ATE480294T1 - Gerät zur verabreichung von medikamenten und genen mittels elektroporation - Google Patents

Gerät zur verabreichung von medikamenten und genen mittels elektroporation

Info

Publication number
ATE480294T1
ATE480294T1 AT98938256T AT98938256T ATE480294T1 AT E480294 T1 ATE480294 T1 AT E480294T1 AT 98938256 T AT98938256 T AT 98938256T AT 98938256 T AT98938256 T AT 98938256T AT E480294 T1 ATE480294 T1 AT E480294T1
Authority
AT
Austria
Prior art keywords
electroporation
ept
therapy
vivo
tumors
Prior art date
Application number
AT98938256T
Other languages
English (en)
Inventor
Gunter Hofmann
Sukhendu Dev
Steven Dimmer
Jeffrey Levatter
Gurvinder S Nanda
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE480294T1 publication Critical patent/ATE480294T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrotherapy Devices (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98938256T 1997-08-01 1998-07-31 Gerät zur verabreichung von medikamenten und genen mittels elektroporation ATE480294T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/905,240 US6055453A (en) 1997-08-01 1997-08-01 Apparatus for addressing needle array electrodes for electroporation therapy
PCT/US1998/016042 WO1999006101A1 (en) 1997-08-01 1998-07-31 Method and apparatus for using electroporation mediated delivery of drugs and genes

Publications (1)

Publication Number Publication Date
ATE480294T1 true ATE480294T1 (de) 2010-09-15

Family

ID=25420478

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98938256T ATE480294T1 (de) 1997-08-01 1998-07-31 Gerät zur verabreichung von medikamenten und genen mittels elektroporation

Country Status (13)

Country Link
US (5) US6055453A (de)
EP (1) EP0999867B1 (de)
JP (2) JP2000503586A (de)
KR (1) KR100756252B1 (de)
CN (2) CN1768873B (de)
AT (1) ATE480294T1 (de)
AU (1) AU734343B2 (de)
BR (1) BR9806069A (de)
CA (1) CA2268026C (de)
DE (1) DE69841888D1 (de)
RU (1) RU2195332C2 (de)
TW (1) TW396043B (de)
WO (1) WO1999006101A1 (de)

Families Citing this family (403)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602248B1 (en) 1995-06-07 2003-08-05 Arthro Care Corp. Methods for repairing damaged intervertebral discs
US20050004634A1 (en) * 1995-06-07 2005-01-06 Arthrocare Corporation Methods for electrosurgical treatment of spinal tissue
US7393351B2 (en) 1995-06-07 2008-07-01 Arthrocare Corporation Apparatus and methods for treating cervical inter-vertebral discs
WO2003024506A2 (en) * 2001-09-14 2003-03-27 Arthrocare Corporation Methods and apparatus for treating intervertebral discs
IL125756A (en) 1996-02-15 2003-05-29 Biosense Inc Catheter for use in surgery
US6726684B1 (en) * 1996-07-16 2004-04-27 Arthrocare Corporation Methods for electrosurgical spine surgery
US6620155B2 (en) 1996-07-16 2003-09-16 Arthrocare Corp. System and methods for electrosurgical tissue contraction within the spine
US7357798B2 (en) * 1996-07-16 2008-04-15 Arthrocare Corporation Systems and methods for electrosurgical prevention of disc herniations
US20060089751A1 (en) * 1997-01-27 2006-04-27 Ewa Herbst Electronic delivery systems and methods with feedback
US6708066B2 (en) * 1999-12-10 2004-03-16 Ewa Herbst Electrochemical treatment of tissues, especially tumors
DE69826124T3 (de) 1997-06-30 2007-10-11 Institut Gustave Roussy Verabreichung der nukleinsäure in den quergestreiften muskel
IL133708A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6208893B1 (en) 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US20030113303A1 (en) * 1998-02-05 2003-06-19 Yitzhack Schwartz Homing of embryonic stem cells to a target zone in tissue using active therapeutics or substances
US7749215B1 (en) 1998-02-05 2010-07-06 Biosense, Inc. Intracardiac cell delivery and cell transplantation
DE69838526T2 (de) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Gerät zum Freisetzen eines Medikaments im Herzen
US20030129750A1 (en) * 1998-02-05 2003-07-10 Yitzhack Schwartz Homing of donor cells to a target zone in tissue using active therapeutics or substances
US6045532A (en) * 1998-02-20 2000-04-04 Arthrocare Corporation Systems and methods for electrosurgical treatment of tissue in the brain and spinal cord
CA2626830A1 (en) 1998-02-24 1999-08-26 Boston Scientific Limited High flow rate dialysis catheters and related methods
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
WO1999063049A1 (de) * 1998-05-29 1999-12-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Neues verfahren zum transfer von biologischem material
ATE369877T1 (de) * 1998-06-26 2007-09-15 Genetronics Inc Synergismus von photodynamischen und elektropermeationseffekten auf die zellvitalität als ein neues cytotoxisches mittel
EP2428250A1 (de) 1998-07-13 2012-03-14 Genetronics, Inc. Haut- und muskelgerichtete Gentherapie mit hilfe eines gepulsten elektrischen Felds
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
DE69921489T2 (de) 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
EP1171189B1 (de) * 1999-03-25 2016-05-11 Inovio Pharmaceuticals, Inc. Gerät zur reduzierung durch elektroporationsinduzierte muskelreaktion und schmerzantwort
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
AU4239300A (en) 1999-04-16 2000-11-02 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6514762B1 (en) 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
US6221071B1 (en) * 1999-06-04 2001-04-24 Scimed Life Systems, Inc. Rapid electrode deployment
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US7074747B1 (en) * 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6387092B1 (en) * 1999-09-07 2002-05-14 Scimed Life Systems, Inc. Systems and methods to identify and disable re-used single use devices based on time elapsed from first therapeutic use
US6237604B1 (en) 1999-09-07 2001-05-29 Scimed Life Systems, Inc. Systems and methods for preventing automatic identification of re-used single use devices
US6611793B1 (en) 1999-09-07 2003-08-26 Scimed Life Systems, Inc. Systems and methods to identify and disable re-use single use devices based on detecting environmental changes
US6651669B1 (en) 1999-09-07 2003-11-25 Scimed Life Systems, Inc. Systems and methods to identify and disable re-used single use devices based on cataloging catheter usage
US6587718B2 (en) * 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
US6549810B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode depth control
US6522927B1 (en) 1999-12-01 2003-02-18 Vertis Neuroscience, Inc. Electrode assembly for a percutaneous electrical therapy system
US6556869B1 (en) 1999-12-01 2003-04-29 Vertis Neuroscience, Inc. Electrode introducer for a percutaneous electrical therapy system
US6560491B1 (en) 1999-12-01 2003-05-06 Vertis Neuroscience, Inc. Percutaneous electrical therapy system providing electrode axial support
US6529776B1 (en) 1999-12-01 2003-03-04 Vertis Neuroscience, Inc. Method and apparatus for repositioning a percutaneous probe
US6622051B1 (en) 1999-12-01 2003-09-16 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode entry angle control
US6539264B1 (en) 1999-12-01 2003-03-25 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with sharp point protection
US6904324B2 (en) * 1999-12-01 2005-06-07 Meagan Medical, Inc. Method and apparatus for deploying a percutaneous probe
US6549797B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Electrode remover for a percutaneous electrical therapy system
US6493592B1 (en) * 1999-12-01 2002-12-10 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode position maintenance
US6912424B2 (en) * 1999-12-01 2005-06-28 Meagan, Medical, Inc. Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient
US6516226B1 (en) 1999-12-01 2003-02-04 Vertis Neuroscience, Inc. Percutaneous electrical therapy system for minimizing electrode insertion discomfort
KR100406729B1 (ko) * 2000-02-15 2003-11-21 사회복지법인삼성생명공익재단(삼성서울병원) 생리학적 전기신호에 동조화된 의료기기
US8447395B2 (en) * 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US8175698B2 (en) * 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7136699B2 (en) * 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7089054B2 (en) * 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7016725B2 (en) * 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7599745B2 (en) * 2000-02-17 2009-10-06 Standen Ltd Treating a tumor or the like with an electric field
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US6868289B2 (en) * 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7146210B2 (en) * 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
EP2335776A1 (de) * 2000-02-17 2011-06-22 Yoram Palti Verfahren und vorrichtung zur zerstörung von teilenden zellen
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US7588554B2 (en) * 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US8251986B2 (en) 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7118555B2 (en) * 2000-09-21 2006-10-10 Meagan Medical, Inc. Method and apparatus for repositioning a percutaneous probe
USD480478S1 (en) 2000-09-28 2003-10-07 Vertis Neuroscience, Inc. Percutaneous probe applicator
US20030158545A1 (en) * 2000-09-28 2003-08-21 Arthrocare Corporation Methods and apparatus for treating back pain
US6846306B1 (en) * 2000-10-10 2005-01-25 Cold Spring Harbor Laboratory Single cell electroporation
US6671557B1 (en) 2000-10-10 2003-12-30 Meagan Medical, Inc. System and method for providing percutaneous electrical therapy
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US6821274B2 (en) 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
AU2002215115A1 (en) 2000-11-17 2002-05-27 Gendel Limited Ablation of cells using combined electric field and ultrasound therapy
US20050043726A1 (en) * 2001-03-07 2005-02-24 Mchale Anthony Patrick Device II
WO2003099382A1 (en) * 2002-05-23 2003-12-04 Gendel Limited Ablation device
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6625486B2 (en) 2001-04-11 2003-09-23 Advanced Cardiovascular Systems, Inc. Method and apparatus for intracellular delivery of an agent
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8206738B2 (en) * 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
CA2447302C (en) * 2001-05-01 2008-07-29 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
RU2276998C2 (ru) * 2001-05-01 2006-05-27 Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук Гидрогелевые композиции
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
ITTO20010534A1 (it) * 2001-06-04 2002-12-04 Igea Srl Dispositivo e metodo per elettroporazione che riduce la contrazione muscolare e la sensazione di dolore.
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US7130697B2 (en) * 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) * 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US7879610B1 (en) * 2001-08-24 2011-02-01 University Of South Florida Electroporation system and method for facilitating entry of molecules into cells in vivo
US7713740B2 (en) * 2001-08-24 2010-05-11 University Of South Florida Method of using electric fields to facilitate the entry of molecules into cells in vivo
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
USD475463S1 (en) 2001-09-28 2003-06-03 Vertis Neuroscience, Inc. Control device for delivering electrical therapy
US8812114B2 (en) 2001-10-18 2014-08-19 Uroplasty, Inc. Lead set for nerve stimulator and method of operation thereof
FR2831026B1 (fr) * 2001-10-18 2004-05-28 Commissariat Energie Atomique Dispositif et procede de traitement par champ electrique pulse d'une substance en ecoulement colonisee par des organismes indesirables
ES2450465T3 (es) * 2001-10-18 2014-03-24 Uroplasty, Inc. Sistema de electroestimulación nerviosa
AU2002353741A1 (en) * 2001-11-27 2003-06-10 Cellectricon Ab A method for combined sequential agent delivery and electroporation for cell structures and use thereof
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
ATE516879T1 (de) * 2002-02-12 2011-08-15 Cellectricon Ab Systeme und verfahren zur schnellen änderung der lösungsumgebung von sensoren
JP2005530695A (ja) * 2002-02-15 2005-10-13 ザイコス インク． 生理活性物質を細胞内に導入するエレクトロポレーション法
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
EP1480720B1 (de) * 2002-03-07 2018-08-22 Inovio Pharmaceuticals, Inc. Elektrodenvorrichtung zur konstantstrom-elektroporation
WO2003082007A2 (en) * 2002-03-22 2003-10-09 The Regent Of The University Of California Method and apparatus for using an electromagnetic field in cellular transplantation
US7218962B2 (en) * 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
JP4499427B2 (ja) 2002-04-16 2010-07-07 サイト パルス サイエンシズ、インコーポレイテッド 電場の移動及び電極極性の反転で生体材料を処理する方法。
US20030204161A1 (en) * 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US10130415B2 (en) * 2002-06-10 2018-11-20 Wisconsin Alumni Research Foundation Circumferential electrode array for tissue ablation
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US20040127893A1 (en) * 2002-12-13 2004-07-01 Arthrocare Corporation Methods for visualizing and treating intervertebral discs
US6997903B2 (en) * 2003-02-10 2006-02-14 Bandula Wijay Local drug delivery catheter
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7794456B2 (en) * 2003-05-13 2010-09-14 Arthrocare Corporation Systems and methods for electrosurgical intervertebral disc replacement
US6969604B1 (en) 2003-06-20 2005-11-29 Yakovenko Sergey A Electroporation chamber
GB0322766D0 (en) * 2003-09-29 2003-10-29 Emcision Ltd Surgical resection device
US7708733B2 (en) 2003-10-20 2010-05-04 Arthrocare Corporation Electrosurgical method and apparatus for removing tissue within a bone body
US8500713B2 (en) * 2003-10-29 2013-08-06 Medtronic, Inc. Implantable electroporation therapy device and method for using same
US8298222B2 (en) 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
ES2543832T3 (es) * 2003-12-24 2015-08-24 The Regents Of The University Of California Ablación de tejido con electroporación irreversible
EP1713450B1 (de) 2004-01-30 2021-10-06 Corium, Inc. Schnell auflösender film zur abgabe eines wirkstoffs
RU2252793C1 (ru) * 2004-02-02 2005-05-27 Карасев Александр Александрович Электродное устройство
FR2867054B1 (fr) 2004-03-04 2006-09-15 Future Medical System Systeme d'endoscopie et connecteur a detecteur de pression destine a un tel systeme
NZ585119A (en) 2004-03-08 2011-08-26 Ichor Medical Systems Inc Medical injector with surrounding electrical field generating penetrating electrodes
CA2560840C (en) * 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
JP4899020B2 (ja) * 2004-03-25 2012-03-21 ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク 組織の予防的処置又は治療に用いるための装置
JP4443278B2 (ja) * 2004-03-26 2010-03-31 テルモ株式会社 拡張体付カテーテル
WO2005107848A2 (en) 2004-04-01 2005-11-17 The General Hospital Corporation Method for dermatological treatment using chromophores
US20050226991A1 (en) * 2004-04-07 2005-10-13 Hossainy Syed F Methods for modifying balloon of a catheter assembly
WO2005099367A2 (en) 2004-04-16 2005-10-27 Critical Care Innovations, Inc. Systems and methods for improving image-guided tissue ablation
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
CA2572122A1 (fr) 2004-06-24 2006-02-02 Sphergen Dispositif pour le transfert de molecules aux cellules utilisant une force electrique
FR2872055B1 (fr) 2004-06-24 2008-02-08 Yves Leon Scherman Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
CN101039706A (zh) * 2004-08-05 2007-09-19 考里安国际公司 粘合剂组合物
ES2344215T3 (es) * 2004-12-07 2010-08-20 Standen Ltd. Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo.
JP5559460B2 (ja) * 2004-12-27 2014-07-23 スタンデン・リミテッド 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法
WO2007012907A2 (en) * 2005-02-08 2007-02-01 Allen, John Electric therapy machine
US7850645B2 (en) * 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
AU2006226753A1 (en) * 2005-03-19 2006-09-28 The Regents Of The University Of California Ultra low strength electric field network-mediated ex vivo gene, protein and drug delivery in cells
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
WO2006124639A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
EP2790207B1 (de) * 2005-06-20 2016-01-06 Nippon Telegraph And Telephone Corporation Diamantenhalbleiterelement und Verfahren zu dessen Herstellung
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US20060293731A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
US20060293730A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
EP1913578B1 (de) * 2005-06-30 2012-08-01 LG Electronics Inc. Verfahren und vorrichtung zum decodieren eines audiosignals
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
CA2624624C (en) 2005-10-03 2016-07-19 Novocure Limited Optimizing characteristics of an electric field to increase the field's effect on proliferating cells
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
EA200870252A1 (ru) * 2006-02-11 2009-02-27 Дженетроникс, Инк. Устройство и способ одноигольного электропорообразования in vivo
US7879034B2 (en) * 2006-03-02 2011-02-01 Arthrocare Corporation Internally located return electrode electrosurgical apparatus, system and method
CN101426550B (zh) * 2006-03-03 2012-10-31 基因特伦尼克斯公司 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的方法和装置
US20070232984A1 (en) * 2006-03-30 2007-10-04 Michael Lovell Hand-held electrical stimulation device
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
WO2007117651A2 (en) 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
US7856272B2 (en) * 2006-04-28 2010-12-21 Flint Hills Scientific, L.L.C. Implantable interface for a medical device system
US7668598B2 (en) 2006-05-18 2010-02-23 Uroplasty, Inc. Method and apparatus for stimulating a nerve of a patient
DK2032057T3 (da) * 2006-06-12 2010-02-08 Region Hovedstaden V Herlev Ho Elektrodeindføringsindretning
CN101472645A (zh) * 2006-06-22 2009-07-01 皇家飞利浦电子股份有限公司 离子导入电迁移设备
WO2008020967A2 (en) * 2006-08-08 2008-02-21 Peak Biosciences, Inc. Catheter and array for anticancer therapy
WO2008048620A2 (en) 2006-10-16 2008-04-24 The Regents Of The University Of California Gels with predetermined conductivity used in irreversible electroporation of tissue
PT3524316T (pt) 2006-10-17 2024-11-29 Inovio Pharmaceuticals Inc Dispositivos de eletroporação para eletroporação de células em mamíferos
DK2548438T3 (en) 2006-11-08 2015-10-19 Veritas Bio LLC IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
EP2121111B1 (de) * 2007-01-22 2018-03-14 Corium International, Inc. Applikator für mikronadelanordnung
WO2009044289A1 (en) 2007-03-06 2009-04-09 Novocure Ltd. Treating cancer using electromagnetic fields in combination with photodynamic therapy
US20110135569A1 (en) * 2007-03-20 2011-06-09 Peak Biosciences Inc. Method for therapeutic administration of radionucleosides
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
US8470295B2 (en) * 2007-05-10 2013-06-25 Peak Biosciences, Inc. Methods of treatment of androgenic steroidal hormone dependent cancer with auger electron-emitting nucleoside analogs
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
CN101820947A (zh) * 2007-08-14 2010-09-01 诺沃库勒有限公司 用电场治疗寄生物
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
EP2211982B1 (de) * 2007-10-11 2016-04-06 Region Hovedstaden v/Herlev Hospital Elektroporationsvorrichtung für verbesserte elektrofeld-kontrolle
US20100004623A1 (en) * 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
WO2009121009A2 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Irreversible electroporation device for use in attenuating neointimal
WO2009124309A2 (en) 2008-04-04 2009-10-08 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
ES2588738T3 (es) * 2008-04-04 2016-11-04 The Trustees Of The University Of Pennsylvania Secuencias de consenso de proteínas del virus Chikungunya, moléculas de ácido nucleico que las codifican, y composiciones y métodos de uso de las mismas
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9198733B2 (en) * 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
WO2009134876A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
WO2009137609A2 (en) * 2008-05-06 2009-11-12 Cellutions, Inc. Apparatus and systems for treating a human tissue condition
US20090281477A1 (en) * 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8849395B2 (en) 2008-05-30 2014-09-30 Boston Scientific Scimed, Inc. Guide catheter having vasomodulating electrodes
US9173704B2 (en) * 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
US9681909B2 (en) * 2008-06-23 2017-06-20 Angiodynamics, Inc. Treatment devices and methods
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
KR100943089B1 (ko) * 2009-01-23 2010-02-18 강동환 피부처치 장치
WO2010085765A2 (en) * 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
WO2010093692A2 (en) * 2009-02-10 2010-08-19 Hobbs Eamonn P Irreversible electroporation and tissue regeneration
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010118387A1 (en) * 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
EP2429627B1 (de) * 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US20100298825A1 (en) * 2009-05-08 2010-11-25 Cellutions, Inc. Treatment System With A Pulse Forming Network For Achieving Plasma In Tissue
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US9272138B2 (en) * 2009-09-10 2016-03-01 University College Cork—National University of Ireland, Cork Device for treating tissue
CN102821790A (zh) 2009-09-14 2012-12-12 宾夕法尼亚大学托管会 包含IL-15受体α和/或编码IL-15受体α的核酸分子的疫苗和免疫治疗剂,以及其使用方法
US20110118732A1 (en) 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US11097099B2 (en) * 2010-03-01 2021-08-24 Inovio Pharmaceuticals, Inc. Multiple tissue layer electroporation applicator and device
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
US8979838B2 (en) 2010-05-24 2015-03-17 Arthrocare Corporation Symmetric switching electrode method and related system
US9289606B2 (en) * 2010-09-02 2016-03-22 St. Jude Medical, Atrial Fibrillation Division, Inc. System for electroporation therapy
EP2621522A2 (de) 2010-09-27 2013-08-07 China Agricultural University Kombinierter antigen- und dna-impfstoff zur vorbeugung und behandlung von autoimmunkrankheiten
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
WO2012088149A2 (en) 2010-12-20 2012-06-28 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US20120220813A1 (en) * 2011-01-25 2012-08-30 Sanford Lane Devices and methods for applying energy to a muscular layer
WO2012158132A1 (en) 2011-05-18 2012-11-22 Eteka Llc Apparatus for the enhancement of food properties by electroporation or pulsed electric fields
US9457183B2 (en) 2011-06-15 2016-10-04 Tripep Ab Injection needle and device
WO2012178095A1 (en) * 2011-06-22 2012-12-27 Ifluidics, Inc. Electromotive system for high-throughput screening
AU2012333211A1 (en) * 2011-06-28 2013-12-19 Inovio Pharmaceuticals, Inc. A miniminally invasive dermal electroporation device
AU2012321317B2 (en) 2011-07-12 2016-01-28 Inovio Pharmaceuticals, Inc Novel clostridium difficile DNA vaccine
CN102334988B (zh) * 2011-07-28 2013-07-03 河海大学常州校区 手动组合式微电极推进器及制作方法
US10421960B2 (en) 2011-09-16 2019-09-24 The Trustees Of The University Of Pennsylvania RNA engineered T cells for the treatment of cancer
US9708384B2 (en) 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
US8951251B2 (en) * 2011-11-08 2015-02-10 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
CN103169510B (zh) * 2011-12-20 2016-07-06 刘兴鹏 用于治疗房颤的化学消融装置
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
SG11201404769UA (en) 2012-02-22 2014-11-27 Univ Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
SG11201404284SA (en) 2012-02-22 2014-10-30 Univ Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
AU2013289971A1 (en) 2012-07-13 2015-01-22 The Trustees Of The University Of Pennsylvania Enhancing activity of CAR T cells by co-introducing a bispecific antibody
AR092745A1 (es) 2012-10-01 2015-04-29 Univ Pennsylvania Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
PL2931304T3 (pl) 2012-12-13 2021-11-08 The Trustees Of The University Of Pennsylvania Szczepionka wt1
AU2013364053B2 (en) 2012-12-21 2018-08-30 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2903748C (en) 2013-03-12 2021-11-02 Corium International, Inc. Microprojection applicators
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US20160056020A1 (en) * 2013-03-27 2016-02-25 Washington State University Systems and methods for treating material surfaces
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2014194244A1 (en) 2013-05-30 2014-12-04 Duke University Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
KR20160037196A (ko) 2013-07-31 2016-04-05 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 종양 연관된 탄수화물 항원을 표적으로 하는 암을 치료하고 예방하기 위한 조성물과 방법
KR101582988B1 (ko) * 2013-09-30 2016-01-06 (주)휴먼드림 전립선 고주파 치료기
JP6649252B2 (ja) 2013-10-07 2020-02-19 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア アジュバントとしてのインターロイキン−３３を有するワクチン
US10370664B2 (en) 2013-11-07 2019-08-06 University Of Southern California Use of IKK epsilon inhibitors to activate NFAT and T cell response
KR20220061285A (ko) 2013-11-14 2022-05-12 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 HIV-1 EnV DNA 백신과 단백질 부스터
CN112057613A (zh) 2013-11-29 2020-12-11 宾夕法尼亚大学理事会 MERS-CoV疫苗
CA3156357A1 (en) 2014-01-06 2015-07-09 The Trustees Of The University Of Pennsylvania Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
CN103861202B (zh) 2014-03-18 2016-06-01 苏州壹达生物科技有限公司 一种利用空心电极针电穿孔给药的装置
US12070601B2 (en) * 2014-03-28 2024-08-27 Pinnacle Bionics. Inc. Stimulation system for exercising diaphragm and method of operation thereof
CN112807074A (zh) 2014-05-12 2021-05-18 弗吉尼亚暨州立大学知识产权公司 电穿孔系统
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
KR20250108761A (ko) 2014-10-01 2025-07-15 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
KR20170075013A (ko) 2014-10-31 2017-06-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Cart 세포에서 유전자 발현의 변경 및 그의 용도
AU2015338984A1 (en) 2014-10-31 2017-04-27 The Trustees Of The University Of Pennsylvania Methods and compositions for modified T cells
ES2910227T3 (es) 2014-10-31 2022-05-12 Univ Pennsylvania Composición y métodos para la estimulación y expansión de células T
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CN107427567A (zh) 2015-01-29 2017-12-01 宾夕法尼亚大学理事会 检查点抑制剂和疫苗组合物及其用于免疫疗法的用途
EP4223873A3 (de) 2015-01-31 2023-09-06 The Trustees of the University of Pennsylvania Zusammensetzungen und verfahren zur t-zell-freisetzung von therapeutischen molekülen
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
CN112998846B (zh) 2015-05-01 2025-03-07 因特科学股份有限公司 用于使用脉冲形状设计的组织消融的方法、系统及设备
AU2016257721B2 (en) 2015-05-01 2019-11-14 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017024182A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
CN108348551A (zh) 2015-08-28 2018-07-31 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
WO2017062753A1 (en) 2015-10-07 2017-04-13 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
WO2017070196A1 (en) * 2015-10-21 2017-04-27 The Methodist Hospital System Cellular vectors for delivery of therapeutics
US20190015520A1 (en) 2015-12-21 2019-01-17 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
CN115068812B (zh) * 2015-12-28 2025-02-11 因诺维奥制药公司 具有改进的信号发生器的电穿孔装置
ES2970438T3 (es) * 2015-12-30 2024-05-28 Inovio Pharmaceuticals Inc Dispositivo de electroporación con conjunto de agujas desmontable con sistema de bloqueo
US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
NZ747635A (en) 2016-03-28 2024-05-31 Ichor Medical Systems Inc Method and apparatus for delivery of therapeutic agents
WO2017173398A1 (en) 2016-04-01 2017-10-05 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
ES3032333T3 (en) 2016-04-29 2025-07-17 Inovio Pharmaceuticals Inc The in vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
CN109788979B (zh) 2016-06-27 2022-04-19 盖能适治疗股份有限公司 发生器和具有电极的导管以及用于治疗肺通道的方法
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
WO2018053201A1 (en) 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
EP3515928B1 (de) 2016-09-23 2026-01-28 Duke University Unstrukturierte nichtrepititive polypeptide mit lcst-verhalten
US10613005B2 (en) 2016-10-31 2020-04-07 Agilent Technologies, Inc. Deparaffinization of tissue by electric field generation and ionization
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US10376495B2 (en) 2016-11-23 2019-08-13 University Of South Florida Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
EP3558265B1 (de) 2016-12-22 2025-04-16 Ohio State Innovation Foundation Interpenetrierende mikrostrukturen für nanokanalbasierte frachtlieferung
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
CN107212920A (zh) * 2017-01-23 2017-09-29 杭州安杰思医学科技有限公司 内窥镜用处理装置、内窥镜、及扩展支架
US10813935B2 (en) 2017-02-23 2020-10-27 Transgenex Nanobiotech, Inc. Methods and compositions for treating drug resistance in cancer
US11318155B2 (en) 2017-02-24 2022-05-03 University Of South Florida Hsp90 activator Aha1 drives production of pathological tau aggregates
US10272052B2 (en) 2017-02-24 2019-04-30 University Of South Florida Compositions and methods for the treatment of tauopathies
EP3600355B1 (de) 2017-03-28 2025-11-05 The Trustees of the University of Pennsylvania Hla-a2-spezifisches car zur behandlung von abstossungsreaktionen bei transplantiertem gewebe
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
EP3658168A4 (de) 2017-06-30 2021-07-14 Duke University Ordnung und unordnung als designprinzip für auf stimuli ansprechende biopolymernetzwerke
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SE541651C2 (en) * 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
US11590345B2 (en) 2017-08-08 2023-02-28 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
US10850095B2 (en) 2017-08-08 2020-12-01 Pulse Biosciences, Inc. Treatment of tissue by the application of energy
US10857347B2 (en) * 2017-09-19 2020-12-08 Pulse Biosciences, Inc. Treatment instrument and high-voltage connectors for robotic surgical system
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
CN118383863A (zh) 2017-12-26 2024-07-26 盖能适治疗股份有限公司 用于各种应用的能量输送的优化
JP7372920B2 (ja) 2017-12-29 2023-11-01 セレクティス Ｃａｒ ｔ細胞の作製を改良するための方法
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11525759B2 (en) 2018-04-24 2022-12-13 Agilent Technologies, Inc. Deparaffinization of tissue utilizing electric field
EP3788343B1 (de) 2018-04-30 2024-03-27 Duke University Auf stimuli reagierende plattform zur abgabe von auf peg-like-polymer basierendem arzneimittel
US20190336757A1 (en) 2018-05-02 2019-11-07 Oncosec Medical Incorporated Electroporation systems, methods, and apparatus
US12343397B2 (en) 2018-05-17 2025-07-01 Regents Of The University Of Minnesota Drug-resistant immune cells and methods of use thereof
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US12497611B2 (en) 2018-08-17 2025-12-16 Yale University Compositions and methods for high-throughput activation screening to boost T cell effector function
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
WO2020092455A2 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Car t cell transcriptional atlas
DK3877039T3 (da) * 2018-11-05 2023-07-03 Herlev Hospital Elektrodeanordning til forbedret fordeling af et elektrisk felt
TWI850282B (zh) 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
US20220054827A1 (en) * 2018-12-13 2022-02-24 Newsouth Innovations Pty Limited Method and system for controlling molecular electrotransfer
US11071860B2 (en) * 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US11571569B2 (en) 2019-02-15 2023-02-07 Pulse Biosciences, Inc. High-voltage catheters for sub-microsecond pulsing
WO2020191102A1 (en) 2019-03-18 2020-09-24 The Broad Institute, Inc. Type vii crispr proteins and systems
JP7654557B2 (ja) 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔｎ－ＭＵＣ１キメラ抗原受容体（ＣＡＲ）Ｔ細胞療法
WO2020209961A1 (en) 2019-04-08 2020-10-15 Udayan Patel Inflatable balloon over catheter with bypass passageway
AU2020257266A1 (en) 2019-04-18 2021-11-11 Galvanize Therapeutics, Inc. Devices, systems and methods for the treatment of abnormal tissue
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021011733A1 (en) 2019-07-16 2021-01-21 Galary, Inc. Treatment of the reproductive tract with pulsed electric fields
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
US11890467B2 (en) 2019-08-30 2024-02-06 Novocure Gmbh Delivering tumor treating fields (TTFields) to the neck
TW202128775A (zh) 2019-10-16 2021-08-01 英商阿法克塔生命科學有限公司 PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
IL292334A (en) 2019-10-21 2022-06-01 Endogenex Inc Devices, systems and methods for treatment with a pulsed electric field in the duodenum
US20220387626A1 (en) 2019-10-23 2022-12-08 Yale University Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy
CN110946642A (zh) * 2019-12-13 2020-04-03 天津市鹰泰利安康医疗科技有限责任公司 一种高频双极性不可恢复电穿孔系统
IL295697B1 (en) 2020-02-25 2026-02-01 Inovio Pharmaceuticals Inc Coronavirus vaccines and methods of use
US20230126689A1 (en) 2020-03-06 2023-04-27 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
WO2021191870A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
PH12022553102A1 (en) 2020-05-14 2023-11-20 Inovio Pharmaceuticals Inc Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
CA3181680A1 (en) 2020-06-12 2021-12-16 University Of Rochester Encoding and expression of ace-trnas
KR20230033647A (ko) 2020-06-30 2023-03-08 멘두스 비.브이. 난소암 백신에서 백혈병 유래 세포의 용도
EP4210832A1 (de) 2020-09-14 2023-07-19 Vor Biopharma, Inc. Chimäre antigenrezeptoren zur behandlung von krebs
WO2022097068A1 (en) 2020-11-05 2022-05-12 Dcprime B.V. Use of tumor-independent antigens in immunotherapies
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
AU2022211682A1 (en) 2021-01-22 2023-08-03 Mendus B.V. Methods of tumor vaccination
US20250326855A1 (en) 2021-03-05 2025-10-23 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
CA3223587A1 (en) * 2021-06-30 2023-01-05 Paul Fisher Side-port injection devices for use with electroporation, and related systems and methods
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
JP2024528086A (ja) 2021-07-29 2024-07-26 ブイオーアール バイオファーマ インコーポレーテッド がん治療用キメラ抗原受容体
US20250101126A1 (en) 2021-08-05 2025-03-27 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
MX2024001948A (es) 2021-08-13 2024-05-17 Inovio Pharmaceuticals Inc Terapia combinada para tratar el cáncer cerebral.
AU2022339819A1 (en) 2021-09-03 2024-04-11 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
WO2023034569A1 (en) 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
EP4412711A1 (de) 2021-10-07 2024-08-14 Avacta Life Sciences Limited Serumhalbwertszeiterweiterte pd-l1-bindende polypeptide
US20250134919A1 (en) 2022-02-07 2025-05-01 University Of Rochester OPTIMIZED SEQUENCES FOR ENHANCED tRNA EXPRESSION OR/AND NONSENSE MUTATION SUPPRESSION
WO2023153876A1 (ko) 2022-02-10 2023-08-17 주식회사 아피셀테라퓨틱스 Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
JP2025537200A (ja) 2022-11-07 2025-11-14 パインツリー・セラピューティクス・インコーポレイテッド Ｎｒｐ１結合ドメインを含む二重特異性抗体を含む、組み合わせ治療
WO2024129459A1 (en) 2022-12-16 2024-06-20 University Of Rochester Repairmen! of barrier dysfunction in esophagus
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function
WO2026047626A1 (en) 2024-08-30 2026-03-05 Inceptor Bio, Llc Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE863111C (de) 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
DE2800039C2 (de) 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US5370675A (en) * 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US5421819A (en) * 1992-08-12 1995-06-06 Vidamed, Inc. Medical probe device
US4712559A (en) * 1985-06-28 1987-12-15 Bsd Medical Corporation Local current capacitive field applicator for interstitial array
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US5547467A (en) 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
ATE131081T1 (de) * 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US4860752A (en) * 1988-02-18 1989-08-29 Bsd Medical Corporation Invasive microwave array with destructive and coherent phase
EP0346513A1 (de) 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
ES2012944A6 (es) 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US6001617A (en) 1989-06-07 1999-12-14 Queen's University At Kingston Electroporation device and method of use
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
DE4000893A1 (de) 1990-01-15 1991-07-18 Bosch Gmbh Robert Mehrkanaliges geraet zur elektrostimulation
US5620481A (en) * 1991-07-05 1997-04-15 Desai; Jawahar M. Device for multi-phase radio-frequency ablation
US5328451A (en) 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5425752A (en) 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US5545130A (en) * 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5514131A (en) * 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5549644A (en) * 1992-08-12 1996-08-27 Vidamed, Inc. Transurethral needle ablation device with cystoscope and method for treatment of the prostate
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
WO1994027670A1 (en) 1993-06-02 1994-12-08 Cardiac Pathways Corporation Catheter having tip with fixation means
US5551426A (en) * 1993-07-14 1996-09-03 Hummel; John D. Intracardiac ablation and mapping catheter
US5536267A (en) * 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5814599A (en) 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5571083A (en) * 1994-02-18 1996-11-05 Lemelson; Jerome H. Method and system for cell transplantation
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5728094A (en) * 1996-02-23 1998-03-17 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5786454A (en) 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
US5645526A (en) * 1994-09-30 1997-07-08 Becton Dickinson And Company Apparatus and method for ensuring compatibility of a reusable iontophoretic controller with an iontophoretic patch
US5720921A (en) 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5868740A (en) * 1995-03-24 1999-02-09 Board Of Regents-Univ Of Nebraska Method for volumetric tissue ablation
US5810762A (en) * 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5780052A (en) 1995-04-24 1998-07-14 Northeastern University Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell
US5789213A (en) 1995-05-11 1998-08-04 Health Research Inc. Method and compositions for high efficiency loading, transfection and fusion of cells by electric pulses
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5980517A (en) * 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
WO1997007826A1 (en) 1995-08-29 1997-03-06 Cbr Laboratories, Inc. In vivo electroporation of cells
US5688232A (en) * 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
WO1997047355A1 (en) 1996-06-12 1997-12-18 Alza Corporation Reduction of skin sensitization in electrotransport drug delivery
GB2314274A (en) * 1996-06-20 1997-12-24 Gyrus Medical Ltd Electrode construction for an electrosurgical instrument
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US5874268A (en) 1996-09-23 1999-02-23 Duke University Method of introducing exogenous compounds into cells by electroporation and apparatus for same
US5908753A (en) 1996-10-04 1999-06-01 Merck & Co., Inc. Transformation of Candida albicans by electroporation
US5845646A (en) 1996-11-05 1998-12-08 Lemelson; Jerome System and method for treating select tissue in a living being
IL132103A0 (en) 1997-04-03 2001-03-19 Eletrofect As Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5879891A (en) 1997-09-17 1999-03-09 Merck & Co., Inc. Transformation of saccharomyces cerevisiae by electroporation
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
JP2003511098A (ja) 1998-04-14 2003-03-25 ジーエムピー・ドラツグ・デリバリー・インコーポレーテツド 動脈及び他の身体組織への局所的薬物移送のためのイオン導入、エレクトロポレーション及び組み合わせカテーテル
US6040184A (en) 1998-10-09 2000-03-21 Stratagene Method for more efficient electroporation

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