ATE470151T1 - Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpern - Google Patents
Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpernInfo
- Publication number
- ATE470151T1 ATE470151T1 AT06795161T AT06795161T ATE470151T1 AT E470151 T1 ATE470151 T1 AT E470151T1 AT 06795161 T AT06795161 T AT 06795161T AT 06795161 T AT06795161 T AT 06795161T AT E470151 T1 ATE470151 T1 AT E470151T1
- Authority
- AT
- Austria
- Prior art keywords
- autoantibodies
- vascular disease
- 1alpha
- diagnosis
- prevention
- Prior art date
Links
- 208000019553 vascular disease Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 2
- 108010002352 Interleukin-1 Proteins 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Rehabilitation Therapy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70445005P | 2005-08-02 | 2005-08-02 | |
| PCT/IB2006/002038 WO2007015128A1 (en) | 2005-08-02 | 2006-07-26 | DIAGNOSIS, TREATMENT, AND PREVENTION OF VASCULAR DISORDERS USING IL-1α AUTOANTIBODIES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE470151T1 true ATE470151T1 (de) | 2010-06-15 |
Family
ID=37442093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06795161T ATE470151T1 (de) | 2005-08-02 | 2006-07-26 | Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpern |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8187817B2 (de) |
| EP (2) | EP1915620B1 (de) |
| JP (2) | JP5645361B2 (de) |
| CN (2) | CN101253409A (de) |
| AT (1) | ATE470151T1 (de) |
| AU (1) | AU2006274698B2 (de) |
| CA (1) | CA2617637C (de) |
| DE (1) | DE602006014691D1 (de) |
| DK (1) | DK1915620T3 (de) |
| ES (1) | ES2346691T3 (de) |
| WO (1) | WO2007015128A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2617637C (en) * | 2005-08-02 | 2017-07-18 | Xbiotech Inc. | Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies |
| WO2007132338A2 (en) | 2006-05-15 | 2007-11-22 | Xbiotech Inc. | IL-1α IMMUNIZATION INDUCES AUTOANTIBODIES PROTECTIVE AGAINST ATHEROSCLEROSIS |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| US20100040574A1 (en) * | 2006-05-22 | 2010-02-18 | Xbiotech Inc. | TREATMENT OF CANCER WITH ANTI-IL-1alpha ANTIBODIES |
| EP2285409B1 (de) * | 2008-05-30 | 2016-04-20 | XBiotech, Inc | Il-1-alpha-antikörper |
| CA2737056C (en) * | 2008-09-12 | 2018-10-30 | Xbiotech Inc. | Targeting pathogenic monocytes |
| EP2569640A1 (de) | 2010-05-12 | 2013-03-20 | The University of Birmingham | Biomarker |
| AR081246A1 (es) | 2010-05-14 | 2012-07-18 | Abbott Lab | Proteinas de union a il-1 |
| EP2582391B1 (de) | 2010-06-18 | 2018-10-03 | XBiotech, Inc | Arthritis-behandlung |
| KR101910760B1 (ko) | 2010-08-23 | 2018-10-22 | 엑스바이오테크, 인크. | 종양성 질병들에 대한 치료 |
| JP5904553B2 (ja) * | 2010-11-17 | 2016-04-13 | 国立大学法人愛媛大学 | 自己免疫疾患に関与するタンパク質の解析方法及び該疾患の検査方法 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| CN108404127B (zh) | 2011-09-23 | 2025-12-12 | 埃克斯生物科技公司 | 恶病质治疗 |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| EP3582813A4 (de) | 2017-02-16 | 2020-12-30 | XBiotech, Inc | Behandlung von hidradenitis suppurativa |
| CA3093469A1 (en) * | 2018-03-09 | 2019-09-12 | The Brigham And Women's Hospital, Inc. | Combination therapy for cardiovascular diseases |
| US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
| KR20220019674A (ko) * | 2019-05-03 | 2022-02-17 | 유니베르시태트 취리히 | 뇌 허혈-재관류 손상의 치료 |
| CA3095679A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleuken 1 alpha (il-1a) |
| CA3095740A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin alpha (il-1a) |
| CA3095676A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
| CA3095675A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
| JP2023173360A (ja) * | 2022-05-25 | 2023-12-07 | 日本メナード化粧品株式会社 | 生体老化レベルの評価方法 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH652145A5 (de) * | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4965198A (en) * | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
| DE3631229A1 (de) * | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| DK590387A (da) | 1986-11-13 | 1988-05-14 | Otsuka Pharma Co Ltd | Antistoffer mod interleukin-1 |
| US5034316A (en) * | 1987-03-30 | 1991-07-23 | The Regents Of The University Of California | In vitro human monoclonal IgG rheumatoid factor autoantibody |
| FR2640146B1 (fr) | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0434879A1 (de) | 1989-12-14 | 1991-07-03 | Schering-Plough | Verfahren zur Herstellung von faktorabhÀ¤ngigen menschlichen B-Zellinien |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| ES2140469T3 (es) * | 1992-10-14 | 2000-03-01 | Nycomed Imaging As | Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes. |
| DE69427928T3 (de) * | 1993-03-05 | 2012-05-10 | Bayer Healthcare Llc | Humane monoklonale anti-TNF alpha Antikörper |
| EP0659766A1 (de) | 1993-11-23 | 1995-06-28 | Schering-Plough | Menschliche Monoklonalantikörper gegen menschliche Cytokine und Verfahren zur Herstellung dieser Antikörper |
| US5959085A (en) | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| GB9509620D0 (en) | 1995-05-12 | 1995-07-05 | Nat Blood Authority | Transepithelial transport of molecular species |
| WO1997002479A2 (en) * | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US6524795B1 (en) * | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
| SE9802402D0 (sv) * | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| US20030040617A9 (en) * | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US20030232054A1 (en) * | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US6623736B2 (en) * | 2000-05-02 | 2003-09-23 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| AU2001295442A1 (en) * | 2000-10-17 | 2002-04-29 | Besst-Test Aps | Assay for directly detecting an inflammatory indicator in a body fluid sample |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| JP2005510524A (ja) | 2001-11-16 | 2005-04-21 | アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド | ポリアミン経路の調節による神経変性障害の治療 |
| KR101317045B1 (ko) * | 2002-09-06 | 2013-10-16 | 암젠 인코포레이티드 | 치료학적 인체 항-il-1r1 모노클로날 항체 |
| US20040224893A1 (en) | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| US7799327B2 (en) * | 2003-12-24 | 2010-09-21 | Henry John Smith | Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| US20050276807A1 (en) | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of acne |
| US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| US8603483B2 (en) | 2004-12-09 | 2013-12-10 | Janssen Biotech, Inc. | Anti-integrin immunoconjugates, methods and uses |
| CA2617637C (en) * | 2005-08-02 | 2017-07-18 | Xbiotech Inc. | Diagnosis, treatment, and prevention of vascular disorders using il-1.alpha. autoantibodies |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| NZ566971A (en) | 2005-09-28 | 2011-06-30 | Cytos Biotechnology Ag | Vaccine containing a virus like particle linked with an interleukin-1 molecule |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| WO2007132338A2 (en) | 2006-05-15 | 2007-11-22 | Xbiotech Inc. | IL-1α IMMUNIZATION INDUCES AUTOANTIBODIES PROTECTIVE AGAINST ATHEROSCLEROSIS |
| US20100040574A1 (en) | 2006-05-22 | 2010-02-18 | Xbiotech Inc. | TREATMENT OF CANCER WITH ANTI-IL-1alpha ANTIBODIES |
| EP2032606B1 (de) * | 2006-05-30 | 2013-11-27 | Genentech, Inc. | Antikörper und immunkonjugate sowie ihre verwendungen |
| EP2114443A4 (de) | 2006-12-29 | 2011-08-10 | Abbott Lab | Doppelt spezifische il-1a/il-1b-antikörper |
| WO2009128934A1 (en) | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
| EP2285409B1 (de) | 2008-05-30 | 2016-04-20 | XBiotech, Inc | Il-1-alpha-antikörper |
| CA2737056C (en) | 2008-09-12 | 2018-10-30 | Xbiotech Inc. | Targeting pathogenic monocytes |
| EP2391652A4 (de) | 2009-01-29 | 2013-01-02 | Abbott Lab | Il-1-bindende proteine |
-
2006
- 2006-07-26 CA CA2617637A patent/CA2617637C/en active Active
- 2006-07-26 DE DE602006014691T patent/DE602006014691D1/de active Active
- 2006-07-26 EP EP06795161A patent/EP1915620B1/de active Active
- 2006-07-26 JP JP2008524607A patent/JP5645361B2/ja active Active
- 2006-07-26 ES ES06795161T patent/ES2346691T3/es active Active
- 2006-07-26 CN CNA2006800319580A patent/CN101253409A/zh active Pending
- 2006-07-26 DK DK06795161.6T patent/DK1915620T3/da active
- 2006-07-26 AU AU2006274698A patent/AU2006274698B2/en active Active
- 2006-07-26 AT AT06795161T patent/ATE470151T1/de active
- 2006-07-26 EP EP10164642A patent/EP2216653A1/de not_active Withdrawn
- 2006-07-26 WO PCT/IB2006/002038 patent/WO2007015128A1/en not_active Ceased
- 2006-07-26 US US11/997,496 patent/US8187817B2/en active Active
- 2006-07-26 CN CN201811136397.1A patent/CN109187944A/zh active Pending
-
2012
- 2012-05-17 US US13/473,939 patent/US8865175B2/en active Active
- 2012-12-27 JP JP2012283791A patent/JP5717256B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013127469A (ja) | 2013-06-27 |
| EP1915620A1 (de) | 2008-04-30 |
| EP2216653A1 (de) | 2010-08-11 |
| DK1915620T3 (da) | 2010-10-04 |
| CN109187944A (zh) | 2019-01-11 |
| AU2006274698A1 (en) | 2007-02-08 |
| JP5645361B2 (ja) | 2014-12-24 |
| EP1915620B1 (de) | 2010-06-02 |
| US8865175B2 (en) | 2014-10-21 |
| US8187817B2 (en) | 2012-05-29 |
| US20120231012A1 (en) | 2012-09-13 |
| JP5717256B2 (ja) | 2015-05-13 |
| ES2346691T3 (es) | 2010-10-19 |
| JP2009503529A (ja) | 2009-01-29 |
| DE602006014691D1 (de) | 2010-07-15 |
| AU2006274698B2 (en) | 2011-06-09 |
| WO2007015128A1 (en) | 2007-02-08 |
| AU2006274698A2 (en) | 2008-03-06 |
| US20090123415A1 (en) | 2009-05-14 |
| CA2617637A1 (en) | 2007-02-08 |
| CN101253409A (zh) | 2008-08-27 |
| CA2617637C (en) | 2017-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE470151T1 (de) | Diagnose, behandlung und prävention von gefässerkrankungen mittels il-1alpha- autoantikörpern | |
| NO20074999L (no) | Metode og preparat for behandling av perifere vaskulaere sykdommer | |
| EA200802204A1 (ru) | Применение ингибиторов dpp iv | |
| EA201270144A1 (ru) | Комбинированная терапия при лечении диабета | |
| EA200971053A1 (ru) | Способы лечения кожных язв | |
| EA200870254A1 (ru) | Способ лечения воспалительных заболеваний | |
| EP2331095A4 (de) | Bestimmte kynurenin-3-monooxygenase-inhibitoren, pharmazeutische zusammensetzungen und anwendungsverfahren dafür | |
| EA201791669A3 (ru) | Новые терапевтические подходы в лечении смт и связанных с ней расстройств | |
| DE60331236D1 (de) | Orale zusammensetzungen zur behandlung von diabetes | |
| BRPI0712322A2 (pt) | compostos e combinações destes para a inibição da produção de beta-amilóide e métodos de uso dos mesmos | |
| BRPI0814339A2 (pt) | composição farmacêutica, kit para a preparação da composição farmacêutica, conjugado, e, métodos de formação de imagem óptica in vivo do corpo de mamíferos, e de detecção, estabilização, diagnóstico, monitoramento do progresso da doença ou monitoramento do tratamento de um estado doentio do corpon dos mamíferos | |
| BRPI0821895A2 (pt) | Composiçao farmacêutica, método de tratamento ou prevenção de uma doença, uma condição e sintomas das mesmas em animais de sangue quente, incluindo seres humanos, método de preparação da composição farmacêutica e método para diagnosticar uma doença, condição, síndrome. | |
| EA201270071A1 (ru) | Способ лечения пациента, нуждающегося в аспириновой терапии | |
| CY1116938T1 (el) | Αναπληρωτικη θεραπεια της ασθενειας huntington και αλλων ασθενειων πολυγλουταμiνης | |
| NO20076405L (no) | Anvendelse av 24-nor-UDCA | |
| ATE371724T1 (de) | Behandlung neurodegenerativer krankheiten | |
| EP2005194A4 (de) | Auf hämoglobin basierende verfahren zur prophylaxe, diagnose bzw. behandlung von netzhauterkrankungen | |
| EP1744162A4 (de) | Krebsdiagnose und behandlung unter verwendung eines anti-robo1-antikörpers | |
| ATE485037T1 (de) | Krebsbehandlung mittels fts und 2-deoxyglucose | |
| ATE495271T1 (de) | Zusammensetzungen und verfahren zum nachweis von störungen in verbindung mit histamin | |
| WO2006047475A3 (en) | Detection and analysis of ophthalmically-relevant fluorescent molecules | |
| EA201000739A1 (ru) | Новое медицинское применение солей 3-(2,2,2-триметилгидразиниум)пропионата | |
| BRPI0717306A2 (pt) | Composto, composição farmacêutica, uso de um composto, e, método de tratamento, prevenção ou alívio de uma doença ou um distúrbio ou uma condição de um corpo de animal vivo. | |
| ATE495750T1 (de) | Sulfatide zur behandlung von autoimmunkrankheiten | |
| CY1119845T1 (el) | Ενα γαλακτοκομικο προϊον μειωμενης χοληστερολης για χρηση στην θεραπευτικη αντιμετωπιση και/ή προληψη μιας ασθενειας του ηπατος |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1915620 Country of ref document: EP |