ATE475639T1 - Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren - Google Patents

Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren

Info

Publication number
ATE475639T1
ATE475639T1 AT06819799T AT06819799T ATE475639T1 AT E475639 T1 ATE475639 T1 AT E475639T1 AT 06819799 T AT06819799 T AT 06819799T AT 06819799 T AT06819799 T AT 06819799T AT E475639 T1 ATE475639 T1 AT E475639T1
Authority
AT
Austria
Prior art keywords
gamma
selective agonists
treating
biphenyl derivatives
rar receptors
Prior art date
Application number
AT06819799T
Other languages
English (en)
Inventor
Thibaud Biadatti
Etienne Thoreau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Application granted granted Critical
Publication of ATE475639T1 publication Critical patent/ATE475639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Lasers (AREA)
  • Steroid Compounds (AREA)
AT06819799T 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren ATE475639T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512762A FR2894960B1 (fr) 2005-12-15 2005-12-15 Derives biphenyliques agonistes selectifs du recepteurs rar-gamma
PCT/EP2006/068975 WO2007068579A1 (fr) 2005-12-15 2006-11-28 Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Publications (1)

Publication Number Publication Date
ATE475639T1 true ATE475639T1 (de) 2010-08-15

Family

ID=36956106

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06819799T ATE475639T1 (de) 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren

Country Status (14)

Country Link
US (1) US8106235B2 (de)
EP (1) EP1963249B1 (de)
AT (1) ATE475639T1 (de)
BR (1) BRPI0620667A2 (de)
CA (1) CA2632899C (de)
CY (1) CY1110795T1 (de)
DE (1) DE602006015850D1 (de)
DK (1) DK1963249T3 (de)
ES (1) ES2349478T3 (de)
FR (1) FR2894960B1 (de)
PL (1) PL1963249T3 (de)
PT (1) PT1963249E (de)
SI (1) SI1963249T1 (de)
WO (1) WO2007068579A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2613776T3 (pl) 2010-09-01 2021-01-11 Thomas Jefferson University Kompozycja oraz sposób naprawy i regeneracji mięśni
RU2753863C2 (ru) 2016-02-03 2021-08-24 Галдерма Ресерч Энд Девелопмент Новые биароматические соединения пропинила, фармацевтические и косметические композиции, их содержащие, и их применение
CN109952298B (zh) 2017-07-06 2021-09-03 江苏恒瑞医药股份有限公司 吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
EP3683206A4 (de) 2017-09-12 2021-01-13 Jiangsu Hengrui Medicine Co., Ltd. Deuteriumatom-substituiertes indolformamidderivat, herstellungsverfahren dafür und medizinische anwendungen davon
US11135236B2 (en) 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
CN120289357A (zh) * 2024-01-09 2025-07-11 江西科睿药业有限公司 联苯类化合物、其制备方法、中间体、药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
CA2545296C (en) * 2003-12-08 2012-10-16 Galderma Research & Development, S.N.C. Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics

Also Published As

Publication number Publication date
EP1963249B1 (de) 2010-07-28
US8106235B2 (en) 2012-01-31
US20090036536A1 (en) 2009-02-05
PT1963249E (pt) 2010-09-17
WO2007068579A1 (fr) 2007-06-21
BRPI0620667A2 (pt) 2011-11-22
FR2894960B1 (fr) 2008-02-29
PL1963249T3 (pl) 2011-02-28
EP1963249A1 (de) 2008-09-03
CA2632899A1 (fr) 2007-06-21
FR2894960A1 (fr) 2007-06-22
ES2349478T3 (es) 2011-01-03
SI1963249T1 (sl) 2010-10-29
CY1110795T1 (el) 2015-06-10
CA2632899C (fr) 2013-11-19
DK1963249T3 (da) 2010-11-01
DE602006015850D1 (de) 2010-09-09

Similar Documents

Publication Publication Date Title
ATE442347T1 (de) Biphenylderivate als selektive agonisten des gamma-rar-rezeptors
NI200900213A (es) Pirazol amidas de ácido carboxílico útiles como microbicidas.
EA201100875A1 (ru) Новые пиразол-4-n-алкоксикарбоксамиды в качестве микробиоцидов
CY1111758T1 (el) Τρικυκλικες ενωσεις και χρηση αυτων ως ρυθμιστες υποδοχεα γλυκοκορτικοειδους
EA201001456A1 (ru) Новые гетероциклические соединения и их применение
UA103625C2 (en) 5-hetrocyclylalkyl-3-hydroxy-2-phenylcyclopent-2-enons as herbicides
TN2010000064A1 (en) Novel herbicides
EA201000558A1 (ru) Производные имидазола
MX2010001364A (es) Derivados de ciclopentandiona puenteados triciclicos como herbicidas.
UA106880C2 (uk) Нові гербіциди
UA90706C2 (ru) Антагонисты рецептора pgd2 для лечения воспалительных заболеваний
CY1110795T1 (el) ΠΑΡΑΓΩΓΑ ΤΟΥ ΔΙΦΑΙΝΥΛΙΟΥ ΩΣ ΕΚΛΕΚΤΙΚΟΙ ΑΓΩΝΙΣΤΕΣ ΥΠΟΔΟΧΕΩΝ γ-RAR
ATE544751T1 (de) Chinolinderivate als crth2-rezeptorliganden
NO20082105L (no) Pyrazoloisokinolinderivater
ATE427927T1 (de) Phenylacetylenderivate mit affinitat zum mglur5- rezeptor
DE602006012694D1 (de) Benzimidazolthiophenverbindungen als plk-modulatoren
EA201000069A1 (ru) Новые гербициды
DE602006009789D1 (de) Acetylenderivate
EA200901504A1 (ru) Производные пиразолона, как ингибиторы pde4
MX2010002246A (es) Nuevos herbicidas.
DE602006021327D1 (de) Isochinoline als igf-1r-inhibitoren
DE602005005024D1 (de) Substituierte thieno- und thiazoloä2,3-düpyrimidine und ä2,3-cüpyridine als inhibitoren von tie2
EA200702419A1 (ru) Новые соединения как агонисты glp-1
ATE480529T1 (de) 2-hydroxy-propionsäure-derivate und 3-hydroxy- benzofuran-2-on-derivate mit affinität für den gaba-b-rezeptor
CL2008001913A1 (es) Procedimiento de prepararaciacin 2-(3-{6-[2-(2,4-diclorofenil)-etilamino]-2-metoxipirimidin-4-il}-fenil)-2-metil-propionico; y uno de los compuestos intermediarios usado el procedimiento descrito.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1963249

Country of ref document: EP