ATE477049T1 - Mikrofluidische vorrichtung zur analyse und handhabung von flüssigkeiten - Google Patents

Mikrofluidische vorrichtung zur analyse und handhabung von flüssigkeiten

Info

Publication number
ATE477049T1
ATE477049T1 AT05760971T AT05760971T ATE477049T1 AT E477049 T1 ATE477049 T1 AT E477049T1 AT 05760971 T AT05760971 T AT 05760971T AT 05760971 T AT05760971 T AT 05760971T AT E477049 T1 ATE477049 T1 AT E477049T1
Authority
AT
Austria
Prior art keywords
analyzing
microfluidic device
handling liquids
sample
microfluidic devices
Prior art date
Application number
AT05760971T
Other languages
English (en)
Inventor
Patrick Saltsman
Mingchao Shen
Jeffrey Houkal
Christy Lancaster
C Frederick Battrell
Bernhard Weigl
Original Assignee
Micronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micronics Inc filed Critical Micronics Inc
Application granted granted Critical
Publication of ATE477049T1 publication Critical patent/ATE477049T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3141—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit with additional mixing means other than injector mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AT05760971T 2004-06-17 2005-06-15 Mikrofluidische vorrichtung zur analyse und handhabung von flüssigkeiten ATE477049T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/870,717 US7419638B2 (en) 2003-01-14 2004-06-17 Microfluidic devices for fluid manipulation and analysis
PCT/US2005/021092 WO2006009724A2 (en) 2004-06-17 2005-06-15 Microfluidic devices for fluid manipulation and analysis

Publications (1)

Publication Number Publication Date
ATE477049T1 true ATE477049T1 (de) 2010-08-15

Family

ID=34993245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05760971T ATE477049T1 (de) 2004-06-17 2005-06-15 Mikrofluidische vorrichtung zur analyse und handhabung von flüssigkeiten

Country Status (6)

Country Link
US (6) US7419638B2 (de)
EP (1) EP1773481B1 (de)
JP (1) JP4885852B2 (de)
AT (1) ATE477049T1 (de)
DE (1) DE602005022878D1 (de)
WO (1) WO2006009724A2 (de)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US8518328B2 (en) * 2005-12-27 2013-08-27 Honeywell International Inc. Fluid sensing and control in a fluidic analyzer
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
EP1654066B1 (de) 2003-07-31 2014-11-12 Handylab, Inc. Verarbeitung von teilchenhaltigen proben
US20050047967A1 (en) * 2003-09-03 2005-03-03 Industrial Technology Research Institute Microfluidic component providing multi-directional fluid movement
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP2345739B8 (de) 2004-05-03 2016-12-07 Handylab, Inc. Mikrofluidische Vorrichtung zur Verarbeitung polynukleotidhaltiger Proben
DE102005052752A1 (de) * 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
US20060183216A1 (en) * 2005-01-21 2006-08-17 Kalyan Handique Containers for liquid storage and delivery with application to microfluidic devices
KR101381331B1 (ko) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
WO2007005365A2 (en) * 2005-06-29 2007-01-11 Cascade Microtech, Inc. A fluid dispensing system
EP1936383A4 (de) * 2005-10-13 2009-04-29 Nissui Pharm Co Ltd Testeinrichtung
JP5377972B2 (ja) * 2005-11-22 2013-12-25 マイクロラボ ピーティーワイ エルティーディー 流体構造、装置、方法、及び機器構成方法
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7485153B2 (en) * 2005-12-27 2009-02-03 Honeywell International Inc. Fluid free interface for a fluidic analyzer
US8182767B2 (en) * 2005-12-27 2012-05-22 Honeywell International Inc. Needle-septum interface for a fluidic analyzer
JP5254949B2 (ja) 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
DK2001990T3 (en) 2006-03-24 2016-10-03 Handylab Inc Integrated microfluidic sample processing system and method for its use
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US20070280857A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Positioning Dried Reagent In Microfluidic Devices
EP2041573B1 (de) * 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Verfahren und vorrichtung für mikrofluidische point-of-care-immunoassays
WO2008147382A1 (en) * 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US20090042241A1 (en) 2007-04-06 2009-02-12 California Institute Of Technology Microfluidic device
JP4947139B2 (ja) * 2007-04-13 2012-06-06 株式会社島津製作所 反応容器プレート及び反応処理方法
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
EP2171420A1 (de) * 2007-07-31 2010-04-07 Micronics, Inc. Tupferaufnahmesystem, mikrofluidische testvorrichtung und verfahren für diagnosetests
JP2010535502A (ja) * 2007-08-07 2010-11-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 遺伝子合成のための一体型マイクロ流体デバイス
EP2040073A1 (de) 2007-09-20 2009-03-25 Iline Microsystems, S.L. Mikrofluidische Vorrichtung und Verfahren zur Flüssigkeitsgerinnungs-Zeitbestimmung
EP2055384A1 (de) * 2007-10-31 2009-05-06 Leukocare AG Vorrichtung zum Nachweis von Bestandteilen in einem Fluid
GB0802084D0 (en) * 2008-02-05 2008-03-12 Univ Dublin City Microfluidic device for assessing cell surface interactions
US9664619B2 (en) * 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
EP3002489B1 (de) * 2008-05-16 2017-09-20 President and Fellows of Harvard College Ventile und andere flusssteuerungen für fluidische systeme einschliesslich mikrofluidischer systeme
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
WO2010012281A1 (en) * 2008-07-29 2010-02-04 Jacques Jonsmann A microfluidic device
JP4722977B2 (ja) * 2008-08-27 2011-07-13 シャープ株式会社 検出器具、分析装置、検出方法および検出器具の制御方法
US8318439B2 (en) 2008-10-03 2012-11-27 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching
EP2202517B1 (de) * 2008-12-23 2012-08-08 C A Casyso AG Kartuschenvorrichtung für ein Messsystem zur Messung der viskoelastischen Eigenschaften einer Probenflüssigkeit, zugehöriges Messsystem und zugehöriges Verfahren
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
WO2010101621A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Devices and methods for the analysis of an extractable medium
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20110105952A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Relatively small devices applied to the skin, modular systems, and methods of use thereof
US20110105951A1 (en) * 2009-10-30 2011-05-05 Seventh Sense Biosystems, Inc. Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
CN102448612B (zh) 2009-04-13 2014-12-03 精密公司 微流体临床分析器
WO2011062738A1 (en) 2009-11-23 2011-05-26 Mikhail Briman Controlled electrochemical activation of carbon-based electrodes
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
EP2576066A4 (de) * 2010-05-27 2015-01-07 3M Innovative Properties Co Integrierte systeme und anordnungen zur probenverarbeitung
JP2013538069A (ja) 2010-07-16 2013-10-10 セブンス センス バイオシステムズ，インコーポレーテッド 流体移動デバイスのための低圧環境
EP2596347B1 (de) 2010-07-22 2017-09-06 Hach Company Alkalinitätsanalyse mittels lab-on-chip
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
US9387476B2 (en) * 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
EP2637562B1 (de) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systeme und schnittstellen zur blutabnahme
US9157903B2 (en) 2011-02-25 2015-10-13 Honeywell International Inc. Microfluidic separation of plasma for colormetric assay
EP2697657B8 (de) 2011-04-15 2017-08-16 Becton, Dickinson and Company Mikrofluidischer abtastender echtzeit-thermocycler und verfahren zur optischen detektion mittels synchronisierter thermozyklierung und abtastung
JP2014516644A (ja) 2011-04-29 2014-07-17 セブンス センス バイオシステムズ，インコーポレーテッド 血斑または他の体液の収集および／または操作のためのデバイスおよび方法
EP2701600B1 (de) 2011-04-29 2016-06-08 Seventh Sense Biosystems, Inc. Ausgabe und/oder aufnahme von flüssigkeiten
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
US9599613B2 (en) 2011-07-20 2017-03-21 University Of Washington Through Its Center For Commercialization Photonic blood typing
US9638663B2 (en) 2011-07-25 2017-05-02 Proxim Diagnostics Corporation Cartridge for diagnostic testing
US8975193B2 (en) 2011-08-02 2015-03-10 Teledyne Dalsa Semiconductor, Inc. Method of making a microfluidic device
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
DK3273253T3 (da) 2011-09-30 2020-10-12 Becton Dickinson Co Forenet reagensstrimmel
EP2773892B1 (de) 2011-11-04 2020-10-07 Handylab, Inc. Vorrichtung zur vorbereitung von polynukleotidproben
JP6190822B2 (ja) 2012-01-09 2017-08-30 マイクロニクス， インコーポレイテッド マイクロ流体リアクタシステム
USD709620S1 (en) * 2012-01-13 2014-07-22 Hewlett-Packard Development Company, L. P. Fluidic dispense device
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
DK2810080T3 (da) 2012-02-03 2024-06-17 Becton Dickinson Co Eksterne filer til fordeling af molekylære diagnostiske tests og bestemmelse af kompatabilitet imellem tests
CN102588256B (zh) * 2012-02-22 2014-08-06 重庆理工大学 一种具有自关闭单向阀的单层双腔真空驱动的蠕动泵
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
KR102054678B1 (ko) * 2012-07-12 2020-01-22 삼성전자주식회사 유체 분석 카트리지
JP6319590B2 (ja) 2012-10-08 2018-05-09 ゼネラル・エレクトリック・カンパニイ マイクロ流体素子を用いるｌａｌ反応性物質試験方法及び装置
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP3427830B1 (de) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrierte multiplex-zielanalyse
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
WO2014089120A1 (en) 2012-12-07 2014-06-12 Integrated Plasmonics Corporation Plasmonic spectroscopic sensor and cuvette therefor
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
JP6298474B2 (ja) 2012-12-17 2018-03-20 レウコドゥックス，リミテッド 生物学的状態を検出するシステムおよび方法
US20140170678A1 (en) * 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
WO2014100743A2 (en) 2012-12-21 2014-06-26 Micronics, Inc. Low elasticity films for microfluidic use
US9976963B2 (en) * 2012-12-21 2018-05-22 Integrated Plasmonics Corporation Microcuvette cartridge
EP2935559B1 (de) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluoreszenznachweissystem
EP2935908B1 (de) 2012-12-21 2019-08-14 PerkinElmer Health Sciences, Inc. Fluidkreisläufe und zugehörige herstellungsverfahren
EP3450984B1 (de) 2013-01-31 2020-10-07 Luminex Corporation Flüssigkeitsretentionsplatten und analysepatronen
US10481089B2 (en) 2013-03-12 2019-11-19 Integrated Plasmonics Corporation Optical detection system with tilted sensor
US9995623B2 (en) 2013-03-14 2018-06-12 Integrated Plasmonics Corporation Ambient light assisted spectroscopy
WO2014143234A1 (en) 2013-03-14 2014-09-18 Integrated Plasmonics Corporation Self-aligned spatial filter
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス， インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
BR112015022738B1 (pt) * 2013-03-15 2022-11-29 Labrador Diagnostics Llc Dispositivo para utilização com um componente de amostra líquida formado
US9506934B2 (en) * 2013-04-29 2016-11-29 Honeywell International Inc. Polymer test cartridge mixer for cell lysis
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
EP2994532B1 (de) 2013-05-07 2017-11-15 Micronics, Inc. Verfahren zur herstellung von nukleinsäurehaltigen proben mittels tonmineralien und alkalischen lösungen
EP2994543B1 (de) 2013-05-07 2018-08-15 Micronics, Inc. Vorrichtung zur herstellung und analyse von nukleinsäuren
EP3030352B1 (de) 2013-08-07 2019-03-20 Roche Diagnostics GmbH Kartusche zur abgabe einer flüssigkeit, automatisches analysegerät und verfahren zur analyse einer biologischen probe
US9562914B2 (en) * 2013-10-16 2017-02-07 President And Fellows Of Harvard College Microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
EP3137935B1 (de) * 2014-04-30 2023-07-05 Hewlett-Packard Development Company, L.P. Bildegebungsvorrichtung mit verwendung von diffraktionsbasierter beleuchtung
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
EP3160647B1 (de) * 2014-06-30 2021-07-28 Siemens Healthcare Diagnostics Inc. Mikrofluidische testkartusche ohne aktive fluidregelung
WO2016033455A1 (en) 2014-08-29 2016-03-03 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, devices, and systems for microfluidic stress emulation
US10816559B2 (en) 2014-09-29 2020-10-27 Ca Casyso Ag Blood testing system and method
US10175225B2 (en) 2014-09-29 2019-01-08 C A Casyso Ag Blood testing system and method
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10981166B2 (en) 2015-06-11 2021-04-20 Neofluidics Llc Manual or electronic pipette driven well plate for nano-liter droplet storage and methods of using same
WO2017001436A1 (en) * 2015-06-29 2017-01-05 Imec Vzw Valve-less mixing method and mixing device
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
JP6903678B2 (ja) * 2016-02-19 2021-07-14 ペルキネルマー ヘルス サイエンシーズ， インコーポレイテッド マイクロ流体混合デバイスおよび方法
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
JP6891191B2 (ja) 2016-03-14 2021-06-18 ルシラ ヘルス インコーポレイテッド 光学的性質を改変するための装置および方法
JP2019509740A (ja) * 2016-03-14 2019-04-11 ディアスセス インコーポレイテッド 選択的に通気される生物学的アッセイ装置および関連の方法
EP3493908B1 (de) * 2016-08-05 2023-11-29 Vital Signs Solutions Limited Vorrichtung und verfahren zur flüssigkeitsanalyse zur detektion von biomarkern
US11192102B2 (en) * 2017-02-28 2021-12-07 Lmsera Inc. Microfluidic device
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
WO2018175169A1 (en) * 2017-03-20 2018-09-27 Wainamics, Inc. Small volume self-metered blood separation device
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
DE102017205978B4 (de) * 2017-04-07 2021-11-04 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidisches System zur Kultivierung von oder der Analyse an lebenden Zellen oder Biomolekülen sowie ein Verfahren zu seiner Herstellung
MX392516B (es) 2017-09-14 2025-03-24 Pfizer Dispositivo de ensayo biologico multiplexado con lectura electronica
CN111247433B (zh) * 2017-10-23 2023-05-30 国立大学法人山梨大学 分配设备、使用分配设备的分配装置及方法、以及检查装置及方法
USD878622S1 (en) * 2018-04-07 2020-03-17 Precision Nanosystems Inc. Microfluidic chip
US11925932B2 (en) 2018-04-24 2024-03-12 Hewlett-Packard Development Company, L.P. Microfluidic devices
US11931738B2 (en) 2018-04-24 2024-03-19 Hewlett-Packard Development Company, L.P. Sequenced droplet ejection to deliver fluids
DE102018206463A1 (de) * 2018-04-26 2019-10-31 Robert Bosch Gmbh Verfahren zum Verdünnen, Mischen und/oder Aliquotieren von zwei Flüssigkeiten in einem mikrofluidisches System
CN108855264A (zh) * 2018-07-12 2018-11-23 北京乐普智慧医疗科技有限公司 一种多用途多指标微流控芯片
US11325380B2 (en) 2018-07-17 2022-05-10 Hewlett-Packard Development Company, L.P. Droplet ejectors to provide fluids to droplet ejectors
US11547993B2 (en) 2018-07-17 2023-01-10 Hewlett-Packard Development Company, L.P. Droplet ejectors with target media
CN110237763A (zh) * 2019-05-15 2019-09-17 铜仁学院 一种基础医学实验用药剂混合制备装置
USD993443S1 (en) * 2020-02-04 2023-07-25 Ut-Battelle, Llc Microfluidic glass chip interface bracket
USD989342S1 (en) * 2020-02-04 2023-06-13 Ut-Battelle, Llc Microfluidic polymer chip interface bracket
JP2023529913A (ja) 2020-06-09 2023-07-12 ベクトン・ディキンソン・アンド・カンパニー 生物学的流体分離デバイス
CN111855993A (zh) * 2020-07-21 2020-10-30 北京化工大学 一种基于声波微流体的高灵敏度快速免疫检测方法和应用
US11680875B2 (en) 2020-12-16 2023-06-20 International Business Machines Corporation Microfluidic devices with capillary dilutors
AT525192A1 (de) 2021-06-15 2023-01-15 Genspeed Biotech Gmbh Mikrofluidischer chip
EP4162875A1 (de) * 2021-10-08 2023-04-12 Homedicus GmbH Mikrofluidische flüssigkeitsentnahmevorrichtung
CN113952892B (zh) * 2021-12-03 2023-10-10 花安堂生物科技集团有限公司 一种利用负压制备悬浮微液滴的方法
CN114324753A (zh) * 2021-12-21 2022-04-12 广州万孚生物技术股份有限公司 试剂卡
CN114324958B (zh) * 2022-03-17 2022-05-24 天津德祥生物技术有限公司 一种基于加样组件进行检测的方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL89406C (de) 1951-07-28
LU61733A1 (de) * 1969-12-04 1971-01-18
US3640267A (en) 1969-12-15 1972-02-08 Damon Corp Clinical sample container
US3799742A (en) 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
US5128104A (en) 1987-04-27 1992-07-07 Murphy Harold R Cuvette for automated testing machine
US4952516A (en) 1987-06-12 1990-08-28 Pall Corporation Self-venting diagnostic test device
US5338689A (en) 1987-08-24 1994-08-16 Stiftung Fur Diagnostische Forschung Method and card for detecting antigens and/or antibodies
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
JPH0417861A (ja) * 1990-05-11 1992-01-22 Ube Ind Ltd 血漿採取装置
US5387526A (en) * 1990-09-11 1995-02-07 General Atomics Coated capillary tube for the controlled release of reagent
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US5478751A (en) 1993-12-29 1995-12-26 Abbott Laboratories Self-venting immunodiagnositic devices and methods of performing assays
US5728352A (en) * 1994-11-14 1998-03-17 Advanced Care Products Disposable electronic diagnostic instrument
US5731212A (en) * 1994-12-20 1998-03-24 International Technidyne Corporation Test apparatus and method for testing cuvette accommodated samples
AU6541596A (en) 1995-06-16 1997-01-15 University Of Washington Microfabricated differential extraction device and method
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
JP3213566B2 (ja) 1996-04-26 2001-10-02 アークレイ株式会社 検体分析用具およびそれを用いた検体分析方法並びに検体分析装置
US6001307A (en) * 1996-04-26 1999-12-14 Kyoto Daiichi Kagaku Co., Ltd. Device for analyzing a sample
US5788927A (en) * 1996-07-30 1998-08-04 Bayer Corporation Unified fluid circuit assembly for a clinical hematology instrument
US6136272A (en) 1997-09-26 2000-10-24 University Of Washington Device for rapidly joining and splitting fluid layers
US5984129A (en) 1997-12-29 1999-11-16 Pasinski; Tom Movable paint tray assembly for applying a liquid to a roller
JP3654779B2 (ja) 1998-01-06 2005-06-02 東京エレクトロン株式会社 基板洗浄具及び基板洗浄方法
WO1999060397A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6451610B1 (en) * 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
WO2001013127A1 (en) * 1999-08-11 2001-02-22 Asahi Kasei Kabushiki Kaisha Analyzing cartridge and liquid feed control device
AU7101000A (en) * 1999-09-10 2001-04-10 Caliper Technologies Corporation Microfabrication methods and devices
WO2001026813A2 (en) 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
EP1263533B1 (de) * 2000-03-14 2010-03-03 Micronics, Inc. Mikrofluid-analysekassette
EP1285106A2 (de) 2000-03-31 2003-02-26 Micronics, Inc. Proteinkristallisierung in mikroflüssigkeitstrukturen
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002001081A2 (en) * 2000-06-23 2002-01-03 Micronics, Inc. Valve for use in microfluidic structures
JP3406281B2 (ja) 2000-07-05 2003-05-12 清水製薬株式会社 カテーテル
EP1336097A4 (de) * 2000-10-13 2006-02-01 Fluidigm Corp Probeninjektionssystem auf der basis einer mikrofluidischen einrichtung für analytische einrichtungen
WO2002040874A1 (en) * 2000-11-16 2002-05-23 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
EP1488454B1 (de) * 2001-02-16 2013-01-16 Ignis Innovation Inc. Pixeltreiberschaltung für eine organische leuchtdiode
EP1377821A2 (de) * 2001-04-03 2004-01-07 Micronics, Inc. Pneumatische ventilanpassung für mikrofluide schaltkreise
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
US20020155010A1 (en) 2001-04-24 2002-10-24 Karp Christoph D. Microfluidic valve with partially restrained element
JP2002371955A (ja) * 2001-06-15 2002-12-26 Sanuki Kogyo Kk 往復駆動装置及び該装置を使用した送液ポンプ
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
US7524462B2 (en) * 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
US7467928B2 (en) * 2002-12-12 2008-12-23 Board Of Trustees Of The University Of Arkansas Microfluidic device utilizing magnetohydrodynamics and method for fabrication thereof
JP2006517029A (ja) 2003-01-14 2006-07-13 マイクロニクス， インコーポレイテッド 流体操作および分析のための微小流体デバイス
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
AU2004205671A1 (en) * 2003-01-21 2004-08-05 Perkinelmer Health Sciences, Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
WO2004089810A2 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US20060245978A1 (en) * 2003-04-04 2006-11-02 Koninklijke Philips Electronics N.V. Fluid partitioning in multiple microchannels
US7079092B2 (en) * 2003-04-25 2006-07-18 Barco Nv Organic light-emitting diode (OLED) pre-charge circuit for use in a common anode large-screen display
US20040224425A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Biomolecule open channel solid phase extraction systems and methods
JP4168836B2 (ja) * 2003-06-03 2008-10-22 ソニー株式会社 表示装置
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
WO2007005365A2 (en) * 2005-06-29 2007-01-11 Cascade Microtech, Inc. A fluid dispensing system
CA2518276A1 (en) * 2005-09-13 2007-03-13 Ignis Innovation Inc. Compensation technique for luminance degradation in electro-luminance devices
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7976795B2 (en) * 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems
US20070280856A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Controlling Bubble Formation in Microfluidic Devices

Also Published As

Publication number Publication date
US20050106066A1 (en) 2005-05-19
DE602005022878D1 (de) 2010-09-23
US8557198B2 (en) 2013-10-15
JP4885852B2 (ja) 2012-02-29
WO2006009724A2 (en) 2006-01-26
US7419638B2 (en) 2008-09-02
WO2006009724A3 (en) 2006-05-04
US8318109B2 (en) 2012-11-27
JP2008503722A (ja) 2008-02-07
US20120064612A1 (en) 2012-03-15
US20090022624A1 (en) 2009-01-22
EP1773481A2 (de) 2007-04-18
US20140010736A1 (en) 2014-01-09
US8697009B2 (en) 2014-04-15
US20140370581A1 (en) 2014-12-18
US20100173395A1 (en) 2010-07-08
EP1773481B1 (de) 2010-08-11

Similar Documents

Publication Publication Date Title
DE602005022878D1 (de) Mikrofluidische vorrichtung zur analyse und handhabung von flüssigkeiten
WO2004065930A3 (en) Microfluidic devices for fluid manipulation and analysis
DE602004018256D1 (de) Wegwerfbare vorsterilisierte Flüssigkeitsentnahmevorrichtung
ATE540750T1 (de) Mikrofluidische vorrichtung und verfahren
US10981166B2 (en) Manual or electronic pipette driven well plate for nano-liter droplet storage and methods of using same
EP3258240A3 (de) Screening-kit und -verfahren
WO2007137119A3 (en) Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
WO2012048096A3 (en) Improved sample test cards
WO2007081386A3 (en) Microfluidic devices and methods of use
EP2297586A4 (de) Kartusche mit einem reagens, mikrofluidische vorrichtung mit der kartusche, verfahren zur herstellung der mikrofluidischen vorrichtung sowie verfahren für biochemische analysen mit der mikrofluidischen vorrichtung
SE0601354L (sv) Ny analysanordning
ATE541639T1 (de) Analysesystem und verfahren zur analyse einer körperflüssigkeitsprobe auf einen darin enthaltenen analyten
WO2007111651A3 (en) Systems and methods of sample processing and fluid control in a fluidic system
DE60039336D1 (de) Fluid-Transport durch Druckvariation zur Analyse biologischer Flüssigkeiten
CA2931582C (en) Microfluidic cartridge for molecular diagnosis, docking station using such a microfluidic cartridge, and process for analyzing a biological sample
WO2006081324A3 (en) Dnd purification and analysis on nanoengineered surfaces
WO2006127191A3 (en) Analysis engine and database for manipulating parameters for fluidic systems on a chip
EP3954457A3 (de) Mikrohergestellte vorrichtung mit mikroumgebungssensoren zur prüfung der koagulation in fluidproben
WO2008051659A8 (en) Apparatus for aspirating and dispensing liquids in an automated analyzer
ATE370312T1 (de) Vorrichtung zur analyse mindestens eines in einer flüssigkeit, insbesondere einer bohrflüssigkeit, enthaltenen gases
SE0702489L (sv) Anordning för biokemisk bearbetning och analys av provvätska
Rho et al. Programmable v-type valve for cell and particle manipulation in microfluidic devices
EP4286053A4 (de) Strömungskanal zur sortierung biologischer partikel und mikrofluidischer chip
WO2008133698B1 (en) Hydrodynamic isolation method and apparatus
GB2598174B (en) Operation of a microfluidic device in the analysis of sample substances

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties