ATE477814T1 - Stabile faktor-viii enthaltende pharmazeutische zusammensetzung - Google Patents

Stabile faktor-viii enthaltende pharmazeutische zusammensetzung

Info

Publication number: ATE477814T1
Authority: AT; Austria
Prior art keywords: viii; pharmaceutical composition; composition containing; containing stable; stable factor
Prior art date: 2002-03-26

Application number

AT03712418T

Other languages

English (en)

Inventor

Mary White

Paul Webb

Original Assignee

Ipsen Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-26

Filing date

2003-03-26

Publication date

2010-09-15

2003-03-26 Application filed by Ipsen Pharma filed Critical Ipsen Pharma

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE477814T1 publication Critical patent/ATE477814T1/de

Links

229960000301 factor viii Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT03712418T 2002-03-26 2003-03-26 Stabile faktor-viii enthaltende pharmazeutische zusammensetzung ATE477814T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0207092.8A GB0207092D0 (en)	2002-03-26	2002-03-26	Stable pharmaceutical composition containing factor VIII
PCT/GB2003/001297 WO2003080108A1 (en)	2002-03-26	2003-03-26	Stable pharmaceutical composition containing factor viii

Publications (1)

Publication Number	Publication Date
ATE477814T1 true ATE477814T1 (de)	2010-09-15

Family

ID=9933726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03712418T ATE477814T1 (de)	2002-03-26	2003-03-26	Stabile faktor-viii enthaltende pharmazeutische zusammensetzung

Country Status (26)

Country	Link
US (1)	US7790680B2 (de)
EP (2)	EP2292216A3 (de)
JP (4)	JP2005530714A (de)
KR (1)	KR20040093482A (de)
CN (2)	CN1642570B (de)
AR (1)	AR039123A1 (de)
AT (1)	ATE477814T1 (de)
AU (1)	AU2003217030B2 (de)
BR (1)	BR0308442A (de)
CA (1)	CA2480226C (de)
DE (1)	DE60333825D1 (de)
DK (1)	DK1490095T3 (de)
ES (1)	ES2350337T3 (de)
GB (1)	GB0207092D0 (de)
HR (1)	HRP20040882B1 (de)
IL (2)	IL163849A0 (de)
IS (1)	IS7458A (de)
MX (1)	MXPA04009275A (de)
MY (1)	MY149831A (de)
NO (1)	NO328450B1 (de)
NZ (1)	NZ535032A (de)
PL (1)	PL208009B1 (de)
PT (1)	PT1490095E (de)
RU (1)	RU2314825C2 (de)
TW (1)	TWI285106B (de)
WO (1)	WO2003080108A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7560107B2 (en)	1996-06-26	2009-07-14	Emory University	Modified factor VIII
RU2329823C2 (ru) *	2002-10-29	2008-07-27	Алза Корпорейшн	Стабилизированные твердые полипептидные частицы
US7485291B2 (en)	2003-06-03	2009-02-03	Cell Genesys, Inc.	Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
WO2005017149A1 (en)	2003-06-03	2005-02-24	Cell Genesys, Inc.	Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
EP1685160A1 (de) *	2003-11-10	2006-08-02	Arriva-Prometic Inc.	Trockene rekombinante humane alpha 1-antitrypsin-zusammensetzung
DK1750733T3 (da) *	2004-05-03	2014-01-20	Univ Emory	FREMGANGSMÅDE TIL INDGIVELSE AF SVINE-B-DOMÆNELØS fVIII
ES2640343T3 (es)	2008-04-21	2017-11-02	Novo Nordisk Health Care Ag	Composición de transglutaminasa anhidra
EP2113564A1 (de)	2008-05-01	2009-11-04	Arecor Limited	Proteinformulierung
MX2011001624A (es)	2008-08-21	2011-03-28	Octapharma Ag	Factor viii y ix humano producido en forma recombinante.
WO2010026186A1 (en) *	2008-09-03	2010-03-11	Octapharma Ag	New protecting compositions for recombinantly produced factor viii
MX339060B (es)	2008-11-07	2016-05-09	Baxter Int	Formulaciones del factor viii.
GB0915480D0 (en) *	2009-09-04	2009-10-07	Arecor Ltd	Stable formulation of factor viii
DK2635297T3 (da)	2010-11-05	2019-05-06	Baxalta GmbH	En ny variant af antihæmofil faktor viii, der har en øget specifik aktivitet
EP4122487A1 (de)	2013-03-15	2023-01-25	Bioverativ Therapeutics Inc.	Faktor-viii-polypeptidformulierungen
SG10201803999UA (en) *	2013-03-15	2018-06-28	Bayer Healthcare Llc	Recombinant factor viii formulations
CN106687126B (zh)	2014-08-04	2020-07-28	杰特有限公司	因子viii制剂
JP6781508B2 (ja) *	2014-11-18	2020-11-04	塩野義製薬株式会社	安定化されたペプチド組成物
WO2021001522A1 (en)	2019-07-04	2021-01-07	CSL Behring Lengnau AG	A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
JP2025512143A (ja)	2020-11-09	2025-04-17	武田薬品工業株式会社	酸化ケイ素吸着を使用する血漿からのｆｖｉｉｉの精製

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6281327A (ja) *	1985-10-04	1987-04-14	Green Cross Corp:The	人トロンビン製剤の加熱処理方法
JPS6485927A (en) *	1987-09-29	1989-03-30	Green Cross Corp	Hepatitis b vaccine
US5605884A (en)	1987-10-29	1997-02-25	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Factor VIII formulations in high ionic strength media
WO1989009784A1 (en) *	1988-04-08	1989-10-19	Commonwealth Serum Laboratories Commission	Production of heat-stable factor viii concentrate
GB8822857D0 (en) *	1988-09-29	1988-11-02	Patralan Ltd	Pharmaceutical formulations
SE465222C5 (sv)	1989-12-15	1998-02-10	Pharmacia & Upjohn Ab	Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
IE64738B1 (en) *	1990-03-20	1995-09-06	Akzo Nv	Stabilized gonadotropin containing preparations
DE4111393A1 (de) *	1991-04-09	1992-10-15	Behringwerke Ag	Stabilisierte faktor viii-praeparationen
CA2124690C (en)	1992-10-02	2007-09-11	Thomas Osterberg	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
SE9301581D0 (sv)	1993-05-07	1993-05-07	Kabi Pharmacia Ab	Protein formulation
SE504074C2 (sv)	1993-07-05	1996-11-04	Pharmacia Ab	Proteinberedning för subkutan, intramuskulär eller intradermal administrering
ZA955642B (en) *	1994-07-07	1997-05-06	Ortho Pharma Corp	Lyophilized imaging agent formulation
JPH0899999A (ja)	1994-09-30	1996-04-16	Chemo Sero Therapeut Res Inst	α１プロテアーゼインヒビターの製造方法
US6458563B1 (en) *	1996-06-26	2002-10-01	Emory University	Modified factor VIII
US5763401A (en)	1996-07-12	1998-06-09	Bayer Corporation	Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
DK1820516T3 (da) *	1999-02-22	2013-10-28	Univ Connecticut	Nye albuminfrie faktor VIII-præparater
DE60024268T2 (de) *	1999-07-13	2006-08-03	Biovitrum Ab	Zusammensetzungen mit stabilem faktor viii
DE60009926T2 (de) *	1999-08-17	2005-04-07	Novo Nordisk Health Care Ag	Stabilisierung von gefriergetrocknetem kuchen
US6586574B1 (en) *	1999-08-17	2003-07-01	Nn A/S	Stabilization of freeze-dried cake
US7576182B1 (en) *	1999-08-31	2009-08-18	Genentech, Inc.	Compositions and methods for the treatment of immune related diseases

2002
- 2002-03-26 GB GBGB0207092.8A patent/GB0207092D0/en not_active Ceased
2003
- 2003-03-14 TW TW092105665A patent/TWI285106B/zh not_active IP Right Cessation
- 2003-03-19 MY MYPI20030960A patent/MY149831A/en unknown
- 2003-03-25 AR ARP030101024A patent/AR039123A1/es not_active Application Discontinuation
- 2003-03-26 EP EP10172869A patent/EP2292216A3/de not_active Withdrawn
- 2003-03-26 WO PCT/GB2003/001297 patent/WO2003080108A1/en not_active Ceased
- 2003-03-26 MX MXPA04009275A patent/MXPA04009275A/es active IP Right Grant
- 2003-03-26 PT PT03712418T patent/PT1490095E/pt unknown
- 2003-03-26 EP EP03712418A patent/EP1490095B1/de not_active Expired - Lifetime
- 2003-03-26 KR KR10-2004-7015295A patent/KR20040093482A/ko not_active Ceased
- 2003-03-26 US US10/507,956 patent/US7790680B2/en not_active Expired - Lifetime
- 2003-03-26 PL PL372414A patent/PL208009B1/pl unknown
- 2003-03-26 AU AU2003217030A patent/AU2003217030B2/en not_active Expired
- 2003-03-26 RU RU2004131556/15A patent/RU2314825C2/ru active
- 2003-03-26 HR HRP20040882AA patent/HRP20040882B1/hr not_active IP Right Cessation
- 2003-03-26 ES ES03712418T patent/ES2350337T3/es not_active Expired - Lifetime
- 2003-03-26 JP JP2003577934A patent/JP2005530714A/ja active Pending
- 2003-03-26 CN CN038069911A patent/CN1642570B/zh not_active Expired - Lifetime
- 2003-03-26 CN CN201210563117.1A patent/CN103006540B/zh not_active Expired - Lifetime
- 2003-03-26 CA CA2480226A patent/CA2480226C/en not_active Expired - Lifetime
- 2003-03-26 BR BR0308442-6A patent/BR0308442A/pt not_active Application Discontinuation
- 2003-03-26 AT AT03712418T patent/ATE477814T1/de active
- 2003-03-26 DK DK03712418.7T patent/DK1490095T3/da active
- 2003-03-26 DE DE60333825T patent/DE60333825D1/de not_active Expired - Lifetime
- 2003-03-26 NZ NZ535032A patent/NZ535032A/xx not_active IP Right Cessation
- 2003-03-26 IL IL16384903A patent/IL163849A0/xx unknown
2004
- 2004-08-31 IL IL163849A patent/IL163849A/en not_active IP Right Cessation
- 2004-09-17 IS IS7458A patent/IS7458A/is unknown
- 2004-10-11 NO NO20044305A patent/NO328450B1/no not_active IP Right Cessation
2011
- 2011-01-07 JP JP2011002185A patent/JP2011079862A/ja active Pending
2013
- 2013-04-16 JP JP2013085801A patent/JP5770775B2/ja not_active Expired - Lifetime
2015
- 2015-03-18 JP JP2015055071A patent/JP2015143245A/ja active Pending

Also Published As

Publication number	Publication date
JP2005530714A (ja)	2005-10-13
EP1490095A1 (de)	2004-12-29
KR20040093482A (ko)	2004-11-05
AU2003217030A1 (en)	2003-10-08
CA2480226C (en)	2012-09-18
HRP20040882A2 (en)	2004-12-31
GB0207092D0 (en)	2002-05-08
IL163849A (en)	2010-12-30
TW200304827A (en)	2003-10-16
HRP20040882B1 (hr)	2013-02-28
CN103006540A (zh)	2013-04-03
RU2314825C2 (ru)	2008-01-20
IS7458A (is)	2004-09-17
US7790680B2 (en)	2010-09-07
MXPA04009275A (es)	2005-01-25
AR039123A1 (es)	2005-02-09
HK1080713A1 (en)	2006-05-04
TWI285106B (en)	2007-08-11
NO328450B1 (no)	2010-02-22
PL208009B1 (pl)	2011-03-31
RU2004131556A (ru)	2005-08-20
AU2003217030B2 (en)	2008-12-04
CA2480226A1 (en)	2003-10-02
ES2350337T3 (es)	2011-01-21
WO2003080108A1 (en)	2003-10-02
PT1490095E (pt)	2010-10-21
JP5770775B2 (ja)	2015-08-26
BR0308442A (pt)	2005-01-18
MY149831A (en)	2013-10-31
JP2011079862A (ja)	2011-04-21
HK1183446A1 (en)	2013-12-27
PL372414A1 (en)	2005-07-25
DK1490095T3 (da)	2010-11-08
DE60333825D1 (de)	2010-09-30
IL163849A0 (en)	2005-12-18
JP2015143245A (ja)	2015-08-06
JP2013147508A (ja)	2013-08-01
EP2292216A2 (de)	2011-03-09
CN103006540B (zh)	2015-09-16
CN1642570A (zh)	2005-07-20
EP2292216A3 (de)	2011-05-11
EP1490095B1 (de)	2010-08-18
NO20044305L (no)	2004-10-11
US20050256038A1 (en)	2005-11-17
NZ535032A (en)	2006-03-31
CN1642570B (zh)	2013-01-09

Legal Events

Date

Code

Title

Description

2011-02-15

UEP

Publication of translation of european patent specification

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