ATE474938T1 - Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung - Google Patents

Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung

Info

Publication number
ATE474938T1
ATE474938T1 AT07835726T AT07835726T ATE474938T1 AT E474938 T1 ATE474938 T1 AT E474938T1 AT 07835726 T AT07835726 T AT 07835726T AT 07835726 T AT07835726 T AT 07835726T AT E474938 T1 ATE474938 T1 AT E474938T1
Authority
AT
Austria
Prior art keywords
accuracy
increase
nucleic acid
acid sequencing
sequencing
Prior art date
Application number
AT07835726T
Other languages
English (en)
Inventor
Timothy Harris
Original Assignee
Helicos Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicos Biosciences Corp filed Critical Helicos Biosciences Corp
Application granted granted Critical
Publication of ATE474938T1 publication Critical patent/ATE474938T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT07835726T 2006-04-14 2007-04-13 Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung ATE474938T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/404,695 US7282337B1 (en) 2006-04-14 2006-04-14 Methods for increasing accuracy of nucleic acid sequencing
PCT/US2007/009151 WO2008016399A1 (en) 2006-04-14 2007-04-13 Methods for increasing accuracy of nucleic acid sequencing

Publications (1)

Publication Number Publication Date
ATE474938T1 true ATE474938T1 (de) 2010-08-15

Family

ID=38997463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07835726T ATE474938T1 (de) 2006-04-14 2007-04-13 Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung

Country Status (7)

Country Link
US (2) US7282337B1 (de)
EP (1) EP2007908B1 (de)
JP (1) JP2009533060A (de)
AT (1) ATE474938T1 (de)
CA (1) CA2649291A1 (de)
DE (1) DE602007007924D1 (de)
WO (1) WO2008016399A1 (de)

Families Citing this family (328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156002A0 (en) 1997-02-12 2003-12-23 Eugene Y Chan Methods and products for analyzing polymers
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7668697B2 (en) * 2006-02-06 2010-02-23 Andrei Volkov Method for analyzing dynamic detectable events at the single molecule level
US20060035233A1 (en) * 2002-12-02 2006-02-16 Niall Gormley Recovery of original template
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
ATE463584T1 (de) * 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7622296B2 (en) 2004-05-28 2009-11-24 Wafergen, Inc. Apparatus and method for multiplex analysis
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US20090075252A1 (en) * 2006-04-14 2009-03-19 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
US7282337B1 (en) * 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2007133710A2 (en) 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20100267041A1 (en) * 2007-09-14 2010-10-21 Predictive Biosciences, Inc. Serial analysis of biomarkers for disease diagnosis
US20090156412A1 (en) * 2007-12-17 2009-06-18 Helicos Biosciences Corporation Surface-capture of target nucleic acids
US20090163366A1 (en) * 2007-12-24 2009-06-25 Helicos Biosciences Corporation Two-primer sequencing for high-throughput expression analysis
WO2009091798A1 (en) * 2008-01-16 2009-07-23 Helicos Biosciences Corporation Quantitative genetic analysis
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US7767400B2 (en) * 2008-02-03 2010-08-03 Helicos Biosciences Corporation Paired-end reads in sequencing by synthesis
US9017973B2 (en) 2008-03-19 2015-04-28 Intelligent Biosystems, Inc. Methods and compositions for incorporating nucleotides
JP2011515102A (ja) * 2008-03-28 2011-05-19 パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド 核酸シーケンシング用組成物及び方法
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
US8143030B2 (en) * 2008-09-24 2012-03-27 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8628940B2 (en) * 2008-09-24 2014-01-14 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US8383369B2 (en) * 2008-09-24 2013-02-26 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
US8486630B2 (en) 2008-11-07 2013-07-16 Industrial Technology Research Institute Methods for accurate sequence data and modified base position determination
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011133175A1 (en) 2009-09-23 2011-10-27 Celmatix, Inc. Methods and devices for assessing infertility and/or egg quality
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
EP2425240A4 (de) 2009-04-30 2012-12-12 Good Start Genetics Inc Verfahren und zusammensetzung zur bewertung genetischer marker
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
DK2456892T3 (en) 2009-07-24 2014-12-08 Illumina Inc Procedure for sequencing of a polynukleotidskabelon
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
DK2816111T3 (en) * 2009-08-14 2016-06-06 Epicentre Tech Corp Methods, compositions, and kits for the generation of rRNA-depleted samples or isolation of rRNA from samples
EP3135772B1 (de) 2009-09-08 2019-10-23 Laboratory Corporation of America Holdings Verfahren zur diagnostizierung von autistischen erkrankungen
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US9890408B2 (en) 2009-10-15 2018-02-13 Ibis Biosciences, Inc. Multiple displacement amplification
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4435111A1 (de) 2010-02-12 2024-09-25 Bio-Rad Laboratories, Inc. Digitale analytanalyse
US8575124B2 (en) 2010-02-18 2013-11-05 Anthony P. Shuber Compositions and methods for treating cancer
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
JP2013527769A (ja) 2010-05-06 2013-07-04 アイビス バイオサイエンシズ インコーポレイティッド 統合された試料調製システムおよび安定化酵素混合物
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2596127A2 (de) 2010-07-23 2013-05-29 Esoterix Genetic Laboratories, LLC Ermittlung differentiell vertretener fötaler oder mütterlicher genom-regionen und verwendungen davon
AU2011301935B2 (en) 2010-09-16 2015-06-11 Ibis Biosciences, Inc. Stabilization of ozone-labile fluorescent dyes by thiourea
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012092265A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (de) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzymquantifizierung
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9670538B2 (en) 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
EP3323897A1 (de) 2011-10-03 2018-05-23 Celmatix, Inc. Verfahren und vorrichtungen zur bewertung des risikos einer angenommenen auswirkung der entwicklung eines zustands
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2764458B1 (de) 2011-10-06 2021-04-07 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
EP2768983A4 (de) 2011-10-17 2015-06-03 Good Start Genetics Inc Analyseverfahren
WO2013063308A1 (en) 2011-10-25 2013-05-02 University Of Massachusetts An enzymatic method to enrich for capped rna, kits for performing same, and compositions derived therefrom
EP2794927B1 (de) 2011-12-22 2017-04-12 Ibis Biosciences, Inc. Amplifikationsprimer und verfahren
WO2013096819A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
WO2013096838A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
EP3269820A1 (de) 2011-12-22 2018-01-17 Ibis Biosciences, Inc. Kit für die amplifizierung einer sequenz aus einer ribonukleinsäure
US9334491B2 (en) 2011-12-22 2016-05-10 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
US9506113B2 (en) 2011-12-28 2016-11-29 Ibis Biosciences, Inc. Nucleic acid ligation systems and methods
US9803231B2 (en) 2011-12-29 2017-10-31 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
US9822417B2 (en) 2012-01-09 2017-11-21 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
CN104334739A (zh) 2012-01-13 2015-02-04 Data生物有限公司 通过新一代测序进行基因分型
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
US20130210659A1 (en) 2012-02-10 2013-08-15 Andrew Watson Molecular diagnostic screening assay
SMT202100154T1 (it) 2012-02-17 2021-05-07 Hutchinson Fred Cancer Res Composizioni e metodi per identificare precisamente mutazioni
US9176031B2 (en) 2012-02-24 2015-11-03 Raindance Technologies, Inc. Labeling and sample preparation for sequencing
WO2013152114A1 (en) 2012-04-03 2013-10-10 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and crohn's disease
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
WO2013165748A1 (en) 2012-04-30 2013-11-07 Raindance Technologies, Inc Digital analyte analysis
WO2013166302A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Nucleic acid sequencing systems and methods
WO2013166303A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
WO2013166444A2 (en) 2012-05-04 2013-11-07 Boreal Genomics Corp. Biomarker analysis using scodaphoresis
EP4026912A1 (de) 2012-05-10 2022-07-13 The General Hospital Corporation Verfahren zur bestimmung einer nukleotidsequenz
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
JP2015526092A (ja) * 2012-08-24 2015-09-10 ライフ テクノロジーズ コーポレーション 核酸ペアエンド配列決定のための方法、組成物、システム、装置、およびキット
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2909343B1 (de) 2012-10-16 2018-10-10 Abbott Molecular Inc. Verfahren zum sequenzieren einer nukleinsäure
US9177098B2 (en) 2012-10-17 2015-11-03 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US10162800B2 (en) 2012-10-17 2018-12-25 Celmatix Inc. Systems and methods for determining the probability of a pregnancy at a selected point in time
US9836577B2 (en) 2012-12-14 2017-12-05 Celmatix, Inc. Methods and devices for assessing risk of female infertility
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
CN105190656B (zh) 2013-01-17 2018-01-16 佩索纳里斯公司 用于遗传分析的方法和系统
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014134403A2 (en) 2013-03-01 2014-09-04 Vivonics, Inc. Aptamers that bind cd271
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
EP2971159B1 (de) 2013-03-14 2019-05-08 Molecular Loop Biosolutions, LLC Verfahren zur analyse von nukleinsäuren
EP2971154A4 (de) 2013-03-14 2017-03-01 Ibis Biosciences, Inc. Nukleinsäurekontrollpanels
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
EP3533884A1 (de) 2013-03-15 2019-09-04 Ibis Biosciences, Inc. Dna-sequenzen zur beurteilung der kontamination in der dna-sequenzierung
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US9890425B2 (en) 2013-03-15 2018-02-13 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
EP4187543A1 (de) 2013-04-03 2023-05-31 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
EP2986762B1 (de) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digitale analyse von analyten
US9725724B2 (en) 2013-05-16 2017-08-08 Vivonics, Inc. Neutral nucleic acid ligands
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014197377A2 (en) 2013-06-03 2014-12-11 Good Start Genetics, Inc. Methods and systems for storing sequence read data
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
ES2873850T3 (es) 2013-08-19 2021-11-04 Abbott Molecular Inc Bibliotecas de secuenciación de próxima generación
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
GB2534067B (en) 2013-08-30 2021-07-21 Personalis Inc Methods and systems for genomic analysis
AU2014324438B2 (en) 2013-09-30 2019-12-05 Seven Bridges Genomics Inc. Methods and system for detecting sequence variants
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム, インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
EP3057985A4 (de) 2013-10-18 2017-05-31 The Regents Of The University Of Michigan Systeme und verfahren zur bestimmung einer behandlungsvorgehensweise
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
JP2017500004A (ja) 2013-10-18 2017-01-05 セブン ブリッジズ ジェノミクス インコーポレイテッド 遺伝子試料について遺伝子型解析するための方法およびシステム
US10053736B2 (en) 2013-10-18 2018-08-21 Seven Bridges Genomics Inc. Methods and systems for identifying disease-induced mutations
WO2015058120A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
US10832797B2 (en) 2013-10-18 2020-11-10 Seven Bridges Genomics Inc. Method and system for quantifying sequence alignment
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
DE202014010499U1 (de) 2013-12-17 2015-10-20 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
US10768181B2 (en) 2013-12-17 2020-09-08 The Brigham And Women's Hospital, Inc. Detection of an antibody against a pathogen
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
US10867693B2 (en) 2014-01-10 2020-12-15 Seven Bridges Genomics Inc. Systems and methods for use of known alleles in read mapping
WO2015107430A2 (en) 2014-01-16 2015-07-23 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
AU2015209079B2 (en) 2014-01-27 2021-07-15 Archerdx, Llc Methods of preparing nucleic acids for sequencing
US9817944B2 (en) 2014-02-11 2017-11-14 Seven Bridges Genomics Inc. Systems and methods for analyzing sequence data
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
EP3151733B1 (de) 2014-06-06 2020-04-15 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur charakterisierung und diagnose von parodontaler erkrankung
AU2015280069B2 (en) 2014-06-23 2021-08-12 The General Hospital Corporation Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)
CN114214314A (zh) 2014-06-24 2022-03-22 生物辐射实验室股份有限公司 数字式pcr条码化
EP3332790A1 (de) 2014-07-15 2018-06-13 Kymab Limited Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
EP4328245A3 (de) 2014-07-15 2024-06-05 Kymab Ltd. Antikörper zur verwendung bei der behandlung von erkrankungen im zusammenhang mit spezifischen pcsk9-varianten in bestimmten patientenpopulationen
DE202015009006U1 (de) 2014-07-15 2016-08-19 Kymab Limited Targeting von humaner PCSK9 zur Cholesterinbehandlung
WO2016011377A1 (en) 2014-07-17 2016-01-21 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
BR112017001500A2 (pt) 2014-07-24 2018-02-20 Abbott Molecular Inc composições e métodos para a detecção e análise de tuberculose por micobactéria
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
WO2016023916A1 (en) 2014-08-12 2016-02-18 Kymab Limited Treatment of disease using ligand binding to targets of interest
WO2016025818A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
US10429399B2 (en) 2014-09-24 2019-10-01 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
US9558321B2 (en) 2014-10-14 2017-01-31 Seven Bridges Genomics Inc. Systems and methods for smart tools in sequence pipelines
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
US10000799B2 (en) 2014-11-04 2018-06-19 Boreal Genomics, Inc. Methods of sequencing with linked fragments
WO2016071701A1 (en) 2014-11-07 2016-05-12 Kymab Limited Treatment of disease using ligand binding to targets of interest
EP3227684B1 (de) 2014-12-03 2019-10-02 Isoplexis Corporation Analyse und screening für die sekretionprofile von zellen
EP3271480B8 (de) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Abtastung auf strukturelle varianten
JP6929778B2 (ja) 2015-01-15 2021-09-01 グッド スタート ジェネティクス, インコーポレイテッド 着床前遺伝子スクリーニングにおける一塩基多型を用いた品質管理方法
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
US10192026B2 (en) 2015-03-05 2019-01-29 Seven Bridges Genomics Inc. Systems and methods for genomic pattern analysis
WO2016168561A1 (en) 2015-04-15 2016-10-20 Sundaresan Tilak K Lna-based mutant enrichment next-generation sequencing assays
US10275567B2 (en) 2015-05-22 2019-04-30 Seven Bridges Genomics Inc. Systems and methods for haplotyping
WO2017011565A1 (en) 2015-07-14 2017-01-19 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
US10392613B2 (en) 2015-07-14 2019-08-27 Abbott Molecular Inc. Purification of nucleic acids using copper-titanium oxides
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CA3000816A1 (en) 2015-09-11 2017-03-16 The General Hospital Corporation Full interrogation of nuclease dsbs and sequencing (find-seq)
CA3000762A1 (en) 2015-09-30 2017-04-06 The General Hospital Corporation Comprehensive in vitro reporting of cleavage events by sequencing (circle-seq)
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
US20170199960A1 (en) 2016-01-07 2017-07-13 Seven Bridges Genomics Inc. Systems and methods for adaptive local alignment for graph genomes
EP3400298B1 (de) 2016-01-08 2024-03-06 Bio-Rad Laboratories, Inc. Auflösung mehrerer beads pro tropfen
US10364468B2 (en) 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
JP6902036B2 (ja) 2016-01-22 2021-07-14 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation 荷電質量標識系
US10460829B2 (en) 2016-01-26 2019-10-29 Seven Bridges Genomics Inc. Systems and methods for encoding genetic variation for a population
JP6902052B2 (ja) 2016-02-08 2021-07-14 アールジーン・インコーポレイテッドRgene, Inc. 複数のリガーゼ組成物、システム、および方法
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
CN109477127A (zh) 2016-03-14 2019-03-15 R基因股份有限公司 超热稳定的赖氨酸-突变型ssDNA/RNA连接酶
US10961573B2 (en) 2016-03-28 2021-03-30 Boreal Genomics, Inc. Linked duplex target capture
WO2017168331A1 (en) 2016-03-28 2017-10-05 Boreal Genomics, Inc. Linked duplex fragment sequencing
US11355328B2 (en) 2016-04-13 2022-06-07 Purdue Research Foundation Systems and methods for isolating a target ion in an ion trap using a dual frequency waveform
WO2017201315A1 (en) 2016-05-18 2017-11-23 Roche Sequencing Solutions, Inc. Quantitative real time pcr amplification using an electrowetting-based device
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
US11624064B2 (en) 2016-06-13 2023-04-11 Grail, Llc Enrichment of mutated cell free nucleic acids for cancer detection
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
WO2018013558A1 (en) 2016-07-12 2018-01-18 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
CN109070044B (zh) 2016-07-21 2021-07-30 宝生物工程(美国)有限公司 使用多孔装置进行的多z平面成像和分配
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
US11543417B2 (en) 2016-08-29 2023-01-03 Oslo Universitetssykehus Hf ChIP-seq assays
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
US20200166518A1 (en) 2016-09-12 2020-05-28 IsoPlexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
US12630864B2 (en) 2016-09-15 2026-05-19 Laboratory Corporation Of America Holdings Methods of nucleic acid sample preparation
CN109937254B (zh) 2016-09-15 2023-05-30 阿谢尔德克斯有限责任公司 核酸样品制备方法
CA3037190A1 (en) 2016-09-15 2018-03-22 ArcherDX, Inc. Methods of nucleic acid sample preparation for analysis of cell-free dna
US10487358B2 (en) 2016-09-23 2019-11-26 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
CA3042391A1 (en) 2016-11-02 2018-05-11 ArcherDX, Inc. Methods of nucleic acid sample preparation for immune repertoire sequencing
US20180203974A1 (en) 2016-11-07 2018-07-19 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
US11493508B2 (en) 2016-11-11 2022-11-08 IsoPlexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
US11525783B2 (en) 2016-11-22 2022-12-13 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
JP7048609B2 (ja) 2016-12-09 2022-04-05 ボリアル ジェノミクス, インコーポレイテッド 連結型ライゲーション
EP3551768B1 (de) 2016-12-12 2024-03-06 Grail, LLC Verfahren zur markierung und amplifizierung von rna-template-molekülen zur herstellung von sequenzierungsbibliotheken
CN118441026A (zh) 2016-12-19 2024-08-06 生物辐射实验室股份有限公司 液滴加标的相邻性保留的标签化dna
WO2018119399A1 (en) 2016-12-23 2018-06-28 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
CA3207879C (en) 2017-01-24 2026-06-16 Sequenom, Inc. Methods and processes for assessment of genetic variations
DK3354746T3 (da) 2017-01-30 2019-09-02 Gmi Gregor Mendel Inst Fuer Molekulare Pflanzenbiologie Gmbh Nye spike-in-nukleotider til normalisering af sekvensdata
EP3998350B1 (de) 2017-03-17 2025-05-07 Sequenom, Inc. Verfahren und vorgänge zur beurteilung von genetischem mosaizismus
WO2018183918A1 (en) 2017-03-30 2018-10-04 Grail, Inc. Enhanced ligation in sequencing library preparation
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US11118222B2 (en) 2017-03-31 2021-09-14 Grail, Inc. Higher target capture efficiency using probe extension
CA3057420C (en) 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
CA3057421C (en) 2017-05-12 2022-10-25 Laboratory Corporation Of America Holdings Compositions and methods to detect non-coeliac gluten sensitivity
EP4414704A3 (de) 2017-06-08 2024-10-30 The Brigham and Women's Hospital, Inc. Verfahren und zusammensetzungen zur identifizierung von epitopen
US11186862B2 (en) 2017-06-20 2021-11-30 Bio-Rad Laboratories, Inc. MDA using bead oligonucleotide
JP7390285B2 (ja) 2017-06-26 2023-12-01 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン 老化細胞を検出するための新規バイオマーカー
JP6998404B2 (ja) 2017-08-01 2022-02-04 深▲セン▼恒特基因有限公司 標的ヌクレオチド配列の富化及び決定方法
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
KR20240157126A (ko) 2017-09-20 2024-10-31 가던트 헬쓰, 인크. 체세포 및 생식세포계열 변이체를 구별하기 위한 방법 및 시스템
WO2019067973A1 (en) 2017-09-28 2019-04-04 Grail, Inc. ENRICHMENT OF SHORT NUCLEIC ACID FRAGMENTS IN THE PREPARATION OF SEQUENCING LIBRARIES
CN111787930B (zh) 2017-10-06 2024-12-20 芝加哥大学 针对癌症特异性抗原对t淋巴细胞的筛选
EP4180534A1 (de) 2017-11-02 2023-05-17 Bio-Rad Laboratories, Inc. Auf transposase basierende genomanalyse
WO2019092269A1 (en) 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
WO2019118925A1 (en) 2017-12-15 2019-06-20 Grail, Inc. Methods for enriching for duplex reads in sequencing and error correction
JP7227254B2 (ja) 2017-12-20 2023-02-21 ラボラトリー コーポレイション オブ アメリカ ホールディングス 頭頸部癌を検出するための組成物および方法
US20190237161A1 (en) 2017-12-22 2019-08-01 Grail, Inc. Error removal using improved library preparation methods
EP3746552B1 (de) 2018-01-31 2023-12-27 Bio-Rad Laboratories, Inc. Verfahren und zusammensetzungen zur dekonvolution von partitionsbarcodes
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
US12235273B2 (en) 2018-05-04 2025-02-25 Abbott Laboratories HBV diagnostic, prognostic, and therapeutic methods and products
WO2019217899A2 (en) 2018-05-11 2019-11-14 Laboratory Corporation Of America Holdings Compositions and methods to detect kidney fibrosis
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US20190385700A1 (en) 2018-06-04 2019-12-19 Guardant Health, Inc. METHODS AND SYSTEMS FOR DETERMINING The CELLULAR ORIGIN OF CELL-FREE NUCLEIC ACIDS
CN120193081A (zh) 2018-07-23 2025-06-24 夸登特健康公司 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统
EP4249651B1 (de) 2018-08-20 2025-01-29 Bio-Rad Laboratories, Inc. Generierung von nukleotidsequenzen durch barcode-kügelchen-co-lokalisierung in partitionen
US12098419B2 (en) 2018-08-23 2024-09-24 Ncan Genomics, Inc. Linked target capture and ligation
KR20210052501A (ko) 2018-08-30 2021-05-10 가던트 헬쓰, 인크. 샘플 사이의 오염을 검출하기 위한 방법 및 시스템
JP7539367B2 (ja) 2018-08-31 2024-08-23 ガーダント ヘルス, インコーポレイテッド 無細胞dnaにおけるマイクロサテライト不安定性の検出
US20200075124A1 (en) 2018-09-04 2020-03-05 Guardant Health, Inc. Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples
DK3814533T3 (da) 2018-09-20 2021-11-15 Tamirna Gmbh Mikro-RNA-signaturer til forudsigelse af leverdysfunktion
EP3864403A1 (de) 2018-10-12 2021-08-18 F. Hoffmann-La Roche AG Nachweisverfahren für die automation eines epitachophoreseablaufs
CA3116176A1 (en) 2018-10-31 2020-05-07 Guardant Health, Inc. Methods, compositions and systems for calibrating epigenetic partitioning assays
WO2020102513A1 (en) 2018-11-14 2020-05-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing and treating cancer
US11680261B2 (en) 2018-11-15 2023-06-20 Grail, Inc. Needle-based devices and methods for in vivo diagnostics of disease conditions
US11512349B2 (en) 2018-12-18 2022-11-29 Grail, Llc Methods for detecting disease using analysis of RNA
CN113454218A (zh) 2018-12-20 2021-09-28 夸登特健康公司 用于改进核酸分子的回收的方法、组合物和系统
EP4538389A3 (de) 2019-01-03 2025-07-30 Ncan Genomics, Inc. Verknüpfte zielerfassung
US20220081714A1 (en) 2019-01-04 2022-03-17 Northwestern University Storing temporal data into dna
CN113518584B (zh) * 2019-01-28 2024-11-08 美国雅培糖尿病护理公司 检测肌酐的分析物传感器和感测方法
EP4567131A3 (de) 2019-01-31 2025-09-03 Guardant Health, Inc. Zusammensetzungen und verfahren zur isolierung von zellfreier dna
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
JP7441243B2 (ja) 2019-05-14 2024-02-29 エフ. ホフマン-ラ ロシュ アーゲー 試料分析のための装置および方法
EP3976822A1 (de) 2019-05-31 2022-04-06 Guardant Health, Inc. Verfahren und systeme zur verbesserung der patientenüberwachung nach der operation
EP3980536A4 (de) 2019-06-07 2023-11-15 Bio-Rad Laboratories, Inc. Auflösung mehrerer beads pro tropfen
CA3140171A1 (en) * 2019-06-10 2020-12-17 Boreal Genomics, Inc. Linked target capture
JP2022543278A (ja) 2019-08-05 2022-10-11 ミッション バイオ インコーポレイテッド 細胞軌道を測定するためのシングルセル分析のための方法及び装置
US12359247B2 (en) 2019-08-26 2025-07-15 Adoc Ssf, Llc Methods of performing GUIDE-Seq on primary human T cells
US20220351806A1 (en) 2019-10-02 2022-11-03 Endpoint Health Inc. Biomarker Panels for Guiding Dysregulated Host Response Therapy
WO2021072275A1 (en) 2019-10-11 2021-04-15 Guardant Health, Inc. Use of cell free bacterial nucleic acids for detection of cancer
DK3812472T3 (da) 2019-10-21 2023-02-20 Univ Freiburg Albert Ludwigs Virkelig uvildig in vitro-undersøgelse til profilering af off-target-aktivitet af en eller flere målspecifikke programmerbare nukleaser i celler (abnoba-seq)
WO2021091859A1 (en) 2019-11-04 2021-05-14 Bio-Rad Laboratories, Inc. Cell barcoding for single cell sequencing
JP7470787B2 (ja) 2019-11-05 2024-04-18 パーソナリス,インコーポレイティド 単一試料からの腫瘍純度の推定
ES3031713T3 (en) 2019-11-26 2025-07-10 Guardant Health Inc Methods, compositions and systems for improving the binding of methylated polynucleotides
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
CN115176158A (zh) 2020-02-27 2022-10-11 伊索普莱克西斯公司 用于多路分析的系统、装置及方法
JP2023518250A (ja) 2020-03-20 2023-04-28 ミッション バイオ インコーポレイテッド 全ゲノム増幅のためのシングルセルワークフロー
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
WO2021222828A1 (en) 2020-04-30 2021-11-04 Guardant Health, Inc. Methods for sequence determination using partitioned nucleic acids
WO2021224677A1 (en) 2020-05-05 2021-11-11 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
JP7842700B2 (ja) 2020-05-14 2026-04-08 ガーダント ヘルス, インコーポレイテッド 相同組換え修復欠損の検出
EP4407042A3 (de) 2020-07-10 2024-09-18 Guardant Health, Inc. Verfahren zum nachweis von genomischen neuanordnungen unter verwendung zellfreier nukleinsäuren
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
US12116637B2 (en) 2020-07-24 2024-10-15 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
ES3018032T3 (en) 2020-07-30 2025-05-14 Guardant Health Inc Methods for isolating cell-free dna
WO2022046947A1 (en) 2020-08-25 2022-03-03 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
JP2023544720A (ja) 2020-09-30 2023-10-25 ガーダント ヘルス, インコーポレイテッド Dnaメチル化分配アッセイのシグナル対ノイズ比を改善するための方法およびシステム
WO2022087309A1 (en) 2020-10-23 2022-04-28 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and base conversion
EP4267757A1 (de) 2020-12-23 2023-11-01 Guardant Health, Inc. Verfahren und systeme zur analyse methylierter polynukleotide
KR20230156364A (ko) 2021-03-05 2023-11-14 가던트 헬쓰, 인크. 분자 반응을 분석하기 위한 방법 및 관련 측면
EP4305200A1 (de) 2021-03-09 2024-01-17 Guardant Health, Inc. Nachweis des vorhandenseins eines tumors auf der basis von off-target-polynukleotidsequenzierungsdaten
WO2022194764A1 (en) 2021-03-15 2022-09-22 F. Hoffmann-La Roche Ag Targeted next-generation sequencing via anchored primer extension
WO2022204321A1 (en) 2021-03-24 2022-09-29 Ambry Genetics Corporation Conservative concurrent evaluation of dna modifications
IL309799A (en) 2021-07-20 2024-02-01 Regeneron Pharma Butyrophilin-2-like substances for the treatment of inflammatory disorders
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring
EP4253550A1 (de) 2022-04-01 2023-10-04 GenCC GmbH 6 Co. KG Verfahren zur herstellung eines viralen, eines vektoriellen oder eines beliebigen transportsystems und krebsspezifischer crispr-komplexe
US20230360725A1 (en) 2022-05-09 2023-11-09 Guardant Health, Inc. Detecting degradation based on strand bias
US20250382676A1 (en) 2022-05-11 2025-12-18 Freya Biosciences Aps Methods of identifying strains associated with the human female genitourinary tract
EP4619985A1 (de) 2022-11-15 2025-09-24 Guardant Health, Inc. Verfahren zur vorhersage der drogenantwort oder zeit bis zum tod oder zur krebsprogression von ctdna-signalen
AU2023409008A1 (en) 2022-12-21 2025-06-26 Guardant Health, Inc. Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules
WO2024233502A1 (en) 2023-05-05 2024-11-14 Guardant Health, Inc. Cell-free dna blood-based test for cancer screening
WO2024259251A1 (en) 2023-06-15 2024-12-19 Guardant Health, Inc. Method for hrd detection in targeted cfdna samples using de novo mutational signatures
WO2025006972A1 (en) 2023-06-30 2025-01-02 Laboratory Corporation Of America Holdings Methods, compositions, and systems to detect head and neck cancer in saliva samples
EP4784800A1 (de) 2023-09-29 2026-08-05 Guardant Health, Inc. Genotypisierung von cyp2d6
WO2025090646A1 (en) 2023-10-27 2025-05-01 Guardant Health, Inc. Monitoring molecular response by allelic imbalance
WO2025104499A1 (en) 2023-11-15 2025-05-22 Freya Biosciences Aps Microbial consortia for treating vaginal conditions
WO2025104501A1 (en) 2023-11-15 2025-05-22 Freya Biosciences Aps Microbial consortia and uses thereof
WO2025179170A2 (en) 2024-02-22 2025-08-28 Canal Biosciences, Inc. Single-stranded end preserving adaptors
WO2026006629A1 (en) 2024-06-27 2026-01-02 Personalis, Inc. System and method for management of compressed sequencing files
EP4711456A1 (de) 2024-09-11 2026-03-18 GenCC GmbH & Co. KG Verfahren zur herstellung individualisierter crispr/cas-komplexe und individualisierter crispr/cas-komplexe

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
WO2001025485A2 (en) * 1999-10-06 2001-04-12 Amersham Biosciences Corp Method for detecting mutations using arrayed primer extension
US7282337B1 (en) * 2006-04-14 2007-10-16 Helicos Biosciences Corporation Methods for increasing accuracy of nucleic acid sequencing

Also Published As

Publication number Publication date
JP2009533060A (ja) 2009-09-17
CA2649291A1 (en) 2008-02-07
US7282337B1 (en) 2007-10-16
EP2007908A1 (de) 2008-12-31
WO2008016399A1 (en) 2008-02-07
EP2007908A4 (de) 2009-04-29
US20090053705A1 (en) 2009-02-26
EP2007908B1 (de) 2010-07-21
DE602007007924D1 (de) 2010-09-02
US20070243535A1 (en) 2007-10-18

Similar Documents

Publication Publication Date Title
DE602007007924D1 (de) Verfahren zur erhöhung der genauigkeit einer nukleinsäuresequenzierung
WO2007120859A3 (en) Methods for increasing accuracy of nucleic acid sequencing
ATE507305T1 (de) Verfahren zur nukleinsäureimmobilisierung
EP4424843C0 (de) Verfahren zur räumlichen analyse unter verwendung von rna-template-ligation
DE602006012052D1 (de) Verfahren zur sequenzierung einer polynukleotidmatrize
ATE548466T1 (de) Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktion
DE602006019261D1 (de) Verfahren zur sequenzierung einer polynukleotidmatrize
ATE522627T1 (de) Verfahren zur herstellung von nukleinsäuresonden
EP2168728A4 (de) Verfahren zur beurteilung von roboterfehlern
DE502004000787D1 (de) Verfahren zur Umsetzung von Polyorganosiloxanen
DE602007005911D1 (de) Verfahren zur Zubereitung von Kohlenstoff- Nanoröhrchen-verstärkten Fluorpolymerbeschichtungen
ATE445019T1 (de) Verfahren zur enzymatischen herstellung von (s)-3-cyano-5-methylhexansäure
EP4081648A4 (de) Verfahren und kit zur vorlagenunabhängigen nukleinsäuresynthese
DE602004023631D1 (de) Verfahren zur einführung einer nukleinsäure
EP3981757A4 (de) Verfahren zur herstellung von (e)-1,2-difluorethylen-haltigen reaktionsgasen
EP3765478C0 (de) Verfahren zur quantifizierung von rna- und dna-varianten durch sequenzierung unter verwendung von phosphorothioaten
EP4116438A4 (de) Verfahren zur detektion von coronavirus (sars-cov-2)
DE602007011380D1 (de) Verfahren zur Wiederherstellung einer Elektrode für die Elektrolyse
EP4555690A4 (de) Verfahren zur sicherung des einsatzes einer infrastruktur als code
WO2013017861A3 (en) Analysing sequencing bias
DE502006006803D1 (de) Verfahren zur herstellung von leder
EP3908677C0 (de) Verfahren zur detektion von nukleinsäuresequenzen
DE602005025002D1 (de) Verfahren zur herstellung von brenztraubensäure
EP4365287A4 (de) Verfahren zur förderung einer enzymatischen reaktion
ATE430716T1 (de) Verfahren zur reinigung einer wässrigen lösung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties