DK1963249T3 - Biphenylderivater som selektive agonister af gamma-RAR-receptorer - Google Patents

Biphenylderivater som selektive agonister af gamma-RAR-receptorer

Info

Publication number
DK1963249T3
DK1963249T3 DK06819799.5T DK06819799T DK1963249T3 DK 1963249 T3 DK1963249 T3 DK 1963249T3 DK 06819799 T DK06819799 T DK 06819799T DK 1963249 T3 DK1963249 T3 DK 1963249T3
Authority
DK
Denmark
Prior art keywords
gamma
selective agonists
treating
biphenyl derivatives
rar receptors
Prior art date
Application number
DK06819799.5T
Other languages
English (en)
Inventor
Thibaud Biadatti
Etienne Thoreau
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Application granted granted Critical
Publication of DK1963249T3 publication Critical patent/DK1963249T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/17—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Lasers (AREA)
DK06819799.5T 2005-12-15 2006-11-28 Biphenylderivater som selektive agonister af gamma-RAR-receptorer DK1963249T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0512762A FR2894960B1 (fr) 2005-12-15 2005-12-15 Derives biphenyliques agonistes selectifs du recepteurs rar-gamma
PCT/EP2006/068975 WO2007068579A1 (fr) 2005-12-15 2006-11-28 Derives biphenyliques agonistes selectifs du recepteur rar-gamma

Publications (1)

Publication Number Publication Date
DK1963249T3 true DK1963249T3 (da) 2010-11-01

Family

ID=36956106

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06819799.5T DK1963249T3 (da) 2005-12-15 2006-11-28 Biphenylderivater som selektive agonister af gamma-RAR-receptorer

Country Status (14)

Country Link
US (1) US8106235B2 (da)
EP (1) EP1963249B1 (da)
AT (1) ATE475639T1 (da)
BR (1) BRPI0620667A2 (da)
CA (1) CA2632899C (da)
CY (1) CY1110795T1 (da)
DE (1) DE602006015850D1 (da)
DK (1) DK1963249T3 (da)
ES (1) ES2349478T3 (da)
FR (1) FR2894960B1 (da)
PL (1) PL1963249T3 (da)
PT (1) PT1963249E (da)
SI (1) SI1963249T1 (da)
WO (1) WO2007068579A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111773213B (zh) 2010-09-01 2023-02-24 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
SG11201806628UA (en) * 2016-02-03 2018-09-27 Galderma Res & Dev New bi-aromatic propynyl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof
RU2742770C1 (ru) 2017-07-06 2021-02-10 Цзянсу Хэнжуй Медицин Ко., Лтд. Производное индола и формамида, способ его получения и применение в медицине
US20200277278A1 (en) 2017-09-12 2020-09-03 Jiangsu Hengrui Medicine Co., Ltd. Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof
US11135236B2 (en) 2018-04-10 2021-10-05 Northwestern University Retinoic acid receptor gamma agonists to attenuate anthracycline-induced cardiotoxicity
CN120289357A (zh) * 2024-01-09 2025-07-11 江西科睿药业有限公司 联苯类化合物、其制备方法、中间体、药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
CA2545296C (en) * 2003-12-08 2012-10-16 Galderma Research & Development, S.N.C. Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics

Also Published As

Publication number Publication date
EP1963249A1 (fr) 2008-09-03
SI1963249T1 (sl) 2010-10-29
ES2349478T3 (es) 2011-01-03
WO2007068579A1 (fr) 2007-06-21
PL1963249T3 (pl) 2011-02-28
FR2894960B1 (fr) 2008-02-29
PT1963249E (pt) 2010-09-17
BRPI0620667A2 (pt) 2011-11-22
CY1110795T1 (el) 2015-06-10
EP1963249B1 (fr) 2010-07-28
ATE475639T1 (de) 2010-08-15
FR2894960A1 (fr) 2007-06-22
US8106235B2 (en) 2012-01-31
DE602006015850D1 (de) 2010-09-09
CA2632899A1 (fr) 2007-06-21
US20090036536A1 (en) 2009-02-05
CA2632899C (fr) 2013-11-19

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