ATE480526T1 - Als inhibitor von retroviraler protease geeignete ritonavir-analoge verbindung, herstellung der ritonavir-analogen verbindung und pharmazeutische zusammenetzung für die ritonavir-analoge verbindung - Google Patents
Als inhibitor von retroviraler protease geeignete ritonavir-analoge verbindung, herstellung der ritonavir-analogen verbindung und pharmazeutische zusammenetzung für die ritonavir-analoge verbindungInfo
- Publication number
- ATE480526T1 ATE480526T1 AT05738457T AT05738457T ATE480526T1 AT E480526 T1 ATE480526 T1 AT E480526T1 AT 05738457 T AT05738457 T AT 05738457T AT 05738457 T AT05738457 T AT 05738457T AT E480526 T1 ATE480526 T1 AT E480526T1
- Authority
- AT
- Austria
- Prior art keywords
- ritonavir
- analogue compound
- preparation
- compound
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 RITONAVIR ANALOGUE COMPOUND Chemical class 0.000 title 3
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 abstract 2
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 abstract 2
- 229960000311 ritonavir Drugs 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0401742A BRPI0401742B8 (pt) | 2004-05-13 | 2004-05-13 | composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir |
| PCT/BR2005/000077 WO2005111006A1 (en) | 2004-05-13 | 2005-05-11 | Ritonavir analogous compound useful as retroviral protease inhibitor, preparation of the ritonavir analogous compound and pharmaceutical composition for the ritonavir analogous compound. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE480526T1 true ATE480526T1 (de) | 2010-09-15 |
Family
ID=36072150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05738457T ATE480526T1 (de) | 2004-05-13 | 2005-05-11 | Als inhibitor von retroviraler protease geeignete ritonavir-analoge verbindung, herstellung der ritonavir-analogen verbindung und pharmazeutische zusammenetzung für die ritonavir-analoge verbindung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7763733B2 (de) |
| EP (1) | EP1751125B1 (de) |
| JP (1) | JP4993747B2 (de) |
| CN (1) | CN100584833C (de) |
| AT (1) | ATE480526T1 (de) |
| BR (1) | BRPI0401742B8 (de) |
| DE (1) | DE602005023437D1 (de) |
| MX (1) | MXPA06013188A (de) |
| WO (1) | WO2005111006A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2049506T5 (pl) | 2006-07-07 | 2024-09-09 | Gilead Sciences, Inc. | Modulatory farmakokinetycznych właściwości leków |
| EP2081917A2 (de) * | 2006-08-31 | 2009-07-29 | Abbott Laboratories | Inhibitoren von cytochrom-p450-oxidase und anwendungen davon |
| MX2009008935A (es) | 2007-02-23 | 2009-11-02 | Gilead Sciences Inc | Moduladores de las propiedades farmacocineticas de productos terapeuticos. |
| ES2438275T3 (es) | 2007-07-06 | 2014-01-16 | Gilead Sciences, Inc. | Moduladores de propiedades farmacocinéticas de agentes terapéuticos |
| CN102786494B (zh) * | 2012-07-26 | 2016-01-06 | 合肥华方医药科技有限公司 | 利托那韦异构体杂质的合成研究及控制方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5539122A (en) | 1989-05-23 | 1996-07-23 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5354866A (en) * | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IE20010533A1 (en) * | 1990-11-20 | 2003-03-05 | Abbott Lab | Intermediates for preparing retroviral protease inhibiting compounds |
| US5567823A (en) | 1995-06-06 | 1996-10-22 | Abbott Laboratories | Process for the preparation of an HIV protease inhibiting compound |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| ZA9710071B (en) | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
| MY121765A (en) | 1998-07-20 | 2006-02-28 | Abbott Lab | Polymorph of ritonavir |
-
2004
- 2004-05-13 BR BRPI0401742A patent/BRPI0401742B8/pt not_active IP Right Cessation
-
2005
- 2005-05-11 AT AT05738457T patent/ATE480526T1/de not_active IP Right Cessation
- 2005-05-11 JP JP2007511791A patent/JP4993747B2/ja not_active Expired - Fee Related
- 2005-05-11 EP EP05738457A patent/EP1751125B1/de not_active Expired - Lifetime
- 2005-05-11 US US11/596,469 patent/US7763733B2/en not_active Expired - Fee Related
- 2005-05-11 MX MXPA06013188A patent/MXPA06013188A/es active IP Right Grant
- 2005-05-11 WO PCT/BR2005/000077 patent/WO2005111006A1/en not_active Ceased
- 2005-05-11 CN CN200580021778A patent/CN100584833C/zh not_active Expired - Fee Related
- 2005-05-11 DE DE602005023437T patent/DE602005023437D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005023437D1 (de) | 2010-10-21 |
| JP2007537166A (ja) | 2007-12-20 |
| EP1751125B1 (de) | 2010-09-08 |
| BRPI0401742B1 (pt) | 2019-04-16 |
| WO2005111006A1 (en) | 2005-11-24 |
| BRPI0401742A (pt) | 2006-01-10 |
| BRPI0401742B8 (pt) | 2021-05-25 |
| HK1107699A1 (zh) | 2008-04-11 |
| CN1980907A (zh) | 2007-06-13 |
| JP4993747B2 (ja) | 2012-08-08 |
| US7763733B2 (en) | 2010-07-27 |
| MXPA06013188A (es) | 2007-02-14 |
| CN100584833C (zh) | 2010-01-27 |
| US20070244168A1 (en) | 2007-10-18 |
| EP1751125A1 (de) | 2007-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |