ATE480263T1 - Ultraschall kontrastmittel und verfahren zur erstellung - Google Patents
Ultraschall kontrastmittel und verfahren zur erstellungInfo
- Publication number
- ATE480263T1 ATE480263T1 AT04707586T AT04707586T ATE480263T1 AT E480263 T1 ATE480263 T1 AT E480263T1 AT 04707586 T AT04707586 T AT 04707586T AT 04707586 T AT04707586 T AT 04707586T AT E480263 T1 ATE480263 T1 AT E480263T1
- Authority
- AT
- Austria
- Prior art keywords
- phospholipid
- emulsion
- creation
- gas
- microbubbles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03002375 | 2003-02-04 | ||
| PCT/IB2004/000243 WO2004069284A2 (en) | 2003-02-04 | 2004-02-03 | Ultrasound contrast agents and process for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480263T1 true ATE480263T1 (de) | 2010-09-15 |
Family
ID=32842689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04707586T ATE480263T1 (de) | 2003-02-04 | 2004-02-03 | Ultraschall kontrastmittel und verfahren zur erstellung |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9364569B2 (de) |
| EP (1) | EP1590006B1 (de) |
| JP (1) | JP4670083B2 (de) |
| KR (1) | KR101076053B1 (de) |
| CN (1) | CN100374165C (de) |
| AT (1) | ATE480263T1 (de) |
| AU (1) | AU2004210221B2 (de) |
| CA (1) | CA2512454C (de) |
| DE (1) | DE602004029010D1 (de) |
| DK (1) | DK1590006T3 (de) |
| ES (1) | ES2352087T3 (de) |
| IL (1) | IL169677A (de) |
| MX (1) | MXPA05007730A (de) |
| NO (1) | NO331966B1 (de) |
| RU (1) | RU2345793C2 (de) |
| WO (1) | WO2004069284A2 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| EP2213310A1 (de) † | 2004-01-20 | 2010-08-04 | Sunnybrook and Women's College Health Sciences Centre | Hochfrequenz Ultraschallabbildung, welche Kontrastmittel verwendet |
| US9248204B2 (en) * | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
| EP1714642A1 (de) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung |
| CN101374955B (zh) | 2005-12-09 | 2013-03-27 | 布拉科瑞士有限公司 | 靶向载体-磷脂缀合物 |
| EP1797919A1 (de) | 2005-12-16 | 2007-06-20 | Bracco Research S.A. | Vorrichtung zum Übertragen von Flüssigkeiten für Behälter zur Abgabe von Medikamenten |
| WO2007136554A1 (en) * | 2006-05-15 | 2007-11-29 | Mayo Foundation For Medical Education And Research | Method for imaging intracavitary blood flow patterns |
| EP2050074A2 (de) * | 2006-07-13 | 2009-04-22 | The Regents Of The University Of Colorado | System und verfahren zur echoteilchenbildgebung und echoteilchenverfolgung und geschwindigkeitsmessung |
| JP5154554B2 (ja) | 2006-08-01 | 2013-02-27 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 非線形イメージングのためのパルスインバージョンシーケンス |
| US9446156B2 (en) | 2006-09-05 | 2016-09-20 | Bracco Suisse S.A. | Gas-filled microvesicles with polymer-modified lipids |
| WO2008042841A2 (en) * | 2006-10-02 | 2008-04-10 | Dr. Reddy's Laboratories Limited | Docetaxel compositions |
| WO2008075192A2 (en) | 2006-12-19 | 2008-06-26 | Bracco International Bv | Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds |
| US20090191244A1 (en) * | 2007-09-27 | 2009-07-30 | Children's Medical Center Corporation | Microbubbles and methods for oxygen delivery |
| EP2090322A1 (de) | 2008-02-18 | 2009-08-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verwendung von FSH-Rezeptorliganden zur Diagnose und Behandlung von Krebs |
| JP2010005512A (ja) * | 2008-06-25 | 2010-01-14 | Kao Corp | 微細気泡前駆体組成物 |
| GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
| US20110045095A1 (en) * | 2008-10-08 | 2011-02-24 | The Regents Of The University Of California | Polymer-phospholipid shelled microbubbles |
| CN101745126B (zh) * | 2008-12-10 | 2012-04-25 | 温州医学院 | 一种包载水溶性药物超声造影剂的制备方法 |
| CA2744296C (en) | 2008-12-16 | 2016-05-17 | Laurent Jakob | Device for bolus administration of contrast agent |
| KR20130080786A (ko) * | 2010-04-30 | 2013-07-15 | 에이치 알 디 코포레이션 | 약물 전달에서의 고 전단 응용 |
| CN103079599B (zh) | 2010-08-09 | 2017-05-10 | 博莱科瑞士股份有限公司 | 靶向气体填充微囊 |
| WO2012065060A2 (en) * | 2010-11-12 | 2012-05-18 | Children's Medical Center Corporation | Gas-filled microbubbles and systems for gas delivery |
| EP2668961A4 (de) | 2010-11-19 | 2016-07-06 | Univ Sapporo Medical | Pharmazeutisches kombinationspräparat |
| WO2012085072A1 (en) | 2010-12-24 | 2012-06-28 | Bracco Suisse Sa | Gas-filled microvesicles for use as vaccine |
| RU2485976C2 (ru) * | 2011-05-17 | 2013-06-27 | Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития России) | Контрастное средство для ультразвуковой визуализации |
| CN107260679B (zh) | 2012-02-10 | 2020-07-31 | 台湾微脂体股份有限公司 | 用以减少眼用类固醇的并发症的药物组合物 |
| US10357450B2 (en) * | 2012-04-06 | 2019-07-23 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| MX374926B (es) | 2012-04-30 | 2025-03-06 | Ge Healthcare As | Metodo para llenar un contenedor con una composicion espumable. |
| US9713459B2 (en) | 2012-06-11 | 2017-07-25 | The Regents Of The University Of California | Method and system for in vivo hydrogen peroxide detection with ultrasound |
| CN103099780B (zh) * | 2012-12-11 | 2015-11-25 | 中国科学院深圳先进技术研究院 | 制备含氢气微泡水溶液的方法，其产品及应用 |
| CN105026030B (zh) | 2012-12-21 | 2017-04-12 | 博莱科瑞士股份有限公司 | 充气微泡 |
| WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
| WO2015000953A1 (en) | 2013-07-03 | 2015-01-08 | Bracco Suisse S.A. | Devices and methods for the ultrasound treatment of ischemic stroke |
| KR101520443B1 (ko) * | 2013-11-06 | 2015-05-14 | 서울대학교산학협력단 | 유기 마이크로 버블 복합 입자의 제조 방법, 유기 마이크로 버블 복합 입자 및 조영제 |
| KR101595795B1 (ko) * | 2014-03-19 | 2016-02-22 | (주)아이엠지티 | 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법 |
| CN106164089B (zh) | 2014-04-02 | 2020-11-03 | 日东电工株式会社 | 靶向分子及其用途 |
| DK3233136T3 (da) | 2014-12-18 | 2019-05-20 | Bracco Suisse Sa | Formulering med målrettede gasfyldte mikrovesikler |
| EP3236999B1 (de) | 2014-12-22 | 2019-03-20 | Bracco Suisse SA | Gasgefüllte mikrovesikel zur verwendung als impfstoff |
| CN104622848A (zh) * | 2015-02-13 | 2015-05-20 | 西安交通大学 | 一种等离子体活化包膜微气泡 |
| EP3308779B1 (de) * | 2015-06-10 | 2019-08-07 | Teikyo University | Herstellung von theranostischen blasen (tb) und verfahren zur verwendung davon |
| US11284910B2 (en) | 2015-12-09 | 2022-03-29 | Koninklijke Philips N.V. | Interleaved beam pattern for sonothhrombolysis and other vascular acoustic resonator mediated therapies |
| CN117919456A (zh) * | 2016-02-01 | 2024-04-26 | 博信生物科技股份有限公司 | 脂质微泡及其制备方法 |
| BR112018015143A2 (en) | 2016-02-09 | 2018-12-18 | Bracco Suisse Sa | recombinant chimeric protein for selectin targeting |
| CN107233583B (zh) * | 2016-03-29 | 2020-04-24 | 北京飞锐达医疗科技有限公司 | 一种具有超长持续时间的超声造影剂及其制备方法 |
| WO2017214468A1 (en) * | 2016-06-09 | 2017-12-14 | Tien Yang Der | Nanodroplet compositions for the efficient delivery of anti-cancer agents |
| IL265070B (en) | 2016-08-30 | 2022-09-01 | Bracco Suisse Sa | Preparation of size-controlled microparticles |
| KR102052945B1 (ko) | 2016-09-29 | 2019-12-11 | 연세대학교 산학협력단 | 나노 조영제의 재분산 방법 |
| WO2018160752A1 (en) | 2017-02-28 | 2018-09-07 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| WO2018198008A1 (en) | 2017-04-24 | 2018-11-01 | Abdolahad Mohammad | In-situ microbubbles generation for ultrasonic biomedical applications |
| AU2019232508B2 (en) * | 2018-03-07 | 2024-12-19 | Bracco Suisse Sa | Preparation of size-controlled microvesicles |
| FR3082422B1 (fr) * | 2018-06-14 | 2021-01-22 | Univ D'avignon Et Des Pays De Vaucluse | Emulsion pour la chirurgie d'ablation ultrasonore |
| CA3120179A1 (en) | 2018-12-21 | 2020-06-25 | Bracco Suisse Sa | Gas-filled microvesicles with ligand |
| GB201821049D0 (en) * | 2018-12-21 | 2019-02-06 | Ge Healthcare As | Ultrasound contrast agent and methods for use therof |
| KR102180629B1 (ko) * | 2018-12-24 | 2020-11-20 | 서강대학교 산학협력단 | 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법 |
| CN110051630A (zh) * | 2019-02-03 | 2019-07-26 | 彭盛 | 一种载氧聚合物微泡及其制备方法 |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| EP3980016A4 (de) * | 2019-06-05 | 2023-11-15 | Microvascular Therapeutics LLC | Zusammensetzungen und verfahren zur detektion und behandlung von thrombose und vaskulären plaques |
| EP3990033B1 (de) * | 2019-06-25 | 2023-12-06 | Bracco Suisse SA | Gefriergetrocknete zusammensetzung zur herstellung von kalibrierten gasgefüllten mikrovesikeln |
| WO2020260420A1 (en) * | 2019-06-25 | 2020-12-30 | Bracco Suisse Sa | Freeze-dried composition for preparing calibrated gas-filled microvesicles |
| JP7321015B2 (ja) * | 2019-07-12 | 2023-08-04 | 株式会社コーセー | バイセル構造体を含有する組成物 |
| US20220409569A1 (en) * | 2019-10-29 | 2022-12-29 | The Chemist's Cabinet, Llc | Cannabinoid Products with High Bioavailability |
| WO2021160659A1 (en) | 2020-02-11 | 2021-08-19 | Bracco Suisse Sa | Gas-filled microvesicles for therapeutic use |
| JP7582646B2 (ja) * | 2020-07-31 | 2024-11-13 | 学校法人帝京大学 | マイクロバブル製剤 |
| CN111939122B (zh) * | 2020-08-06 | 2022-04-05 | 温州医科大学 | 肺动脉高压靶向治疗的速效制剂 |
| CN116897055A (zh) * | 2020-12-27 | 2023-10-17 | 索尔斯蒂斯制药有限公司 | 用于混合旨在用于体内使用的磷脂组合物的筒 |
| CN113041365B (zh) * | 2021-03-25 | 2022-04-08 | 黑龙江中医药大学 | 一种增强颈动脉硬化超声诊断的靶向超声造影剂及其制备方法 |
| EP4568711A1 (de) * | 2022-08-12 | 2025-06-18 | Bracco Suisse SA | Gefriergetrocknete nanotröpfchen mit fluorierter verbindung |
| CN120529925A (zh) | 2022-12-21 | 2025-08-22 | 博莱科瑞士股份有限公司 | 含全氟烯烃的充气微泡 |
| WO2025021942A1 (en) | 2023-07-27 | 2025-01-30 | Bracco Suisse Sa | Ultrasound responsive vesicles containing lipid-polyamino acid conjugates |
| WO2025073838A1 (en) | 2023-10-04 | 2025-04-10 | Bracco Suisse Sa | Freeze-drying process |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| US4675381A (en) | 1983-07-01 | 1987-06-23 | Battelle Memorial Institute | Biodegradable polypeptide and its use for the gradual release of drugs |
| SE463651B (sv) | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
| EP0179023B1 (de) | 1984-10-19 | 1991-01-23 | Battelle Memorial Institute | Durch Mikroorganismen abbaubares Polypeptid und seine Verwendung für die fortschreitende Abgabe von Medikamenten |
| CH667874A5 (fr) | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US6146657A (en) * | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| IN172208B (de) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US5562099A (en) | 1990-10-05 | 1996-10-08 | Massachusetts Institute Of Technology | Polymeric microparticles containing agents for imaging |
| US5487390A (en) | 1990-10-05 | 1996-01-30 | Massachusetts Institute Of Technology | Gas-filled polymeric microbubbles for ultrasound imaging |
| JP2974083B2 (ja) | 1990-11-26 | 1999-11-08 | 株式会社 小松製作所 | 静油圧―機械式伝動機の制御装置 |
| JPH06511481A (ja) | 1991-07-05 | 1994-12-22 | ユニバーシティ オブ ロチェスター | 気泡を取り込む超微小非凝集多孔質粒子 |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| DE4208527A1 (de) | 1992-03-17 | 1993-09-23 | Max Planck Gesellschaft | Liposomen mit negativer ueberschussladung |
| AU4563093A (en) * | 1992-07-03 | 1994-01-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Echographic contrast agent composition |
| US5464696A (en) | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| GB9305349D0 (en) * | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5798091A (en) * | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| EP0711179B2 (de) | 1993-07-30 | 2010-09-01 | IMCOR Pharmaceutical Co. | Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| ATE234638T1 (de) | 1993-12-15 | 2003-04-15 | Bracco Research Sa | Gas-mischungen verwendbar als ultraschallkontrastmittel |
| NO940711D0 (no) | 1994-03-01 | 1994-03-01 | Nycomed Imaging As | Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging |
| EP0699445A3 (de) | 1994-08-04 | 1996-04-17 | Gakko Houjin Toin Gakuen | Verfahren zur Herstellung eines Mikrobläschen-Ultraschallkontrastmittels mit einem Tensid |
| GB9417941D0 (en) | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| JPH10508578A (ja) * | 1994-09-23 | 1998-08-25 | ザ リポソーム カンパニー、インコーポレーテッド | 凍結乾燥リポソーム生成物の製造方法 |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
| US5833948A (en) | 1995-06-15 | 1998-11-10 | Bracco Research S.A. | Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant |
| CA2246778A1 (en) | 1996-02-19 | 1997-08-21 | Per Helge Gulliksen | Thermally stabilized contrast agent |
| US6165442A (en) | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
| JP4418033B2 (ja) | 1996-02-19 | 2010-02-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤のまたはそれに関する改良 |
| JP3647047B2 (ja) | 1996-07-22 | 2005-05-11 | シーゲイト テクノロジー エルエルシー | 位相検出推定器 |
| MXPA99001053A (es) * | 1996-08-02 | 2002-03-11 | Nycomed Imaging As | Mejoramientos en o que se relacionan con agentes de contraste. |
| DE69738406T2 (de) | 1996-10-21 | 2008-12-04 | Ge Healthcare As | Verbesserungen in oder an Kontrastmitteln |
| US6331289B1 (en) * | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| WO1998018501A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| CN1238700A (zh) | 1996-10-28 | 1999-12-15 | 奈科姆成像有限公司 | 诊断和/或治疗剂的改进或与其相关的改进 |
| GB9701237D0 (en) | 1997-01-22 | 1997-03-12 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
| GB9717589D0 (en) * | 1997-08-19 | 1997-10-22 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| JP2001520207A (ja) | 1997-10-21 | 2001-10-30 | ニユコメド・イメージング・アクシエセルカペト | 微小血管に標的設定された造影剤および血管拡張剤による超音波造影 |
| US20020169138A1 (en) | 1997-10-24 | 2002-11-14 | Southern Research Institute | Delivery vehicles for bioactive agents and uses thereof |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| WO1999039738A1 (en) | 1998-02-09 | 1999-08-12 | Bracco Research S.A. | Targeted delivery of biologically active media |
| GB9808599D0 (en) | 1998-04-22 | 1998-06-24 | Nycomed Imaging As | Improvements in or realting to contrast agents |
| GB9809084D0 (en) | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| FR2782006B1 (fr) | 1998-08-07 | 2002-04-19 | Gattefosse Ets Sa | Composition a liberation prolongee apte a former une micro-emulsion |
| JP2000143550A (ja) | 1998-11-10 | 2000-05-23 | Toin Gakuen | 超音波造影剤 |
| DE10013850A1 (de) | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
| AU2002248222B2 (en) | 2000-12-23 | 2006-04-27 | Dyax Corp. | Fibrin binding polypeptides useful inter alia in medical imaging processes |
| US6793626B2 (en) | 2001-01-17 | 2004-09-21 | Fuji Photo Film Co., Ltd. | Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus |
| JP2002212108A (ja) | 2001-01-17 | 2002-07-31 | Fuji Photo Film Co Ltd | 超音波散乱体 |
| US7179449B2 (en) | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
| ES2243350T3 (es) * | 2001-01-31 | 2005-12-01 | Bracco International B.V. | Agente de contraste liofizable que comprende microburbujas de gas. |
| AU2002317095A1 (en) | 2001-07-03 | 2003-01-21 | Governors Of The University Of Alberta | Magnetic nanoparticles for bioseparation application and methods for producing same |
| WO2003015831A1 (en) | 2001-08-16 | 2003-02-27 | Bristol-Myers Squibb Pharma Company | Gas microsphere liposome composites |
| AU2003213730A1 (en) | 2002-03-01 | 2003-09-16 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| WO2003084574A1 (en) | 2002-03-01 | 2003-10-16 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| CA2489287C (fr) | 2002-06-19 | 2011-04-05 | Dimitrios Patsalaridis | Dispositif de support ancrable dans le sol |
| AU2003303954A1 (en) | 2002-10-25 | 2004-10-11 | Emory University | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
| WO2004069284A2 (en) | 2003-02-04 | 2004-08-19 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| JP5513708B2 (ja) | 2003-12-22 | 2014-06-04 | ブラッコ・シュイス・ソシエテ・アノニム | 造影イメージング用の気体封入マイクロベシクル・アセンブリー |
| EP1696965B1 (de) | 2003-12-22 | 2014-12-10 | Bracco Suisse SA | Anordnung aus gasgefüllten mikrovesikeln mit wirkstoff für die kontrastdarstellung |
| EP2213310A1 (de) | 2004-01-20 | 2010-08-04 | Sunnybrook and Women's College Health Sciences Centre | Hochfrequenz Ultraschallabbildung, welche Kontrastmittel verwendet |
| US9248204B2 (en) | 2004-08-18 | 2016-02-02 | Bracco Suisse S.A. | Gas-filled microvesicles composition for contrast imaging |
-
2004
- 2004-02-03 WO PCT/IB2004/000243 patent/WO2004069284A2/en not_active Ceased
- 2004-02-03 CN CNB2004800029752A patent/CN100374165C/zh not_active Expired - Lifetime
- 2004-02-03 MX MXPA05007730A patent/MXPA05007730A/es active IP Right Grant
- 2004-02-03 ES ES04707586T patent/ES2352087T3/es not_active Expired - Lifetime
- 2004-02-03 EP EP04707586A patent/EP1590006B1/de not_active Expired - Lifetime
- 2004-02-03 JP JP2006502384A patent/JP4670083B2/ja not_active Expired - Lifetime
- 2004-02-03 CA CA2512454A patent/CA2512454C/en not_active Expired - Lifetime
- 2004-02-03 RU RU2005127634/15A patent/RU2345793C2/ru active
- 2004-02-03 DE DE602004029010T patent/DE602004029010D1/de not_active Expired - Lifetime
- 2004-02-03 US US10/544,123 patent/US9364569B2/en active Active
- 2004-02-03 KR KR1020057013951A patent/KR101076053B1/ko not_active Expired - Fee Related
- 2004-02-03 AU AU2004210221A patent/AU2004210221B2/en not_active Ceased
- 2004-02-03 AT AT04707586T patent/ATE480263T1/de active
- 2004-02-03 DK DK04707586.6T patent/DK1590006T3/da active
-
2005
- 2005-07-14 IL IL169677A patent/IL169677A/en active IP Right Grant
- 2005-08-11 US US11/202,008 patent/US20060034770A1/en not_active Abandoned
- 2005-09-02 NO NO20054089A patent/NO331966B1/no not_active IP Right Cessation
-
2011
- 2011-03-03 US US13/039,838 patent/US20110236320A1/en not_active Abandoned
-
2012
- 2012-12-10 US US13/710,189 patent/US20130101522A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO331966B1 (no) | 2012-05-14 |
| DK1590006T3 (da) | 2010-12-20 |
| US20110236320A1 (en) | 2011-09-29 |
| IL169677A (en) | 2011-07-31 |
| US20060034770A1 (en) | 2006-02-16 |
| US9364569B2 (en) | 2016-06-14 |
| EP1590006A2 (de) | 2005-11-02 |
| NO20054089D0 (no) | 2005-09-02 |
| DE602004029010D1 (de) | 2010-10-21 |
| CN1744921A (zh) | 2006-03-08 |
| JP2006520754A (ja) | 2006-09-14 |
| CA2512454A1 (en) | 2004-08-19 |
| KR101076053B1 (ko) | 2011-10-21 |
| MXPA05007730A (es) | 2006-01-31 |
| ES2352087T3 (es) | 2011-02-15 |
| AU2004210221A1 (en) | 2004-08-19 |
| EP1590006B1 (de) | 2010-09-08 |
| RU2005127634A (ru) | 2006-01-20 |
| CA2512454C (en) | 2012-10-30 |
| WO2004069284A3 (en) | 2004-11-25 |
| KR20050096959A (ko) | 2005-10-06 |
| US20060051297A1 (en) | 2006-03-09 |
| RU2345793C2 (ru) | 2009-02-10 |
| US20130101522A1 (en) | 2013-04-25 |
| JP4670083B2 (ja) | 2011-04-13 |
| AU2004210221B2 (en) | 2008-11-20 |
| CN100374165C (zh) | 2008-03-12 |
| NO20054089L (no) | 2005-10-05 |
| WO2004069284A2 (en) | 2004-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602004029010D1 (de) | Ultraschall kontrastmittel und verfahren zur erstellung | |
| Jin et al. | Functional nanoclay suspension for printing-then-solidification of liquid materials | |
| Lapinski et al. | Comparison of liposomes formed by sonication and extrusion: rotational and translational diffusion of an embedded chromophore | |
| DE60003933D1 (de) | Verfahren zur herstellung von mikropartikeln | |
| PT951280E (pt) | Microparticulas hidrofilicas e metodos para a sua preparacao | |
| Matos et al. | Alternating current electric field effects on neural stem cell viability and differentiation | |
| DE10199055I2 (de) | Mikroblasensuspensionen wie verst{rkungagenzien f}r ultraschall-Echographie. | |
| DE60028109D1 (de) | Verfahren zur Herstellung von dreidimensionalen Karten und Navigationsgerät | |
| ATE489939T1 (de) | Verfahren zur herstellung von kristallinischen nanopartikeldispersionen | |
| ATE541528T1 (de) | System zum einführen von biokompatiblen füllmaterialien in innere körperregionen | |
| BRPI0414128A (pt) | sistema e método para aumento de mamas | |
| US20140141500A1 (en) | Microbubble devices, methods and systems | |
| BRPI0516095A (pt) | método para formação dos agregados de retenção de forma de partìculas de gel e seu uso | |
| EA200802252A1 (ru) | Обработка водных суспензий | |
| DE60022664D1 (de) | Herstellungsverfahren von submikrometerwirkstoffpartikeln | |
| ATE556788T1 (de) | Herstellung pharmazeutischer wirkstoffpartikel unter verwendung fokussierter akustischer energie | |
| NZ595185A (en) | Triggered release of a compound or composition into solution using porus particles | |
| NO20060118L (no) | Viskos, kryssbundet, brytbar, vandig vaeske samt fremgangsmate for a behandle underjordiske formasjoner med slik vaeske | |
| Barboro et al. | An intranuclear frame for chromatin compartmentalization and higher‐order folding | |
| ATE555811T1 (de) | Verfahren zur herstellung von molekularkomplexen | |
| Shimanovich et al. | Stabilizing RNA by the sonochemical formation of RNA nanospheres | |
| HK1220120A1 (zh) | 制造注射蛋白质微粒悬浮液的方法 | |
| CN106987579A (zh) | 一种基于天然纯蛋白质制备微胶囊提高界面催化反应效率的方法 | |
| Saint-Pierre-Chazalet et al. | Phospholipid-protein interactions at the air-water interface: a monolayer study | |
| ATE468169T1 (de) | Verfahren zur herstellung von bio-compatibel zusammengesetzten mikrokapseln |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1590006 Country of ref document: EP |