ATE473985T1 - Tricyclische tetrahydrochinoline mit antibakterieller wirkung - Google Patents

Tricyclische tetrahydrochinoline mit antibakterieller wirkung

Info

Publication number
ATE473985T1
ATE473985T1 AT03799056T AT03799056T ATE473985T1 AT E473985 T1 ATE473985 T1 AT E473985T1 AT 03799056 T AT03799056 T AT 03799056T AT 03799056 T AT03799056 T AT 03799056T AT E473985 T1 ATE473985 T1 AT E473985T1
Authority
AT
Austria
Prior art keywords
tetrahydrocinolines
tricyclic
antibacterial effect
antibacterial
effect
Prior art date
Application number
AT03799056T
Other languages
English (en)
Inventor
M R Barbachyn
P J Dobrowolski
A R Hurd
D J Mcnamara
John Palmer
A G Romero
James Ruble
D A Sherry
L M Thomasco
P L Toogood
Gordon Bundy
Gary Martin
Donna L Romero
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Application granted granted Critical
Publication of ATE473985T1 publication Critical patent/ATE473985T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03799056T 2002-10-07 2003-10-03 Tricyclische tetrahydrochinoline mit antibakterieller wirkung ATE473985T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41668502P 2002-10-07 2002-10-07
US42718902P 2002-11-18 2002-11-18
US45762203P 2003-03-26 2003-03-26
PCT/IB2003/004389 WO2004031195A1 (en) 2002-10-07 2003-10-03 Tricyclic tetrahydroquinoline antibacterial agents

Publications (1)

Publication Number Publication Date
ATE473985T1 true ATE473985T1 (de) 2010-07-15

Family

ID=32074379

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03799056T ATE473985T1 (de) 2002-10-07 2003-10-03 Tricyclische tetrahydrochinoline mit antibakterieller wirkung

Country Status (16)

Country Link
US (4) US7208490B2 (de)
EP (1) EP1551849B1 (de)
JP (1) JP4009652B2 (de)
AR (1) AR041546A1 (de)
AT (1) ATE473985T1 (de)
AU (1) AU2003264768A1 (de)
BR (1) BR0315139A (de)
CA (1) CA2500824C (de)
CY (1) CY1110821T1 (de)
DE (1) DE60333379D1 (de)
DK (1) DK1551849T3 (de)
MX (1) MXPA05002701A (de)
PT (1) PT1551849E (de)
SI (1) SI1551849T1 (de)
TW (1) TWI295671B (de)
WO (1) WO2004031195A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
JP2008543739A (ja) * 2005-05-09 2008-12-04 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 抗菌剤
DOP2006000268A (es) * 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
MX2010000130A (es) * 2007-07-02 2010-03-18 Astrazeneca Ab Derivados de 3-espiropirimidintriona-quinolina y su uso como agentes antibacterianos.
CN101687871A (zh) 2007-07-16 2010-03-31 阿斯利康(瑞典)有限公司 用作抗菌剂的螺缩合巴比妥酸衍生物
WO2010043893A1 (en) * 2008-10-14 2010-04-22 Astrazeneca Ab Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
MX2011006333A (es) * 2008-12-23 2011-06-27 Abbott Lab Compuestos antivirales.
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
EP3056486B1 (de) 2010-07-16 2018-07-11 AbbVie Ireland Unlimited Company Verfahren zur herstellung von zwischenverbindungen antiviraler verbindungen
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
EP3461556A1 (de) 2010-07-16 2019-04-03 AbbVie Ireland Unlimited Company Phosphinliganden für katalytische reaktionen
WO2014042647A1 (en) * 2012-09-14 2014-03-20 Levina Elizabeth Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi
US8952149B2 (en) * 2012-09-26 2015-02-10 Zoetis Llc Tricyclic tetrahydroquinoline antibacterial agents
US8889671B2 (en) 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
JP6156845B2 (ja) * 2014-03-04 2017-07-05 株式会社島津製作所 マトリックス支援レーザ脱離イオン化質量分析用マトリックス
EA033459B1 (ru) * 2014-05-29 2019-10-31 Entasis Therapeutics Ltd Конденсированные спироциклические гетероароматические соединения для лечения бактериальных инфекций
WO2017156519A1 (en) 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
US11274106B2 (en) 2017-06-23 2022-03-15 The Board Of Trustees Of The University Of Illinois Topoisomerase inhibitors with antibacterial and anticancer activity
CN108101860B (zh) * 2018-02-08 2021-11-23 苏州敬业医药化工有限公司 顺式-2，6-二甲基吗啉的制备方法
CN115466212B (zh) * 2022-10-26 2023-09-22 河南农业大学 一种2-三氟甲基喹啉类化合物及其合成方法和应用
CN118878546B (zh) * 2024-09-30 2025-01-03 苏州大学 一种螺环巴比妥酸衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011860A (en) 1986-04-11 1991-04-30 Schering Corporation Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases
DE19502178A1 (de) 1994-01-27 1995-08-03 Hoechst Ag Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen
EP1332146A2 (de) 2000-10-26 2003-08-06 Pfizer Products Inc. Spiropyrimidin-2,4,6-trione als metalloproteinase inhibitoren
WO2003091252A1 (en) 2002-04-25 2003-11-06 Bristol-Myers Squibb Company Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
JP2006504726A (ja) 2002-10-10 2006-02-09 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌性１−アリールジヒドロピリドン化合物

Also Published As

Publication number Publication date
MXPA05002701A (es) 2005-08-19
CA2500824A1 (en) 2004-04-15
SI1551849T1 (sl) 2010-11-30
US20100022524A1 (en) 2010-01-28
CY1110821T1 (el) 2015-06-10
JP4009652B2 (ja) 2007-11-21
BR0315139A (pt) 2005-08-09
AR041546A1 (es) 2005-05-18
TW200413394A (en) 2004-08-01
WO2004031195A1 (en) 2004-04-15
US8420646B2 (en) 2013-04-16
EP1551849B1 (de) 2010-07-14
US7208490B2 (en) 2007-04-24
US20110092494A1 (en) 2011-04-21
US20070161630A1 (en) 2007-07-12
US7605157B2 (en) 2009-10-20
JP2006511595A (ja) 2006-04-06
DK1551849T3 (da) 2010-10-25
CA2500824C (en) 2011-03-22
US20040162279A1 (en) 2004-08-19
DE60333379D1 (de) 2010-08-26
EP1551849A1 (de) 2005-07-13
PT1551849E (pt) 2010-09-27
TWI295671B (en) 2008-04-11
AU2003264768A1 (en) 2004-04-23

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