ATE471740T1 - Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer - Google Patents

Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer

Info

Publication number
ATE471740T1
ATE471740T1 AT04773539T AT04773539T ATE471740T1 AT E471740 T1 ATE471740 T1 AT E471740T1 AT 04773539 T AT04773539 T AT 04773539T AT 04773539 T AT04773539 T AT 04773539T AT E471740 T1 ATE471740 T1 AT E471740T1
Authority
AT
Austria
Prior art keywords
inhibitor
topoisomerase
agent containing
histone deacetylase
antitumoral agent
Prior art date
Application number
AT04773539T
Other languages
English (en)
Inventor
Yoshinori Naoe
Yuka Sasakawa
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE471740T1 publication Critical patent/ATE471740T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT04773539T 2003-09-25 2004-09-24 Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer ATE471740T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003334340 2003-09-25
JP2003344315 2003-10-02
PCT/JP2004/014451 WO2005030239A2 (en) 2003-09-25 2004-09-24 Antitumor agent comprising a histone deacetylase inhibitor and a topoisomerase ii inhibitor

Publications (1)

Publication Number Publication Date
ATE471740T1 true ATE471740T1 (de) 2010-07-15

Family

ID=34380371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04773539T ATE471740T1 (de) 2003-09-25 2004-09-24 Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer

Country Status (14)

Country Link
US (1) US7314862B2 (de)
EP (2) EP1670514B1 (de)
JP (1) JP4779971B2 (de)
AT (1) ATE471740T1 (de)
CA (1) CA2540108A1 (de)
CY (1) CY1114359T1 (de)
DE (1) DE602004027824D1 (de)
DK (1) DK2263694T3 (de)
ES (2) ES2425083T3 (de)
MX (1) MXPA06003222A (de)
PL (2) PL1670514T3 (de)
PT (1) PT2263694E (de)
SI (1) SI2263694T1 (de)
WO (1) WO2005030239A2 (de)

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US7381825B2 (en) * 2003-03-17 2008-06-03 Takeda San Diego, Inc. Histone deacetylase inhibitors
ES2425083T3 (es) 2003-09-25 2013-10-11 Astellas Pharma Inc. Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II
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US7951780B2 (en) * 2004-02-25 2011-05-31 Astellas Pharma Inc. Antitumor agent
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US7943568B2 (en) * 2005-09-30 2011-05-17 The Ohio State University Research Foundation Antitumor agents
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AU2007342028B2 (en) * 2006-12-29 2013-06-13 Celgene Corporation Purifiction of romidepsin
CN101687010A (zh) * 2006-12-29 2010-03-31 格洛斯特制药公司 制备Romidepsin
US8034768B2 (en) * 2007-06-22 2011-10-11 Board Of Regents, The University Of Texas System Composition and method for the treatment of diseases affected by histone deacetylase inhibitors
US20110021517A1 (en) * 2008-02-26 2011-01-27 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
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US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
JP6330118B2 (ja) 2011-09-13 2018-05-30 ファーマサイクリックス エルエルシー ベンダムスチンと組み合わせたヒストンデアセチラーゼ阻害剤の製剤とその使用
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
US20150283159A1 (en) * 2012-11-01 2015-10-08 Microbial Chemistry Research Foundation Anticancer agent, and combination use anticancer agent
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN116327887B (zh) * 2023-04-24 2023-11-03 南京捷因诊断技术有限公司 一种lsd1抑制剂作为抗肿瘤药物的应用

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Also Published As

Publication number Publication date
PL1670514T3 (pl) 2010-11-30
CA2540108A1 (en) 2005-04-07
PL2263694T3 (pl) 2013-11-29
US7314862B2 (en) 2008-01-01
EP2263694A1 (de) 2010-12-22
EP1670514B1 (de) 2010-06-23
ES2344899T3 (es) 2010-09-09
CY1114359T1 (el) 2016-08-31
US20050070467A1 (en) 2005-03-31
ES2425083T3 (es) 2013-10-11
JP2007506647A (ja) 2007-03-22
MXPA06003222A (es) 2006-05-22
PT2263694E (pt) 2013-08-27
DK2263694T3 (da) 2013-08-26
EP1670514A2 (de) 2006-06-21
DE602004027824D1 (de) 2010-08-05
SI2263694T1 (sl) 2013-09-30
WO2005030239A3 (en) 2005-07-28
WO2005030239A2 (en) 2005-04-07
JP4779971B2 (ja) 2011-09-28
EP2263694B1 (de) 2013-06-12

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