ATE473746T1 - Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens - Google Patents
Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrensInfo
- Publication number
- ATE473746T1 ATE473746T1 AT08705076T AT08705076T ATE473746T1 AT E473746 T1 ATE473746 T1 AT E473746T1 AT 08705076 T AT08705076 T AT 08705076T AT 08705076 T AT08705076 T AT 08705076T AT E473746 T1 ATE473746 T1 AT E473746T1
- Authority
- AT
- Austria
- Prior art keywords
- steroid
- substances
- treating
- derivatives
- female
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 2
- 208000000509 infertility Diseases 0.000 title abstract 2
- 230000036512 infertility Effects 0.000 title abstract 2
- 231100000535 infertility Toxicity 0.000 title abstract 2
- 239000000126 substance Substances 0.000 abstract 4
- 150000003431 steroids Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000008217 follicular development Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000001592 luteinising effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07100215 | 2007-01-08 | ||
| PCT/NL2008/050007 WO2008085038A2 (en) | 2007-01-08 | 2008-01-07 | Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE473746T1 true ATE473746T1 (de) | 2010-07-15 |
Family
ID=38124134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08705076T ATE473746T1 (de) | 2007-01-08 | 2008-01-07 | Verfahren zur behandlung oder prävention von unfruchtbarkeit bei weiblichen säugern und pharmazeutisches kit zur anwendung dieses verfahrens |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8236785B2 (de) |
| EP (1) | EP2114412B1 (de) |
| CN (1) | CN101583363B (de) |
| AT (1) | ATE473746T1 (de) |
| CA (1) | CA2674325A1 (de) |
| DE (1) | DE602008001783D1 (de) |
| WO (1) | WO2008085038A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG195118A1 (en) | 2011-06-01 | 2013-12-30 | Estetra S A | Process for the production of estetrol intermediates |
| PT2714712T (pt) | 2011-06-01 | 2016-11-08 | Estetra Sprl | Processo para a produção de intermediários de estetrol |
| EP2383279A1 (de) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Herstellungsverfahren für Esterol |
| WO2013034780A2 (en) | 2012-12-20 | 2013-03-14 | Crystal Pharma, S.A.U. | Process for the preparation of estetrol and related compounds |
| EP3046928B1 (de) | 2013-09-18 | 2017-02-08 | Crystal Pharma, S.A.U. | Verfahren zur herstellung von estetrol |
| LT3310346T (lt) | 2015-06-18 | 2021-06-10 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| LT3310345T (lt) | 2015-06-18 | 2021-06-25 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| DK3701944T3 (da) | 2015-06-18 | 2022-03-14 | Estetra Srl | Oro-dispergerbar doseringsenhed indeholdende en estetrolkomponent |
| CR20180042A (es) | 2015-06-18 | 2018-05-03 | Mithra Pharmaceuticals S A | Unidad de dosificación orodispersable que contiene un componente estetrol. |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| CN111989105B (zh) | 2018-04-19 | 2024-07-19 | 埃斯特拉私人有限责任公司 | 化合物以及它们在缓解绝经相关症状中的用途 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| HUP2400151A1 (hu) | 2024-02-28 | 2025-09-28 | Richter Gedeon Nyrt | Ösztetrol-monohidrát kristályosítási eljárás |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3440320A (en) | 1964-06-18 | 1969-04-22 | Mortimer D Sackler | Chelated suppository and method of using same |
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US4722941A (en) | 1978-06-07 | 1988-02-02 | Kali-Chemie Pharma Gmbh | Readily absorbable pharmaceutical compositions of per se poorly absorbable pharmacologically active agents and preparation thereof |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| US4697856A (en) * | 1984-04-30 | 1987-10-06 | Aleyamma Abraham | Portable cabinet for dispensing medication |
| US4624665A (en) | 1984-10-01 | 1986-11-25 | Biotek, Inc. | Method of transdermal drug delivery |
| US4937238A (en) | 1986-03-04 | 1990-06-26 | The Board Of Regents Of The University Of Nebraska | Prevention of mammary carcinoma |
| US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
| US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
| US5043331A (en) | 1989-06-15 | 1991-08-27 | Orion-Yhtyma Oy | Treatment of postmenopausal disorders |
| US5130137A (en) | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| JPH04235171A (ja) | 1990-07-26 | 1992-08-24 | Sumitomo Chem Co Ltd | スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤 |
| US5063507A (en) | 1990-09-14 | 1991-11-05 | Plains Cotton Cooperative Association | Goods database employing electronic title or documentary-type title |
| US5340585A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| US5211952A (en) * | 1991-04-12 | 1993-05-18 | University Of Southern California | Contraceptive methods and formulations for use therein |
| US5340586A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
| US5468736A (en) | 1993-02-25 | 1995-11-21 | The Medical College Of Hampton Road | Hormone replacement therapy |
| US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
| NL9301562A (nl) | 1993-09-09 | 1995-04-03 | Saturnus Ag | Preparaat voor substitutietherapie. |
| DE4344405C2 (de) | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| WO1996003929A1 (en) | 1994-08-04 | 1996-02-15 | Biex, Inc. | Method for prediction of premature delivery using estetrol (e4) as an indicator |
| DE4429374C1 (de) | 1994-08-12 | 1996-02-01 | Jenapharm Gmbh | Pharmazeutische Präparate zur Kontrazeption/Hormonsubstitution mit biogener Estrogenkomponente |
| ATE302018T1 (de) * | 1997-06-20 | 2005-09-15 | Akzo Nobel Nv | Gonadotropin releasing hormon antagonist |
| DE19739916C2 (de) | 1997-09-11 | 2001-09-13 | Hesch Rolf Dieter | Verwendung einer Kombination aus einem Gestagen und einem Estrogen zur kontinuierlichen Ovulationshemmung und ggf. gleichzeitigen Behandlung und/oder Prophylaxe von Tumoren der Brustdrüsen |
| US6214815B1 (en) | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
| DE19917930A1 (de) | 1999-04-15 | 2000-10-19 | Schering Ag | Ent-Steroide als selektiv wirksame Estrogene |
| EP1171091A1 (de) | 1999-04-16 | 2002-01-16 | Jenapharm GmbH & Co. KG | Pharmazeutische oder kosmetische zusammensetzungen zur lokalen, intradermalen applikation von estrogenen |
| AU5137900A (en) | 1999-05-28 | 2000-12-18 | University Of Cincinnati, The | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use |
| US20030092628A1 (en) * | 1999-06-23 | 2003-05-15 | De Greef Henrik Johan Matthieu Maria | Gonadotropin releasing hormone antagonist |
| WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| WO2001085154A2 (en) | 2000-05-12 | 2001-11-15 | Oregon Health Sciences University | Method of treating immune pathologies with low dose estrogen |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| EP1260225A1 (de) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | Pharmazeutische Zusammensetzung für die Hormonersatztherapie |
| ES2337129T3 (es) * | 2001-05-23 | 2010-04-21 | Pantarhei Bioscience B.V. | Sistema de administracion de medicamento comprendiendo un estrogeno tetrahidroxilado para el uso en la anticoncepcion hormonal. |
| US8026228B2 (en) * | 2001-11-15 | 2011-09-27 | Pantarhei Bioscience B.V. | Estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
| US7815912B2 (en) * | 2002-06-07 | 2010-10-19 | Ares Trading, S.A. | Method of controlled ovarian hyperstimulation and pharmaceutical kit for use in such method |
| CN100352445C (zh) * | 2002-06-11 | 2007-12-05 | 潘塔希生物科学股份有限公司 | 一种皮肤护理组合物及其用途 |
| AU2003274943A1 (en) * | 2002-06-11 | 2003-12-22 | Pantarhei Bioscience B.V. | Use of estetrol and analogues for treating or preventing cardiovascular pathologies, in particular atherosclerosis |
-
2008
- 2008-01-07 AT AT08705076T patent/ATE473746T1/de not_active IP Right Cessation
- 2008-01-07 US US12/522,313 patent/US8236785B2/en active Active
- 2008-01-07 DE DE602008001783T patent/DE602008001783D1/de active Active
- 2008-01-07 CA CA002674325A patent/CA2674325A1/en not_active Abandoned
- 2008-01-07 EP EP08705076A patent/EP2114412B1/de active Active
- 2008-01-07 CN CN2008800018296A patent/CN101583363B/zh active Active
- 2008-01-07 WO PCT/NL2008/050007 patent/WO2008085038A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE602008001783D1 (de) | 2010-08-26 |
| US20100113346A1 (en) | 2010-05-06 |
| EP2114412A2 (de) | 2009-11-11 |
| CA2674325A1 (en) | 2008-07-17 |
| EP2114412B1 (de) | 2010-07-14 |
| CN101583363A (zh) | 2009-11-18 |
| WO2008085038A3 (en) | 2008-09-12 |
| WO2008085038A2 (en) | 2008-07-17 |
| US8236785B2 (en) | 2012-08-07 |
| CN101583363B (zh) | 2013-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |