ATE478852T1 - Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase - Google Patents

Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase

Info

Publication number: ATE478852T1
Authority: AT; Austria
Prior art keywords: compounds; cyano; amino; imidazoä1; aüpyridines
Prior art date: 2005-09-09

Application number

AT06802808T

Other languages

English (en)

Inventor

Alan Mallams

Vincent Madison

Kamil Paruch

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-09

Filing date

2006-08-31

Publication date

2010-09-15

2006-08-31 Application filed by Schering Corp filed Critical Schering Corp

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE478852T1 publication Critical patent/ATE478852T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 5
BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title abstract 2
VMJNTFXCTXAXTC-UHFFFAOYSA-N 2,2-difluoro-1,3-benzodioxole-5-carbonitrile Chemical compound C1=C(C#N)C=C2OC(F)(F)OC2=C1 VMJNTFXCTXAXTC-UHFFFAOYSA-N 0.000 title abstract 2
102000003903 Cyclin-dependent kinases Human genes 0.000 title abstract 2
108090000266 Cyclin-dependent kinases Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
108091007914 CDKs Proteins 0.000 abstract 2
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
MIFJMFOVENWQDP-UHFFFAOYSA-N imidazo[1,5-a]pyrazine Chemical class C1=CN=CC2=CN=CN21 MIFJMFOVENWQDP-UHFFFAOYSA-N 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
LNTIZOKGHGTDTL-UHFFFAOYSA-N pyrazolo[1,5-c]pyrimidine Chemical compound C1=CN=CN2N=CC=C21 LNTIZOKGHGTDTL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06802808T 2005-09-09 2006-08-31 Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase ATE478852T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71562105P	2005-09-09	2005-09-09
PCT/US2006/034233 WO2007032936A2 (en)	2005-09-09	2006-08-31	Azafused cyclin dependent kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE478852T1 true ATE478852T1 (de)	2010-09-15

Family

ID=37487994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06802808T ATE478852T1 (de)	2005-09-09	2006-08-31	Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase

Country Status (9)

Country	Link
US (3)	US7700773B2 (de)
EP (1)	EP1931641B1 (de)
JP (1)	JP2009507843A (de)
CN (1)	CN101300233A (de)
AT (1)	ATE478852T1 (de)
CA (1)	CA2621983A1 (de)
DE (1)	DE602006016455D1 (de)
ES (1)	ES2349476T3 (de)
WO (1)	WO2007032936A2 (de)

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NZ596185A (en) *	2009-04-16	2013-01-25	Ct Nac Investigaciones Oncologicas Cnio	Imidazopyrazines for use as kinase inhibitors
WO2011089400A1 (en)	2010-01-22	2011-07-28	Centro Nacional De Investigaciones Oncológicas (Cnio)	Inhibitors of pi3 kinase
WO2011141713A1 (en)	2010-05-13	2011-11-17	Centro Nacional De Investigaciones Oncologicas (Cnio)	New bicyclic compounds as pi3-k and mtor inhibitors
EP2651944B1 (de) *	2010-12-17	2015-09-23	Bayer Intellectual Property GmbH	Substituierte 6-imidazopyrazines zur verwendung als mps-1 und tkk-inhibitoren zur behandlung von hyperproliferativen erkrankungen
CA2821819A1 (en) *	2010-12-17	2012-06-21	Marcus Koppitz	6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
CA2832310A1 (en)	2011-04-06	2012-10-11	Bayer Intellectual Property Gmbh	Substituted imidazopyridines and intermediates thereof
US8883819B2 (en)	2011-09-01	2014-11-11	Irm Llc	Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
SG10201610869TA (en)	2012-06-26	2017-02-27	Del Mar Pharmaceuticals	Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti
CN104837842A (zh) *	2012-12-10	2015-08-12	霍夫曼-拉罗奇有限公司	新型二环苯基-吡啶/吡嗪用于治疗癌症
CA2885392A1 (en) *	2012-12-10	2014-06-19	Zhanling CHENG	Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer
US9073921B2 (en)	2013-03-01	2015-07-07	Novartis Ag	Salt forms of bicyclic heterocyclic derivatives
EP2983674A4 (de)	2013-04-08	2017-05-10	Dennis M. Brown	Therapeutischer nutzen suboptimal verabreichter chemischer verbindungen
KR102421235B1 (ko)	2014-02-13	2022-07-15	인사이트 코포레이션	Lsd1 저해제로서 사이클로프로필아민
NZ723203A (en)	2014-02-13	2020-08-28	Incyte Corp	Cyclopropylamines as lsd1 inhibitors
WO2015157955A1 (en) *	2014-04-17	2015-10-22	Abbvie Inc.	Heterocyclic btk inhibit ors
WO2016007722A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
UA122688C2 (uk)	2015-04-03	2020-12-28	Інсайт Корпорейшн	Гетероциклічні сполуки як інгібітори lsd1
JP7427363B2 (ja)	2015-08-12	2024-02-05	インサイト・ホールディングス・コーポレイション	Ｌｓｄ１阻害剤の塩
WO2020047198A1 (en)	2018-08-31	2020-03-05	Incyte Corporation	Salts of an lsd1 inhibitor and processes for preparing the same
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US7417053B2 (en) *	2005-04-07	2008-08-26	Teijin Pharma Limited	Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
US7700773B2 (en) *	2005-09-09	2010-04-20	Schering Corporation	4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors

2006
- 2006-08-31 US US11/514,548 patent/US7700773B2/en not_active Expired - Fee Related
- 2006-08-31 ES ES06802808T patent/ES2349476T3/es active Active
- 2006-08-31 CN CNA2006800412880A patent/CN101300233A/zh active Pending
- 2006-08-31 WO PCT/US2006/034233 patent/WO2007032936A2/en not_active Ceased
- 2006-08-31 CA CA002621983A patent/CA2621983A1/en not_active Abandoned
- 2006-08-31 JP JP2008530115A patent/JP2009507843A/ja active Pending
- 2006-08-31 AT AT06802808T patent/ATE478852T1/de not_active IP Right Cessation
- 2006-08-31 DE DE602006016455T patent/DE602006016455D1/de active Active
- 2006-08-31 EP EP06802808A patent/EP1931641B1/de active Active
2010
- 2010-02-16 US US12/706,551 patent/US20100143384A1/en not_active Abandoned
- 2010-02-17 US US12/706,814 patent/US20100137326A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1931641A2 (de)	2008-06-18
JP2009507843A (ja)	2009-02-26
HK1112229A1 (en)	2008-08-29
EP1931641B1 (de)	2010-08-25
ES2349476T3 (es)	2011-01-03
CN101300233A (zh)	2008-11-05
CA2621983A1 (en)	2007-03-22
WO2007032936A3 (en)	2007-05-03
DE602006016455D1 (de)	2010-10-07
US20100137326A1 (en)	2010-06-03
US20070066621A1 (en)	2007-03-22
WO2007032936A2 (en)	2007-03-22
US7700773B2 (en)	2010-04-20
US20100143384A1 (en)	2010-06-10

Legal Events

Date	Code	Title	Description
2011-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602006016455D1 (de)	2010-10-07	Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
ATE470668T1 (de)	2010-06-15	Pyrazolopyrimidine als inhibitoren von cyclinabhängiger kinase zur behandlung von krebs
BRPI0314001B8 (pt)	2021-05-25	pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas
TW200745123A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
TW200745128A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
MX2009011355A (es)	2009-11-05	Nuevas pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas.
MY149044A (en)	2013-07-15	Pyrazolopyrimidines - derivatives as cyclin dependent kinase inhibitors
WO2007044449A3 (en)	2007-05-24	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200407322A (en)	2004-05-16	Novel imidazopyridines as cyclin dependent kinase inhibitors
MY139336A (en)	2009-09-30	N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY137843A (en)	2009-03-31	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MX2009003733A (es)	2009-04-22	Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
WO2007044401A3 (en)	2007-06-07	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2007058873A3 (en)	2007-07-19	Imidazopyrazines as cyclin depentend kinase inhibitors
MY134589A (en)	2007-12-31	Imidazopyrazines as cyclin dependent kinase inhibitors
TW200745127A (en)	2007-12-16	Pyrazolopyrimidines as protein kinase inhibitors
TW200420564A (en)	2004-10-16	Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
WO2008045267A3 (en)	2008-07-31	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL1758871T3 (pl)	2008-04-30	Pirazolopirymidyny
MY188335A (en)	2021-11-30	Imidazotriazines and imidazopyrimidines as kinase inhibitors
MX2009003734A (es)	2009-06-11	Pirazolopirimidinas como inhibidor de cinasas dependientes de ciclina.
WO2004026310A8 (en)	2005-06-30	Novel imidazopyrazines as cyclin dependent kinase inhibitors
WO2008121687A3 (en)	2008-11-20	Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
ATE493401T1 (de)	2011-01-15	Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen
ZA200802998B (en)	2009-10-28	Use of pyrazolo [1,5-a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases