ATE475639T1 - Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren - Google Patents

Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren

Info

Publication number
ATE475639T1
ATE475639T1 AT06819799T AT06819799T ATE475639T1 AT E475639 T1 ATE475639 T1 AT E475639T1 AT 06819799 T AT06819799 T AT 06819799T AT 06819799 T AT06819799 T AT 06819799T AT E475639 T1 ATE475639 T1 AT E475639T1
Authority
AT
Austria
Prior art keywords
gamma
selective agonists
treating
biphenyl derivatives
rar receptors
Prior art date
Application number
AT06819799T
Other languages
English (en)
Inventor
Thibaud Biadatti
Etienne Thoreau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Application granted granted Critical
Publication of ATE475639T1 publication Critical patent/ATE475639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Lasers (AREA)
AT06819799T 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren ATE475639T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512762A FR2894960B1 (fr) 2005-12-15 2005-12-15 Derives biphenyliques agonistes selectifs du recepteurs rar-gamma
PCT/EP2006/068975 WO2007068579A1 (fr) 2005-12-15 2006-11-28 Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Publications (1)

Publication Number Publication Date
ATE475639T1 true ATE475639T1 (de) 2010-08-15

Family

ID=36956106

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06819799T ATE475639T1 (de) 2005-12-15 2006-11-28 Biphenylderivate als selektive agonisten von gamma-rar-rezeptoren

Country Status (14)

Country Link
US (1) US8106235B2 (de)
EP (1) EP1963249B1 (de)
AT (1) ATE475639T1 (de)
BR (1) BRPI0620667A2 (de)
CA (1) CA2632899C (de)
CY (1) CY1110795T1 (de)
DE (1) DE602006015850D1 (de)
DK (1) DK1963249T3 (de)
ES (1) ES2349478T3 (de)
FR (1) FR2894960B1 (de)
PL (1) PL1963249T3 (de)
PT (1) PT1963249E (de)
SI (1) SI1963249T1 (de)
WO (1) WO2007068579A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4066826B1 (de) 2010-09-01 2024-03-06 Thomas Jefferson University Retinsäure-rezeptor-gamma-agonisten zur muskelreparatur und -regeneration
CN109414384A (zh) * 2016-02-03 2019-03-01 高德美研究及发展公司 新的双芳香基丙炔基化合物，包含该化合物的药物和化妆品组合物及其用途
RU2742770C1 (ru) 2017-07-06 2021-02-10 Цзянсу Хэнжуй Медицин Ко., Лтд. Производное индола и формамида, способ его получения и применение в медицине
AU2018331125A1 (en) 2017-09-12 2020-03-05 Jiangsu Hengrui Medicine Co., Ltd. Deuterium atom-substituted indole formamide derivative, preparation method therefor, and medical applications thereof
US11135236B2 (en) 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
TW202542114A (zh) * 2024-01-09 2025-11-01 大陸商江西科睿藥業有限公司 聯苯類化合物、其製備方法、中間體、藥物組合物和應用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
EP1692093B1 (de) * 2003-12-08 2008-11-19 Galderma Research & Development Biphenylderivate, die sich als rar-rezeptor-aktivierende liganden eignen, verfahren zu deren herstellung und deren verwendung in der humanmedizin und in kosmetika

Also Published As

Publication number Publication date
FR2894960B1 (fr) 2008-02-29
CY1110795T1 (el) 2015-06-10
EP1963249A1 (de) 2008-09-03
US20090036536A1 (en) 2009-02-05
WO2007068579A1 (fr) 2007-06-21
EP1963249B1 (de) 2010-07-28
BRPI0620667A2 (pt) 2011-11-22
PT1963249E (pt) 2010-09-17
DK1963249T3 (da) 2010-11-01
CA2632899A1 (fr) 2007-06-21
ES2349478T3 (es) 2011-01-03
DE602006015850D1 (de) 2010-09-09
FR2894960A1 (fr) 2007-06-22
SI1963249T1 (sl) 2010-10-29
US8106235B2 (en) 2012-01-31
CA2632899C (fr) 2013-11-19
PL1963249T3 (pl) 2011-02-28

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