ATE473975T1 - Chemische verbindungen - Google Patents

Chemische verbindungen

Info

Publication number: ATE473975T1
Authority: AT; Austria
Prior art keywords: chemical compounds; novel compounds; cancer; formula; treatment
Prior art date: 2005-02-16

Application number

AT06709759T

Other languages

English (en)

Inventor

Yongxin Han

Michelle Lamb

Peter Mohr

Dingwei Yu

Bin Wang

Tao Wang

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-02-16

Filing date

2006-02-15

Publication date

2010-07-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36129856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE473975(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-02-15 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE473975T1 publication Critical patent/ATE473975T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT06709759T 2005-02-16 2006-02-15 Chemische verbindungen ATE473975T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US65333005P	2005-02-16	2005-02-16
US73296505P	2005-11-03	2005-11-03
PCT/GB2006/000522 WO2006087538A1 (en)	2005-02-16	2006-02-15	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE473975T1 true ATE473975T1 (de)	2010-07-15

Family

ID=36129856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06709759T ATE473975T1 (de)	2005-02-16	2006-02-15	Chemische verbindungen

Country Status (21)

Country	Link
US (1)	US7622482B2 (de)
EP (1)	EP1853602B1 (de)
JP (1)	JP2008530191A (de)
KR (1)	KR20070104936A (de)
AT (1)	ATE473975T1 (de)
AU (1)	AU2006215394B2 (de)
BR (1)	BRPI0608160A2 (de)
CA (1)	CA2598076A1 (de)
CY (1)	CY1110900T1 (de)
DE (1)	DE602006015431D1 (de)
DK (1)	DK1853602T3 (de)
ES (1)	ES2347172T3 (de)
HR (1)	HRP20100477T1 (de)
IL (1)	IL184872A0 (de)
MX (1)	MX2007009842A (de)
NO (1)	NO20073790L (de)
NZ (1)	NZ561526A (de)
PL (1)	PL1853602T3 (de)
PT (1)	PT1853602E (de)
SI (1)	SI1853602T1 (de)
WO (1)	WO2006087538A1 (de)

Families Citing this family (55)

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BRPI0606793A8 (pt)	2005-02-04	2018-03-13	Astrazeneca Ab	composto ou um sal farmaceuticamente aceitável do mesmo, processo para a preparação e uso do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de câncer e para a produção de um efeito anti-proliferativo em um animal de sangue quente, e, composição farmacêutica
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JP2009513615A (ja)	2005-10-28	2009-04-02	アストラゼネカアクチボラグ	癌の治療においてチロシンキナーゼ阻害剤として使用するための４−（３−アミノピラゾール）ピリミジン誘導体
US7989459B2 (en)	2006-02-17	2011-08-02	Pharmacopeia, Llc	Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US7767685B2 (en) *	2006-06-29	2010-08-03	King Pharmaceuticals Research And Development, Inc.	Adenosine A2B receptor antagonists
US7919490B2 (en)	2006-10-04	2011-04-05	Wyeth Llc	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
US7902187B2 (en)	2006-10-04	2011-03-08	Wyeth Llc	6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
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US8461147B2 (en) *	2007-12-03	2013-06-11	Boehringer Ingelheim International Gmbh	Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
WO2010033941A1 (en) *	2008-09-22	2010-03-25	Array Biopharma Inc.	Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
AU2015200511B2 (en) *	2008-10-22	2017-08-31	Array Biopharma Inc.	SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
MY169791A (en) *	2008-10-22	2019-05-15	Array Biopharma Inc	Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
PA8851101A1 (es)	2008-12-16	2010-07-27	Lilly Co Eli	Compuesto amino pirazol
WO2010088924A1 (en)	2009-02-06	2010-08-12	Telormedix Sa	Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
AR077468A1 (es)	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
EA030141B1 (ru) *	2009-12-31	2018-06-29	Хатчисон Медифарма Лимитед	Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
PH12012501662A1 (en)	2010-02-18	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Triazolo [4,5 - b] pyridin derivatives
AU2011247358B2 (en)	2010-04-30	2014-10-30	Urogen Pharma Ltd.	Phospholipid drug analogs
US9050319B2 (en)	2010-04-30	2015-06-09	Telormedix, Sa	Phospholipid drug analogs
ME03376B (de)	2010-05-20	2020-01-20	Array Biopharma Inc	Makrocyclische verbindungen als trk-kinasehemmer
WO2012097478A1 (en) *	2011-01-21	2012-07-26	Abbott Laboratories	Bicyclic carboxamide inhibitors of kinases
EP2731439A4 (de) *	2011-07-12	2014-12-03	Merck Sharp & Dohme	Trka-kinase-hemmer, zusammensetzungen daraus und verfahren dafür
WO2013138617A1 (en)	2012-03-16	2013-09-19	Axikin Pharmaceuticals, Inc.	3,5-diaminopyrazole kinase inhibitors
WO2013176970A1 (en)	2012-05-22	2013-11-28	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
TWI585088B (zh)	2012-06-04	2017-06-01	第一三共股份有限公司	作爲激酶抑制劑之咪唑并［１，２－ｂ］嗒衍生物
WO2015038417A1 (en) *	2013-09-10	2015-03-19	Asana Biosciences, Llc	Compounds for regulating fak and/or src pathways
NZ631142A (en)	2013-09-18	2016-03-31	Axikin Pharmaceuticals Inc	Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015039334A1 (en)	2013-09-22	2015-03-26	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2015039333A1 (en)	2013-09-22	2015-03-26	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2015143654A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143653A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143652A1 (en)	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
CN113354649B (zh)	2014-11-16	2024-12-10	阵列生物制药公司	一种新的晶型
TWI703133B (zh)	2014-12-23	2020-09-01	美商艾克斯基製藥公司	３,５-二胺基吡唑激酶抑制劑
WO2016161572A1 (en)	2015-04-08	2016-10-13	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
EP3368039A1 (de)	2015-10-26	2018-09-05	The Regents of The University of Colorado, A Body Corporate	Punktmutationen bei trk-inhibitor-resistentem krebs und zugehörige verfahren
FI3439662T3 (fi)	2016-04-04	2024-09-04	Loxo Oncology Inc	(s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
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US10045991B2 (en)	2016-04-04	2018-08-14	Loxo Oncology, Inc.	Methods of treating pediatric cancers
EP3458456B1 (de)	2016-05-18	2020-11-25	Loxo Oncology Inc.	Herstellung von (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
AU2017317123B9 (en)	2016-08-22	2021-11-25	Medshine Discovery Inc.	PDE4 inhibitor
JOP20190092A1 (ar)	2016-10-26	2019-04-25	Array Biopharma Inc	عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar)	2017-03-16	2019-09-16	Array Biopharma Inc	مركبات حلقية ضخمة كمثبطات لكيناز ros1
JP7443373B2 (ja)	2018-09-03	2024-03-05	タイリガンドバイオサイエンス（シャンハイ）リミテッド	抗がん性薬物としてのｔｒｋ阻害剤
EA202192575A1 (ru)	2019-03-21	2022-01-14	Онксео	Соединения dbait в сочетании с ингибиторами киназ для лечения рака
TWI899080B (zh) *	2019-05-27	2025-10-01	大陸商迪哲（江蘇）醫藥股份有限公司	Ｄｎａ依賴性蛋白激酶抑制劑
CN114761006A (zh)	2019-11-08	2022-07-15	Inserm(法国国家健康医学研究院)	对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN113278022B (zh) *	2020-07-07	2023-12-12	南京纳丁菲医药科技有限公司	吡唑并嘧啶化合物和药物组合物及其应用
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2006
- 2006-02-15 ES ES06709759T patent/ES2347172T3/es not_active Expired - Lifetime
- 2006-02-15 AT AT06709759T patent/ATE473975T1/de active
- 2006-02-15 MX MX2007009842A patent/MX2007009842A/es not_active Application Discontinuation
- 2006-02-15 DK DK06709759.2T patent/DK1853602T3/da active
- 2006-02-15 WO PCT/GB2006/000522 patent/WO2006087538A1/en not_active Ceased
- 2006-02-15 PL PL06709759T patent/PL1853602T3/pl unknown
- 2006-02-15 CA CA002598076A patent/CA2598076A1/en not_active Abandoned
- 2006-02-15 HR HR20100477T patent/HRP20100477T1/hr unknown
- 2006-02-15 JP JP2007555690A patent/JP2008530191A/ja active Pending
- 2006-02-15 SI SI200630760T patent/SI1853602T1/sl unknown
- 2006-02-15 KR KR1020077021200A patent/KR20070104936A/ko not_active Ceased
- 2006-02-15 NZ NZ561526A patent/NZ561526A/en not_active IP Right Cessation
- 2006-02-15 BR BRPI0608160-6A patent/BRPI0608160A2/pt not_active IP Right Cessation
- 2006-02-15 DE DE602006015431T patent/DE602006015431D1/de not_active Expired - Lifetime
- 2006-02-15 AU AU2006215394A patent/AU2006215394B2/en not_active Ceased
- 2006-02-15 EP EP06709759A patent/EP1853602B1/de not_active Expired - Lifetime
- 2006-02-15 US US11/816,376 patent/US7622482B2/en not_active Expired - Fee Related
- 2006-02-15 PT PT06709759T patent/PT1853602E/pt unknown
2007
- 2007-07-20 NO NO20073790A patent/NO20073790L/no not_active Application Discontinuation
- 2007-07-26 IL IL184872A patent/IL184872A0/en unknown
2010
- 2010-09-09 CY CY20101100825T patent/CY1110900T1/el unknown

Also Published As

Publication number	Publication date
CA2598076A1 (en)	2006-08-24
PT1853602E (pt)	2010-08-25
WO2006087538A1 (en)	2006-08-24
EP1853602B1 (de)	2010-07-14
IL184872A0 (en)	2007-12-03
US7622482B2 (en)	2009-11-24
AU2006215394B2 (en)	2009-10-08
CY1110900T1 (el)	2015-06-10
ES2347172T3 (es)	2010-10-26
PL1853602T3 (pl)	2010-11-30
HRP20100477T1 (hr)	2010-10-31
KR20070104936A (ko)	2007-10-29
SI1853602T1 (sl)	2010-11-30
JP2008530191A (ja)	2008-08-07
US20090137624A1 (en)	2009-05-28
AU2006215394A1 (en)	2006-08-24
EP1853602A1 (de)	2007-11-14
DE602006015431D1 (de)	2010-08-26
MX2007009842A (es)	2007-08-23
NZ561526A (en)	2010-11-26
NO20073790L (no)	2007-09-03
BRPI0608160A2 (pt)	2010-11-09
DK1853602T3 (da)	2010-09-20
HK1113352A1 (en)	2008-10-03

Legal Events

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2011-04-15

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Publication	Publication Date	Title
ATE473975T1 (de)	2010-07-15	Chemische verbindungen
ATE398613T1 (de)	2008-07-15	Chemische verbindungen
TW200716606A (en)	2007-05-01	Chemical compounds
TW200800963A (en)	2008-01-01	Chemical compounds
EA200900023A1 (ru)	2009-06-30	Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
BRPI0510177B8 (pt)	2021-05-25	composto, composição farmacêutica e uso do mesmo
MY149512A (en)	2013-09-13	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
EA201190235A1 (ru)	2012-05-30	Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750
EA201690265A2 (ru)	2016-06-30	Фармацевтические композиции, содержащие замещенные ациланилиды
SE0301700D0 (sv)	2003-06-10	Novel compounds
EA200970156A1 (ru)	2009-08-28	Пиридизиноновые производные
EA201170772A1 (ru)	2012-03-30	Органические соединения
IN2012DN00869A (de)	2015-07-10
EA200801997A1 (ru)	2009-04-28	Новые соединения
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
BRPI0714885B8 (pt)	2021-05-25	compostos terapêuticos e seu uso
TW200738659A (en)	2007-10-16	Novel compounds
TW200616977A (en)	2006-06-01	Enantiomers of selected fused heterocyclics and uses thereof
ATE474574T1 (de)	2010-08-15	Imidazoazephinonverbindungen
IL191670A0 (en)	2008-12-29	Compounds for the inhibition of apoptosis
TW200621260A (en)	2006-07-01	Selected fused heterocyclics and uses thereof
NO20083352L (no)	2008-07-30	2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
EA200702590A1 (ru)	2008-06-30	Ингибиторы растворимой аденилатциклазы
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