucleotides and uses thereof
|
|
WO2026151811A1
(en)
|
2025-01-07 |
2026-07-16 |
Camp4 Therapeutics Corporation |
Compositions and methods for treating urea cycle disorders
|
|
WO2026162796A1
(en)
|
2025-02-03 |
2026-08-06 |
Novo Nordisk A/S |
Chromatography method for thiolated oligonucleotides
|