ATE479762T1 - Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung - Google Patents

Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung

Info

Publication number
ATE479762T1
ATE479762T1 AT05789469T AT05789469T ATE479762T1 AT E479762 T1 ATE479762 T1 AT E479762T1 AT 05789469 T AT05789469 T AT 05789469T AT 05789469 T AT05789469 T AT 05789469T AT E479762 T1 ATE479762 T1 AT E479762T1
Authority
AT
Austria
Prior art keywords
collagen
production
plant
producing plants
collagen producing
Prior art date
Application number
AT05789469T
Other languages
English (en)
Inventor
Oded Shoseyov
Hanan Stein
Original Assignee
Collplant Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35788568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE479762(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Collplant Ltd filed Critical Collplant Ltd
Application granted granted Critical
Publication of ATE479762T1 publication Critical patent/ATE479762T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11004—Procollagen-lysine 5-dioxygenase (1.14.11.4), i.e. lysine-hydroxylase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fertilizers (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
AT05789469T 2004-09-29 2005-09-28 Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung ATE479762T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61371904P 2004-09-29 2004-09-29
PCT/IL2005/001045 WO2006035442A2 (en) 2004-09-29 2005-09-28 Collagen producing plants and methods of generating and using same

Publications (1)

Publication Number Publication Date
ATE479762T1 true ATE479762T1 (de) 2010-09-15

Family

ID=35788568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05789469T ATE479762T1 (de) 2004-09-29 2005-09-28 Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung

Country Status (15)

Country Link
US (4) US8455717B2 (de)
EP (6) EP2357241B1 (de)
JP (2) JP5100386B2 (de)
KR (1) KR20070083870A (de)
CN (1) CN101065491B (de)
AT (1) ATE479762T1 (de)
BR (1) BRPI0516303B1 (de)
CA (1) CA2582051C (de)
DE (1) DE602005023332D1 (de)
HK (1) HK1251611B (de)
IL (1) IL182320A (de)
MX (1) MX2007003767A (de)
NZ (1) NZ554787A (de)
WO (1) WO2006035442A2 (de)
ZA (1) ZA200703369B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7378506B2 (en) 1997-07-21 2008-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6639050B1 (en) 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
EP2133427B1 (de) 2004-01-14 2013-12-11 Ohio University Verfahren zur Herstellung von Peptiden/Proteinen in Pflanzen und damit hergestellte Peptide/Proteine
CA2573918A1 (en) 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same
EP2357241B1 (de) 2004-09-29 2015-03-04 Collplant Ltd. Kollagenproduzierende Pflanzen sowie Verfahren zu deren Erzeugung und Verwendung
EP2084285A4 (de) * 2006-07-10 2010-01-13 Univ Ohio Coexpression von prolin-hydroxylasen zur erleichterung der hyp-glykosylierung von in pflanzenzellen exprimierten und sezernierten proteinen
WO2009053985A1 (en) * 2007-10-26 2009-04-30 Collplant Ltd. Methods of processing recombinant procollagen
EP2220112B1 (de) 2007-11-26 2015-08-26 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Faserartige polypeptide und polysaccharide enthaltende zusammensetzungen
EP2288376B1 (de) * 2008-04-18 2016-01-13 Collplant Ltd. Verfahren zur regeneration und verwendung von prokollagen
WO2011064773A1 (en) 2009-11-24 2011-06-03 Collplant Ltd. Method of generating collagen fibers
WO2012066543A2 (en) 2010-11-16 2012-05-24 Collplant Ltd. Collagen structures and method of fabricating the same
WO2013030840A2 (en) 2011-09-01 2013-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Adhesive biopolymers and uses thereof
WO2013093921A1 (en) 2011-12-20 2013-06-27 Collplant Ltd. Collagen coated synthetic polymer fibers
KR102063686B1 (ko) * 2012-01-02 2020-02-11 (주)아모레퍼시픽 콩뿌리 추출물을 함유하는 피부 외용제 조성물
ES2891752T3 (es) * 2013-03-21 2022-01-31 Evonik Operations Gmbh Purificación de proteínas de triple hélice
CA2907680A1 (en) 2013-03-21 2014-09-25 Collplant Ltd. Compositions comprising collagen and prp for tissue regeneration
GB201308120D0 (en) * 2013-05-06 2013-06-12 Baden Wuerttemberg Stiftung Gmbh Recombinant protein and method for its production
TWI738631B (zh) 2013-09-09 2021-09-11 德商贏創運營有限公司 經修飾之細菌類膠原蛋白蛋白質
EA038931B9 (ru) 2014-11-20 2022-02-18 Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений
CN104630227A (zh) * 2015-02-09 2015-05-20 安徽农业大学 一种草莓镶脉病毒的组成型表达启动子
US20170319750A1 (en) 2016-05-09 2017-11-09 Bioventus, Llc Composite matrices designed for enhanced bone repair
AU2018282131B2 (en) 2017-06-09 2024-05-09 Collplant Ltd. Additive manufacturing using recombinant collagen-containing formulation
WO2019056377A1 (zh) * 2017-09-25 2019-03-28 吴侑峻 非人类转基因哺乳动物及从其结缔组织分离的蛋白质粗萃物及其方法与用途
IL306070A (en) 2018-05-03 2023-11-01 Collplant Ltd Dermal fillers and their uses
FR3082726A1 (fr) * 2018-06-24 2019-12-27 Michel Assor Implant méniscal : composite en polyuréthane et autres polymères, avec collagène humain recombinant de plante, biodégradable et colonisable, dans l’arthrose évoluée du genou
KR20210042430A (ko) * 2018-07-31 2021-04-19 콜플랜트 리미티드 담배 형질전환 이벤트 및 이의 검출 방법 및 용도
CN109988234A (zh) * 2019-02-20 2019-07-09 江苏悦智生物医药有限公司 酵母重组人源I型胶原α1链蛋白、合成方法及其应用
EP3789048B1 (de) * 2019-09-03 2023-06-07 Michel Assor Kompositgerüst enthaltend ein humanes rekombinates kollagens zur wiederherstellung des meniskus
CH718385B1 (de) * 2019-11-11 2025-07-15 Welldrinks Ltd Getränk mit Kollagen und weiteren Zusätzen.
FR3105792B1 (fr) 2019-12-26 2022-08-12 Michel Assor Matériau biocomposite collagène/matrice polymérique poreuse et son utilisation comme implant de réparation de lésions méniscales du genou et/ou de prévention ou de traitement de l’arthrose du genou
CA3162540A1 (en) * 2020-02-14 2021-08-19 Lixin Dai Monomeric proteins for hydroxylating amino acids and products
EP3872182A1 (de) * 2020-02-28 2021-09-01 Alganelle Rekombinante mikroalgen, die in der lage sind, peptide, polypeptide oder proteine von kollagen, elastin und ihren derivaten in dem chloroplast von mikroalgen zu produzieren, und zugehöriges verfahren
WO2021229577A1 (en) 2020-05-12 2021-11-18 Collplant Ltd. Collagen as a delivery tool for metal-based anti-viral agents
EP4504761B1 (de) * 2022-04-04 2026-02-04 SwiftPharma BV Rekombinante, in pflanzen produzierte und mit spinnenseidenprotein verstärkte kollagenproteine und ihre verwendung
WO2024029529A1 (ja) * 2022-08-02 2024-02-08 株式会社 UniBio コラーゲン産生方法
CN117209592A (zh) * 2023-07-26 2023-12-12 浙江大学 一种人源化i型胶原蛋白及其制备方法与应用
CN119979489B (zh) * 2024-07-31 2025-09-30 东莞恒医生物科技有限公司 一种BaP4H突变体及其应用
WO2026062643A1 (en) 2024-09-20 2026-03-26 Collplant Ltd. Formulations and designs for degradable soft tissue implants
CN121717897A (zh) * 2026-02-26 2026-03-24 北京齐禾生科生物科技有限公司 一种在大豆中表达i型胶原蛋白的多基因表达盒及方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
CA1192510A (en) 1981-05-27 1985-08-27 Lawrence E. Pelcher Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom
JPS6054684A (ja) 1983-09-05 1985-03-29 Teijin Ltd 新規ｄνａ及びハイブリツドｄνａ
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
GB8608850D0 (en) 1986-04-11 1986-05-14 Diatech Ltd Packaging system
JPS6314693A (ja) 1986-07-04 1988-01-21 Sumitomo Chem Co Ltd 植物ウイルスｒｎａベクタ−
ATE108828T1 (de) 1987-02-09 1994-08-15 Lubrizol Genetics Inc Hybrides rns-virus.
US5316931A (en) 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US5693507A (en) 1988-09-26 1997-12-02 Auburn University Genetic engineering of plant chloroplasts
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5593859A (en) * 1991-10-23 1997-01-14 Thomas Jefferson University Synthesis of human procollagens and collagens in recombinant DNA systems
US20020142391A1 (en) 1991-06-12 2002-10-03 Kivirikko Kari I. Synthesis of human procollagens and collagens in recombinant DNA systems
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US20020098578A1 (en) 1992-10-22 2002-07-25 Darwin J. Prockop Synthesis of human procollagens and collagens in recombinant dna systems
US6713662B1 (en) 1994-07-27 2004-03-30 Pharming Intellectual Property B.V. Production of collagen in the milk of transgenic mammals
WO1997004123A1 (en) 1995-07-19 1997-02-06 Gel Tech Group Inc. Collagen compound production in plants
WO1997038710A1 (en) 1996-04-12 1997-10-23 Fibrogen, Inc. Synthesis of human procollagens and collagens in recombinant dna systems
FR2757874B1 (fr) * 1996-12-17 2003-04-25 Biocem Collagenes recombinants et proteines derivees produits par les plantes, leurs procedes d'obtention et leurs utilisations
CA2305628C (en) 1997-09-30 2008-08-26 The Regents Of The University Of California Production of proteins in plant seeds
AU2003203147B2 (en) * 1998-03-23 2008-05-29 Novozymes A/S Phytase variants
RU2001111881A (ru) 1998-10-07 2003-06-20 Зингента Партисипейшнс Аг (Ch) Терапевтически активные протеины в растениях
CA2388432A1 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
ATE374787T1 (de) 1999-11-12 2007-10-15 Fibrogen Inc Rinder-kollagen und verfahren zur herstelling rekombinantes gelatin
BR0015507A (pt) 1999-11-12 2002-10-22 Fibrogen Inc Gelatinas e colágenos animais
JP2005525081A (ja) * 2001-06-05 2005-08-25 カレン ケイ． オオイシ 植物からの生物活性ミュラー管抑制物質を含むＴＧＦ−βタンパク質の遺伝子発現および産生法
AU2003296638B2 (en) * 2002-12-19 2009-06-11 University Of Bristol Method for the production of polyunsaturated fatty acids
EP1587920A1 (de) * 2002-12-20 2005-10-26 Basf Aktiengesellschaft Malat dehydrogenase als target für herbizide
US20050059053A1 (en) 2003-07-21 2005-03-17 Rainer Fischer Complex formation for the stabilisation and purification of proteins of interest
EP2357241B1 (de) 2004-09-29 2015-03-04 Collplant Ltd. Kollagenproduzierende Pflanzen sowie Verfahren zu deren Erzeugung und Verwendung

Also Published As

Publication number Publication date
BRPI0516303A (pt) 2008-09-02
NZ554787A (en) 2009-05-31
US20180044692A1 (en) 2018-02-15
EP2357241B1 (de) 2015-03-04
KR20070083870A (ko) 2007-08-24
EP2357241A1 (de) 2011-08-17
EP1809751B1 (de) 2010-09-01
HK1160176A1 (en) 2012-08-10
JP5517309B2 (ja) 2014-06-11
CN101065491A (zh) 2007-10-31
CA2582051A1 (en) 2006-04-06
US20130289243A1 (en) 2013-10-31
CA2582051C (en) 2015-08-11
EP2360261A1 (de) 2011-08-24
EP2816117A2 (de) 2014-12-24
DE602005023332D1 (de) 2010-10-14
EP3312282B1 (de) 2019-07-03
WO2006035442A3 (en) 2006-05-04
IL182320A0 (en) 2007-07-24
ZA200703369B (en) 2008-08-27
EP1809751A2 (de) 2007-07-25
JP5100386B2 (ja) 2012-12-19
WO2006035442A2 (en) 2006-04-06
CN101065491B (zh) 2012-01-11
EP2816117A3 (de) 2015-05-27
MX2007003767A (es) 2007-07-17
IL182320A (en) 2015-06-30
US20120284817A1 (en) 2012-11-08
BRPI0516303B1 (pt) 2021-04-13
EP3088528A1 (de) 2016-11-02
JP2012085644A (ja) 2012-05-10
EP3088528B1 (de) 2019-07-03
EP2816117B1 (de) 2016-11-30
HK1114405A1 (zh) 2008-10-31
US8455717B2 (en) 2013-06-04
EP3312282A1 (de) 2018-04-25
US20070186312A1 (en) 2007-08-09
US10626408B2 (en) 2020-04-21
JP2008514225A (ja) 2008-05-08
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WO2006035442A8 (en) 2006-06-29
US9783816B2 (en) 2017-10-10

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