ATE471986T1 - Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen - Google Patents

Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen

Info

Publication number
ATE471986T1
ATE471986T1 AT01999652T AT01999652T ATE471986T1 AT E471986 T1 ATE471986 T1 AT E471986T1 AT 01999652 T AT01999652 T AT 01999652T AT 01999652 T AT01999652 T AT 01999652T AT E471986 T1 ATE471986 T1 AT E471986T1
Authority
AT
Austria
Prior art keywords
interest
secretion
homogeneity
relates
improvement
Prior art date
Application number
AT01999652T
Other languages
English (en)
Inventor
Hagit Amitai
Edith Chitlaru
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of ATE471986T1 publication Critical patent/ATE471986T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01999652T 2000-12-05 2001-12-05 Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen ATE471986T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL14011000A IL140110A0 (en) 2000-12-05 2000-12-05 Improvement of homogeneity and secretion of recombinant proteins in mammalian systems
PCT/IL2001/001125 WO2002046430A2 (en) 2000-12-05 2001-12-05 Improvement of homogeneity and secretion of recombinant proteins in mammalian systems

Publications (1)

Publication Number Publication Date
ATE471986T1 true ATE471986T1 (de) 2010-07-15

Family

ID=11074884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01999652T ATE471986T1 (de) 2000-12-05 2001-12-05 Verbesserung der homogenität und sekretion von rekombinanten proteinen in säugetiersystemen

Country Status (14)

Country Link
US (2) US20040115775A1 (de)
EP (1) EP1339855B1 (de)
JP (1) JP2004516830A (de)
AT (1) ATE471986T1 (de)
AU (2) AU2002222454B2 (de)
CA (1) CA2429094A1 (de)
CY (1) CY1110670T1 (de)
DE (1) DE60142446D1 (de)
DK (1) DK1339855T3 (de)
ES (1) ES2346956T3 (de)
IL (1) IL140110A0 (de)
PT (1) PT1339855E (de)
SI (1) SI1339855T1 (de)
WO (1) WO2002046430A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004094592A2 (en) * 2003-04-18 2004-11-04 Biogen Idec Ma Inc. Polymer-conjugated glycosylated neublastin
GB0314856D0 (en) 2003-06-25 2003-07-30 Unitargeting Res As Protein expression system
ATE448312T1 (de) 2003-09-26 2009-11-15 Merck Serono Sa Leitsequenzen zur verwendung bei der produktion von proteinen
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
KR101241551B1 (ko) 2004-08-19 2013-03-11 바이오겐 아이덱 엠에이 인코포레이티드 전환 성장 인자 베타 패밀리 단백질의 리폴딩
ES2385639T3 (es) * 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
WO2007009082A1 (en) * 2005-07-12 2007-01-18 Codon Devices, Inc. Compositions and methods for biocatalytic engineering
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
JPWO2008108344A1 (ja) * 2007-03-02 2010-06-17 セルジェンテック株式会社 Ｌｃａｔ欠損症の遺伝子治療用細胞並びに遺伝子治療用細胞組成物
ES2476253T3 (es) 2007-05-01 2014-07-14 Biogen Idec Ma Inc. P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado
TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
WO2010118360A1 (en) 2009-04-09 2010-10-14 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Production of proteins using transposon-based vectors
MY186731A (en) 2013-03-08 2021-08-14 Neuclone Biologics Pty Ltd A cell expression system
ES2882110T3 (es) * 2013-03-14 2021-12-01 Translate Bio Inc Métodos y composiciones para administrar anticuerpos codificados con ARNm
ES2860712T3 (es) 2015-03-24 2021-10-05 Univ California Variantes de virus adenoasociados y métodos de uso de las mismas
SG11202009761YA (en) 2018-04-02 2020-10-29 Pact Pharma Inc Peptide-mhc compacts
CN111304243A (zh) * 2018-12-12 2020-06-19 普莱柯生物工程股份有限公司 一种高效表达外源蛋白的cho细胞株的构建方法、构建的cho细胞株及其应用
EP3999647A1 (de) * 2019-07-18 2022-05-25 Lysogene Zusammensetzungen und verfahren zur behandlung von sanfilippo-syndrom und anderen erkrankungen
EP4206222A4 (de) * 2020-08-28 2024-04-10 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Signalpeptid zur reduzierung der heterogenität des endes eines heterologen polypeptids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923805A (en) 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
US5417970A (en) * 1988-10-21 1995-05-23 Sanofi Drugs containing a glycosylated interleukin-2
PT1538202E (pt) * 1996-09-13 2014-04-22 Shire Human Genetic Therapies Produção de alga-galactosidase a humana
IL126562A0 (en) * 1998-10-14 1999-08-17 Interpharm Lab Ltd Expression and secretion of icil-1 receptor antagonist type ii

Also Published As

Publication number Publication date
SI1339855T1 (sl) 2010-08-31
WO2002046430A2 (en) 2002-06-13
PT1339855E (pt) 2010-07-07
CA2429094A1 (en) 2002-06-13
WO2002046430A3 (en) 2003-01-03
US20040115775A1 (en) 2004-06-17
AU2245402A (en) 2002-06-18
US20060234352A1 (en) 2006-10-19
US7282352B2 (en) 2007-10-16
DE60142446D1 (de) 2010-08-05
CY1110670T1 (el) 2015-06-10
DK1339855T3 (da) 2010-08-30
AU2002222454B2 (en) 2007-04-05
IL140110A0 (en) 2002-02-10
EP1339855A2 (de) 2003-09-03
JP2004516830A (ja) 2004-06-10
EP1339855B1 (de) 2010-06-23
ES2346956T3 (es) 2010-10-22

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