ATE473975T1 - Chemische verbindungen - Google Patents

Chemische verbindungen

Info

Publication number: ATE473975T1
Authority: AT; Austria
Prior art keywords: chemical compounds; novel compounds; cancer; formula; treatment
Prior art date: 2005-02-16

Application number

AT06709759T

Other languages

English (en)

Inventor

Yongxin Han

Michelle Lamb

Peter Mohr

Dingwei Yu

Bin Wang

Tao Wang

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-16

Filing date

2006-02-15

Publication date

2010-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36129856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE473975(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-02-15 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE473975T1 publication Critical patent/ATE473975T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT06709759T 2005-02-16 2006-02-15 Chemische verbindungen ATE473975T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US65333005P	2005-02-16	2005-02-16
US73296505P	2005-11-03	2005-11-03
PCT/GB2006/000522 WO2006087538A1 (en)	2005-02-16	2006-02-15	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE473975T1 true ATE473975T1 (de)	2010-07-15

Family

ID=36129856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06709759T ATE473975T1 (de)	2005-02-16	2006-02-15	Chemische verbindungen

Country Status (21)

Country	Link
US (1)	US7622482B2 (de)
EP (1)	EP1853602B1 (de)
JP (1)	JP2008530191A (de)
KR (1)	KR20070104936A (de)
AT (1)	ATE473975T1 (de)
AU (1)	AU2006215394B2 (de)
BR (1)	BRPI0608160A2 (de)
CA (1)	CA2598076A1 (de)
CY (1)	CY1110900T1 (de)
DE (1)	DE602006015431D1 (de)
DK (1)	DK1853602T3 (de)
ES (1)	ES2347172T3 (de)
HR (1)	HRP20100477T1 (de)
IL (1)	IL184872A0 (de)
MX (1)	MX2007009842A (de)
NO (1)	NO20073790L (de)
NZ (1)	NZ561526A (de)
PL (1)	PL1853602T3 (de)
PT (1)	PT1853602E (de)
SI (1)	SI1853602T1 (de)
WO (1)	WO2006087538A1 (de)

Families Citing this family (55)

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DK2383268T3 (en)	2005-02-04	2015-09-14	Astrazeneca Ab	PYRAZOLYLAMINOPYRIDINDERIVATER useful as kinase inhibitors
KR101362621B1 (ko)	2005-02-16	2014-02-13	아스트라제네카 아베	화합물
BRPI0618011A2 (pt)	2005-10-28	2011-08-16	Astrazeneca Ab	composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para produzir um efeito anti-proliferativo e um efeito pró-apoptósico em um animal de sangue quente, para tratar doença e para produzir um efeito inibidor de jak em um animal de sangue quente
US7989459B2 (en)	2006-02-17	2011-08-02	Pharmacopeia, Llc	Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US7767685B2 (en) *	2006-06-29	2010-08-03	King Pharmaceuticals Research And Development, Inc.	Adenosine A2B receptor antagonists
TW200831104A (en)	2006-10-04	2008-08-01	Pharmacopeia Inc	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
TW200837064A (en)	2006-10-04	2008-09-16	Pharmacopeia Inc	8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
US7902187B2 (en)	2006-10-04	2011-03-08	Wyeth Llc	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
ES2627352T3 (es) *	2006-10-19	2017-07-27	Signal Pharmaceuticals, Llc	Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas
CN101679429A (zh) *	2007-04-18	2010-03-24	阿斯利康(瑞典)有限公司	5-氨基吡唑-3-基-3h-咪唑并[4,5-b]吡啶衍生物及其治疗癌的用途
MX2009012612A (es) *	2007-05-23	2009-12-07	Pharmacopeia Llc	Purinonas e inhibidores 1h-imidazopiridinonas como pkc-theta.
US8461147B2 (en) *	2007-12-03	2013-06-11	Boehringer Ingelheim International Gmbh	Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
SI2350075T1 (sl) *	2008-09-22	2014-06-30	Array Biopharma, Inc.	Substituirane imidazo (1,2b)piridazinske spojine kot Trk kinazni inhibitorji
CN102264736B (zh) *	2008-10-22	2013-08-14	阵列生物制药公司	作为TRK激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物
AU2015200511B2 (en) *	2008-10-22	2017-08-31	Array Biopharma Inc.	SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
PA8851101A1 (es)	2008-12-16	2010-07-27	Lilly Co Eli	Compuesto amino pirazol
WO2010088924A1 (en)	2009-02-06	2010-08-12	Telormedix Sa	Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
PT3511330T (pt) *	2009-12-31	2020-12-24	Hutchison Medipharma Ltd	Intermediário sintético útil na preparação de inibidores de triazolopiridina c-met
JP2013519719A (ja)	2010-02-18	2013-05-30	セントロナシオナルデインベスティガシオネスオンコロヒカス（セエネイオ）	トリアゾロ［４，５−ｂ］ピリジン誘導体
EP2563404B1 (de)	2010-04-30	2016-09-21	Urogen Pharma Ltd.	Phospholipid-wirkstoffanaloga
US9050319B2 (en)	2010-04-30	2015-06-09	Telormedix, Sa	Phospholipid drug analogs
BR122019024201B1 (pt)	2010-05-20	2021-08-03	Array Biopharma Inc	Composto macrocíclico como inibidores de trk quinase, seu uso, e composição farmacêutica
WO2012097478A1 (en) *	2011-01-21	2012-07-26	Abbott Laboratories	Bicyclic carboxamide inhibitors of kinases
US9102673B2 (en)	2011-07-12	2015-08-11	Merck Sharp & Dohme Corp.	Substituted pyrrolo[3,2-c]pyridines as TrkA kinase inhibitors
CN104302640A (zh)	2012-03-16	2015-01-21	埃克希金医药品有限公司	3,5-二氨基吡唑激酶抑制剂
WO2013176970A1 (en)	2012-05-22	2013-11-28	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
TWI585088B (zh)	2012-06-04	2017-06-01	第一三共股份有限公司	作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物
US20160222014A1 (en) *	2013-09-10	2016-08-04	Asana Biosciences, Llc	Compounds for regulating fak and/or src pathways
NZ631142A (en)	2013-09-18	2016-03-31	Axikin Pharmaceuticals Inc	Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015039334A1 (en)	2013-09-22	2015-03-26	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2015039333A1 (en)	2013-09-22	2015-03-26	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2015143654A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143653A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143652A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
TWI746426B (zh)	2014-11-16	2021-11-21	美商亞雷生物製藥股份有限公司	(S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
MY191736A (en)	2014-12-23	2022-07-13	Axikin Pharmaceuticals Inc	3,5-diaminopyrazole kinase inhibitors
WO2016161572A1 (en)	2015-04-08	2016-10-13	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
EP3368039A1 (de)	2015-10-26	2018-09-05	The Regents of The University of Colorado, A Body Corporate	Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren
UA125025C2 (uk)	2016-04-04	2021-12-29	Локсо Онколоджі, Інк.	Способи лікування дитячих ракових захворювань
UA125026C2 (uk)	2016-04-04	2021-12-29	Локсо Онколоджі, Інк.	РІДКІ КОМПОЗИЦІЇ (S)-N-(5-((R)-2-(2,5-ДИФТОРФЕНІЛ)ПІРОЛІДИН-1-ІЛ)ПІРАЗОЛО[1,5-a]ПІРИМІДИН-3-ІЛ)-3-ГІДРОКСИПІРОЛІДИН-1-КАРБОКСАМІДУ
MX392604B (es)	2016-05-18	2025-03-24	Array Biopharma Inc	Procesos para la preparacion de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidin-1-carboxamida y sales del mismo.
WO2018036469A1 (zh)	2016-08-22	2018-03-01	南京明德新药研发股份有限公司	Pde4抑制剂
JOP20190092A1 (ar)	2016-10-26	2019-04-25	Array Biopharma Inc	عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar)	2017-03-16	2019-09-16	Array Biopharma Inc	مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN112739691B (zh)	2018-09-03	2023-05-23	泰励生物科技（上海）有限公司	用作抗癌药的trk抑制剂
CA3129665A1 (en)	2019-03-21	2020-09-24	Onxeo	A dbait molecule in combination with kinase inhibitor for the treatment of cancer
TWI899080B (zh)	2019-05-27	2025-10-01	大陸商迪哲（江蘇）醫藥股份有限公司	Ｄｎａ依賴性蛋白激酶抑制劑
KR20220098759A (ko)	2019-11-08	2022-07-12	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN113278022B (zh) *	2020-07-07	2023-12-12	南京纳丁菲医药科技有限公司	吡唑并嘧啶化合物和药物组合物及其应用
CN115141195B (zh) *	2021-03-03	2024-02-06	成都先导药物开发股份有限公司	一种nuak抑制剂及其用途
WO2022266190A1 (en)	2021-06-16	2022-12-22	Blueprint Medicines Corporation	Substituted pyrimidinyl-pyrazoles as cdk2 inhibitors
CN117897384A (zh) *	2021-06-28	2024-04-16	缆图药品公司	Cdk2抑制剂
US20260216148A1 (en) *	2023-01-04	2026-07-30	Blueprint Medicines Corporation	Cdk2 inhibitors

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BR0116493A (pt) *	2000-12-21	2003-09-30	Vertex Pharma	Compostos de pirazol úteis como inibidores de proteìna cinase
DE60139510D1 (de) *	2001-04-06	2009-09-17	Biocryst Pharm Inc	Biarylverbindungen als serinproteaseinhibitoren
US7015231B2 (en) *	2001-09-27	2006-03-21	Smithkline Beecham Corporation	Chemical compounds

2006
- 2006-02-15 KR KR1020077021200A patent/KR20070104936A/ko not_active Ceased
- 2006-02-15 JP JP2007555690A patent/JP2008530191A/ja active Pending
- 2006-02-15 NZ NZ561526A patent/NZ561526A/en not_active IP Right Cessation
- 2006-02-15 WO PCT/GB2006/000522 patent/WO2006087538A1/en not_active Ceased
- 2006-02-15 CA CA002598076A patent/CA2598076A1/en not_active Abandoned
- 2006-02-15 MX MX2007009842A patent/MX2007009842A/es not_active Application Discontinuation
- 2006-02-15 AT AT06709759T patent/ATE473975T1/de active
- 2006-02-15 AU AU2006215394A patent/AU2006215394B2/en not_active Ceased
- 2006-02-15 SI SI200630760T patent/SI1853602T1/sl unknown
- 2006-02-15 PL PL06709759T patent/PL1853602T3/pl unknown
- 2006-02-15 EP EP06709759A patent/EP1853602B1/de not_active Expired - Lifetime
- 2006-02-15 HR HR20100477T patent/HRP20100477T1/hr unknown
- 2006-02-15 US US11/816,376 patent/US7622482B2/en not_active Expired - Fee Related
- 2006-02-15 BR BRPI0608160-6A patent/BRPI0608160A2/pt not_active IP Right Cessation
- 2006-02-15 ES ES06709759T patent/ES2347172T3/es not_active Expired - Lifetime
- 2006-02-15 DE DE602006015431T patent/DE602006015431D1/de not_active Expired - Lifetime
- 2006-02-15 PT PT06709759T patent/PT1853602E/pt unknown
- 2006-02-15 DK DK06709759.2T patent/DK1853602T3/da active
2007
- 2007-07-20 NO NO20073790A patent/NO20073790L/no not_active Application Discontinuation
- 2007-07-26 IL IL184872A patent/IL184872A0/en unknown
2010
- 2010-09-09 CY CY20101100825T patent/CY1110900T1/el unknown

Also Published As

Publication number	Publication date
CY1110900T1 (el)	2015-06-10
SI1853602T1 (sl)	2010-11-30
PT1853602E (pt)	2010-08-25
US20090137624A1 (en)	2009-05-28
NZ561526A (en)	2010-11-26
MX2007009842A (es)	2007-08-23
JP2008530191A (ja)	2008-08-07
EP1853602B1 (de)	2010-07-14
ES2347172T3 (es)	2010-10-26
HK1113352A1 (en)	2008-10-03
EP1853602A1 (de)	2007-11-14
DE602006015431D1 (de)	2010-08-26
CA2598076A1 (en)	2006-08-24
WO2006087538A1 (en)	2006-08-24
KR20070104936A (ko)	2007-10-29
IL184872A0 (en)	2007-12-03
PL1853602T3 (pl)	2010-11-30
HRP20100477T1 (hr)	2010-10-31
BRPI0608160A2 (pt)	2010-11-09
US7622482B2 (en)	2009-11-24
NO20073790L (no)	2007-09-03
AU2006215394B2 (en)	2009-10-08
AU2006215394A1 (en)	2006-08-24
DK1853602T3 (da)	2010-09-20

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2011-04-15

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Publication	Publication Date	Title
DE602006015431D1 (de)	2010-08-26	Chemische verbindungen
ATE398613T1 (de)	2008-07-15	Chemische verbindungen
TW200716606A (en)	2007-05-01	Chemical compounds
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MY149512A (en)	2013-09-13	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
BRPI0510177B8 (pt)	2021-05-25	composto, composição farmacêutica e uso do mesmo
EA201190235A1 (ru)	2012-05-30	Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750
EA201690265A3 (ru)	2016-10-31	Фармацевтические композиции, содержащие замещенные ациланилиды
SE0301700D0 (sv)	2003-06-10	Novel compounds
EA200970156A1 (ru)	2009-08-28	Пиридизиноновые производные
EA201170772A1 (ru)	2012-03-30	Органические соединения
IN2012DN00869A (de)	2015-07-10
EA200801997A1 (ru)	2009-04-28	Новые соединения
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
BRPI0714885B8 (pt)	2021-05-25	compostos terapêuticos e seu uso
TW200738659A (en)	2007-10-16	Novel compounds
TW200616977A (en)	2006-06-01	Enantiomers of selected fused heterocyclics and uses thereof
ATE474574T1 (de)	2010-08-15	Imidazoazephinonverbindungen
IL191670A0 (en)	2008-12-29	Compounds for the inhibition of apoptosis
TW200621260A (en)	2006-07-01	Selected fused heterocyclics and uses thereof
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