ATE482959T1 - Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung - Google Patents

Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung

Info

Publication number: ATE482959T1
Authority: AT; Austria
Prior art keywords: compounds; methods; nachr; diazatricycloalkanes; substituted
Prior art date: 2005-08-22

Application number

AT06813627T

Other languages

English (en)

Inventor

Anatoly Mazurov

Lan Miao

Jozef Klucik

Original Assignee

Targacept Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-22

Filing date

2006-08-21

Publication date

2010-10-15

2006-08-21 Application filed by Targacept Inc filed Critical Targacept Inc

2010-10-15 Application granted granted Critical

2010-10-15 Publication of ATE482959T1 publication Critical patent/ATE482959T1/de

Links

238000000034 method Methods 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 abstract 7
102000015296 acetylcholine-gated cation-selective channel activity proteins Human genes 0.000 abstract 5
108040006409 acetylcholine-gated cation-selective channel activity proteins Proteins 0.000 abstract 5
230000000694 effects Effects 0.000 abstract 3
150000001408 amides Chemical class 0.000 abstract 2
QUIJMHDIAFOPRK-UHFFFAOYSA-N 1-cyclooctylazocane Chemical compound C1CCCCCCC1N1CCCCCCC1 QUIJMHDIAFOPRK-UHFFFAOYSA-N 0.000 abstract 1
102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 1
108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 abstract 1
125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
238000002405 diagnostic procedure Methods 0.000 abstract 1
150000002390 heteroarenes Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
230000009834 selective interaction Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
150000003672 ureas Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT06813627T 2005-08-22 2006-08-21 Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung ATE482959T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US71013005P	2005-08-22	2005-08-22
PCT/US2006/032685 WO2007024814A1 (en)	2005-08-22	2006-08-21	HETEROARYL-SUBSTiTUTED DIAZATRICYCLOALKANES, METHODS FOR ITS PREPARATION AND USE THEREOF

Publications (1)

Publication Number	Publication Date
ATE482959T1 true ATE482959T1 (de)	2010-10-15

Family

ID=37508012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06813627T ATE482959T1 (de)	2005-08-22	2006-08-21	Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung

Country Status (17)

Country	Link
US (2)	US7732607B2 (de)
EP (1)	EP1917265B1 (de)
JP (1)	JP2009506037A (de)
KR (1)	KR20080035649A (de)
CN (1)	CN101248073A (de)
AT (1)	ATE482959T1 (de)
AU (1)	AU2006283453A1 (de)
BR (1)	BRPI0614874A2 (de)
CA (1)	CA2618700A1 (de)
DE (1)	DE602006017235D1 (de)
EA (1)	EA014738B1 (de)
IL (1)	IL189204A0 (de)
MX (1)	MX2008002467A (de)
NO (1)	NO20080594L (de)
NZ (1)	NZ565628A (de)
WO (1)	WO2007024814A1 (de)
ZA (1)	ZA200801242B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200840569A (en) *	2007-03-13	2008-10-16	Targacept Inc	Sub-type selective amides of diazabicycloalkanes
SA08290475B1 (ar)	2007-08-02	2013-06-22	Targacept Inc	(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US20100179186A1 (en) *	2008-10-10	2010-07-15	University Of Kentucky Research Foundation	USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS
US20110262407A1 (en) *	2008-11-11	2011-10-27	Targacept, Inc.	Treatment with alpha7 selective ligands
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
ES2708965T3 (es) *	2014-06-13	2019-04-12	Bristol Myers Squibb Co	Compuestos tricíclicos como ligandos del receptor de alfa-7 nicotínico de acetilcolina
CN107438614B (zh) *	2015-04-03	2020-01-31	拜欧蒂姆公司	杂环化合物及它们在预防或治疗细菌感染中的应用
CA2997545C (en) *	2015-09-04	2022-01-11	Janssen Pharmaceutica Nv	Therapeutic compounds for pain and synthesis thereof
US11345681B1 (en)	2020-06-05	2022-05-31	Kinnate Biopharma Inc.	Inhibitors of fibroblast growth factor receptor kinases

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1989000158A1 (en)	1987-07-02	1989-01-12	Pfizer Inc.	Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4922901A (en) *	1988-09-08	1990-05-08	R. J. Reynolds Tobacco Company	Drug delivery articles utilizing electrical energy
US5187166A (en) *	1990-07-31	1993-02-16	Nisshin Flour Milling Co., Ltd.	Azabicyclo derivatives and their use as antiemetics
JP2553020B2 (ja) *	1991-11-07	1996-11-13	吉富製薬株式会社	キヌクリジン化合物およびその医薬用途
US5273972A (en) *	1992-03-26	1993-12-28	A. H. Robins Company, Incorporated	[(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates
IL107184A (en)	1992-10-09	1997-08-14	Abbott Lab	Heterocyclic ether compounds that enhance cognitive function
US5852041A (en) *	1993-04-07	1998-12-22	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acethylcholine receptors
US5493026A (en) *	1993-10-25	1996-02-20	Organix, Inc.	Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
IT1274018B (it) *	1994-02-23	1997-07-14	Riace Ets	Derivati del 3,8-diazabiciclo(3.2.1.)ottano ad attivita' analgesica
GB2295387A (en)	1994-11-23	1996-05-29	Glaxo Inc	Quinazoline antagonists of alpha 1c adrenergic receptors
US5604231A (en) *	1995-01-06	1997-02-18	Smith; Carr J.	Pharmaceutical compositions for prevention and treatment of ulcerative colitis
US5597919A (en) *	1995-01-06	1997-01-28	Dull; Gary M.	Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en)	1995-04-07	1996-12-17	Sibia Neurosciences, Inc.	Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) *	1995-05-17	1996-12-10	Bencherif; Merouane	Pharmaceutical compositions for the treatment of central nervous system disorders
IL118279A (en)	1995-06-07	2006-10-05	Abbott Lab	Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
US5712270A (en) *	1995-11-06	1998-01-27	American Home Products Corporation	2-arylamidothiazole derivatives with CNS activity
US5616716A (en) *	1996-01-06	1997-04-01	Dull; Gary M.	(3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds
SE9600683D0 (sv)	1996-02-23	1996-02-23	Astra Ab	Azabicyclic esters of carbamic acids useful in therapy
AT403803B (de) *	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US5663356A (en) *	1996-04-23	1997-09-02	Ruecroft; Graham	Method for preparation of aryl substituted alefinic secondary amino compounds
US5726189A (en) *	1996-05-03	1998-03-10	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method for imaging nicotinic acetylcholinergic receptors in the brain using radiolabeled pyridyl-7-azabicyclo 2.2.1!heptanes
ZA9711092B (en)	1996-12-11	1999-07-22	Smithkline Beecham Corp	Novel compounds.
AR013184A1 (es)	1997-07-18	2000-12-13	Astrazeneca Ab	Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
EE04588B1 (et)	1997-10-27	2006-02-15	Neurosearch A/S	Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon
US5952339A (en) *	1998-04-02	1999-09-14	Bencherif; Merouane	Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
DK1083889T3 (da)	1998-06-01	2004-04-13	Ortho Mcneil Pharm Inc	Tetrahydronaphthalenforbindelser og deres anvendelse til behandling af neurodegenerative sygdomme
US6310043B1 (en) *	1998-08-07	2001-10-30	Governors Of The University Of Alberta	Treatment of bacterial infections
GB9821503D0 (en) *	1998-10-02	1998-11-25	Novartis Ag	Organic compounds
US6953855B2 (en) *	1998-12-11	2005-10-11	Targacept, Inc.	3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US6734215B2 (en) *	1998-12-16	2004-05-11	University Of South Florida	Exo-S-mecamylamine formulation and use in treatment
AU4980200A (en)	1999-05-27	2000-12-18	Pharmacia & Upjohn Company	Methods and compositions for measuring ion channel conductance
SE9904176D0 (sv)	1999-11-18	1999-11-18	Astra Ab	New use
KR100751981B1 (ko) *	2000-06-27	2007-08-28	라보라토리오스 살바트, 에스.에이.	아릴알킬아민으로부터 유도된 카바메이트
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
WO2002016357A2 (en)	2000-08-18	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
AU2001284645A1 (en)	2000-08-18	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
AU2001282875A1 (en)	2000-08-21	2002-03-04	Pharmacia And Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002016355A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic) acetylcholine receptor ligands
US6599916B2 (en)	2000-08-21	2003-07-29	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
NZ526580A (en)	2000-12-22	2005-04-29	Almirall Prodesfarma Ag	Quinuclidine carbamate derivatives and their use as M3 antagonists
PE20021019A1 (es) *	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos

2006
- 2006-08-21 US US11/465,914 patent/US7732607B2/en not_active Expired - Fee Related
- 2006-08-21 NZ NZ565628A patent/NZ565628A/en unknown
- 2006-08-21 MX MX2008002467A patent/MX2008002467A/es active IP Right Grant
- 2006-08-21 JP JP2008528050A patent/JP2009506037A/ja active Pending
- 2006-08-21 CA CA002618700A patent/CA2618700A1/en not_active Abandoned
- 2006-08-21 AT AT06813627T patent/ATE482959T1/de not_active IP Right Cessation
- 2006-08-21 KR KR1020087004226A patent/KR20080035649A/ko not_active Withdrawn
- 2006-08-21 WO PCT/US2006/032685 patent/WO2007024814A1/en not_active Ceased
- 2006-08-21 EP EP06813627A patent/EP1917265B1/de active Active
- 2006-08-21 CN CNA200680030681XA patent/CN101248073A/zh active Pending
- 2006-08-21 AU AU2006283453A patent/AU2006283453A1/en not_active Abandoned
- 2006-08-21 EA EA200800656A patent/EA014738B1/ru not_active IP Right Cessation
- 2006-08-21 BR BRPI0614874-3A patent/BRPI0614874A2/pt not_active IP Right Cessation
- 2006-08-21 DE DE602006017235T patent/DE602006017235D1/de active Active
2008
- 2008-02-01 NO NO20080594A patent/NO20080594L/no not_active Application Discontinuation
- 2008-02-03 IL IL189204A patent/IL189204A0/en unknown
- 2008-02-05 ZA ZA200801242A patent/ZA200801242B/xx unknown
2010
- 2010-04-07 US US12/755,799 patent/US20100197720A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE602006017235D1 (de)	2010-11-11
CA2618700A1 (en)	2007-03-01
AU2006283453A1 (en)	2007-03-01
US20100197720A1 (en)	2010-08-05
JP2009506037A (ja)	2009-02-12
US20070197579A1 (en)	2007-08-23
BRPI0614874A2 (pt)	2011-04-19
MX2008002467A (es)	2008-04-07
HK1115594A1 (en)	2008-12-05
ZA200801242B (en)	2009-02-25
CN101248073A (zh)	2008-08-20
KR20080035649A (ko)	2008-04-23
EA014738B1 (ru)	2011-02-28
EP1917265B1 (de)	2010-09-29
NZ565628A (en)	2011-03-31
WO2007024814A1 (en)	2007-03-01
IL189204A0 (en)	2009-08-03
EA200800656A1 (ru)	2008-08-29
NO20080594L (no)	2008-05-16
EP1917265A1 (de)	2008-05-07
US7732607B2 (en)	2010-06-08

Legal Events

Date	Code	Title	Description
2011-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
NO20080594L (no)	2008-05-16	Heteroaryl-substituerte diazatricykloalkaner, fremgangsmater for fremstilling og anvendelse derav
EA200971143A1 (ru)	2010-06-30	Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения
NZ612000A (en)	2015-05-29	Bicyclo[3.2.1]octyl amide derivatives and uses of same
EA200700117A1 (ru)	2007-06-29	N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
NO20080475L (no)	2008-04-15	Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
NO20054052D0 (no)	2005-08-31	3-Substituerte 2(Akrylalkyl)-1-Azabicycloalkaner og deres anvendelse.
EA200701036A1 (ru)	2007-12-28	Лактамные соединения и их применение в качестве фармацевтических препаратов
GEP20156351B (en)	2015-08-25	Glucagon receptor modulator
BRPI0418939A (pt)	2008-04-08	derivados de nicotinamida e sua utilização como agentes terapêuticos
ATE489088T1 (de)	2010-12-15	N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration
TW200740773A (en)	2007-11-01	Diaminopyrimidines as P2X3 and P2X2/3 modulators
ATE503754T1 (de)	2011-04-15	1h-indol-3-carbonsäure-chinuclidin-4- ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit
MX2010009922A (es)	2010-09-28	Activadores de piridazinona glucocinasa.
MXPA05011739A (es)	2006-01-26	Derivados de quinuclidina que se enlazan con los receptores muscarinicos m3.
BR112014023384A8 (pt)	2018-01-16	inibidores de bace espirocíclicos de di-hidro-tiazina e di-hidro-oxazina, e composições e usos dos mesmos.
ECSP088326A (es)	2008-04-28	Derivados de benzotiazol ciclobutil amina y su uso como ligandos de los receptores 3 de histamina
ATE502675T1 (de)	2011-04-15	Verbindungen, die den ampa-rezeptor verstärken, und deren anwendung in der medizin
JO2749B1 (en)	2014-03-15	Indole-2-Wen derivatives bilaterally substituted at position 3, their preparation and therapeutic application
MX2010009756A (es)	2010-10-15	Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y proceso para preparacion de los mismos.
ATE521609T1 (de)	2011-09-15	Aminothiazolylpyrimidinderivate und ihre verwendung bei der behandlung von krebs
MX2009013197A (es)	2010-04-27	Derivados terapeuticos de pirazolonaftiridina.
ATE525359T1 (de)	2011-10-15	Modulatoren der aktivität des glucokortikoidrezeptors von ap-1 und/oder von nf- kb und anwendung davon
ATE541839T1 (de)	2012-02-15	Pyrrolidiniumderivate als m3-muskarinische rezeptoren
EA200870223A1 (ru)	2009-02-27	Производные бензоизоиндола для лечения боли
JOP20250092A1 (ar)	2025-04-27	مشتقات بيرازين-كاربوكساميد المستبدلة الجديدة